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Page 21 of 32

  1. Oxidized LDL (oxLDL) is involved in the development of atherosclerotic heart disease through a mechanism that is not fully understood. In this study, we examined the role of malondialdehyde (MDA), an important...

    Authors: Tzu-Ching Yang, Yi-Jie Chen, Shwu-Fen Chang, Chu-Huang Chen, Po-Yuan Chang and Shao-Chun Lu
    Citation: Journal of Biomedical Science 2014 21:11
  2. Bisphosphonates are an important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Recent studies have shown that nitrogen-containing bisphosphonates induced apoptosis in rabbit o...

    Authors: Masanobu Tsubaki, Makiko Komai, Tatsuki Itoh, Motohiro Imano, Kotaro Sakamoto, Hirotaka Shimaoka, Tomoya Takeda, Naoki Ogawa, Kenji Mashimo, Daiichiro Fujiwara, Junji Mukai, Katsuhiko Sakaguchi, Takao Satou and Shozo Nishida
    Citation: Journal of Biomedical Science 2014 21:10
  3. The increase in fructose ingestion has been linked to overdrive of sympathetic activity and hypertension associated with the metabolic syndrome. The premotor neurons for generation of sympathetic vasomotor act...

    Authors: Kay LH Wu, Chun-Ying Hung, Julie YH Chan and Chih-Wei Wu
    Citation: Journal of Biomedical Science 2014 21:8
  4. The occurrence of Congenital Heart Disease (CHD) is resulted from either genetic or environmental factors or the both. The CITED2 gene deletion or mutation is associated with the development of cardiac malform...

    Authors: Min Xu, Xiaoyun Wu, Yonggang Li, Xiaofei Yang, Jihua Hu, Min Zheng and Jie Tian
    Citation: Journal of Biomedical Science 2014 21:7
  5. Tolerance to the analgesic effect of opioids is a pharmacological phenomenon that occurs after their prolonged administration. It has been shown that morphine-induced tolerance is associated with apoptosis in ...

    Authors: Mozhdeh Sharifipour, Esmaeal Izadpanah, Bahram Nikkhoo, Samad Zare, Ali Abdolmaleki, Katayoun Hassanzadeh, Farshid Moradi and Kambiz Hassanzadeh
    Citation: Journal of Biomedical Science 2014 21:6
  6. Several lines of evidence have demonstrated that bone marrow-derived mesenchymal stem cells (BM-MSC) release bioactive factors and provide neuroprotection for CNS injury. However, it remains elusive whether BM...

    Authors: May-Jywan Tsai, Shen-Kou Tsai, Bo-Ruei Hu, Dann-Ying Liou, Shih-Ling Huang, Ming-Chao Huang, Wen-Cheng Huang, Henrich Cheng and Shiang-Suo Huang
    Citation: Journal of Biomedical Science 2014 21:5
  7. The Maillard reaction is a chemical reaction occurring between a reducing sugar and an amino acid, generally requiring thermal processing. Maillard reaction products (MRPs) have antioxidant, antimutagenic, and...

    Authors: Jung-Il Chae, RaHam Lee, JinHyoung Cho, JinTae Hong and Jung-Hyun Shim
    Citation: Journal of Biomedical Science 2014 21:4
  8. Hemodynamic shear stress, the blood flow-generated frictional force acting on the vascular endothelial cells, is essential for endothelial homeostasis under normal physiological conditions. Mechanosensors on e...

    Authors: Hsyue-Jen Hsieh, Ching-Ann Liu, Bin Huang, Anne HH Tseng and Danny Ling Wang
    Citation: Journal of Biomedical Science 2014 21:3
  9. Polycystic ovary syndrome (PCOS) is a state of altered steroid hormone production and activity. Chronic estrogen exposure or lack of progesterone due to ovarian dysfunction can result in endometrial hyperplasi...

