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  1. Content type: Research

    Diabetes Mellitus is a chronic disease and many patients of which require frequent subcutaneous insulin injection to maintain proper blood glucose levels. Due to the inconvenience of insulin administration, an...

    Authors: Henry J Tsai and Shan-Yen Chou

    Citation: Journal of Biomedical Science 2009 16:68

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  2. Content type: Research

    Parkinson's disease (PD) is the second most common form of human degenerative disorder. Mutation of parkin is one of the most prevalent causes of autosomal recessive PD. Parkin is an E3 ubiquitin ligase that acts...

    Authors: Shyan-Yuan Kao

    Citation: Journal of Biomedical Science 2009 16:67

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  3. Content type: Research

    In this study, we report the physico-chemical and biological properties of a novel biodegradable composite scaffold made of nano-hydroxyapatite and natural derived polymers of chitosan and carboxymethyl cellul...

    Authors: Jiang Liuyun, Li Yubao and Xiong Chengdong

    Citation: Journal of Biomedical Science 2009 16:65

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  4. Content type: Research

    This study aimed to investigate if food components that exert anti-inflammatory effects may be used for inflammatory disorders by examining alfalfa sprout ethyl acetate extract (ASEA). The cytokine profile and...

    Authors: Yong-Han Hong, Wen-Wan Chao, Miaw-Ling Chen and Bi-Fong Lin

    Citation: Journal of Biomedical Science 2009 16:64

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  5. Content type: Research

    Parkinson's disease (PD) is a neurodegenerative disorder. The diagnosis of Parkinsonism is challenging because currently none of the clinical tests have been proven to help in diagnosis. PD may produce charact...

    Authors: Shiek SSJ Ahmed, Winkins Santosh, Suresh Kumar and Hema T Thanka Christlet

    Citation: Journal of Biomedical Science 2009 16:63

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  6. Content type: Research

    The genotype of Hepatitis C Virus (HCV) strains is an important determinant of the severity and aggressiveness of liver infection as well as patient response to antiviral therapy. Fast and accurate determinati...

    Authors: Ping Qiu, Xiao-Yan Cai, Wei Ding, Qing Zhang, Ellie D Norris and Jonathan R Greene

    Citation: Journal of Biomedical Science 2009 16:62

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  7. Content type: Research

    Oxidative stress induced by the production of reactive oxygen species may play a critical role in the stimulation of HIV replication and the development of immunodeficiency. This study was conducted as there a...

    Authors: DR Suresh, Vamseedhar Annam, K Pratibha and BV Maruti Prasad

    Citation: Journal of Biomedical Science 2009 16:61

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  8. Content type: Research

    Apart from their well-known peripheral cardiovascular effects, emerging evidence indicates that estrogen acts as a modulator in the brain to regulate cardiovascular functions. The underlying mechanisms of estr...

    Authors: Cheng-Dean Shih

    Citation: Journal of Biomedical Science 2009 16:60

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  9. Content type: Research

    During apoptosis several mitochondrial proteins are released. Some of them participate in caspase-independent nuclear DNA degradation, especially apoptosis-inducing factor (AIF) and endonuclease G (endoG). Ano...

    Authors: Miroslav Vařecha, Michal Zimmermann, Jana Amrichová, Vladimír Ulman, Pavel Matula and Michal Kozubek

    Citation: Journal of Biomedical Science 2009 16:59

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  10. Content type: Research

    Airborne particulate matter, from cooking oil, smoking, engine exhaust and other sources, is associated with the development of atherosclerosis and myocardial infarction. In order to explore the cellular and m...

    Authors: Li Ping-Chia, Lai I-Ju, Lin Yu-Ching, Chang Li-Ching and Chen Wen-Chung

    Citation: Journal of Biomedical Science 2009 16:58

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  11. Content type: Research

    Lysophosphatidylcholine (LPC), an atherogenic component of oxidized low-density lipoprotein, has been shown to induce the attenuation of endothelium-dependent vascular relaxation. Although benidipine, a dihydr...

