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  1. Several lines of evidence point to a particularly important role of the left atrium (LA) in initiating and maintaining atrial fibrillation (AF). This role may be related to the location of pulmonary veins (PVs...

    Authors: Yue-Xia Loh, Kuo-Ho Wu, Yao-Chang Chen, Chih-Hsiung Hsu, Jeng Wei and Cheng-I Lin

    Citation: Journal of Biomedical Science 2009 16:114

    Content type: Research

    Published on:

  2. The uptake of abortion-inducing pathogens by trophoblast giant (TG) cells is a key event in infectious abortion. However, little is known about phagocytic functions of TG cells against the pathogens. Here we s...

    Authors: Kenta Watanabe, Masato Tachibana, Suk Kim and Masahisa Watarai

    Citation: Journal of Biomedical Science 2009 16:113

    Content type: Research

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  3. An important role in atherogenesis is played by oxidative stress, which may be induced by common risk factors. Mitochondria are both sources and targets of reactive oxygen species, and there is growing evidenc...

    Authors: Paolo Puddu, Giovanni M Puddu, Eleonora Cravero, Susanna De Pascalis and Antonio Muscari

    Citation: Journal of Biomedical Science 2009 16:112

    Content type: Review

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  4. After publication of our article, it was noted that we inadvertently failed to include the complete list of authors. The full list, including co-authors, has now been added and the Authors' contributions and C...

    Authors: Sang Soo Hah, Paul T Henderson and Kenneth W Turteltaub

    Citation: Journal of Biomedical Science 2009 16:111

    Content type: Erratum

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    The original article was published in Journal of Biomedical Science 2009 16:54

  5. Autophagy has been shown recently to play an important role in the intracellular survival of several pathogenic bacteria. In this study, we investigated the effect of a novel small-molecule autophagy-inducing ...

    Authors: Hao-Chieh Chiu, Shilpa Soni, Samuel K Kulp, Heather Curry, Dasheng Wang, John S Gunn, Larry S Schlesinger and Ching-Shih Chen

    Citation: Journal of Biomedical Science 2009 16:110

    Content type: Research

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  7. Neural tissue repair and regeneration strategies have received a great deal of attention because it directly affects the quality of the patient's life. There are many scientific challenges to regenerate nerve ...

    Authors: Anuradha Subramanian, Uma Maheswari Krishnan and Swaminathan Sethuraman

    Citation: Journal of Biomedical Science 2009 16:108

    Content type: Review

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  8. Human cytomegalovirus (HCMV) is known to induce chromosome aberrations in infected cells, which can lead to congenital abnormalities in infected fetuses. HCMV UL76 belongs to a conserved protein family from he...

    Authors: Voon-Kwan Siew, Chang-Yih Duh and Shang-Kwei Wang

    Citation: Journal of Biomedical Science 2009 16:107

    Content type: Research

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  9. Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presente...

    Authors: Ling-Yi Wu, Jain-Fang Chen, Pao-Luh Tao and Eagle Yi-Kung Huang

    Citation: Journal of Biomedical Science 2009 16:106

    Content type: Research

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  10. Epithelial-mesenchymal transition (EMT) is an important process in tumor metastasis. The EMT-related events associated with metastasis of NPC in the absence of EBV have not been elucidated. We established an E...

    Authors: Jung-Chung Lin, Shuen-Kuei Liao, En-Huei Lee, Man-Shan Hung, Yiyang Sayion, Hung-Chang Chen, Chen-Chen Kang, Liang-Sheng Huang and Jaw-Ming Cherng

    Citation: Journal of Biomedical Science 2009 16:105

    Content type: Research

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  12. Picornaviruses cause several diseases, not only in humans but also in various animal hosts. For instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina, myocarditis, acute flaccid paral...

    Authors: Jing-Yi Lin, Tzu-Chun Chen, Kuo-Feng Weng, Shih-Cheng Chang, Li-Lien Chen and Shin-Ru Shih

    Citation: Journal of Biomedical Science 2009 16:103

    Content type: Review

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  13. Anaemia is a frequent complication of infection with the human immunodeficiency virus (HIV) and may have multiple causes. The objective of this study was to find out if blood haemoglobin measurement could be u...

    Authors: Christian Obirikorang and Francis A Yeboah

    Citation: Journal of Biomedical Science 2009 16:102

    Content type: Research

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  14. The diastolic oscillatory after-potential Vos and pre-potential ThVos play an essential role in the pacemaker mechanism of sino-atrial node (SAN). The aim of this study was to investigate whether these oscillator...

