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Table 3 Embryonic expression profiles of mouse Scube genes

From: The biology of SCUBE

Stage

Scube1

[1, 52]

Scube2

[3, 126]

Scube3

[129, 162, 163, 165]

E8.5

Ventral forebrain

  

E9.5

Ventral neural tube; head mesenchyme; mesenchyme of the first pharyngeal arch derivatives; limb buds

Forebrain: posterior telencephalon and the entire diencephalon, neuroepithelium of the optic cup; midbrain; hindbrain; spinal cord; rhombomere 5 and 6

Epithelium of early facial region (the first and second branchial arches, medial and lateral nasal process and otic vesicle); limb bud; neural tube

E10.5

Limb buds; infundibulum; derma myotome (somites); ventral neural tube; epithelium of Rathke’s pouch; trigeminal ganglion; lung bud; head mesenchyme; proximal mesenchyme of the second pharyngeal arch; early odontogenic mesenchyme of the maxillary and mandibular processes

Forebrain: telencephalic vesicle, optic cup; midbrain; hindbrain; spinal cord

Epithelium of the nasal pits and facial processes; midline of the frontonasal and maxillary processes; epithelium of otic vesicle and apical ectodermal ridge of the limb bud

E11.5

Neuroepithelium of the telencephalon; mesenchyme of the medial and lateral nasal processes; maxillary and mandibular process of the first pharyngeal arch; mesenchyme of the second and third pharyngeal arches

Forebrain: telencephalic vesicle, optic cup; midbrain; hindbrain; spinal cord; in the wall of 3rd ventricle; central canal

Epithelium of the fusing facial processes; otic vesicle; apical ectodermal ridge; ventral neural tube; ventral and dorsal dermomyotome

E12.5

 

Dorsal neural tube; dorsal diencephalon; wall of 4th ventricle; cartilage primordium of basioccipital bone and developing cervical vertebrae

Optic eminence; external nares; lip philtrum; vibrissae; developing incisor and molar tooth buds of the maxilla and mandible; epithelium of palatine processes

E13.5–

E15.5

Mesenchyme of the nasal cavity; tongue root; periocular region; not In palatal shelves; mesenchyme surrounding the tooth buds; condensing mesenchyme of the dental papilla (E14.0)

Heart (ventricular tissue and major blood vessel); peripheral region of cartilaginous condensations of the axial skeleton; roof of 3rd ventricle; nasal septum; tongue mesoderm; genioglossus muscle

Medial epithelium seam between the palatal shelves; developing teeth of the maxilla and mandible; early tooth bud epithelium, within the cap, staining was predominant in the enamel knot, internal and external enamel epithelium; at the bell stage, activity was seen throughout the differentiated cell populations within the enamel organ, including pre-ameloblasts and stellate reticulum; in the vibrissae, expression was seen in the dermal papilla, outer root sheath, and hair matrix; in the eye, expression was seen in the lens fibers, blood vessels of the hyaloid cavity, and in the neural layer of the retina; in E15.5, cartilaginous condensations of the peripheral skeleton, including the ribs, limbs and vertebra; the glomerular apparatus of the kidney