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Table 4 Plasma and urine electrolyte levels in Rrbp1-WT and Rrbp1-KO mice under high K+ intake for 48 h with and without fludrocortisone treatment

From: ER ribosomal-binding protein 1 regulates blood pressure and potassium homeostasis by modulating intracellular renin trafficking

Genotype + treatment (n)

Rrbp1-WT + saline (n = 22)

Rrbp1-KO + saline (n = 27)

Rrbp1-KO + Fludrocortisone (n = 18)

Blood

[K+], mmol/L

7.49 ± 0.10

8.19 ± 0.14 ‡

7.73 ± 0.16

[Na+], mmol/L

161.5 ± 1.10

163.6 ± 0.72

161.6 ± 0.88

[Cl−], mmol/L

124.6 ± 0.99

127.1 ± 0.77

124.6 ± 1.35

Urine

TTKG

29.9 ± 1.1

30.2 ± 1.3

30.6 ± 1.6

FEK+

25.3 ± 3.4

27.8 ± 2.9

20.9 ± 3.6

FENa+

0.62 ± 0.09

0.65 ± 0.06

0.48 ± 0.07

FECl−

1.15 ± 0.17

1.39 ± 0.15

0.98 ± 0.15

  1. TTKG, transtubular potassium gradient; FE, fractional excretion
  2. ‡P < 0.001 Rrbp1-KO (knock-out) vs. Rrbp1-WT (wild-type)
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Journal of Biomedical Science

ISSN: 1423-0127