    Authors: Mario Vassalle, John N Catanzaro, Michael P Nett and Marcello Rota

    Citation: Journal of Biomedical Science 2009 16:101

    Content type: Research

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  15. The progression and metastasis of solid tumors, including head and neck squamous cell carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer stem cells. Here, we have establish...

    Authors: Chi-Yuan Chen, Shih-Hwa Chiou, Chih-Yang Huang, Chia-Ing Jan, Shu-Chun Lin, Ming-Long Tsai and Jeng-Fan Lo

    Citation: Journal of Biomedical Science 2009 16:100

    Content type: Research

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  16. Metabotrophic glutamate receptors (mGluRs) modulate cellular activities involved in the processes of differentiation and degeneration. In this study, we have analysed the expression pattern of group-I metabotr...

    Authors: Savitha Balakrishnan, Peeyush Kumar T and CS Paulose

    Citation: Journal of Biomedical Science 2009 16:99

    Content type: Research

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  17. Reactive oxygen species (ROS) play an important role in aging and age-related diseases such as Parkinson's disease and Alzheimer's disease. Much of the ROS production under conditions of toxic stress is from m...

    Authors: Yuanbin Liu and David R Schubert

    Citation: Journal of Biomedical Science 2009 16:98

    Content type: Research

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  18. To investigate the mechanism how Transforming growth factor-β(TGF-β) represses Interleukin-1β (IL-1β)-induced Proteinase-Activated Receptor-2 (PAR-2) expression in human primary synovial cells (h PSCs). Human cho...

    Authors: Shin-Han Tsai, Ming-Thau Sheu, Yu-Chih Liang, Hsiu-Tan Cheng, Sheng-Shiung Fang and Chien-Ho Chen

    Citation: Journal of Biomedical Science 2009 16:97

    Content type: Research

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  19. The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intri...

    Authors: Ya-Hui Chi, Zi-Jie Chen and Kuan-Teh Jeang

    Citation: Journal of Biomedical Science 2009 16:96

    Content type: Review

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  21. The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal hyperalgesia induced by gl...

    Authors: Yi-Ruu Lin, Hwei-Hsien Chen, Yu-Chin Lin, Chien-Hsin Ko and Ming-Huan Chan

    Citation: Journal of Biomedical Science 2009 16:94

    Content type: Research

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  22. Glycosylphosphatidylinositol-anchored proteins (GPI-APs) represent an interesting amalgamation of the three basic kinds of cellular macromolecules viz. proteins, carbohydrates and lipids. An unusually hybrid m...

    Authors: Shaheen E Lakhan, Shefali Sabharanjak and Ananya De

    Citation: Journal of Biomedical Science 2009 16:93

    Content type: Review

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  23. Adipogenesis is a complex process that involves many genes/proteins at different stages of differentiation. In order to identify genes critical for adipogeneis, we took a novel approach based on phenotype chan...

    Authors: Masashi Niimi, Lian Tao, Shi-Hua Lin, Jun Yin, Xiaoyun Wu, Hiroyuki Fukui, Junichi Kambayashi, Jianping Ye and Bing Sun

    Citation: Journal of Biomedical Science 2009 16:92

    Content type: Research

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  24. Bacterial adherence to epithelial cells is a key virulence trait of pathogenic bacteria. The type 1 fimbriae and the P-fimbriae of uropathogenic Escherichia coli (UPEC) have both been described to be important fo...

    Authors: Kun-Wei Tsai, Hong-Thih Lai, Tzung-Chieh Tsai, Yi-Chien Wu, Ya-Ting Yang, Kwei-Yi Chen, Chun-Ming Chen, Yi-Shuan J Li and Cheng-Nan Chen

    Citation: Journal of Biomedical Science 2009 16:91

    Content type: Research

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  26. Envelope (E) glycoprotein E2 of the hepatitis C virus (HCV) mediates binding of the virus to target cell receptors. Nevertheless, the precise role of E1 in viral entry remains elusive.

    Authors: Hsiao-Fen Li, Chia-Hsuan Huang, Li-Shuang Ai, Chin-Kai Chuang and Steve SL Chen

    Citation: Journal of Biomedical Science 2009 16:89

    Content type: Research

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  27. Trophoblast differentiation and formation of the placenta are important events linked to post-implantation embryonic development. Models mimicking the biology of trophoblast differentiation in a post-implantat...

    Authors: Kavitha Sivasubramaiyan, Swapnil Totey, Vijay Bhat, Satish M Totey and Kaushik Deb

    Citation: Journal of Biomedical Science 2009 16:88

    Content type: Research

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  28. Stem cell therapy has emerged as a potential therapeutic option for tissue engineering and regenerative medicine, but many issues remain to be resolved, such as the amount of seed cells, committed differentiat...