    Authors: Makoto Takayama, Kozo Yao and Michihito Wada

    Citation: Journal of Biomedical Science 2009 16:57

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  12. Content type: Research

    RhoGDIβ, a Rho GDP dissociation inhibitor, induced hypertrophic growth and cell migration in a cultured cardiomyoblast cell line, H9c2. We demonstrated that RhoGDIβ plays a previously undefined role in regulat...

    Authors: Chih-Yang Huang, Li-Chiu Yang, Kuan-Yu Liu, I-Chang Chang, Pao-Hsin Liao, Janet Ing-Yuh Chou, Ming-Yung Chou, Wei-Wen Lin and Jaw-Ji Yang

    Citation: Journal of Biomedical Science 2009 16:56

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  13. Content type: Research

    Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is th...

    Authors: Anne Jämsä, Karin Agerman, Ann-Cathrin Radesäter, Jan Ottervald, Jonas Malmström, Gösta Hiller, Gang Liu and Mervi Vasänge

    Citation: Journal of Biomedical Science 2009 16:55

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  14. Content type: Review

    The use of radioisotopes has a long history in biomedical science, and the technique of accelerator mass spectrometry (AMS), an extremely sensitive nuclear physics technique for detection of very low-abundant,...

    Authors: Sang Soo Hah

    Citation: Journal of Biomedical Science 2009 16:54

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    The Erratum to this article has been published in Journal of Biomedical Science 2009 16:111

  15. Content type: Research

    Clinical chemical blood analysis including plasma electrolytes is routinely carried out for the diagnosis of various organ diseases. Phenotype-driven N-ethyl-N-nitrosourea (ENU) mouse mutagenesis projects used...

    Authors: Bernhard Aigner, Birgit Rathkolb, Martina Klempt, Sibylle Wagner, Dian Michel, Martin Hrabé de Angelis and Eckhard Wolf

    Citation: Journal of Biomedical Science 2009 16:53

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  16. Content type: Research

    High levels of Hepatoma Up-Regulated Protein (HURP) and Tousled-Like Kinase (TLK) transcripts are found in hepatocellular carcinoma. HURP overexpression induces anchorage-independent growth of 293-T cells and enh...

    Authors: Hsing-Hsi Li, Chuen-Sheue Chiang, Hsiao-Yu Huang and Gwo-Jen Liaw

    Citation: Journal of Biomedical Science 2009 16:51

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  17. Content type: Research

    Atorvastatin has been shown to reduce resistin expression in macrophages after pro-inflammatory stimulation. However, the mechanism of reducing resistin expression by atorvastatin is not known. Therefore, we s...

    Authors: Kou-Gi Shyu, Su-Kiat Chua, Bao-Wai Wang and Peiliang Kuan

    Citation: Journal of Biomedical Science 2009 16:50

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  18. Content type: Research

    It is important to develop innovative therapies for advanced stage cancers in addition to the conventional therapies including chemotherapy, radiation and surgery. Antigen-specific immunotherapy has emerged as...

    Authors: Chi-Mu Chuang, Archana Monie, Annie Wu and Chien-Fu Hung

    Citation: Journal of Biomedical Science 2009 16:49

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  19. Content type: Research

    Human interleukin-15 (hIL15) has anti-tumor activities, but it is not convenient for tumor treatment because of its short half-life. A gene therapy for mouse lung cancer using an adenovirus vector expressing I...

    Authors: Giou-Teng Yiang, Horng-Jyh Harn, Yung-Luen Yu, Sheng-Chuan Hu, Yu-Ting Hung, Chia-Jung Hsieh, Shinn-Zong Lin and Chyou-Wei Wei

    Citation: Journal of Biomedical Science 2009 16:47

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  20. Content type: Research

    Asthma has become an important public health issue and approximately 300 million people have suffered from the disease worldwide. Nowadays, the use of acupuncture in asthma is increasing. This study intended t...

    Authors: Lei-Miao Yin, Gong-Hao Jiang, Yu Wang, Yan Wang, Yan-Yan Liu, Wei-Rong Jin, Yu-Dong Xu, Qing-Hua Zhang and Yong-Qing Yang

    Citation: Journal of Biomedical Science 2009 16:46

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  21. Content type: Research

    Segments of the canine internal mammary artery (35 mm in length) were suspended in vitro in an organ chamber containing physiological salt solution (95% O2/5% CO2, pH = 7.4, 37°C). Segments were individually cann...

