Fig. 4

PES1 inhibits T cell infiltration by weakened the expression of IL15. A The representative image of subcutaneous tumors in indicated group. B, C Tumor growth curves B and tumor weight C of the indicated groups (n = 6 mice per group). Statistical analysis by t test: *p < 0.05; **p < 0.01. D HE and IHC were performed to examine the tumor area and detect the expression of CD3, CD8, and GZMB. Scale bar = 100 μm. E–G The CD3 + T cells (E), CD8 + T cells (F), GZMB + CD8 + T cells G were quantified. n = 6. Data shown as mean ± SD, statistical analysis by t test: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001