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Table 3 Plasma and urine electrolyte levels in Rrbp1-WT and Rrbp1-KO mice under high K+ intake

From: ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking

Genotype (n)

Rrbp1-WT (n = 21)

Rrbp1-KO (n = 16)

Blood

[K+], mmol/L

7.23 ± 0.27

8.53 ± 0.38 †

[Na+], mmol/L

157.7 ± 1.32

155.9 ± 1.62

[Cl−], mmol/L

122.6 ± 1.61

123.4 ± 2.03

Urine

TTKG

18.4 ± 1.0

14.6 ± 0.8 †

FEK+

64.8 ± 6.7

43.1 ± 4.0 ‡

FENa+

0.42 ± 0.05

0.42 ± 0.04

FECl−

3.24 ± 0.33

2.63 ± 0.27

  1. TTKG, transtubular potassium gradient; FE, fractional excretion
  2. †P < 0.01, ‡P < 0.001 Rrbp1-KO (knock-out) vs. Rrbp1-WT (wild-type)
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Journal of Biomedical Science

ISSN: 1423-0127