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  1. Glioblastoma multiforme (GBM) is the most lethal primary brain tumors which remains difficult to cure despite advances in surgery, radiotherapy and chemotherapy. Therefore, the development of new drug is urgen...

    Authors: Hsiao-Chieh Huang, Wei-Ting Liu, Kuo-Su Hua, Hui-Chi Hung, Jui-Ying Tsai, Sheng-Chu Kuo, Li-Jiau Huang and Po-Wu Gean

    Citation: Journal of Biomedical Science 2016 23:10

    Content type: Research

    Published on:

  2. PTEN is a tumor suppressor gene which is involved in cellular proliferation, differentiation, and apoptosis. Loss or down-regulation of PTEN plays an important role in human cancers development. In this study,...

    Authors: Yaghoub Yazdani, Touraj Farazmandfar, Hossein Azadeh and Zeinab Zekavatian

    Citation: Journal of Biomedical Science 2016 23:9

    Content type: Research

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  3. Ischemia and reperfusion (I/R) – induced injury has been described as one of the main factors that contribute to the observed morbidity and mortality in a variety of clinical entities, including myocardial inf...

    Authors: Marios–Konstantinos Tasoulis and Emmanuel E. Douzinas

    Citation: Journal of Biomedical Science 2016 23:7

    Content type: Review

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  4. Developing brain is a major target for alcohol’s actions and neurological/functional abnormalities include microencephaly, reduced frontal cortex, mental retardation and attention-deficits. Previous studies ha...

    Authors: Amanjot Kaur Riar, Madhusudhanan Narasimhan, Mary Latha Rathinam, George I. Henderson and Lenin Mahimainathan

    Citation: Journal of Biomedical Science 2016 23:6

    Content type: Research

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  5. Acetaminophen (APAP) overdose causes acute liver failure (ALF) in animals and humans via the rapid depletion of intracellular glutathione (GSH) and the generation of excess reactive oxygen species (ROS) that d...

    Authors: Yu-Jen Huang, Poda Chen, Chih-Yuan Lee, Sin-Yu Yang, Ming-Tsan Lin, Hsuan-Shu Lee and Yao-Ming Wu

    Citation: Journal of Biomedical Science 2016 23:5

    Content type: Research

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  6. Increased circulating levels of endoglin+ endothelial microparticles (EMPs) have been identified in several cardiovascular disorders, related to severity. Endoglin is an auxilary receptor for transforming growth ...

    Authors: Daria Belik, Hilda Tsang, John Wharton, Luke Howard, Carmelo Bernabeu and Beata Wojciak-Stothard

    Citation: Journal of Biomedical Science 2016 23:4

    Content type: Research

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  7. Granulocyte-colony stimulating factor (G-CSF) is a major regulator of the production and survival of neutrophils. Regulation of G-CSF expression is complex and occurs at both transcription and post-transcripti...

    Authors: Shwu-Fen Chang, Huai-Ci Li, Yu-Pei Huang, Wen-Ju Tasi, Yuan-Yi Chou and Shao-Chun Lu

    Citation: Journal of Biomedical Science 2016 23:3

    Content type: Research

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  8. 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) is a potential anticancer drug that may activate soluble guanylyl cyclase (sGC) and increase the level of cyclic guanosine monophosphate (cGMP). The aim of...

    Authors: Leo Tsui, Shwu-Fen Chang, Hsiang-Po Huang, Tsorng-Harn Fong and I-Jong Wang

    Citation: Journal of Biomedical Science 2016 23:2

    Content type: Research

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  9. Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder and is a common genetic cause of chronic renal failure in children and adults. The enzyme renin plays a key role in the RAAS cascade...

    Authors: Gnanasambandan Ramanathan, Ramprasad Elumalai, Soundararajan Periyasamy and Bhaskar V. K. S. Lakkakula

    Citation: Journal of Biomedical Science 2016 23:1

    Content type: Research

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  10. This study aimed at developing nerve growth factor (NGF) mimetics that selectively activate specific biological signals and, as a result, lack the side effects of the full-length protein. Two dimeric dipeptide...

