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  2. Numerous efforts have been made to elucidate the etiology and improve the treatment of lung cancer, but the overall five-year survival rate is still only 15%. Although cigarette smoking is the primary risk fac...

    Authors: Liang-Chuan Lai, Mong-Hsun Tsai, Pei-Chun Chen, Lee H Chen, Jen-Hao Hsiao, Shin-Kuang Chen, Tzu-Pin Lu, Jang-Ming Lee, Chung-Ping Hsu, Chuhsing K Hsiao and Eric Y Chuang
    Citation: Journal of Biomedical Science 2014 21:24
    Content type: Research Published on:

  3. Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease whose etiology remains largely unknown. The uncontrolled oxidative stress in SLE contributes to functional oxidative modifications of ce...

    Authors: Dilip Shah, Nidhi Mahajan, Sangita Sah, Swapan K Nath and Bishnuhari Paudyal
    Citation: Journal of Biomedical Science 2014 21:23
    Content type: Review Published on:

  5. Stem cell-fate is highly regulated by stem cell niche, which is composed of a distinct microenvironment, including neighboring cells, signals and extracellular matrix. Bone marrow-derived mesenchymal stem cell...

    Authors: Chun-Chun Cheng, Yen-Hua Lee, Shau-Ping Lin, Wei-Chun HuangFu and I-Hsuan Liu
    Citation: Journal of Biomedical Science 2014 21:21
    Content type: Research Published on:

  6. Upon lipopolysaccharide (LPS) stimulation, activation of both the Toll-like receptor 4 (TLR4) and phosphoinositide 3-kinase (PI3K) pathways serves to balance proinflammatory and anti-inflammatory responses. Al...

    Authors: Johnson Chia-Shen Yang, Shao-Chun Wu, Cheng-Shyuan Rau, Tsu-Hsiang Lu, Yi-Chan Wu, Yi-Chun Chen, Ming-Wei Lin, Siou-Ling Tzeng, Chia-Jung Wu and Ching-Hua Hsieh
    Citation: Journal of Biomedical Science 2014 21:20
    Content type: Research Published on:

  7. The apoptosis machinery is a promising target against benign prostatic hyperplasia (BPH). Inhibitors of apoptosis proteins (IAPs) modulate apoptosis by direct inhibition of caspases. Serenoa Repens (SeR) may be c...

    Authors: Letteria Minutoli, Domenica Altavilla, Herbert Marini, Mariagrazia Rinaldi, Natasha Irrera, Gabriele Pizzino, Alessandra Bitto, Salvatore Arena, Sebastiano Cimino, Francesco Squadrito, Giorgio Ivan Russo and Giuseppe Morgia
    Citation: Journal of Biomedical Science 2014 21:19
    Content type: Research Published on:

  9. Cyclooxygenase-2(COX-2) overexpression promotes inflammation and tumorigenesis. COX-2 expression in response to diverse stimuli is tightly controlled to avoid persistent overexpression. 5-methoxyindole metabol...

    Authors: Kenneth K Wu, Huei-Hsuan Cheng and Tzu-Ching Chang
    Citation: Journal of Biomedical Science 2014 21:17
    Content type: Review Published on:

  10. Human enterovirus 71 (EV71) is an important pathogen caused large outbreaks in Asian-Pacific region with severe neurological complications and may lead to death in young children. Understanding of the etiologi...

    Authors: Piyada Linsuwanon, Jiratchaya Puenpa, Sheng-Wen Huang, Ya-Fang Wang, John Mauleekoonphairoj, Jen-Ren Wang and Yong Poovorawan
    Citation: Journal of Biomedical Science 2014 21:16
    Content type: Research Published on:

  11. Stroke is one of the leading causes of neuronal death. Sesamin is known for neuroprotection by its antioxidant and anti-inflammatory properties but it lacks blood–brain barrier (BBB) activity. A panel of sesam...

    Authors: Chien-Wei Hou, Yi-Ling Chen, Shih-Hsien Chuang, Jen-Shu Wang and Kee-Ching Jeng
    Citation: Journal of Biomedical Science 2014 21:15
    Content type: Research Published on:

  13. Excessive saturated fatty acids have been considered to be one of major contributing factors for the dysfunction of skeletal muscle cells as well as pancreatic beta cells, leading to the pathogenesis of type 2...

    Authors: Hyae Gyeong Cheon and Young Sik Cho
    Citation: Journal of Biomedical Science 2014 21:13
    Content type: Research Published on:

  15. Matrix metalloproteinase-9 (MMP-9) has been shown to be induced by cytokines including TNF-α and may contribute to bone inflammatory diseases. However, the mechanisms underlying MMP-9 expression induced by TNF...

