Table 1 Oncogenic role of ETV5 in various cancer

Bladder cancer

–

Proliferation

Positively correlated to TAZ

[112]

Breast cancer

–

EMT

Positively correlated to HER2, EGFR and histoprognostic grading

Correlation with poor overall survival; a prognostic factor on overall survival in lymph node-positive patients

[18, 25, 127]

Chondrosarcoma

High expression in 105KC cell line

Bone resorption

–

[136]

Colorectal cancer

High expression in tumor tissues and TCGA and GEO dataset

High expression in distal region of stage II/III colon cancer tissues

Proliferation, cell-cycle, angiogenesis, and drug resistance

Positively correlation to PDGF-BB, VEGFA and CCL2; negatively correlated to p21

Correlation with poor overall survival and disease-free survival

[16, 143, 146, 153]

Endometrial carcinomas

High expression in FIGO stage IB

High expression at the invasive front of tumor tissues

EMT, migration, invasion, adhesion, oxidative stress

Positively correlation to NID1 in endometrial tumors; positively correlation to NID1 and NUPR1 at the invasion front of endometrial tumors

[17, 21]

Endometrioid endometrial carcinomas

High expression, especially in IA stage

Neoplastic transformation

–

[19, 26]

Esophageal squamous cell carcinoma

High expression in tumor tissues and TCGA and GEO dataset

Adhesion, migration, invasion

Correlation with poor overall survival and progression free survival

[22]

Gastric cancer

–

Migration, invasion

–

[15]

Glioblastoma

High expression in tumor tissues

Proliferation

Correlation with poor overall survival

[117, 122]

Oligodendrogliomas with CIC-mutant

High expression in tumor tissues and TCGA dataset

–

–

[118]

Lung cancer

–

Migration, invasion, tumor initiation

–

[13, 15]

Neuroblastoma

–

Proliferation, migration and invasion

Correlation with poor overall survival and progression free survival

[114, 115]

Ovarian cancer

High expression in tumor tissues

Cell-cycle, migration, invasion, angiogenesis and oxidative stress

Positively correlation to E-cadherin

[144, 147]

High-grade serous ovarian cancer

High expression in tumor tissues and cell lines

Proliferation, migration and invasion

Positively correlation to lncRNA CTBP1-DT and MAP3K3; correlation with poor overall survival and disease-free survival; have a prognostic value with recurrence and FIGO stage

[23]

Prostate cancer

–

Proliferation, migration, invasion

–

[128]

Synovial sarcoma

High expression in tumor tissues

Cell-cycle, chromatin structure

–

[38]

Thyroid cancer

High expression in tumor tissues and TCGA and GEPIA dataset

Proliferation, migration, invasion

Positively correlation to PIK3CA

[24, 34]