    Authors: Nilce Mitiko Matsuda, Paul J Pearson, Hartzell V Schaff, Carlos E Piccinato, Alfredo J Rodrigues and Paulo Roberto Barbosa Evora

    Citation: Journal of Biomedical Science 2009 16:45

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  22. Content type: Research

    An isolated thoracic spinal cord of the neonatal rat in vitro spontaneously generates sympathetic nerve discharge (SND) at ~25°C, but it fails in SND genesis at ≤ 10°C. Basal levels of the c-Fos expression in ...

    Authors: Chun-Kuei Su, Chiu-Ming Ho, Hsiao-Hui Kuo, Yu-Chuan Wen and Chok-Yung Chai

    Citation: Journal of Biomedical Science 2009 16:44

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  23. Content type: Research

    In the present study, we explore the role of apoptosis signal-regulating kinase 1 (ASK1) in denbinobin-induced apoptosis in human lung adenocarcinoma (A549) cells. Denbinobin-induced cell apoptosis was attenua...

    Authors: Chen-Tzu Kuo, Bing-Chang Chen, Chung-Chi Yu, Chih-Ming Weng, Ming-Jen Hsu, Chien-Chih Chen, Mei-Chieh Chen, Che-Ming Teng, Shiow-Lin Pan, Mauo-Ying Bien, Chung-Hung Shih and Chien-Huang Lin

    Citation: Journal of Biomedical Science 2009 16:43

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  24. Content type: Research

    Interleukin-6 (IL-6) is a pleiotropic cytokine with pivotal functions in the regulation of the biological responses of several target cells including hepatocytes. The level of serum IL-6 has been reported to b...

    Authors: Tzer-Min Kuo, Cheng-po Hu, Ya-Ling Chen, Ming-Hsiang Hong, King-Song Jeng, Chun-Chin T Liang, Mong-Liang Chen and Chungming Chang

    Citation: Journal of Biomedical Science 2009 16:41

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  25. Content type: Research

    Replication of the Japanese encephalitis virus (JEV) genome depends on host factors for successfully completing their life cycles; to do this, host factors have been recruited and/or relocated to the site of v...

    Authors: Shang-Hua Yang, Mei-Lan Liu, Chih-Feng Tien, Shih-Jie Chou and Ruey-Yi Chang

    Citation: Journal of Biomedical Science 2009 16:40

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  26. Content type: Research

    It is widely believed that atherosclerotic plaque rupture and subsequent thrombosis leads to acute coronary events and stroke. However, study of the mechanism and treatment of human plaque rupture is hampered ...

    Authors: Shun-Miao Fang, Qing-Hua Zhang and Zhi-Xin Jiang

    Citation: Journal of Biomedical Science 2009 16:39

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  27. Content type: Research

    Acetylcholine (ACh), the first neurotransmitter to be identified, regulate the activities of central and peripheral functions through interactions with muscarinic receptors. Changes in muscarinic acetylcholine...

    Authors: G Gireesh, T Peeyush Kumar, Jobin Mathew and CS Paulose

    Citation: Journal of Biomedical Science 2009 16:38

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  28. Content type: Research

    Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial ap...

    Authors: Bor-Ru Lin, Chia-Jung Yu, Wang-Chuan Chen, Hsuan-Shu Lee, Huei-Min Chang, Yen-Chih Lee, Chiang-Ting Chien and Chau-Fong Chen

    Citation: Journal of Biomedical Science 2009 16:35

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  29. Content type: Research

    Statins reduce cholesterol biosynthesis by inhibiting HMG-CoA reductase and thereby lower total cholesterol and LDL cholesterol levels in serum, which in turn lower the incidence of cardiovascular disease (CVD...

    Authors: Chung-Eun Ha, Ji-Sook Ha, Andre G Theriault and Nadhipuram V Bhagavan

    Citation: Journal of Biomedical Science 2009 16:32

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  30. Content type: Review

    Increasing evidence suggests that immune responses are involved in the control of cancer and that the immune system can be manipulated in different ways to recognize and attack tumors. Progress in immune-based...

