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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites

Fig. 4

Phylogenetic analysis of influenza A virus (IAV) M segments. A phylogenetic tree was constructed based on (a) M segments of human IAV, (b) M2 coding sequences of human IAV, and (c) M sequences of avian and swine IAV, and human H1N1 and H3N2. a The enlarged box shows the details regarding H3N2 emergence (purple circles) among sequences collected before 1970. The single nucleotide variations (SNVs) carried by each strain are denoted in the right-hand column. Orange and yellow arrow heads indicate the first incidence of the 55C to T and 740G to A switches, respectively. c The 55T-type isolates were selected from (a) (M/55T in H3N2 and H1N1 isolates). All sequences were aligned using MAFFT and analyzed using BEAST and TreeAnnotator [50]

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Journal of Biomedical Science

ISSN: 1423-0127