Fig. 2From: Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injuryTFBP, TFNBP and IMiD drug docking pockets in chain C of human cereblon with the binding scores. (A) Determination of pockets for IMiD interactions within chain C of human cereblon showed the top 3 pharmacophores with their attributes (A1), with the pocket #1 (A, B, yellow circles) for binding the classic IMiDs thalidomide and pomalidomide (B, B1, B2). (C) The compounds TFNBP and TFBP docked with a lesser predicted preference at pocket #1 with scores (C-arrows and green strips) that demonstrated a substantially lower affinity than thalidomide and pomalidomide, which docked at pocket #1 with greatest preference and a higher binding affinity and associated Vina scores (B-green strips in insets). The binding pocket preferences and Vina scores of TFNBP and TFBP reflect a poor interaction probability of these compounds within the classic thalidomide binding pharmacophore (pocket #1)Back to article page