    Authors: Tatyana A. Gudasheva, Polina Yu Povarnina, Tatyana A. Antipova, Yulia N. Firsova, Mark A. Konstantinopolsky and Sergey B. Seredenin

    Citation: Journal of Biomedical Science 2015 22:106

    Content type: Research

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  11. Mounting evidences have showed the important role of transforming growth factor-β (TGF-β) in immunological surveillance of tumors. Some studies have also indicated human leukocyte antigen (HLA)-G-associated im...

    Authors: Zhongzheng Guan, Bingtan Song, Fengjun Liu, Dong Sun, Kexin Wang and Hui Qu

    Citation: Journal of Biomedical Science 2015 22:107

    Content type: Research

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  12. Caffeine, the main component of coffee, has showed its protective effect on non-alcoholic fatty liver disease (NAFLD) in many studies. However, the hepatoprotection of caffeine and its mechanisms in zebrafish ...

    Authors: Xinchun Zheng, Wencong Dai, Xiaohui Chen, Kunyuan Wang, Wenqing Zhang, Li Liu and Jinlin Hou

    Citation: Journal of Biomedical Science 2015 22:105

    Content type: Research

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  13. The specification of vein and the patterning of intersegmental vessels (ISV) controlled by transcription factor is not fully characterized. The orphan nuclear receptor Chicken ovalbumin upstream promoter trans...

    Authors: Ru-Fang Li, Ting-Yun Wu, Yu-Zheng Mou, Yi-Shan Wang, Chun-Lin Chen and Chang-Yi Wu

    Citation: Journal of Biomedical Science 2015 22:104

    Content type: Research

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  14. Highly desaturated n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are synthesized by desaturases and elongase. They exert hepatoprotective effects ...

    Authors: Chih-Lun Cheng, Shin-Jie Huang, Chih-Lu Wu, Hong-Yi Gong, Chuian-Fu Ken, Shao-Yang Hu and Jen-Leih Wu

    Citation: Journal of Biomedical Science 2015 22:103

    Content type: Research

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  15. Mutations in mitogen-activated protein kinase (MAPK) kinase 1 (MEK1) that occur during cell proliferation and tumor formation are well described. Information on the roles of MEK2 in these effects is still limi...

    Authors: Chih-Ming Chou, Yi-Chung Chen, San Su, Gen-Der Chen, Kai-Yun Huang, Huang-Wei Lien, Chang-Jen Huang and Chia-Hsiung Cheng

    Citation: Journal of Biomedical Science 2015 22:102

    Content type: Research

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  16. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor expressed in many cell types, including osteoblasts, osteocytes, and osteoclasts. Nrf2 has been considered a master regulator of cyt...

    Authors: Yong-Xin Sun, Ai-Hua Xu, Yang Yang and Jiliang Li

    Citation: Journal of Biomedical Science 2015 22:101

    Content type: Review

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  17. Growth arrest-specific 5 (GAS5) was reported to be implicated and aberrantly express in multiple cancers. However, the expression and mechanism of action of GAS5 were largely poor understood in endometrial car...

    Authors: Chen Guo, Wei-qi Song, Ping Sun, Lian Jin and Hong-yan Dai

    Citation: Journal of Biomedical Science 2015 22:100

    Content type: Research

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  18. The H-RAS-like suppressor (HRASLS) subfamily consists of five enzymes (1–5) in humans and three (1, 3, and 5) in mice and rats that share sequence homology with lecithin:retinol acyltransferase (LRAT). All HRA...

    Authors: Emily B. Mardian, Ryan M. Bradley and Robin E. Duncan

    Citation: Journal of Biomedical Science 2015 22:99

    Content type: Review

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  19. Notch may behave as an oncogene or a tumor suppressor gene in lung cancer cells. Notch receptor undergoes cleavage by enzymes, including γ-secretase, generating the active Notch intracellular domain (NICD). Th...