    Authors: Xin Li, Yi Feng, Jin-Fang Lin, Håkan Billig and Ruijin Shao
    Citation: Journal of Biomedical Science 2014 21:2
  10. Patients with colorectal cancer (CRC) often develop liver metastases, in which case surgery is considered the only potentially curative treatment option. However, liver surgery is associated with a risk of isc...

    Authors: Shu-Fan Jiao, Kai Sun, Xiao-Jing Chen, Xue Zhao, Ning Cai, Yan-Jun Liu, Long-Mei Xu, Xian-Ming Kong and Li-Xin Wei
    Citation: Journal of Biomedical Science 2014 21:1
  11. The polymorphic species Candida albicans is the major cause of candidiasis in humans. The secreted aspartyl proteinases (Saps) of C. albicans, encoded by a family of 10 SAP genes, have been investigated as the vi...

    Authors: Leh-Miauh Buu and Yee-Chun Chen
    Citation: Journal of Biomedical Science 2013 20:101
  12. Hypoxia-inducible factor-1 alpha (HIF-1α) is one of the key regulators of hypoxia/ischemia. MicroRNA-494 (miR-494) had cardioprotective effects against ischemia/reperfusion (I/R)-induced injury, but its functi...

    Authors: Guixiang Sun, Yanni Zhou, Hongsheng Li, Yingjia Guo, Juan Shan, Mengjuan Xia, Youping Li, Shengfu Li, Dan Long and Li Feng
    Citation: Journal of Biomedical Science 2013 20:100
  13. Zinc finger protein 179 (Znf179), also known as ring finger protein 112 (Rnf112), is a member of the RING finger protein family and plays an important role in neuronal differentiation. To investigate novel mec...

    Authors: Ding-Yen Lin, Chi-Chen Huang, Ya-Ting Hsieh, Hsin-Chuan Lin, Ping-Chieh Pao, Jen-Hui Tsou, Chien-Ying Lai, Liang-Yi Hung, Ju-Ming Wang, Wen-Chang Chang and Yi-Chao Lee
    Citation: Journal of Biomedical Science 2013 20:98
  14. CDC4, which encodes an F-box protein that is a member of the Skp1-Cdc53/Cul1-F-box (SCF) ubiquitin E3 ligase, was initially identified in the budding yeast Saccharomyces cerevisiae as an essential gene for progre...

    Authors: Chuen Chin, Wei-Chung Lai, Tai-Lin Lee, Tzu-Ling Tseng and Jia-Ching Shieh
    Citation: Journal of Biomedical Science 2013 20:97
  15. MicroRNA (miRNA) emerges as important player in drug abuse. Yet, their expression profile in neurological disorder of cocaine abuse has not been well characterized. Here, we explored the changes of miRNA expre...

    Authors: Chun-Lin Chen, Hailin Liu and Xiaowei Guan
    Citation: Journal of Biomedical Science 2013 20:96
  16. Obesity is an important risk factor for atrial fibrillation (AF). Leptin is an important adipokine. However, it is not clear whether leptin directly modulates the electrophysiological characteristics of atrial...

    Authors: Yung-Kuo Lin, Yao-Chang Chen, Jen-Hung Huang, Yenn-Jiang Lin, Shiang-Suo Huang, Shih-Ann Chen and Yi-Jen Chen
    Citation: Journal of Biomedical Science 2013 20:94
  17. Infertility, spontaneous abortion and conception of trisomic offspring increase exponentially with age in mammals but in women there is an apparent acceleration in the rate from about age 37. The problems most...

    Authors: Judith H Ford
    Citation: Journal of Biomedical Science 2013 20:93
  18. DNA transposons are primitive genetic elements which have colonized living organisms from plants to bacteria and mammals. Through evolution such parasitic elements have shaped their host genomes by replicating...

    Authors: Kristian Alsbjerg Skipper, Peter Refsing Andersen, Nynne Sharma and Jacob Giehm Mikkelsen
    Citation: Journal of Biomedical Science 2013 20:92
  19. Noise induced injury of the cochlea causes shifts in activation thresholds and changes of frequency response in the inferior colliculus (IC). Noise overexposure also induces pathological changes in the cochlea...

