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  1. Content type: Research

    It is widely believed that atherosclerotic plaque rupture and subsequent thrombosis leads to acute coronary events and stroke. However, study of the mechanism and treatment of human plaque rupture is hampered ...

    Authors: Shun-Miao Fang, Qing-Hua Zhang and Zhi-Xin Jiang

    Citation: Journal of Biomedical Science 2009 16:39

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  2. Content type: Research

    Acetylcholine (ACh), the first neurotransmitter to be identified, regulate the activities of central and peripheral functions through interactions with muscarinic receptors. Changes in muscarinic acetylcholine...

    Authors: G Gireesh, T Peeyush Kumar, Jobin Mathew and CS Paulose

    Citation: Journal of Biomedical Science 2009 16:38

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  3. Content type: Research

    Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial ap...

    Authors: Bor-Ru Lin, Chia-Jung Yu, Wang-Chuan Chen, Hsuan-Shu Lee, Huei-Min Chang, Yen-Chih Lee, Chiang-Ting Chien and Chau-Fong Chen

    Citation: Journal of Biomedical Science 2009 16:35

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  4. Content type: Research

    Statins reduce cholesterol biosynthesis by inhibiting HMG-CoA reductase and thereby lower total cholesterol and LDL cholesterol levels in serum, which in turn lower the incidence of cardiovascular disease (CVD...

    Authors: Chung-Eun Ha, Ji-Sook Ha, Andre G Theriault and Nadhipuram V Bhagavan

    Citation: Journal of Biomedical Science 2009 16:32

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  5. Content type: Review

    Increasing evidence suggests that immune responses are involved in the control of cancer and that the immune system can be manipulated in different ways to recognize and attack tumors. Progress in immune-based...

    Authors: Pablo Matar, Laura Alaniz, Viviana Rozados, Jorge B Aquino, Mariana Malvicini, Catalina Atorrasagasti, Manuel Gidekel, Marcelo Silva, O Graciela Scharovsky and Guillermo Mazzolini

    Citation: Journal of Biomedical Science 2009 16:30

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  6. Content type: Research

    Exposure to protein allergen epicutaneously, inducing a Th2-dominant immune response, sensitizes the host to the development of atopic disease. Antigen-driven bystander effect demonstrates that polarized T cel...

    Authors: Li-Fang Wang, Jau-Shiuh Chen, Chih-Jung Hsu, Ching-Yi Liu, Jhang-Sian Yu and Shi-Chuen Miaw

    Citation: Journal of Biomedical Science 2009 16:28

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  7. Content type: Research

    Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by mutations leading to dysfunction of one of enzymes involved in degradation of glycosaminoglycans (GAGs). Due to their impaired degradatio...

    Authors: Joanna Jakóbkiewicz-Banecka, Ewa Piotrowska, Magdalena Narajczyk, Sylwia Barańska and Grzegorz Węgrzyn

    Citation: Journal of Biomedical Science 2009 16:26

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  8. Content type: Research

    Histone acetyltransferases (HATs), p300 and cAMP response element binding protein (CREB)-binding protein (CBP) are two structurally related transcriptional co-activators that activate expression of many eukary...

    Authors: Guozhen Chen, Jing Zhu, Tiewei Lv, Gang Wu, Huichao Sun, Xupei Huang and Jie Tian

    Citation: Journal of Biomedical Science 2009 16:24

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  9. Content type: Research

    The Brugada syndrome is characterized by ST segment elevation in the right precodial leads V1-V3 on surface ECG accompanied by episodes of ventricular fibrillation causing syncope or even sudden death. The mol...

    Authors: Chia-Hsiang Hsueh, Wen-Pin Chen, Jiunn-Lee Lin, Chia-Ti Tsai, Yen-Bin Liu, Jyh-Ming Juang, Hsuan-Ming Tsao, Ming-Jai Su and Ling-Ping Lai

    Citation: Journal of Biomedical Science 2009 16:23

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  10. Content type: Research

    Interferons (IFNs) are key regulators for both innate and adaptive immune responses. By screening ENU-mutagenized mice, we identified a pedigree- P117 which displayed impaired response to type I, but not type ...

    Authors: Lan-Sun Chen, Pei-Chi Wei, Taming Liu, Chung-Hsuan Kao, Li-Mei Pai and Chien-Kuo Lee

    Citation: Journal of Biomedical Science 2009 16:22

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  11. Content type: Research

    The endocardial endothelium that lines the inner cavity of the heart is distinct from the microvascular endothelial cells and modulates cardiac muscle performance in a manner similar to the vascular endothelia...

