Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria

Liu, He; Hu, Zhen; Li, Mengyang; Yang, Yi; Lu, Shuguang; Rao, Xiancai

doi:10.1186/s12929-023-00919-1

Journal of Biomedical Science

Table 3 Endolysins and related derivatives active against G⁺ bacteria

From: Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria

Endolysin and/or derivative	Phage	Antimicrobial spectrum	Enzymatic activity	Type of infection treated in vivo	Clinical trial phase	Clinical trials identifier/accession No	References
SAL200	SAP-1	S. aureus	Amidase and endopeptidase	Bacteremia	IIa	NCT03089697	[61]
Exebacase (CF-301 or PlySs2)	Prophage of S. suis	S. aureus, Streptococcus	Peptidase	Bacteremia	III	NCT04160468	[28, 62]
P128	CHAP domain (TAME phage K) + SH3b (lysostaphin)	S. aureus	CHAP	Bacteremia	II	NCT01746654	[96,97,98]
Staphefekt SA.100	M23 endopeptidase (lysostaphin) + Amidase (Ply2638) + SH3b (Ply2638)	S. aureus	Amidase and endopeptidase	Atopic dermatitis	I/II	NCT02840955	[64, 99]
Medolysin®	–	S. aureus	–	Bacterial wound infections	–	–	[100]
XZ.700	Staphefekt SA.100 deleted 44 amino acids region deleted	S. aureus	Amidase and endopeptidase	Skin infection	Pre-clinical	–	[64]
MV-L	MR11	S. aureus, S. simulans	Amidase and endopeptidase	Nares infection, sepsis	Pre-clinical	BAF33253	[81]
LysP108	P108	S. aureus	Amidase	Subcutaneous abscess	Pre-clinical	YP_009099525	[17]
80α	phi80α	S. aureus	Amidase and endopeptidase	Systemic infection	Pre-clinical	ABF71642	[101]
phi11	phi11	S. aureus	Amidase and endopeptidase	Systemic infection	Pre-clinical	YP_500516	[101]
LysK	K	S. aureus	Amidase and endopeptidase	Systemic infection	Pre-clinical	YP_024461	[101]
Ply2638	2638A	S. aureus	Amidase and endopeptidase	Systemic infection	Pre-clinical	AAX90995	[101]
Twort	Twort	S. aureus	Amidase and endopeptidase	Systemic infection	Pre-clinical	AAX92311	[101]
phiSH2	phiSH2 prophage	S. aureus	Amidase and endopeptidase	Systemic infection	Pre-clinical	BAE05642	[101]
LysWMY	phiWMY	S. aureus	Amidase and endopeptidase	Systemic infection	Pre-clinical	BAD83402	[101]
CHAP_K	K	S. aureus	Endopeptidase	Nasal infection	Pre-clinical	4CT3_D	[18, 102]
ClyF	CD domain (Ply187) + CBD domain (PlySs2)	S. aureus	CHAP	Bacteremia and burn wound infection	Pre-clinical	-	[22]
LysSS	SS3e	S. aureus, Salmonella, Escherichia coli	–	Systemic infection	Pre-clinical	AAW51228	[103]
Ply6A3	PD-6A3	Acinetobacter baumannii, E. coli, S. aureus	–	Sepsis	Pre-clinical	ALM01856	[104]
gp144	ΦKZ	Pseudomonas aeruginosa, S. aureus, E. coli, B. cereus	Transglycosylase	–	–	AAL83045	[105]
LysGH15	GH15	Staphylococcus	Amidase and CHAP	Bacteremia	Pre-clinical	ADG26756	[26, 67, 106, 107]
PlyGRCS	GRCS	S. aureus, S. epidermidis	Endopeptidase	–	–	AHJ10590	[19]
