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  1. Nephrotoxicity is a dose limiting side effect of tenofovir, a reverse transcriptase inhibitor that is used for the treatment of HIV infection. The mechanism of tenofovir nephrotoxicity is not clear. Tenofovir ...

    Authors: Premila Abraham, Hemalatha Ramamoorthy and Bina Isaac
    Citation: Journal of Biomedical Science 2013 20:61
  2. The NKG2D receptor confers important activating signals to NK cells via ligands expressed during cellular stress and viral infection. This receptor has generated great interest because not only is it expressed...

    Authors: Mariel Garcia-Chagollan, Luis F Jave-Suarez, Jesse Haramati, Pedro E Sanchez-Hernandez, Adriana Aguilar-Lemarroy, Miriam R Bueno-Topete, Ana L Pereira-Suarez, Mary Fafutis-Morris, Angel Cid-Arregui and Susana del Toro-Arreola
    Citation: Journal of Biomedical Science 2013 20:60
  3. Although donor age-related effects of characteristics of mesenchymal stem cells (MSC), such as a decrease in the proliferation and differentiation capacity and an increase of senescence and apoptosis, are evid...

    Authors: Dah-Ching Ding, Hsiang-Lan Chou, Wei-Ting Hung, Hwan-Wun Liu and Tang-Yuan Chu
    Citation: Journal of Biomedical Science 2013 20:59
  4. The relevance of recurrent molecular abnormalities in cytogenetically normal (CN) acute myeloid leukemia (AML) was recently acknowledged by the inclusion of molecular markers such as NPM1, FLT3, and CEBPA as a co...

    Authors: Wen-Chi Yang, Wan-Chi Tsai, Pai-Mei Lin, Ming-Yu Yang, Yi-Chang Liu, Chao-Sung Chang, Wen-Hui Yu and Sheng-Fung Lin
    Citation: Journal of Biomedical Science 2013 20:58
  5. Brain- derived neurotrophic factor (BDNF) is linked to neurodegenerative diseases (e.g. Alzheimer disease and Parkinson disease) which are often characterized by olfactory impairment. A specific single nucleot...

    Authors: Alessandro Tonacci, Andrea Borghini, Antonella Mercuri, Giovanni Pioggia and Maria Grazia Andreassi
    Citation: Journal of Biomedical Science 2013 20:57
  6. CIP4 is a scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking. Although expressed in the...

    Authors: Francesca Rusconi, Hrishikesh Thakur, Jinliang Li and Michael S Kapiloff
    Citation: Journal of Biomedical Science 2013 20:56

    The Erratum to this article has been published in Journal of Biomedical Science 2014 21:45

  7. Microglial inflammation may significantly contribute to the pathology of Alzheimer’s disease. To examine the potential of Cudrania cochinchinensis to ameliorate amyloid β protein (Aβ)-induced microglia activation...

    Authors: Chung-Jen Wang, Chien-Chih Chen, Huey-Jen Tsay, Feng-Yi Chiang, Mine-Fong Wu and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2013 20:55
  8. Insufficient clearance of soluble oligomeric amyloid-β peptide (oAβ) in the central nervous system leads to the synaptic and memory deficits in Alzheimer's disease (AD). Previously we have identified scavenger...

    Authors: Fong-Lee Huang, Young-Ji Shiao, Sheue-Jane Hou, Cheng-Ning Yang, Yi-Jen Chen, Chao-Hsiung Lin, Feng-Shiun Shie and Huey-Jen Tsay
    Citation: Journal of Biomedical Science 2013 20:54
  9. Antioxidants have been shown to enhance the proliferation of adipose-derived mesenchymal stem cells (ADMSCs) in vitro, although the detailed mechanism(s) and potential side effects are not fully understood.

    Authors: Li-Yi Sun, Cheng-Yoong Pang, Dian-Kun Li, Chia-Hsin Liao, Wei-Chao Huang, Chao-Chuan Wu, Yi-Yo Chou, Wei Wu Li, Shin-Yuan Chen, Hwan-Wun Liu, Yao-Jen Chang and Ching-Feng Cheng
    Citation: Journal of Biomedical Science 2013 20:53
  10. Cancer cell differentiation is an important characteristic of malignant tumor and has a great impact on prognosis and therapeutic decision for patients. The N-myc downstream regulated gene 1 (NDRG1), a putativ...