    Authors: Leena Kuruvilla and Cheranellore Chandrasekharan Kartha

    Citation: Journal of Biomedical Science 2009 16:21

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  12. Content type: Research

    Prolonged ischemia amplified iscehemia/reperfusion (IR) induced renal apoptosis and autophagy. We hypothesize that ischemic conditioning (IC) by a briefly intermittent reperfusion during a prolonged ischemic p...

    Authors: Hsing-Hui Wu, Tzu-Yu Hsiao, Chiang-Ting Chien and Ming-Kuen Lai

    Citation: Journal of Biomedical Science 2009 16:19

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  13. Content type: Research

    Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA ...

    Authors: Yi-Hsuan Wu, Mei-Ling Cheng, Hung-Yao Ho, Daniel Tsun-Yee Chiu and Tzu-Chien V Wang

    Citation: Journal of Biomedical Science 2009 16:18

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  14. Content type: Research

    Despite infections by the dengue virus being a significant problem in tropical and sub-tropical countries, the mechanism by which the dengue virus enters into mammalian cells remains poorly described.

    Authors: Lukkana Suksanpaisan, Tharinee Susantad and Duncan R Smith

    Citation: Journal of Biomedical Science 2009 16:17

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  15. Content type: Research

    Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, isolated from the traditional Chinese herb Artemisia annua, is recommended as the first-line anti-malarial drug with low toxicity. DHA has ...

    Authors: Ying-Ying Lu, Tong-Sheng Chen, Jun-Le Qu, Wen-Liang Pan, Lei Sun and Xun-Bin Wei

    Citation: Journal of Biomedical Science 2009 16:16

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  16. Content type: Research

    Increased reactive oxygen species (ROS) and hyperlipidemia can promote arterial thrombus. We evaluated the potential of a partially hydrolyzed guar gum (PHGG) as dietary fiber on lipid profiles and FeCl3-induced ...

    Authors: Dar-Chih Kuo, Shih-Ping Hsu and Chiang-Ting Chien

    Citation: Journal of Biomedical Science 2009 16:15

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  17. Content type: Research

    Human parvovirus B19 infection has been postulated to the anti-phospholipid syndrome (APS) in autoimmunity. However, the influence of anti-B19-VP1u antibody in autoimmune diseases is still obscure.

    Authors: Chun-Chou Tsai, Bor-Show Tzang, Szu-Yi Chiang, Gwo-Jong Hsu and Tsai-Ching Hsu

    Citation: Journal of Biomedical Science 2009 16:14

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  18. Content type: Research

    Activity of secreted phospholipase A (sPLA2) has been implicated in a wide range of cellular responses. However, little is known about the function of human parvovirus B19-VP1 unique region (VP1u) with sPLA2 a...

    Authors: Bor-Show Tzang, Chun-Ching Chiu, Chun-Chou Tsai, Yi-Ju Lee, I-Jung Lu, Jing-Yu Shi and Tsai-Ching Hsu

    Citation: Journal of Biomedical Science 2009 16:13

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  19. Content type: Research

    Vascular endothelial cells (ECs) constantly experience fluid shear stresses generated by blood flow. Laminar flow is known to produce atheroprotective effects on ECs. Nrf2 is a transcription factor that is ess...

    Authors: Chung-Yu Hsieh, Huai-Yu Hsiao, Wan-Yi Wu, Ching-Ann Liu, Yu-Chih Tsai, Yuen-Jen Chao, Danny L Wang and Hsyue-Jen Hsieh

    Citation: Journal of Biomedical Science 2009 16:12

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  20. Content type: Research

    We found that overexpression of RhoGDIβ, a Rho GDP dissociation inhibitor, induced hypertrophic growth and suppressed cell cycle progression in a cultured cardiomyoblast cell line. Knockdown of RhoGDIβ express...

    Authors: Chih-Yang Huang, Li-Chiu Yang, Kuan-Yu Liu, Pao-Hsin Liao, Janet Ing-Yuh Chou, Ming-Yung Chou, Wei-Wen Lin and Jaw-Ji Yang

    Citation: Journal of Biomedical Science 2009 16:11

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  21. Content type: Review

    Liver cancer is the predominant cause of cancer mortality in males of Southern China and Taiwan. The current therapy is not satisfactory, and more effective treatments are needed. In the search for new therapi...

