From: The biology of SCUBE
Stage | Scube1 | Scube2 | Scube3 |
---|---|---|---|
E8.5 | Ventral forebrain | Â | Â |
E9.5 | Ventral neural tube; head mesenchyme; mesenchyme of the first pharyngeal arch derivatives; limb buds | Forebrain: posterior telencephalon and the entire diencephalon, neuroepithelium of the optic cup; midbrain; hindbrain; spinal cord; rhombomere 5 and 6 | Epithelium of early facial region (the first and second branchial arches, medial and lateral nasal process and otic vesicle); limb bud; neural tube |
E10.5 | Limb buds; infundibulum; derma myotome (somites); ventral neural tube; epithelium of Rathke’s pouch; trigeminal ganglion; lung bud; head mesenchyme; proximal mesenchyme of the second pharyngeal arch; early odontogenic mesenchyme of the maxillary and mandibular processes | Forebrain: telencephalic vesicle, optic cup; midbrain; hindbrain; spinal cord | Epithelium of the nasal pits and facial processes; midline of the frontonasal and maxillary processes; epithelium of otic vesicle and apical ectodermal ridge of the limb bud |
E11.5 | Neuroepithelium of the telencephalon; mesenchyme of the medial and lateral nasal processes; maxillary and mandibular process of the first pharyngeal arch; mesenchyme of the second and third pharyngeal arches | Forebrain: telencephalic vesicle, optic cup; midbrain; hindbrain; spinal cord; in the wall of 3rd ventricle; central canal | Epithelium of the fusing facial processes; otic vesicle; apical ectodermal ridge; ventral neural tube; ventral and dorsal dermomyotome |
E12.5 | Â | Dorsal neural tube; dorsal diencephalon; wall of 4th ventricle; cartilage primordium of basioccipital bone and developing cervical vertebrae | Optic eminence; external nares; lip philtrum; vibrissae; developing incisor and molar tooth buds of the maxilla and mandible; epithelium of palatine processes |
E13.5– E15.5 | Mesenchyme of the nasal cavity; tongue root; periocular region; not In palatal shelves; mesenchyme surrounding the tooth buds; condensing mesenchyme of the dental papilla (E14.0) | Heart (ventricular tissue and major blood vessel); peripheral region of cartilaginous condensations of the axial skeleton; roof of 3rd ventricle; nasal septum; tongue mesoderm; genioglossus muscle | Medial epithelium seam between the palatal shelves; developing teeth of the maxilla and mandible; early tooth bud epithelium, within the cap, staining was predominant in the enamel knot, internal and external enamel epithelium; at the bell stage, activity was seen throughout the differentiated cell populations within the enamel organ, including pre-ameloblasts and stellate reticulum; in the vibrissae, expression was seen in the dermal papilla, outer root sheath, and hair matrix; in the eye, expression was seen in the lens fibers, blood vessels of the hyaloid cavity, and in the neural layer of the retina; in E15.5, cartilaginous condensations of the peripheral skeleton, including the ribs, limbs and vertebra; the glomerular apparatus of the kidney |