    Authors: Feng Wang, Li Zuo, Bo Hong, Dongyi Han, Ethan M Range, Lingyun Zhao, Yanan Sui, Weiwei Guo and Liangfa Liu
    Citation: Journal of Biomedical Science 2013 20:91
  20. The roles of caspase 3 on the kainic acid-mediated neurodegeneration, dendritic plasticity alteration, neurogenesis, microglial activation and gliosis are not fully understood. Here, we investigate hippocampal...

    Authors: Tsai-Teng Tzeng, Huey-Jen Tsay, Luping Chang, Chia-Lin Hsu, Tzu-Hsuan Lai, Fong-Lee Huang and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2013 20:90
  21. Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making ...

    Authors: Jih-Jin Tsai, Kulkanya Chokephaibulkit, Po-Chih Chen, Li-Teh Liu, Hui-Mien Hsiao, Yu-Chih Lo and Guey Chuen Perng
    Citation: Journal of Biomedical Science 2013 20:88
  22. Long non-coding RNAs (lncRNAs) have different functions in cells. They work as signals, decoys, guides, and scaffolds. Altered lncRNA levels can affect the expression of gene products. There are seldom studies...

    Authors: Yu Qi Qiao, Mei Lan Huang, An Tao Xu, Di Zhao, Zhi Hua Ran and Jun Shen
    Citation: Journal of Biomedical Science 2013 20:87
  23. Epigallocatechin-3-gallate (EGCg) with its potent anti-oxidative capabilities is known for its beneficial effects ameliorating oxidative injury to cardiac cells. Although studies have provided convincing evide...

    Authors: Shih-Ron Hsieh, Chen-Sen Hsu, Chen-Hua Lu, Wei-Cheng Chen, Chun-Hwei Chiu and Ying-Ming Liou
    Citation: Journal of Biomedical Science 2013 20:86
  24. Clinical and experimental evidence demonstrates that sleep and epilepsy reciprocally affect each other. Previous studies indicated that epilepsy alters sleep homeostasis; in contrast, sleep disturbance deterio...

    Authors: Pei-Lu Yi, Chin-Yu Lu, Chiung-Hsiang Cheng, Yi-Fong Tsai, Chung-Tien Lin and Fang-Chia Chang
    Citation: Journal of Biomedical Science 2013 20:85
  25. Wedelolactone (WEL), a major coumestan ingredient in Wedelia chinensis, has been used to treat septic shock, hepatitis and venom poisoning in traditional Chinese medicines. The objective of the study was to eluci...

    Authors: Fang Yuan, Jie Chen, Ping-ping Sun, Su Guan and Jing Xu
    Citation: Journal of Biomedical Science 2013 20:84
  26. Two isoforms of Rho-associated protein kinase (ROCK), ROCKI and ROCKII, play a pivotal role in regulation of cytoskeleton and are involved in multiple cellular processes in mammalian cells. Knockout mice exper...

    Authors: Hsiang-Hao Chuang, Shao-Wei Liang, Zee-Fen Chang and Hsiao-Hui Lee
    Citation: Journal of Biomedical Science 2013 20:83
  27. This study investigated the association between innate immune reaction and myocardial damage after acute myocardial infarction (AMI) and anti-inflammatory role of tacrolimus in reducing infarct size. Male mini...

    Authors: Jiunn-Jye Sheu, Pei-Hsun Sung, Steve Leu, Han-Tan Chai, Yen-Yi Zhen, Yi-Ching Chen, Sarah Chua, Yung-Lung Chen, Tzu-Hsien Tsai, Fan-Yen Lee, Hsueh-Wen Chang, Sheung-Fat Ko and Hon-Kan Yip
    Citation: Journal of Biomedical Science 2013 20:82
  28. Tamsulosin, an α1-adrenoceptor antagonist, and sildenafil, a phosphodiesterase (PDE) inhibitor, are reported to improve lower urinary tract symptoms including overactive bladder (OAB). This study is aimed at i...

