Fig. 7
From: The biology of SCUBE
SCUBE2 functions as a tumor suppressor, preventing the migration and invasion of breast cancer cells by reversing epithelial-mesenchymal transition (EMT). By promoting the expression of forkhead box A1, an E-cadherin positive regulator, and subsequent transactivation of E-cadherin, SCUBE2 increases the formation of E-cadherin-containing adherens junctions. This process causes breast cancer cells to undergo epithelial transition by reversing EMT. During EMT, SCUBE2 is epigenetically silenced by binding of DNA methyltransferase 1 at its CpG islands