Fig. 6From: Degradation of neurodegenerative disease-associated TDP-43 aggregates and oligomers via a proteolysis-targeting chimeraA schematic summary of the results. PROTAC 2 reduced C-TDP-43 aggregation and oligomerization, increased viability in the cell model, and improved the motility of the neuronal C-TDP-43 transgenic C. elegansBack to article page