    Authors: Sung-Eun Kim, Il-Gyu Ko, Lakkyong Hwang, In-Young Choi, Mal-Soon Shin, Chang-Ju Kim and Khae-Hawn Kim
    Citation: Journal of Biomedical Science 2013 20:81
  29. Type 2 diabetes mellitus (T2DM) is a non-autoimmune, complex, heterogeneous and polygenic metabolic disease condition characterized by persistent elevated blood glucose levels (hyperglycemia). India as said to...

    Authors: Shania Abbas, Syed Tasleem Raza, Faisal Ahmed, Absar Ahmad, Saliha Rizvi and Farzana Mahdi
    Citation: Journal of Biomedical Science 2013 20:80
  30. MiR-155 has emerged as an “oncomiR”, which is the most significantly up-regulated miRNA in breast cancer. However, the mechanisms of miR-155 functions as an oncomiR are mainly unknown. In this study, the aims ...

    Authors: Chun-Mei Zhang, Jing Zhao and Hua-Yu Deng
    Citation: Journal of Biomedical Science 2013 20:79
  31. The specific role of microglia on Aβ-mediated neurotoxicity is difficult to assign in vivo due to their complicated environment in the brain. Therefore, most of the current microglia-related studies employed the ...

    Authors: Huey-Jen Tsay, Yung-Cheng Huang, Fong-Lee Huang, Chia-Ping Chen, Yu-Chun Tsai, Ying-Hsiu Wang, Mine-Fong Wu, Feng-Yi Chiang and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2013 20:78
  32. The exact mechanisms of morphine-induced dependence and withdrawal symptoms remain unclear. In order to identify an agent that can prevent withdrawal syndrome, many studies have been performed. This study was ...

    Authors: Sabah Moradi, Mohammad Charkhpour, Hamed Ghavimi, Rasoul Motahari, Majid Ghaderi and Kambiz Hassanzadeh
    Citation: Journal of Biomedical Science 2013 20:77
  33. Tamoxifen is the most widely used anti-estrogen for the treatment of breast cancer. Studies show that the combination therapy with other substances that helps the activity of tamoxifen. The objective of this s...

    Authors: Sara Darakhshan and Ali Ghanbari
    Citation: Journal of Biomedical Science 2013 20:76

    The Erratum to this article has been published in Journal of Biomedical Science 2013 20:89

  34. Early diagnosis of dengue virus infection during the febrile stage is essential for adjusting appropriate management. This study is to identify the predictive markers of clinical and laboratory findings in the...

    Authors: Tzong-Shiann Ho, Shih-Min Wang, Yee-Shin Lin and Ching-Chuan Liu
    Citation: Journal of Biomedical Science 2013 20:75
  35. Hematological and biochemical abnormalities are among the most common clinicopathological manifestations of HIV patients on ART. Consequently, the development and assessment of indigenous antiretroviral drugs ...

    Authors: Bartholomew Okecuhukwu Ibeh, Olushola D Omodamiro, Urenna Ibeh and Josiah Bitrus Habu
    Citation: Journal of Biomedical Science 2013 20:73
  36. The microRNAs let-7 g and miR-221 have been demonstrated to be related to the glucose metabolism. This study assessed the serum levels of these two microRNAs in subjects with and without metabolic syndrome (Me...

    Authors: Yu-Ting Wang, Pei-Chien Tsai, Yi-Chu Liao, Chung-Y Hsu and Suh-Hang Hank Juo
    Citation: Journal of Biomedical Science 2013 20:72
  37. Mesenchymal Stem Cells (MSC) are important candidates for therapeutic applications due to their ex vivo proliferation and differentiation capacity. MSC differentiation is controlled by both intrinsic and extri...