    Authors: Lin-Lin Han, Lin Hou, Ming-Jin Zhou, Zhong-liang Ma, Dong-Liang Lin, Li Wu and Yin-lin Ge
    Citation: Journal of Biomedical Science 2013 20:52
  11. Wound healing is a complex biologic process that involves the integration of inflammation, mitosis, angiogenesis, synthesis, and remodeling of the extracellular matrix. However, some wounds fail to heal proper...

    Authors: Sheng-Ping Huang, Chun-Hsiang Huang, Jia-Fwu Shyu, Herng-Sheng Lee, Shyi-Gen Chen, James Yi-Hsin Chan and Shih-Ming Huang
    Citation: Journal of Biomedical Science 2013 20:51
  12. The expression of myocardin, a cardiac-restricted gene, increases during environmental stress. How mechanical stretch affects the regulation of myocardin in vascular smooth muscle cells (VSMCs) is not fully un...

    Authors: Chiung-Zuan Chiu, Bao-Wei Wang and Kou-Gi Shyu
    Citation: Journal of Biomedical Science 2013 20:50
  13. Oxidative stress increases the cytosolic content of calcium in the cytoplasm through a combination of effects on calcium pumps, exchangers, channels and binding proteins. In this study, oxidative stress was pr...

    Authors: Tso-Hao Tang, Chiung-Tan Chang, Hsiu-Jen Wang, Joshua D Erickson, Rhett A Reichard, Alexis G Martin, Erica K Shannon, Adam L Martin, Yue-Wern Huang and Robert S Aronstam
    Citation: Journal of Biomedical Science 2013 20:48
  14. The coupling between neuronal activity and vascular responses is controlled by the neurovascular unit (NVU), which comprises multiple cell types. Many different types of dysfunction in these cells may impair t...

    Authors: Chiao-Chi V Chen, Yu-Chen Chen, Han-Yun Hsiao, Chen Chang and Yijuang Chern
    Citation: Journal of Biomedical Science 2013 20:47
  15. Prostate smooth muscle tone is regulated by α1-adrenoceptor-induced contraction and cAMP-mediated relaxation. EPAC is an effector of cAMP, being involved in smooth muscle relaxation and cell cycle control outs...

    Authors: Martin Hennenberg, Frank Strittmatter, Henning Schmetkamp, Beata Rutz, Sebastian Walther, Christian G Stief and Christian Gratzke
    Citation: Journal of Biomedical Science 2013 20:46
  16. Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. However, the role of mitofusion-2 (MFN2), a key factor in mi...

    Authors: Xuemei Zhang, Chao Wang, Guangyao Song, Kexin Gan, Dexian Kong, Qian Nie and Luping Ren
    Citation: Journal of Biomedical Science 2013 20:45
  17. gp340, a member of scavenger receptor cysteine rich family encoded by Deleted in Malignant Brain Tumors 1 (DMBT1), is an important component in innate immune defense. The first scavenger receptor cysteine rich do...

    Authors: Ying Chu, Jiahuang Li, Xilin Wu, Zichun Hua and Zhiwei Wu
    Citation: Journal of Biomedical Science 2013 20:44
  18. Dysregulated epidermal growth factor receptor (EGFR)-phosphoinositide-3-kinase (PI3K)-AKT signaling is considered pivotal for oral cancer, and the pathway is a potential candidate for therapeutic targeting.

    Authors: Kwang-Yu Chang, Shan-Yin Tsai, Shang-Hung Chen, Hsiao-Hui Tsou, Chia-Jui Yen, Ko-Jiunn Liu, Hsun-Lang Fang, Hung-Chang Wu, Bin-Fay Chuang, Shao-Wen Chou, Careen K Tang, Shyun-Yeu Liu, Pei-Jung Lu, Ching-Yu Yen and Jang-Yang Chang
    Citation: Journal of Biomedical Science 2013 20:43
  19. Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage and abnormal hemorrhage are the two major pathogenic changes found in t...

