Fig. 1

Evaluating the senescence status of individual cell types in the tumor environment. Unified manifold approximation and projection (UMAP) plots show integrated datasets of clusters and cluster cell type annotations from 5 scRNAseq datasets of different tumor entities (A–E, left). Feature plots show the enrichment of senescence-related gene sets per cell in pseudocolors (A–E, middle). Ridge plots (A–E, right) show the distribution of the senescence score across cell clusters; CAF cancer-associated fibroblast, TEC tumor endothelial cells, HPC hepatic progenitor cells