    Authors: Huan-Yao Lei and Chih-Peng Chang

    Citation: Journal of Biomedical Science 2009 16:10

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  22. Content type: Research

    Puerarin, a major isoflavonoid derived from the Chinese medical herb Radix puerariae (kudzu root), has been reported to be useful in the treatment of various cardiovascular diseases. In the present study, we exam...

    Authors: Yi Chang, Cheng-Ying Hsieh, Zi-Aa Peng, Ting-Lin Yen, George Hsiao, Duen-Suey Chou, Chien-Ming Chen and Joen-Rong Sheu

    Citation: Journal of Biomedical Science 2009 16:9

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  23. Content type: Research

    Both overproduction of nitric oxide (NO) and oxidative injury of cardiovascular and pulmonary systems contribute to fatal cardiovascular depression during endotoxemia. We investigated in the present study the ...

    Authors: Yen-Chin Liu, Alice YW Chang, Yu-Chuan Tsai and Julie YH Chan

    Citation: Journal of Biomedical Science 2009 16:8

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  24. Content type: Research

    Endonuclease G (EndoG), a member of DNA/RNA nonspecific ββα-Me-finger nucleases, is involved in apoptosis and normal cellular proliferation. In this study, we analyzed the critical amino acid residues of EndoG...

    Authors: Shih-Lu Wu, Chia-Cheng Li, Jaw-Chyun Chen, Yi-Jin Chen, Ching-Ting Lin, Tin-Yun Ho and Chien-Yun Hsiang

    Citation: Journal of Biomedical Science 2009 16:6

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  25. Content type: Research

    Bactericidal activity of traditional titanium dioxide (TiO2) photocatalyst is effective only upon irradiation by ultraviolet light, which restricts the potential applications of TiO2 for use in our living environ...

    Authors: Chia-Liang Cheng, Der-Shan Sun, Wen-Chen Chu, Yao-Hsuan Tseng, Han-Chen Ho, Jia-Bin Wang, Pei-Hua Chung, Jiann-Hwa Chen, Pei-Jane Tsai, Nien-Tsung Lin, Mei-Shiuan Yu and Hsin-Hou Chang

    Citation: Journal of Biomedical Science 2009 16:7

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  26. Content type: Research

    We previously demonstrated that α3β1 integrins are essential to hepatocyte growth factor (HGF)-independent branching tubulogenesis in Mardin-Darby Canine Kidney (MDCK) cells. However, the involvement of integr...

    Authors: Wei-Chun Wei, Anna K Kopec and Ming-Jer Tang

    Citation: Journal of Biomedical Science 2009 16:5

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  27. Content type: Research

    Steroid 21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia (CAH). Detection of underlying mutations in CYP21A2 gene encoding steroid 21-hydroxylase enzyme is helpful both for con...

    Authors: Sudhisha Dubey, Susan Idicula-Thomas, Mohammad Anwaruddin, Chinnaraj Saravanan, R Raveendra Varma and Anurupa Maitra

    Citation: Journal of Biomedical Science 2009 16:3

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  28. Content type: Research

    Cre/lox P-mediated genetic modification is the most widely used conditional genetic approach used in the mouse. Engineered Cre and the mutated ligand-binding domain of estrogen receptor fusion recombinase (CreERT

    Authors: Chih-Chia Liang, Li-Ru You, Junn-Liang Chang, Ting-Fen Tsai and Chun-Ming Chen

    Citation: Journal of Biomedical Science 2009 16:2

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  29. Content type: Research

    H. pylori infection is less prevalent in childhood. This study validated whether the rates of H. pylori colonization depend on different acquisition ages, and correlate with the different gastric Lewis antigens o...

    Authors: Yao-Jong Yang, Hsiao-Bai Yang, Jiunn-Jong Wu and Bor-Shyang Sheu

    Citation: Journal of Biomedical Science 2008 16:34

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  30. Content type: Research

    Developmentally regulated endothelial cell locus-1 (Del1) is an embryonic angiogenic factor expressed in early embryonic endothelial cells, but recently has been found to be expressed in some forms of cancers ...

    Authors: Xiaolong Zou, Haiquan Qiao, Xian Jiang, Xuesong Dong, Hongchi Jiang and Xueying Sun

    Citation: Journal of Biomedical Science 2008 16:33

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