ClyH	CD domain (Ply187) + non-SH3b (phiNM3)	S. aureus	Amidase	Intraperitoneal infection	Pre-clinical	–	[108]
MR-10	MR-10	S. aureus	–	Subcutaneous	Pre-clinical	–	[109, 110]
LysH5	PhiH5	S. aureus, S. epidermidis	Amidase and endopeptidase	–	–	ACE77796	[59, 68]
ClyS	CD domain (Twort) + CBD domain (phiNM3)	S. aureus	Endopeptidase	Intraperitoneal, nasal and skin infection	Pre-clinical	–	[73, 78]
ClyC	CD domain (Ply187) + CBD domain (LysSA97)	S. aureus	–	Bacteremia	Pre-clinical	–	[38]
Lys16	P68	S. aureus	CHAP	–	–	AAO83890	[101, 111]
LysSAP33	SAP33	S. aureus	CHAP	–	–	QDH45454	[42]
Pal	Dp-1	S. pneumoniae	Amidase	Nasopharyngeal infection	Pre-clinical	O03979	[16]
Cpl-1	Cp1	S. pneumoniae	Muramidase	Endocarditis, bacteremia, pneumonia, meningitis	Pre-clinical	NP_044837	[69, 112,113,114]
Cpl-7	CP-7	S. pneumoniae, S. pyogenes, E. faecalis	Muramidase	Embryo infection	Pre-clinical	P19385	[115, 116]
Cpl-711	CD domain (Cpl-7) + CBD domain (Cpl-1)	S. pneumoniae	Muramidase	Bacteraemia	Pre-clinical	–	[117]
PL3	CD domain (Cpl-7) + CBD domain (LytA)	S. pneumoniae	Amidase	Embryo infection	Pre-clinical	–	[118]
ClyJ	CD domain (PlyC) + CBD domain (SPSL1)	S. pneumoniae	CHAP	Bacteraemia	Pre-clinical	–	[119]
ClyJ-3	ClyJ variant	S. pneumoniae	CHAP	Bacteraemia	Pre-clinical	–	[120]
ClyJ-3 m	ClyJ-3 variant	S. pneumoniae	CHAP	Bacteraemia	Pre-clinical	–	[121]
23TH_48	23TH	S. pneumoniae	Amidase	–	–	QOI69927	[122]
MSlys	MS1	S. pneumoniae	Amidase	–	–	AQY55407	[123]
PlyC	C1	S. pyogenes	Amidase	Mucosal epithelium infection	Pre-clinical	AAP42310	[76]
PlyPy	MGAS5005 prophage	S. pyogenes	Endopeptidase	Bacteremia	Pre-clinical	AAM79913	[124]
PlyGBS	NCTC11261	Group B streptococci, S. agalactiae	Endopeptidase and muramidase	Vaginal and oropharynx infection	Pre-clinical	AAR99416	[74, 125]
PlySK1249	SK1249 prophage	S. agalactiae, Streptococcus dysgalactiae	Amidase and endopeptidase	Bacteremia	Pre-clinical	EGL49245	[126]
PlyG	γ-phage	B. anthracis, B. cereus	Amidase	Intraperitoneal infection	Pre-clinical	PFW40491	[24]
PlyPH	B. anthracis BA2805 genome	B. anthracis, B. cereus	–	Intraperitoneal infection	Pre-clinical	WP_098639153	[127]
LysPBC2	PBC2	B. cereus	Amidase	–	–	AKQ08512	[128]
PlyV12	Φ1	E. faecalis, E. faecium	Amidase	–	–	YP_009814814	[70]
LysEFm5	IME-EFm5	E. faecium	Amidase	–	–	YP_009200901	[129]
LysIME-EF1	IME-EF1	E. faecalis	Endopeptidase	Intraperitoneal infection	Pre-clinical	YP_009042672	[126]
LysEF-P10	EF-P10	E. faecalis	Endopeptidase	Balance of the gut microbiota	Pre-clinical	AQT27695	[130]
Ply3626	phi3626	C. perfringens	Amidase	–	–	NP_612849	[131]
Psa	St13	C. perfringens	Amidase	–	–	WP_011010276	[132]

–, unknown or data not available

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ISSN: 1423-0127

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