Fig. 7
From: Pre-hyperglycemia immune cell trafficking underlies subclinical diabetic cataractogenesis
Diabetic cataractogenesis precedes hyperglycemia. A In female and male NGRs RBG significantly increased with transition from the dotted ring stage to the subsequent types of cataracts (ASC, PSC, cortical) (n = 56 animals). B Percentage of female (n = 16) and male (n = 17) NGRs that developed the hyper-reflective microlesions during normoglycemia. C Averaged blood glucose values as measured in OGTT in animals with different stages of cataract formations (n = 28). D AUC0′–240′ for blood glucose was significantly higher in animals with early cataracts and advanced cataracts compared to animals with clear lens. E As opposed to AUC0′–60′, the AUC60′–240′ for blood glucose was significantly higher in the dotted ring stages, when compared with animals with clear lenses. F Average insulin values in OGTT showed distinct insulin response patterns to glucose at different cataract stages. Insulin data showed a biphasic insulin response in the dotted ring stage (n = 28). G Representative graphs from OGTT experiments show blood glucose and plasma insulin measurements in different stages of cataract progression