Skip to main content

Tabel 1 The host range of representative endolysins

From: Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria

Endolysin and/or derivative

Origin

The number of tested strains

The number of lysed strains

Host range

References

SAL200

Staphylococcal phage SAP-1

425

425

100%

[61]

Exebacase (CF-301 or PlySs2)

Prophage of Streptococcus suis

477

365

77%

[62]

P128

CHAP domain (TAME phage K) + SH3b (lysostaphin)

62

62

100%

[63]

Staphefekt SA.100

M23 endopeptidase (lysostaphin) + Amidase (Ply2638) + SH3b (Ply2638)

11

10

91%

[64]

XZ.700

Staphefekt SA.100 deleted 44 amino acids region

120

107

89%

[64]

LysK

Staphylococcal phage K

27

18

67%

[65]

CHAPK (truncated LysK)

Staphylococcal phage K

31

28

90%

[66]

ClyF

CD domain (Ply187) + CBD domain (PlySs2)

51

45

88%

[22]

LysGH15

Staphylococcal phage GH15

57

52

91%

[67]

LysH5

Staphylococcal phage PhiH5

90

77

86%

[68]

Pal

Streptococcal phage Dp-1

25

19

76%

[16]

Cpl-1

Streptococcal phage Cp-1

27

22

81%

[69]

PlyG

B. anthracis γ-phage

27

16

59%

[24]

  1. TAME tail-associated muralytic enzymes, CHAP cysteine- and histidine-dependent aminopeptidase/hydrolase, CD catalytic domain, CBD cell wall-binding domain