    Authors: Himangshu Sonowal, Atul Kumar, Jina Bhattacharyya, Pabitra Kumar Gogoi and Bithiah Grace Jaganathan
    Citation: Journal of Biomedical Science 2013 20:71
  38. Xeroderma Pigmentosum (XP) is a rare skin disorder characterized by skin hypersensitivity to sunlight and abnormal pigmentation. The aim of this study was to investigate the genetic cause of a severe XP phenot...

    Authors: Muhammad Nasir, Nafees Ahmad, Christian MK Sieber, Amir Latif, Salman Akbar Malik and Abdul Hameed
    Citation: Journal of Biomedical Science 2013 20:70
  39. Reactive oxygen species (ROS) are products of normal cellular metabolism and derive from various sources in different cellular compartments. Oxidative stress resultant from imbalance between ROS generation and...

    Authors: Miroslava Majzunova, Ima Dovinova, Miroslav Barancik and Julie YH Chan
    Citation: Journal of Biomedical Science 2013 20:69
  40. Epithelial barrier dysfunction is associated with the pathogenesis of a number of immune inflammations; the etiology is not fully understood. The fusion of endosome/lysosome is a critical process in the degrad...

    Authors: Yu-Wei Liao, Xing-Mao Wu, Jia Jia, Xiao-Lei Wu, Tao Hong, Ling-Xin Meng and Xiu-Ying Wu
    Citation: Journal of Biomedical Science 2013 20:68
  41. Among viral enzymes, the human HIV-1 protease comprises the most interesting target for drug discovery. There are increasing efforts focused on designing more effective inhibitors for HIV-1 protease in order t...

    Authors: Mohammad Reza Dayer and Mohammad Saaid Dayer
    Citation: Journal of Biomedical Science 2013 20:67
  42. Hematopoietic stem/progenitor cells (HSPCs) maintain the hematopoietic system by balancing their self-renewal and differentiation events. Hematopoietic stem cells also migrate to various sites and interact wit...

    Authors: Bithiah Grace Jaganathan, Fernando Anjos-Afonso, Atul Kumar and Dominique Bonnet
    Citation: Journal of Biomedical Science 2013 20:66
  43. We and others have reported that autophagy is induced by dengue viruses (DVs) in various cell lines, and that it plays a supportive role in DV replication. This study intended to clarify whether DV infection c...

    Authors: Ying-Ray Lee, Hsuan-Yun Hu, Szu-Han Kuo, Huan-Yao Lei, Yee-Shin Lin, Trai-Ming Yeh, Ching-Chuan Liu and Hsiao-Sheng Liu
    Citation: Journal of Biomedical Science 2013 20:65
  44. The lack of noninvasive biomarkers of rejection remains a challenge in the accurate monitoring of deeply buried nerve allografts and precludes optimization of therapeutic intervention. This study aimed to esta...

    Authors: Cheng-Shyuan Rau, Johnson Chia-Shen Yang, Shao-Chun Wu, Yi-Chun Chen, Tsu-Hsiang Lu, Ming-Wei Lin, Yi-Chan Wu, Siou-Ling Tzeng, Chia-Jung Wu and Ching-Hua Hsieh
    Citation: Journal of Biomedical Science 2013 20:64
  45. The efficiency of regenerative medicine can be ameliorated by improving the biological performances of stem cells before their transplantation. Several ex-vivo protocols of non-damaging cell hypoxia have been ...

    Authors: Claudio Muscari, Emanuele Giordano, Francesca Bonafè, Marco Govoni, Alice Pasini and Carlo Guarnieri
    Citation: Journal of Biomedical Science 2013 20:63
  46. Knockout of either toll-like receptor 4 (TLR4) or 2 (TLR2) had been reported to delay the Wallerian degeneration after peripheral nerve injury by deterring the recruitment of the macrophages and clearance of m...

    Authors: Shao-Chun Wu, Cheng-Shyuan Rau, Tsu-Hsiang Lu, Chia-Jung Wu, Yi-Chan Wu, Siou-Ling Tzeng, Yi-Chun Chen and Ching-Hua Hsieh
    Citation: Journal of Biomedical Science 2013 20:62

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