    Authors: Yung-Chun Chuang, Shu-Ying Wang, Yee-Shin Lin, Hong-Ru Chen and Trai-Ming Yeh
    Citation: Journal of Biomedical Science 2013 20:42
  20. In non-excitable cells, one major route for calcium entry is through store-operated calcium (SOC) channels in the plasma membrane. These channels are activated by the emptying of intracellular Ca2+ store. STIM1 a...

    Authors: I-Hui Yang, Yao-Ting Tsai, Siou-Jin Chiu, Li-Teh Liu, Hsuan-Hung Lee, Ming-Feng Hou, Wen-Li Hsu, Ben-Kuen Chen and Wei-Chiao Chang
    Citation: Journal of Biomedical Science 2013 20:41
  21. Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms for DENV are complicated, invo...

    Authors: Tsung-Ting Tsai, Yi-Jui Chuang, Yee-Shin Lin, Shu-Wen Wan, Chia-Ling Chen and Chiou-Feng Lin
    Citation: Journal of Biomedical Science 2013 20:40
  22. Placenta growth factor (PlGF), a dimeric glycoprotein with 53% homology to VEGF, binds to VEGF receptor-1 (Flt-1), but not to VEGF receptor-2 (Flk-1), and may function by modulating VEGF activity. We previousl...

    Authors: Shu-Chen Wei, Po-Nien Tsao, Meng-Tzu Weng, Zhifang Cao and Jau-Min Wong
    Citation: Journal of Biomedical Science 2013 20:39
  23. Effective and validated animal models are valuable to investigate the pathogenesis and potential therapeutics for human diseases. There is much concern for diabetic retinopathy (DR) in that it affects substant...

    Authors: Dong Hyun Jo, Chang Sik Cho, Jin Hyoung Kim, Hyoung Oh Jun and Jeong Hun Kim
    Citation: Journal of Biomedical Science 2013 20:38
  24. Dengue is one of the most important emerging vector-borne viral diseases. There are four serotypes of dengue viruses (DENV), each of which is capable of causing self-limited dengue fever (DF) or even life-thre...

    Authors: Shu-Wen Wan, Chiou-Feng Lin, Shuying Wang, Yu-Hung Chen, Trai-Ming Yeh, Hsiao-Sheng Liu, Robert Anderson and Yee-Shin Lin
    Citation: Journal of Biomedical Science 2013 20:37
  25. Research on the conjugates of synthetic polyelectrolytes with antigenic molecules, such as proteins, peptides, or carbohydrates, is an attractive area due to their highly immunogenic character in comparison to...

    Authors: Murat Topuzogullari, Rabia Cakir Koc, Sevil Dincer Isoglu, Melahat Bagirova, Zeynep Akdeste, Serhat Elcicek, Olga N Oztel, Serap Yesilkir Baydar, Sezen Canim Ates and Adil M Allahverdiyev
    Citation: Journal of Biomedical Science 2013 20:35
  26. TDP-43, a multi-functional DNA/ RNA-binding protein encoded by the TARDBP gene, has emerged as a major patho-signature factor of the ubiquitinated intracellular inclusions (UBIs) in the diseased cells of a range ...

    Authors: Lien-Szu Wu, Wei-Cheng Cheng and Che-Kun James Shen
    Citation: Journal of Biomedical Science 2013 20:33
  27. To characterize single nucleotide polymorphisms (SNPs) within the promoter region of the estrogen receptor beta (ERβ) gene and to analyze the association of ERβ SNPs with susceptibility to breast cancer. Genot...

    Authors: Li Chen, Yan Liang, Juhui Qiu, Lingling Zhang, Xianchun Chen, Xiangdong Luo and Jun Jiang
    Citation: Journal of Biomedical Science 2013 20:32
  28. Even though osteoarthritis (OA) is the most common musculoskeletal dysfunction, there are no effective pharmacological treatments to treat OA due to lack of understanding in OA pathology. To better understand ...

