Skip to main content
Fig. 3 | Journal of Biomedical Science

Fig. 3

From: PES1 reduces CD8+ T cell infiltration and immunotherapy sensitivity via interrupting ILF3-IL15 complex in esophageal squamous cell carcinoma

Fig. 3

Knockdown of PES1 inhibits the expression of IL15. A Volcano map showing the up and down genes in shPES1 and SCR KYSE150 cells. B The process of screening the immune related genes. The immune related genes were from TIMER2.0 database. The correlation between IL15 and CD8 using TCGA database of esophageal cancer. C–E The expression of IL15 and CD8 in the ESCC tissue array was examined by IHC and scored. The representative images were shown in (C), and the correlations between their expression were analyzed (D, E). Scale Bar = 200 μm (upper) and 50 μm (lower). F–G Effect of PES1 knockdown on IL15 transcription in KYSE150 (F) and AKR (G) cells (n = 3 independent experiments). *p < 0.05. H Correlation between PES1 expression and IL15 expression in TCGA_ESCC database. I, J Correlation between PES1 expression and IL15 expression in the ESCC tissue array. The representative IHC images were shown in (I), and the correlations between their expression were analyzed (J). Scale Bar = 200 μm (upper) and 50 μm (lower)

Back to article page