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  1. Content type: Research

    Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, isolated from the traditional Chinese herb Artemisia annua, is recommended as the first-line anti-malarial drug with low toxicity. DHA has ...

    Authors: Ying-Ying Lu, Tong-Sheng Chen, Jun-Le Qu, Wen-Liang Pan, Lei Sun and Xun-Bin Wei

    Citation: Journal of Biomedical Science 2009 16:16

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  2. Content type: Research

    Increased reactive oxygen species (ROS) and hyperlipidemia can promote arterial thrombus. We evaluated the potential of a partially hydrolyzed guar gum (PHGG) as dietary fiber on lipid profiles and FeCl3-induced ...

    Authors: Dar-Chih Kuo, Shih-Ping Hsu and Chiang-Ting Chien

    Citation: Journal of Biomedical Science 2009 16:15

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  3. Content type: Research

    Human parvovirus B19 infection has been postulated to the anti-phospholipid syndrome (APS) in autoimmunity. However, the influence of anti-B19-VP1u antibody in autoimmune diseases is still obscure.

    Authors: Chun-Chou Tsai, Bor-Show Tzang, Szu-Yi Chiang, Gwo-Jong Hsu and Tsai-Ching Hsu

    Citation: Journal of Biomedical Science 2009 16:14

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  4. Content type: Research

    Activity of secreted phospholipase A (sPLA2) has been implicated in a wide range of cellular responses. However, little is known about the function of human parvovirus B19-VP1 unique region (VP1u) with sPLA2 a...

    Authors: Bor-Show Tzang, Chun-Ching Chiu, Chun-Chou Tsai, Yi-Ju Lee, I-Jung Lu, Jing-Yu Shi and Tsai-Ching Hsu

    Citation: Journal of Biomedical Science 2009 16:13

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  5. Content type: Research

    Vascular endothelial cells (ECs) constantly experience fluid shear stresses generated by blood flow. Laminar flow is known to produce atheroprotective effects on ECs. Nrf2 is a transcription factor that is ess...

    Authors: Chung-Yu Hsieh, Huai-Yu Hsiao, Wan-Yi Wu, Ching-Ann Liu, Yu-Chih Tsai, Yuen-Jen Chao, Danny L Wang and Hsyue-Jen Hsieh

    Citation: Journal of Biomedical Science 2009 16:12

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  6. Content type: Research

    We found that overexpression of RhoGDIβ, a Rho GDP dissociation inhibitor, induced hypertrophic growth and suppressed cell cycle progression in a cultured cardiomyoblast cell line. Knockdown of RhoGDIβ express...

    Authors: Chih-Yang Huang, Li-Chiu Yang, Kuan-Yu Liu, Pao-Hsin Liao, Janet Ing-Yuh Chou, Ming-Yung Chou, Wei-Wen Lin and Jaw-Ji Yang

    Citation: Journal of Biomedical Science 2009 16:11

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  7. Content type: Review

    Liver cancer is the predominant cause of cancer mortality in males of Southern China and Taiwan. The current therapy is not satisfactory, and more effective treatments are needed. In the search for new therapi...

    Authors: Huan-Yao Lei and Chih-Peng Chang

    Citation: Journal of Biomedical Science 2009 16:10

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  8. Content type: Research

    Puerarin, a major isoflavonoid derived from the Chinese medical herb Radix puerariae (kudzu root), has been reported to be useful in the treatment of various cardiovascular diseases. In the present study, we exam...

    Authors: Yi Chang, Cheng-Ying Hsieh, Zi-Aa Peng, Ting-Lin Yen, George Hsiao, Duen-Suey Chou, Chien-Ming Chen and Joen-Rong Sheu

    Citation: Journal of Biomedical Science 2009 16:9

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  9. Content type: Research

    Both overproduction of nitric oxide (NO) and oxidative injury of cardiovascular and pulmonary systems contribute to fatal cardiovascular depression during endotoxemia. We investigated in the present study the ...

    Authors: Yen-Chin Liu, Alice YW Chang, Yu-Chuan Tsai and Julie YH Chan

    Citation: Journal of Biomedical Science 2009 16:8

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  10. Content type: Research

    Bactericidal activity of traditional titanium dioxide (TiO2) photocatalyst is effective only upon irradiation by ultraviolet light, which restricts the potential applications of TiO2 for use in our living environ...

    Authors: Chia-Liang Cheng, Der-Shan Sun, Wen-Chen Chu, Yao-Hsuan Tseng, Han-Chen Ho, Jia-Bin Wang, Pei-Hua Chung, Jiann-Hwa Chen, Pei-Jane Tsai, Nien-Tsung Lin, Mei-Shiuan Yu and Hsin-Hou Chang

    Citation: Journal of Biomedical Science 2009 16:7

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  11. Content type: Research

    Endonuclease G (EndoG), a member of DNA/RNA nonspecific ββα-Me-finger nucleases, is involved in apoptosis and normal cellular proliferation. In this study, we analyzed the critical amino acid residues of EndoG...

    Authors: Shih-Lu Wu, Chia-Cheng Li, Jaw-Chyun Chen, Yi-Jin Chen, Ching-Ting Lin, Tin-Yun Ho and Chien-Yun Hsiang

    Citation: Journal of Biomedical Science 2009 16:6

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  12. Content type: Research

    We previously demonstrated that α3β1 integrins are essential to hepatocyte growth factor (HGF)-independent branching tubulogenesis in Mardin-Darby Canine Kidney (MDCK) cells. However, the involvement of integr...

    Authors: Wei-Chun Wei, Anna K Kopec and Ming-Jer Tang

    Citation: Journal of Biomedical Science 2009 16:5

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  13. Content type: Research

    Steroid 21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia (CAH). Detection of underlying mutations in CYP21A2 gene encoding steroid 21-hydroxylase enzyme is helpful both for con...

    Authors: Sudhisha Dubey, Susan Idicula-Thomas, Mohammad Anwaruddin, Chinnaraj Saravanan, R Raveendra Varma and Anurupa Maitra

    Citation: Journal of Biomedical Science 2009 16:3

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  14. Content type: Research

    Cre/lox P-mediated genetic modification is the most widely used conditional genetic approach used in the mouse. Engineered Cre and the mutated ligand-binding domain of estrogen receptor fusion recombinase (CreERT

    Authors: Chih-Chia Liang, Li-Ru You, Junn-Liang Chang, Ting-Fen Tsai and Chun-Ming Chen

    Citation: Journal of Biomedical Science 2009 16:2

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  15. Content type: Research

    H. pylori infection is less prevalent in childhood. This study validated whether the rates of H. pylori colonization depend on different acquisition ages, and correlate with the different gastric Lewis antigens o...

    Authors: Yao-Jong Yang, Hsiao-Bai Yang, Jiunn-Jong Wu and Bor-Shyang Sheu

    Citation: Journal of Biomedical Science 2008 16:34

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  16. Content type: Research

    Developmentally regulated endothelial cell locus-1 (Del1) is an embryonic angiogenic factor expressed in early embryonic endothelial cells, but recently has been found to be expressed in some forms of cancers ...

    Authors: Xiaolong Zou, Haiquan Qiao, Xian Jiang, Xuesong Dong, Hongchi Jiang and Xueying Sun

    Citation: Journal of Biomedical Science 2008 16:33

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