    Authors: Jinsoo Song, Dongkyun Kim, Chang Hoon Lee, Myeung Su Lee, Churl-Hong Chun and Eun-Jung Jin
    Citation: Journal of Biomedical Science 2013 20:31
  29. H-rev107 is a member of the HREV107 type II tumor suppressor gene family which includes H-REV107, RIG1, and HRASLS. H-REV107 has been shown to express at high levels in differentiated tissues of post-meiotic t...

    Authors: Rong-Yaun Shyu, Chang-Chieh Wu, Chun-Hua Wang, Tzung-Chieh Tsai, Lu-Kai Wang, Mao-Liang Chen, Shun-Yuan Jiang and Fu-Ming Tsai
    Citation: Journal of Biomedical Science 2013 20:30
  30. Developmental haemostatic studies may help identifying new elements involved in the control of key haemostatic proteins like antithrombin, the most relevant endogenous anticoagulant.

    Authors: Raúl Teruel, Irene Martínez-Martínez, José A Guerrero, Rocío González-Conejero, María E de la Morena-Barrio, Salam Salloum-Asfar, Ana B Arroyo, Sonia Águila, Nuria García-Barberá, Antonia Miñano, Vicente Vicente, Javier Corral and Constantino Martínez
    Citation: Journal of Biomedical Science 2013 20:29
  31. Tendon injury is one of the orthopedic conditions poses with a significant clinical challenge to both the surgeons and patients. The major limitations to manage these injuries are poor healing response and dev...

    Authors: Abdolhamid Meimandi-Parizi, Ahmad Oryan and Ali Moshiri
    Citation: Journal of Biomedical Science 2013 20:28
  32. Antibodies against spliceosome Sm proteins (anti-Sm autoantibodies) are specific to the autoimmune disease systemic lupus erythematosus (SLE). Anti-Sm autosera have been reported to specifically recognize Sm D...

    Authors: Hong-How Chang, Huan-Hsuan Hu, Yu-Jen Lee, Hung-Ming Wei, Ming-Chun Fan-June, Tsai-Ching Hsu, Gregory J Tsay and Chuan Li
    Citation: Journal of Biomedical Science 2013 20:27
  33. Lynch syndrome is a hereditary cancer predisposition syndrome caused by a mutation in one of the DNA mismatch repair (MMR) genes. About 24% of the mutations identified in Lynch syndrome are missense substituti...

    Authors: Hiroko Terui, Kiwamu Akagi, Hiroshi Kawame and Kei Yura
    Citation: Journal of Biomedical Science 2013 20:25
  34. mTOR is a genetically conserved serine/threonine protein kinase, which controls cell growth, proliferation, and survival. A multifunctional protein CAD, catalyzing the initial three steps in de novo pyrimidine sy...

    Authors: Akio Nakashima, Ippei Kawanishi, Sumiko Eguchi, Eugene Hsin Yu, Satoshi Eguchi, Noriko Oshiro, Ken-ichi Yoshino, Ushio Kikkawa and Kazuyoshi Yonezawa
    Citation: Journal of Biomedical Science 2013 20:24
  35. Intracellular Ca2+ is one of the crucial signalings that modulate various cellular functions. The dysregulation of Ca2+ homeostasis has been suggested as an important event in driving the expression of the malign...

    Authors: Yih-Fung Chen, Ying-Ting Chen, Wen-Tai Chiu and Meng-Ru Shen
    Citation: Journal of Biomedical Science 2013 20:23
  36. Somatic mutations of the epidermal growth factor receptor (EGFR) are reportedly associated with various responses in non-small cell lung cancer (NSCLC) patients receiving the anti-EGFR agents. Detection of the mu...