    Authors: Chia-Lan Tsai, Wei-Chung Chen, Hsi-Lung Hsieh, Pei-Ling Chi, Li-Der Hsiao and Chuen-Mao Yang
    Citation: Journal of Biomedical Science 2014 21:12
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2015 22:20

  16. Oxidized LDL (oxLDL) is involved in the development of atherosclerotic heart disease through a mechanism that is not fully understood. In this study, we examined the role of malondialdehyde (MDA), an important...

    Authors: Tzu-Ching Yang, Yi-Jie Chen, Shwu-Fen Chang, Chu-Huang Chen, Po-Yuan Chang and Shao-Chun Lu
    Citation: Journal of Biomedical Science 2014 21:11
    Content type: Research Published on:

  17. Bisphosphonates are an important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Recent studies have shown that nitrogen-containing bisphosphonates induced apoptosis in rabbit o...

    Authors: Masanobu Tsubaki, Makiko Komai, Tatsuki Itoh, Motohiro Imano, Kotaro Sakamoto, Hirotaka Shimaoka, Tomoya Takeda, Naoki Ogawa, Kenji Mashimo, Daiichiro Fujiwara, Junji Mukai, Katsuhiko Sakaguchi, Takao Satou and Shozo Nishida
    Citation: Journal of Biomedical Science 2014 21:10
    Content type: Research Published on:

  18. The increase in fructose ingestion has been linked to overdrive of sympathetic activity and hypertension associated with the metabolic syndrome. The premotor neurons for generation of sympathetic vasomotor act...

    Authors: Kay LH Wu, Chun-Ying Hung, Julie YH Chan and Chih-Wei Wu
    Citation: Journal of Biomedical Science 2014 21:8
    Content type: Research Published on:

  19. The occurrence of Congenital Heart Disease (CHD) is resulted from either genetic or environmental factors or the both. The CITED2 gene deletion or mutation is associated with the development of cardiac malform...

    Authors: Min Xu, Xiaoyun Wu, Yonggang Li, Xiaofei Yang, Jihua Hu, Min Zheng and Jie Tian
    Citation: Journal of Biomedical Science 2014 21:7
    Content type: Research Published on:

  20. Tolerance to the analgesic effect of opioids is a pharmacological phenomenon that occurs after their prolonged administration. It has been shown that morphine-induced tolerance is associated with apoptosis in ...

    Authors: Mozhdeh Sharifipour, Esmaeal Izadpanah, Bahram Nikkhoo, Samad Zare, Ali Abdolmaleki, Katayoun Hassanzadeh, Farshid Moradi and Kambiz Hassanzadeh
    Citation: Journal of Biomedical Science 2014 21:6
    Content type: Research Published on:

  21. Several lines of evidence have demonstrated that bone marrow-derived mesenchymal stem cells (BM-MSC) release bioactive factors and provide neuroprotection for CNS injury. However, it remains elusive whether BM...

    Authors: May-Jywan Tsai, Shen-Kou Tsai, Bo-Ruei Hu, Dann-Ying Liou, Shih-Ling Huang, Ming-Chao Huang, Wen-Cheng Huang, Henrich Cheng and Shiang-Suo Huang
    Citation: Journal of Biomedical Science 2014 21:5
    Content type: Research Published on:

  22. The Maillard reaction is a chemical reaction occurring between a reducing sugar and an amino acid, generally requiring thermal processing. Maillard reaction products (MRPs) have antioxidant, antimutagenic, and...

    Authors: Jung-Il Chae, RaHam Lee, JinHyoung Cho, JinTae Hong and Jung-Hyun Shim
    Citation: Journal of Biomedical Science 2014 21:4
    Content type: Research Published on:

  23. Hemodynamic shear stress, the blood flow-generated frictional force acting on the vascular endothelial cells, is essential for endothelial homeostasis under normal physiological conditions. Mechanosensors on e...

    Authors: Hsyue-Jen Hsieh, Ching-Ann Liu, Bin Huang, Anne HH Tseng and Danny Ling Wang
    Citation: Journal of Biomedical Science 2014 21:3
    Content type: Review Published on:

  24. Polycystic ovary syndrome (PCOS) is a state of altered steroid hormone production and activity. Chronic estrogen exposure or lack of progesterone due to ovarian dysfunction can result in endometrial hyperplasi...

    Authors: Xin Li, Yi Feng, Jin-Fang Lin, Håkan Billig and Ruijin Shao
    Citation: Journal of Biomedical Science 2014 21:2
    Content type: Review Published on:

  25. Patients with colorectal cancer (CRC) often develop liver metastases, in which case surgery is considered the only potentially curative treatment option. However, liver surgery is associated with a risk of isc...