    Authors: Efstathia Giannopoulou, Achilleas Nikolakopoulos, Dimitra Kotsirilou, Angeliki Lampropoulou, Sofia Raftopoulou, Evangelia Papadimitriou, Achilleas D. Theocharis, Thomas Makatsoris, Konstantinos Fasseas and Haralabos P. Kalofonos

    Citation: Journal of Biomedical Science 2015 22:98

    Content type: Research

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  20. Stem cells of intensely regenerative tissues are susceptible to cellular damage. Although the response to this process in hematopoietic stem cells (HSCs) is crucial, the mechanisms by which hematopoietic homeo...

    Authors: Marcella L. Porto, Bianca P. Rodrigues, Thiago N. Menezes, Sara L. Ceschim, Dulce E. Casarini, Agata L. Gava, Thiago Melo C. Pereira, Elisardo C. Vasquez, Bianca P. Campagnaro and Silvana S. Meyrelles

    Citation: Journal of Biomedical Science 2015 22:97

    Content type: Research

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  21. Serum sialic acid levels are positively correlated with coronary artery disease and inflammation. Although sialic acid is a non-specific marker, it is considered sensitive likely due to its influence in sialyl...

    Authors: Zhang Yida, Mustapha Umar Imam, Maznah Ismail, Norsharina Ismail, Aini Ideris and Maizaton Atmadini Abdullah

    Citation: Journal of Biomedical Science 2015 22:96

    Content type: Research article

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  22. The HCMV UL76 gene is a member of UL24 family in herpes virus and encodes a highly conserved herpes virus protein. Inherited from common ancestor, members of Herpes_UL24 family encode proteins with a conserved N ...

    Authors: Wenchang Zhang, Yao Yao, Jingxian Chen and Mingli Wang

    Citation: Journal of Biomedical Science 2015 22:95

    Content type: Research

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  23. The soluble epoxide hydrolase (sEH) is an important enzyme chiefly involved in the metabolism of fatty acid signaling molecules termed epoxyeicosatrienoic acids (EETs). sEH inhibition (sEHI) has proven to be p...

    Authors: Han-Fang Wu, Hsin-Ju Yen, Chi-Chen Huang, Yi-Chao Lee, Su-Zhen Wu, Tzong-Shyuan Lee and Hui-Ching Lin

    Citation: Journal of Biomedical Science 2015 22:94

    Content type: Research

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  24. Chronic hepatitis B virus (HBV) infection in endemic areas usually starts since infancy and early childhood and persists lifelong. The clinical course varies among different chronic infected subjects. Majority...

    Authors: Jia-Feng Wu and Mei-Hwei Chang

    Citation: Journal of Biomedical Science 2015 22:92

    Content type: Review

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  25. NKG2D, an activating immunoreceptor, is primarily restricted to NK cells and CD8+ T cells. The existence of an atypical cytotoxic CD4+NKG2D+ T cell population has also been found in patients with autoimmune dysfu...

    Authors: Mariel Garcia-Chagollan, Luis Felipe Jave-Suarez, Jesse Haramati, Miriam Ruth Bueno-Topete, Adriana Aguilar-Lemarroy, Ciro Estrada-Chavez, Blanca Estela Bastidas-Ramirez, Ana Laura Pereira-Suarez and Susana del Toro-Arreola

    Citation: Journal of Biomedical Science 2015 22:91

    Content type: Research

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  26. Increasing evidence suggests that transforming growth factor-beta 1 (TGF-β1) triggers epithelial to mesenchymal transition (EMT) and facilitates breast cancer stem cell differentiation. Gelsolin (GSN) is a ubi...

    Authors: Zhi-Yuan Chen, Pei-Wen Wang, Dar-Bin Shieh, Kuan-Ying Chiu and Ying-Ming Liou

    Citation: Journal of Biomedical Science 2015 22:90

    Content type: Research

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  27. Canine parvovirus 2 (CPV-2) remains a significant worldwide canine pathogen and the most common cause of viral enteritis in dogs. The 1 L15 and 7 L15 peptides overlap each other with QPDGGQPAV residues (7-15 o...

