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Table 2 Comparison of average IC50 values and potency of polysaccharides to inhibit TpsA-NT-HAD binding to porcine gastric mucin type III obtained by ELISA

From: Marine prebiotics mediate decolonization of Pseudomonas aeruginosa from gut by inhibiting secreted virulence factor interactions with mucins and enriching Bacteroides population

Inhibitors

IC50

average µg/mL

Range (µg/mL)

SD

Potency vs

Porcine Gastric Mucin = 1

Chondroitin sulfate = 1

Dextrans

     

 Dextran sulfate-500 kDa

0.018

0.001–0.066

0.021

1892.000

25,909.536

 Dextran sulfate 6–11 kDa

0.194

0.046–0.962

0.242

171.926

2354.401

 Dextran 450 kDa

NSI

NSI

NSI

NSI

NSI

 Dextran 9–10 kDa

NSI

NSI

NSI

NSI

NSI

Fucoidans and mucin

     

 Macrosystis pyrifera

0.277

0.113–0.423

0.096

120.529

1650.556

 Undaria pinnatifada

0.430

0.183–9.77

0.252

77.600

1062.674

 Fucus vesiculosus crude

0.491

0.111–1.54

0.318

67.947

930.479

 Ascophyllum nodusum nutri. 0.5%

0.736

0.405–1.29

0.335

45.352

621.067

 A. nodusum + L. digitata (PS-II)

0.764

0.113–0.423

0.096

43.649

597.734

 Fucus vesiculosus 95%

1.008

0.21–2.797

0.760

33.107

453.375

 κ-carrageenan

1.101

0.667–1.883

0.390

30.301

414.948

 Fucus serratus

1.520

0.203–3.099

0.796

21.954

300.648

 F. vesiculosus HCl 10′ 30 kDa

1.690

0.1–2.828

0.685

19.749

270.443

 F. vesiculosus Aus. 30 kDa

2.547

0.656–7.066

0.501

13.100

179.396

 F. vesiculosus—nutri. 0.5%

2.924

0.331–9.67

3.908

11.411

156.262

 F. vesiculosus HCl 10' mix

5.468

3.215–5.215

1.520

6.102

83.568

 Laminaria digitata

5.593

0.227–21.0

5.983

5.966

81.698

 L. japonica

21.103

9.67–44.447

9.806

1.581

21.654

 Porcine Gastric Mucin Type III

33.368

10.156–75.117

15.115

1.000

13.694

 A. nodusum

39.886

7.51–71.197

18.179

0.837

11.456

 F. vesiculosus HCl 60′ 30 kDa

59.022

13.92–113.723

34.505

0.565

7.742

 F. vesiculosus HCl 60' mix

68.958

48.184–86.822

23.351

0.484

6.627

 l-Fucose, d-Fucose, Fuc-BSA, methyl-b-Fuc, methyl-a-Fuc

NSI

NSI

NSI

NSI

NSI

Glycosaminoglycans

     

 Chondroitin sulfate-Sigma

456.950

369.911–674.852

87.803

0.073

1.000

 Heparin, heparan sulfate, keratan sulfate

NSI

NSI

NSI

NSI

NSI

Alginates

     

 A. nodusum alginate

3.587

1.243–7.81

2.210

9.301

127.375

 Alginic acid

4.931

0.975–13.49

5.053

6.767

92.665

 L. japonica alginate

34.228

15.439–55.329

11.284

0.975

13.350

 Azotobacter spp. alginate

NSI

NSI

NSI

NSI

NSI

Others

     

 Lotus lectin (LTL)

17.564

13.943–27.717

8.408

3.968

26.015

 Sambucus Nigra lectin (SNA)

52.924

42.695–631.54

14,466

2.306

8.633

 Concanavalin A lectin (ConA)

140.943

79.19–237.597

84.774

0.393

3.242

 Blood Group Lewis-B

471.548

7.919–23.760

60.393

0.552

0.969

  1. NSI: no significant inhibition (IC50 > 1000 µg/mL); Fuc: fucose, nutri.: nutritional grade fucoidan. The IC50 values were estimated by using a free online program from AAT Bioquest (https://www.aatbio.com/tools/ic50-calculator)