Fig. 6
From: A tumor microenvironment-based prognostic index for osteosarcoma
Molecular characteristics of the TMEindex. A, B GSEA enrichment plots base on HALLMARK gene set showing the relatively enriched pathways in TMEindex-high (A) and TMEindex-low (B) groups. C Differences in different signatures (immune relevant signature, mismatch repair relevant signature, and stromal relevant signature as indicated) between TMEindex-high and TMEindex-low groups. The upper and lower ends of the boxes represented interquartile range of values. The lines in the boxes represented median value, and black dots showed outliers. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. D Correlations between TMEindex and known core biological processes signature scores. E Correlations between TMEindex and immune activation-relevant genes expression. F Correlations between TMEindex and immune-checkpoint-relevant genes expression. G Correlations between TMEindex and TGFβ/EMT pathway-relevant genes expression. Correlation coefficients are calculated by Spearman’s correlation analysis, with red representing negative correlations and blue representing positive correlations. Blank represents a correlation P-value > 0.05