Fig. 4
From: The biology of SCUBE
SCUBE2 is essential for controlling IHH signaling during endochondral ossification. SCUBE2 protein is expressed in peri-chondrial cells and may be secreted (dashed line with arrow). This secreted SCUBE2 could modulate IHH signals derived from pre-hypertrophic chondrocytes (solid line with arrow) by promoting the release and mobilization of IHH, which drives differentiation into osteoblasts during endochondral bone formation. Green arrow indicates the differentiation direction toward hypertrophic chondrocytes within endochondral bone. IHH Indian hedgehog