    Authors: Tiffany Ng Shi Yeen, Rajadurai Pathmanathan, Mohd Sidik Shiran, Fattah Azman Ahmad Zaid and Yoke Kqueen Cheah
    Citation: Journal of Biomedical Science 2013 20:22
  37. Authors: Shui-Yi Tung, Shun-Fu Chang, Ming-Hui Chou, Wen-Shih Huang, Yung-Yu Hsieh, Chien-Heng Shen, Hsing-Chun Kuo and Cheng-Nan Chen
    Citation: Journal of Biomedical Science 2013 20:21

    The original article was published in Journal of Biomedical Science 2012 19:91

  38. A recessive mutation “c” in the Mexican axolotl, Ambystoma mexicanum, results in the failure of normal heart development. In homozygous recessive embryos, the hearts do not have organized myofibrils and fail to b...

    Authors: Andrei Kochegarov, Ashley Moses, William Lian, Jessica Meyer, Michael C Hanna and Larry F Lemanski
    Citation: Journal of Biomedical Science 2013 20:20
  39. Influenza virus has antigen drift and antigen shift effect, vaccination with some influenza vaccine might not induce sufficient immunity for host to the threat of other influenza virus strains. S-OIV H1N1 and ...

    Authors: Hui-Tsu Lin, Chuan-Chang Chuang, Hsieh-Ling Wu, Der-Ming Chu and Yeau-Ching Wang
    Citation: Journal of Biomedical Science 2013 20:19
  40. Houttuynia cordata Thunb (HCT) is commonly used in Taiwan and other Asian countries as an anti-inflammatory, antibacterial and antiviral herbal medicine. In this study, we investigated the anti-human lung cancer ...

    Authors: Yuh-Fung Chen, Jai-Sing Yang, Wen-Shin Chang, Shih-Chang Tsai, Shu-Fen Peng and Yuan-Ru Zhou
    Citation: Journal of Biomedical Science 2013 20:18
  41. Rivaroxaban reduces stroke in patients with atrial fibrillation (AF). Left atrium (LA) plays a critical role in the pathophysiology of AF. However, the electromechanical effects of rivaroxaban on LA are not cl...

    Authors: Chien-Jung Chang, Yao-Chang Chen, Yung-Kuo Lin, Jen-Hung Huang, Shih-Ann Chen and Yi-Jen Chen
    Citation: Journal of Biomedical Science 2013 20:17
  42. Targeted therapy of human cancers is an attractive approach and has been investigated with limited success. We have developed novel cytotoxic agents for targeted therapy of human cancers based on the extracell...

    Authors: Derek V Chan, Rahul Sharma, Chiao-Ying A Ju, Steve R Roffler and Shyr-Te Ju
    Citation: Journal of Biomedical Science 2013 20:16
  43. MicroRNAs (miRNAs) are evolutionarily conserved, naturally abundant, small, regulatory non-coding RNAs that inhibit gene expression at the post-transcriptional level in a sequence-specific manner. Due to invol...

    Authors: Pravin Kumar Singh, Ajay Vir Singh and Devendra Singh Chauhan
    Citation: Journal of Biomedical Science 2013 20:14
  44. In Oncology, the resistance of the cancerous cells to chemotherapy continues to be the principal limitation. The nuclear factor-kappa B (NF-κB) transcription factor plays an important role in tumor escape and ...

    Authors: Alejandro Bravo-Cuellar, Georgina Hernández-Flores, José Manuel Lerma-Díaz, Jorge Ramiro Domínguez-Rodríguez, Luis F Jave-Suárez, Ruth De Célis-Carrillo, Adriana Aguilar-Lemarroy, Paulina Gómez-Lomeli and Pablo Cesar Ortiz-Lazareno
    Citation: Journal of Biomedical Science 2013 20:13
  45. Several studies have demonstrated a fundamental role for the HLA in the susceptibility of, or protection to, type 1 diabetes mellitus (T1DM). However, this has not been adequately studied in Asian Indian popul...

    Authors: Oindrila Raha, Biswanath Sarkar, Bhaskar VKS Lakkakula, Veerraju Pasumarthy, Sudhakar Godi, Subhankar Chowdhury, Pradip Raychaudhuri and Raghavendra Rao Vadlamudi
    Citation: Journal of Biomedical Science 2013 20:12

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