    Authors: Yan Huang, Zhong-Quan Dai, Shu-Kuan Ling, Hong-Yu Zhang, Yu-Min Wan and Ying-Hui Li

    Citation: Journal of Biomedical Science 2009 16:87

    Content type: Research

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  29. Application of superparamagnetic iron oxide nanoparticles (SPIOs) as the contrast agent has improved the quality of magnetic resonance (MR) imaging. Low efficiency of loading the commercially available iron ox...

    Authors: Huey-Chung Huang, Po-Yuan Chang, Karen Chang, Chao-Yu Chen, Chung-Wu Lin, Jyh-Horng Chen, Chung-Yuan Mou, Zee-Fen Chang and Fu-Hsiung Chang

    Citation: Journal of Biomedical Science 2009 16:86

    Content type: Research

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  30. Ionizing radiation (IR) activate the early growth response-1 (Egr-1) promoter by production of radical oxygen intermediates (ROIs). Egr-EF, an expression vector pCIneo containing Egr-1 promoter cloned upstream...

    Authors: Nan Du, Xuetao Pei, Jinming Zhou, Hui Zhao, Xiaosong Li, Yan Fu and Yixin Hao

    Citation: Journal of Biomedical Science 2009 16:85

    Content type: Research

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  31. Chronic hepatitis B virus (HBV) infection is an important cause of hepatocellular carcinoma (HCC) worldwide. The pre-S1 and -S2 mutant large HBV surface antigen (LHBS), in which the pre-S1 and -S2 regions of the ...

    Authors: Fan-Ching Shen, Ih-Jen Su, Han-Chieh Wu, Yi-Hsuan Hsieh, Wei-Jen Yao, Kung-Chia Young, Tsung-Chuan Chang, Hui-Chuan Hsieh, Han-Ni Tsai and Wenya Huang

    Citation: Journal of Biomedical Science 2009 16:84

    Content type: Research

    Published on:

  33. Metastatic renal cell carcinoma (RCC) is highly resistant to conventional systemic treatments, including chemotherapy, radiotherapy and hormonal therapies. Previous studies have shown over-expression of EGFR i...

    Authors: Yeong-Shiau Pu, Chao-Yuan Huang, Yi-Zih Kuo, Wang-Yi Kang, Guang-Yaw Liu, A-Mei Huang, Hong-Jeng Yu, Ming-Kuen Lai, Shu-Pin Huang, Wen-Jeng Wu, Shean-Jaw Chiou and Tzyh-Chyuan Hour

    Citation: Journal of Biomedical Science 2009 16:82

    Content type: Research

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  34. The Mexican axolotl, Ambystoma mexicanum, carries the naturally-occurring recessive mutant gene 'c' that results in a failure of homozygous (c/c) embryos to form hearts that beat because of an absence of organize...

    Authors: Chi Zhang, Pingping Jia, Xupei Huang, Gian Franco Sferrazza, Gagani Athauda, Mohan P Achary, Jikui Wang, Sharon L Lemanski, Dipak K Dube and Larry F Lemanski

    Citation: Journal of Biomedical Science 2009 16:81

    Content type: Research

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  35. To search for cellular genes up-regulated by vaccinia virus (VV) infection, differential display-reverse transcription-polymerase chain reaction (ddRT-PCR) assays were used to examine the expression of mRNAs f...

    Authors: Chia-Wei Chang, Hui-Chun Li, Che-Fang Hsu, Chiao-Yen Chang and Shih-Yen Lo

    Citation: Journal of Biomedical Science 2009 16:80

    Content type: Research

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  36. Heat shock protein 70 (HSP70) protects inner ear cells from damage and death induced by e.g. heat or toxins. Benzoquinone ansamycin antibiotic geldanamycin (GA) was demonstrated to induce the expression of HSP...

    Authors: Yang Yu, Agnieszka J Szczepek, Heidemarie Haupt and Birgit Mazurek

    Citation: Journal of Biomedical Science 2009 16:79

    Content type: Research

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  37. Activation of hepatic stellate cells (HSCs) plays a crucial role in liver fibrogenesis. armepavine (Arm, C19H23O3N), an active compound from Nelumbo nucifera, has been shown to exert immunosuppressive effects on ...

