Fig. 6

Integrative analysis of cellular signatures and transcriptional profiles in cases progressing to DF or DHF. A Chord diagram integrating associations between DF signature genes, immune cell populations and chemokine responses. Blue lines within the chord diagram represent positive correlations between two variables, while red lines represent negative correlations. (Benjamini-Hochberg adjusted Spearman’s Rho, FDR < 5%). B Chord diagram integrating associations between DHF signature genes, immune cell populations and chemokine responses. Blue lines within the chord diagram represent positive correlations between two variables, while red lines represent negative correlations. (Benjamini-Hochberg adjusted Spearman’s Rho, FDR < 5%). C Hierarchical clustering heatmap of genes predicted to be under the control of upstream regulators MYC and FOXM1 amongst patients progressing to DF or DHF. D Bar plots showing significantly enriched GO terms scaled by Log10(P-value) for genes in heatmap in C. E Hierarchical clustering heatmap of genes predicted to be under the control of upstream regulators CD3, CD28 and CD40 amongst patients progressing to DF or DHF. F Bar plots showing significantly enriched GO terms scaled by Log10(P-value) for genes in heatmap in E. Red GO terms are upregulated and blue GO terms are downregulated in DHF compared with DF. G Hierarchical clustering heatmap of genes predicted to be under the control of upstream regulators NONO, IFNA2 and IFNAR amongst patients progressing to DF or DHF. H Bar plots showing significantly enriched GO terms scaled by Log10(P-value) for genes in heatmap in G