    Authors: Pablo Matar, Laura Alaniz, Viviana Rozados, Jorge B Aquino, Mariana Malvicini, Catalina Atorrasagasti, Manuel Gidekel, Marcelo Silva, O Graciela Scharovsky and Guillermo Mazzolini

    Citation: Journal of Biomedical Science 2009 16:30

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  31. Content type: Research

    Exposure to protein allergen epicutaneously, inducing a Th2-dominant immune response, sensitizes the host to the development of atopic disease. Antigen-driven bystander effect demonstrates that polarized T cel...

    Authors: Li-Fang Wang, Jau-Shiuh Chen, Chih-Jung Hsu, Ching-Yi Liu, Jhang-Sian Yu and Shi-Chuen Miaw

    Citation: Journal of Biomedical Science 2009 16:28

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  32. Content type: Research

    Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by mutations leading to dysfunction of one of enzymes involved in degradation of glycosaminoglycans (GAGs). Due to their impaired degradatio...

    Authors: Joanna Jakóbkiewicz-Banecka, Ewa Piotrowska, Magdalena Narajczyk, Sylwia Barańska and Grzegorz Węgrzyn

    Citation: Journal of Biomedical Science 2009 16:26

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  33. Content type: Research

    Histone acetyltransferases (HATs), p300 and cAMP response element binding protein (CREB)-binding protein (CBP) are two structurally related transcriptional co-activators that activate expression of many eukary...

    Authors: Guozhen Chen, Jing Zhu, Tiewei Lv, Gang Wu, Huichao Sun, Xupei Huang and Jie Tian

    Citation: Journal of Biomedical Science 2009 16:24

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  34. Content type: Research

    The Brugada syndrome is characterized by ST segment elevation in the right precodial leads V1-V3 on surface ECG accompanied by episodes of ventricular fibrillation causing syncope or even sudden death. The mol...

    Authors: Chia-Hsiang Hsueh, Wen-Pin Chen, Jiunn-Lee Lin, Chia-Ti Tsai, Yen-Bin Liu, Jyh-Ming Juang, Hsuan-Ming Tsao, Ming-Jai Su and Ling-Ping Lai

    Citation: Journal of Biomedical Science 2009 16:23

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  35. Content type: Research

    Interferons (IFNs) are key regulators for both innate and adaptive immune responses. By screening ENU-mutagenized mice, we identified a pedigree- P117 which displayed impaired response to type I, but not type ...

    Authors: Lan-Sun Chen, Pei-Chi Wei, Taming Liu, Chung-Hsuan Kao, Li-Mei Pai and Chien-Kuo Lee

    Citation: Journal of Biomedical Science 2009 16:22

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  36. Content type: Research

    The endocardial endothelium that lines the inner cavity of the heart is distinct from the microvascular endothelial cells and modulates cardiac muscle performance in a manner similar to the vascular endothelia...

    Authors: Leena Kuruvilla and Cheranellore Chandrasekharan Kartha

    Citation: Journal of Biomedical Science 2009 16:21

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  37. Content type: Research

    Prolonged ischemia amplified iscehemia/reperfusion (IR) induced renal apoptosis and autophagy. We hypothesize that ischemic conditioning (IC) by a briefly intermittent reperfusion during a prolonged ischemic p...

    Authors: Hsing-Hui Wu, Tzu-Yu Hsiao, Chiang-Ting Chien and Ming-Kuen Lai

    Citation: Journal of Biomedical Science 2009 16:19

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  38. Content type: Research

    Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA ...

    Authors: Yi-Hsuan Wu, Mei-Ling Cheng, Hung-Yao Ho, Daniel Tsun-Yee Chiu and Tzu-Chien V Wang

    Citation: Journal of Biomedical Science 2009 16:18

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  39. Content type: Research

    Despite infections by the dengue virus being a significant problem in tropical and sub-tropical countries, the mechanism by which the dengue virus enters into mammalian cells remains poorly described.

    Authors: Lukkana Suksanpaisan, Tharinee Susantad and Duncan R Smith

    Citation: Journal of Biomedical Science 2009 16:17

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