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Fig. 6 | Journal of Biomedical Science

Fig. 6

From: The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis

Fig. 6

Inverse correlation between pHSP27 and Smurf2 in lung tissues of RIPF and IPF patients. A Analysis of smurf2 mRNA expression level in healthy human lung tissues (n = 98) and lung tissues of IPF patients (n = 102), analyzed using the GSE150910 dataset (upper). Analysis of relative mRNA of smurf2 level in healthy human lung tissues (n = 6) and in lung tissues of patients with early (n = 8) and advanced (n = 9) IPF using GSE24206 data (bottom) (mean ± SD). *P < 0.05, **P < 0.01, and ***P < 0.001 vs. control. B Sections from human RIPF tissues were stained for Smurf2 (green), pHSP27 (red), and α-SMA (violet). Representative images of each specimen are shown. The data from 6 specimens are quantitated. The graph shows the intensity of co-localization of Smurf2 (green) and pHSP27 (red) or pHSP27 (red) and α-SMA (violet) in fibrotic areas from 30 independent views in each sample. Magnification, 400 × . Scale bar, 20 μm. C Sections from human control and IPF tissues were stained for Smurf2 (green), pHSP27 (Red), and α-SMA (violet). Representative images of each specimen are shown. The data from 16 specimens are quantitated. The graph shows the intensity of co-localization of Smurf2 (green) and pHSP27 (red) or pHSP27 (red) and α-SMA (violet) in fibrotic areas from 30 independent views in each sample (n = 24). Magnification, 400 × . Scale bar, 20 μm. **P < 0.01, and ***P < 0.001 vs. Non-IR or normal

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