    Authors: Serap Derman, Zeynep Akdeste Mustafaeva, Emrah Sefik Abamor, Melahat Bagirova and Adil Allahverdiyev

    Citation: Journal of Biomedical Science 2015 22:89

    Content type: Research

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  28. It is well known that epigenetic modifications play an important role in controlling the regulation of gene expression during the development. Our previous studies have demonstrated that the expression of feta...

    Authors: Yang Xu, Lingjuan Liu, Bo Pan, Jing Zhu, Changlong Nan, Xupei Huang and Jie Tian

    Citation: Journal of Biomedical Science 2015 22:88

    Content type: Research

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  29. We have shown previously that microvesicle (MV)-delivered miR-130b (miR-130b-MV) is able to target PPAR-γ and subsequently reduce the lipid accumulation in vitro. However, the in vivo effect of miR-130b on fat de...

    Authors: Shifeng Pan, Xiaojing Yang, Yimin Jia, Yue Li, Rirong Chen, Min Wang, Demin Cai and Ruqian Zhao

    Citation: Journal of Biomedical Science 2015 22:86

    Content type: Research

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  30. Reactive oxygen species (ROS) have been long considered simply as harmful by-products of metabolism, which damage cellular proteins, lipids, and nucleic acids. ROS are also known as a wea...

    Authors: Aleksey V. Belikov, Burkhart Schraven and Luca Simeoni

    Citation: Journal of Biomedical Science 2015 22:85

    Content type: Review

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  31. We have previously demonstrated that cigarette smoke is associated with a significant reduction of retinoic acid in rat lungs and the formation of tracheal precancerous lesions. However, the underlying mechani...

    Authors: Yuan Xue, Ethan Harris, Weiqun Wang and Richard C. Baybutt

    Citation: Journal of Biomedical Science 2015 22:84

    Content type: Research

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  32. Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in...

    Authors: Daisy Vanitha John, Yee-Shin Lin and Guey Chuen Perng

    Citation: Journal of Biomedical Science 2015 22:83

    Content type: Review

    Published on:

  33. Morphine-induced tolerance is associated with the spinal neuroinflammation. The aim of this study was to explore the effects of oral administration of the pioglitazone, the peroxisome proliferator activated re...

    Authors: Mohammad Charkhpour, Hamed Ghavimi, Saeed Ghanbarzadeh, Bahman Yousefi, Arash Khorrami, Mehran Mesgari and Kambiz Hassanzadeh

    Citation: Journal of Biomedical Science 2015 22:82

    Content type: Research

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  34. Neuropathic pain is a very troublesome and difficult pain to treat. Although opioids are the best analgesics for cancer and surgical pain in clinic, only oxycodone among opioids shows better efficacy to allevi...

    Authors: Pao-Pao Yang, Geng-Chang Yeh, Eagle Yi-Kung Huang, Ping-Yee Law, Horace H. Loh and Pao-Luh Tao

    Citation: Journal of Biomedical Science 2015 22:81

    Content type: Research

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  35. Cardiac oxidative stress, bioenergetics and catecholamine play major roles in heart failure progression. However, the relationships between these three dominant heart failure factors are not fully elucidated. ...

    Authors: Shih-Yi Lee, Hui-Chun Ku, Yueh-Hsiung Kuo, Kai-Chien Yang, Ping-Chen Tu, His-Lin Chiu and Ming-Jai Su

    Citation: Journal of Biomedical Science 2015 22:80

    Content type: Research

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  36. The descending noradrenergic (NAergic) system is one of the important endogenous analgesia systems. It has been suggested that noxious stimuli could activate descending NAergic system; nevertheless, the underl...