    Authors: Ting-Chun Weng, Chien-Chang Shen, Yung-Tsung Chiu, Yun-Lian Lin, Cheng-Deng Kuo and Yi-Tsau Huang

    Citation: Journal of Biomedical Science 2009 16:78

    Content type: Research

    Published on:

  38. In this study, we established systemic in-vivo evidence from molecular to organism level to explain how diabetes can aggravate myocardial ischemia-reperfusion (I/R) injury and revealed the role of insulin sign...

    Authors: Jiung-Pang Huang, Shiang-Suo Huang, Jen-Ying Deng and Li-Man Hung

    Citation: Journal of Biomedical Science 2009 16:77

    Content type: Research

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  40. Attenuation of inflammatory cell deposits and associated cytokines prevented the apoptosis of transplanted stem cells in a sciatic nerve crush injury model. Suppression of inflammatory cytokines by fermented s...

    Authors: Hung-Chuan Pan, Dar-Yu Yang, Shu-Peng Ho, Meei-Ling Sheu, Chung-Jung Chen, Shiaw-Min Hwang, Ming-Hong Chang and Fu-Chou Cheng

    Citation: Journal of Biomedical Science 2009 16:75

    Content type: Research

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  41. Mesenchymal stem cells (MSCs)-based regenerative therapy is currently regarded as an alternative approach to salvage the acute myocardial infarcted hearts. However, the efficiency of MSCs transplantation is li...

    Authors: Yongwei Yao, Fumin Zhang, Liansheng Wang, Guohui Zhang, Zhaojun Wang, Jianmei Chen and Xiang Gao

    Citation: Journal of Biomedical Science 2009 16:74

    Content type: Research

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  42. The application of a subset of single nucleotide polymorphisms, the tagSNPs, can be useful in capturing untyped SNPs information in a genomic region. TagSNP transferability from the HapMap dataset to admixed p...

    Authors: Tulio C Lins, Breno S Abreu and Rinaldo W Pereira

    Citation: Journal of Biomedical Science 2009 16:73

    Content type: Research

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  43. The study examined the effects of a norepinephrine transporter (NET) inhibitor reboxetine (RBX) on an attentional performance test. Adult SD rats trained with five-choice serial reaction time task (5-CSRTT) we...

    Authors: Yia-Ping Liu, Yu-Lung Lin, Chia-Hsin Chuang, Yu-Cheng Kao, Shang-Tang Chang and Che-Se Tung

    Citation: Journal of Biomedical Science 2009 16:72

    Content type: Research

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  44. Pancreatic islet transplantation is considered an appropriate treatment to achieve insulin independence in type I diabetic patients. However, islet isolation and transplantation-induced oxidative stress and au...

    Authors: Feng-Cheng Chou and Huey-Kang Sytwu

    Citation: Journal of Biomedical Science 2009 16:71

    Content type: Research

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  45. Heart ischemia can rapidly induce apoptosis and mitochondrial dysfunction via mitochondrial permeability transition-induced cytochrome c release. We tested whether nitric oxide (NO) can block this damage in isola...

    Authors: Vilmante Borutaite, Ramune Morkuniene, Odeta Arandarcikaite, Aiste Jekabsone, Jurgita Barauskaite and Guy C Brown

    Citation: Journal of Biomedical Science 2009 16:70

    Content type: Research

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  46. Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. Some VLPs have been proven successful as vaccines, and others have recently found applications ...

    Authors: Chien-Der Lee, Yao-Pei Yan, Shu-Mei Liang and Ting-Fang Wang

    Citation: Journal of Biomedical Science 2009 16:69

    Content type: Research

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  47. Diabetes Mellitus is a chronic disease and many patients of which require frequent subcutaneous insulin injection to maintain proper blood glucose levels. Due to the inconvenience of insulin administration, an...

    Authors: Henry J Tsai and Shan-Yen Chou

    Citation: Journal of Biomedical Science 2009 16:68

    Content type: Research

    Published on:

  48. Parkinson's disease (PD) is the second most common form of human degenerative disorder. Mutation of parkin is one of the most prevalent causes of autosomal recessive PD. Parkin is an E3 ubiquitin ligase that acts...

    Authors: Shyan-Yuan Kao

    Citation: Journal of Biomedical Science 2009 16:67

    Content type: Research

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  50. In this study, we report the physico-chemical and biological properties of a novel biodegradable composite scaffold made of nano-hydroxyapatite and natural derived polymers of chitosan and carboxymethyl cellul...

    Authors: Jiang Liuyun, Li Yubao and Xiong Chengdong

    Citation: Journal of Biomedical Science 2009 16:65

    Content type: Research

    Published on:

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Journal of Biomedical Science

ISSN: 1423-0127