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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: PES1 reduces CD8+ T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma

Fig. 1

The expression of PES1 is upregulated and negatively correlated with CD8+ CTL infiltration in ESCC. A Data sources used in study and the process of gene screening. B, C Correlations between the expression of PES1 and the expression of CD8A and CD8B. Correlation was estimated using TCGA_ESCC data. D IHC staining of PES1 in ESCC tumor and paired nontumor tissues. Scale Bar = 100 μm. E Scatter diagram of PES1 staining score in the tissue of the 60 paired ESCC samples. ***p < 0.001. F Kaplan–Meier analysis of overall survival of tissue microarray (TMA) data containing 230 patients. G–I The expression of PES1 and CD8 in the ESCC tissue array examined and scored by IHC. The representative images from Cohort 230 were shown in panel G and the Pearson correlations between their expressions were shown in panel H for Cohort 230 and panel I for Cohort 60. Scale Bar = 200 μm (upper) and 50 μm (lower)

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Journal of Biomedical Science

ISSN: 1423-0127