    Authors: Chia-Yi Liu, Meng-Lam Lee, Chi-Sheng Yang, Chuan-Mu Chen, Ming-Yuan Min and Hsiu-Wen Yang

    Citation: Journal of Biomedical Science 2015 22:79

    Content type: Research

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  37. In 2011, there was an outbreak of Shiga toxin-producing Escherichia coli (STEC) infections in Japan. Approximately 62 % of patients with hemolytic-uremic syndrome also showed symptoms of encephalopathy. To determ...

    Authors: Naotoshi Sugimoto, Hue Leu, Natsumi Inoue, Masaki Shimizu, Tomoko Toma, Mondo Kuroda, Takekatsu Saito, Taizo Wada and Akihiro Yachie

    Citation: Journal of Biomedical Science 2015 22:78

    Content type: Research

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  38. Cisplatin is one of the most commonly used chemotherapy agent for lung cancer. The therapeutic efficacy of cisplatin is limited by the development of resistance.

    Authors: Chun-Hua Dai, Jian Li, Ping Chen, He-Guo Jiang, Ming Wu and Yong-Chang Chen

    Citation: Journal of Biomedical Science 2015 22:77

    Content type: Research

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  39. Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a key regulator of signal cascades of TNF-α receptor and TLR4, and can induce NF-κB activation for preventing cell apoptosis and eliciting infl...

    Authors: Jang-Shiun Wang, Dean Wu, Duen-Yi Huang and Wan-Wan Lin

    Citation: Journal of Biomedical Science 2015 22:76

    Content type: Research

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  40. Studies in recent years have shown that undercarboxylated osteocalcin (uOC) not only maintains bone mineralization, but is also involved in the regulation of atherosclerosis. However, a correlation between uOC...

    Authors: Minfang Zhang, Zhaohui Ni, Wenyan Zhou and Jiaqi Qian

    Citation: Journal of Biomedical Science 2015 22:75

    Content type: Research

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  41. To construct safer recombinant flavivirus vaccine, we exploited Japanese encephalitis virus (JEV) replicon-based platform to generate single-round infectious particles (SRIPs) that expressed heterologous neutr...

    Authors: Yi-Ting Huang, Jia-Teh Liao, Li-Chen Yen, Yung-Kun Chang, Yi-Ling Lin and Ching-Len Liao

    Citation: Journal of Biomedical Science 2015 22:74

    Content type: Research

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  42. Adiponectin levels have been shown to be associated with colorectal cancer (CRC). Furthermore, a newly identified adiponectin receptor, T-cadherin, has been associated with plasma adiponectin levels. Therefore...

    Authors: Jongkeun Park, Injung Kim, Keum Ji Jung, Soriul Kim, Sun Ha Jee and Sungjoo Kim Yoon

    Citation: Journal of Biomedical Science 2015 22:73

    Content type: Research

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  43. Gene mutations that produce misprocessed proteins are linked to many human disorders. Interestingly, some misprocessed proteins retained their biological function when stabilized by low temperature treatment o...

    Authors: Yueqiang Zhang, William G. O’Brien III, Zhaoyang Zhao and Cheng Chi Lee

    Citation: Journal of Biomedical Science 2015 22:72

    Content type: Research

    Published on:

  44. Many patients with nasopharyngeal carcinoma (NPC) face poor prognosis. Due to its hidden anatomical location, the tumor is usually diagnosed quite late, and despite initially successful treatment with radiatio...

    Authors: Thomas C. Chen, Hee-Yeon Cho, Weijun Wang, Stephanie J. Wetzel, Anupam Singh, Jenny Nguyen, Florence M. Hofman and Axel H. Schönthal

    Citation: Journal of Biomedical Science 2015 22:71

    Content type: Research

    Published on:

  45. In epilepsy, seizures are generated by abnormal synchronous activity in neurons. In the rat hippocampus (HIP), epileptiform activity has been found to be associated with gap junctions (GJs). GJs are formed by ...

    Authors: Medina-Ceja Laura, Flores-Ponce Xóchitl, Santerre Anne and Morales-Villagrán Alberto

    Citation: Journal of Biomedical Science 2015 22:69

    Content type: Research

    Published on:

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