Fig. 6

TFBP significantly decreased cortical lesion volume in CCI-challenged mice. CCI animals show loss of cortical tissue near the lesion site (A), as well as an enlargement of the lateral ventricle size. Treatment with TFBP (16.25 mg/kg and 32.5 mg/kg, i.p.) significantly reduced lesion volume induced by TBI; a similar trend is noticeable for the lateral ventricle size, although this does not reach statistical significance (B). Representative images of Giemsa-stained cortical sections (C). *p < 0.05, ****p < 0.0001 vs control; #p < 0.05 vs CCI). ‘N value of animals’ shown at the base of each bar within brackets