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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites

Fig. 2

Single nucleotide variants contribute to different splice signals of M transcripts in human influenza A viruses (IAVs). a Alignment of the M segment of six IAV strains depicting different splice signals (underlined) in H1N1 and H3N2. The 55C to T and 740G to A variants are highlighted in black boxes. b WEBLOGO plots of the splice donor (SD; 5′ splice site; 5′ SS) and splice acceptor (SA; 3′ SS) of the M segment. The height of each base represents its frequency at a given position within the M sequences. The arrow indicates the position of the 5′ SS and 3′ SS in the SD and SA sites, respectively. Splice site strength was calculated by MaxEntScan (5′: 9 bp, − 3 to + 6; 3′: 23 bp, − 20 to + 3). c Frequency of sequences containing 55T/C and 740A/G in human, avian, and swine IAVs. The y axis of each panel represents the number of isolates containing the annotated nucleotide. d Percentage of the viral subtypes containing the annotated nucleotide. e Yearly distribution plot of 55T and 740A containing sequences of the human H3N2 subtype. The percentage is based on the M sequences of the H3N2 virus

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