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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking

Fig. 4

RRBP1 deficiency increases renin accumulation in ER. A Protocol to stimulate renin trafficking in control and RRBP1 knockdown cells. B–E Representative confocal microscopy images of control and RRBP1 knockdown Calu-6 cells showing renin (green), calnexin (red), and DAPI (blue) after 50 µM of forskolin induction for 0, 60, 120, and 180 min. F Overlap coefficients of renin (green) and calnexin (red) in control and RRBP1 knockdown Calu-6 cells after 50 µM of forskolin induction for 0, 60, 120, and 180 min (n = 8 per group). Data in (F) were analyzed with an unpaired, two-tailed Student’s t-test. Data are represented as mean ± SEM. ns, no significance; *P < 0.05

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