    Authors: Shu-Fan Jiao, Kai Sun, Xiao-Jing Chen, Xue Zhao, Ning Cai, Yan-Jun Liu, Long-Mei Xu, Xian-Ming Kong and Li-Xin Wei
    Citation: Journal of Biomedical Science 2014 21:1
    Content type: Research Published on:

  26. The polymorphic species Candida albicans is the major cause of candidiasis in humans. The secreted aspartyl proteinases (Saps) of C. albicans, encoded by a family of 10 SAP genes, have been investigated as the vi...

    Authors: Leh-Miauh Buu and Yee-Chun Chen
    Citation: Journal of Biomedical Science 2013 20:101
    Content type: Research Published on:

  27. Hypoxia-inducible factor-1 alpha (HIF-1α) is one of the key regulators of hypoxia/ischemia. MicroRNA-494 (miR-494) had cardioprotective effects against ischemia/reperfusion (I/R)-induced injury, but its functi...

    Authors: Guixiang Sun, Yanni Zhou, Hongsheng Li, Yingjia Guo, Juan Shan, Mengjuan Xia, Youping Li, Shengfu Li, Dan Long and Li Feng
    Citation: Journal of Biomedical Science 2013 20:100
    Content type: Research Published on:

  29. Zinc finger protein 179 (Znf179), also known as ring finger protein 112 (Rnf112), is a member of the RING finger protein family and plays an important role in neuronal differentiation. To investigate novel mec...

    Authors: Ding-Yen Lin, Chi-Chen Huang, Ya-Ting Hsieh, Hsin-Chuan Lin, Ping-Chieh Pao, Jen-Hui Tsou, Chien-Ying Lai, Liang-Yi Hung, Ju-Ming Wang, Wen-Chang Chang and Yi-Chao Lee
    Citation: Journal of Biomedical Science 2013 20:98
    Content type: Research Published on:

  30. CDC4, which encodes an F-box protein that is a member of the Skp1-Cdc53/Cul1-F-box (SCF) ubiquitin E3 ligase, was initially identified in the budding yeast Saccharomyces cerevisiae as an essential gene for progre...

    Authors: Chuen Chin, Wei-Chung Lai, Tai-Lin Lee, Tzu-Ling Tseng and Jia-Ching Shieh
    Citation: Journal of Biomedical Science 2013 20:97
    Content type: Research Published on:

  31. MicroRNA (miRNA) emerges as important player in drug abuse. Yet, their expression profile in neurological disorder of cocaine abuse has not been well characterized. Here, we explored the changes of miRNA expre...

    Authors: Chun-Lin Chen, Hailin Liu and Xiaowei Guan
    Citation: Journal of Biomedical Science 2013 20:96
    Content type: Research Published on:

  33. Obesity is an important risk factor for atrial fibrillation (AF). Leptin is an important adipokine. However, it is not clear whether leptin directly modulates the electrophysiological characteristics of atrial...

    Authors: Yung-Kuo Lin, Yao-Chang Chen, Jen-Hung Huang, Yenn-Jiang Lin, Shiang-Suo Huang, Shih-Ann Chen and Yi-Jen Chen
    Citation: Journal of Biomedical Science 2013 20:94
    Content type: Research Published on:

  34. Infertility, spontaneous abortion and conception of trisomic offspring increase exponentially with age in mammals but in women there is an apparent acceleration in the rate from about age 37. The problems most...

    Authors: Judith H Ford
    Citation: Journal of Biomedical Science 2013 20:93
    Content type: Review Published on:

  35. DNA transposons are primitive genetic elements which have colonized living organisms from plants to bacteria and mammals. Through evolution such parasitic elements have shaped their host genomes by replicating...

    Authors: Kristian Alsbjerg Skipper, Peter Refsing Andersen, Nynne Sharma and Jacob Giehm Mikkelsen
    Citation: Journal of Biomedical Science 2013 20:92
    Content type: Review Published on:

  36. Noise induced injury of the cochlea causes shifts in activation thresholds and changes of frequency response in the inferior colliculus (IC). Noise overexposure also induces pathological changes in the cochlea...

    Authors: Feng Wang, Li Zuo, Bo Hong, Dongyi Han, Ethan M Range, Lingyun Zhao, Yanan Sui, Weiwei Guo and Liangfa Liu
    Citation: Journal of Biomedical Science 2013 20:91
    Content type: Research Published on:

  37. The roles of caspase 3 on the kainic acid-mediated neurodegeneration, dendritic plasticity alteration, neurogenesis, microglial activation and gliosis are not fully understood. Here, we investigate hippocampal...

    Authors: Tsai-Teng Tzeng, Huey-Jen Tsay, Luping Chang, Chia-Lin Hsu, Tzu-Hsuan Lai, Fong-Lee Huang and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2013 20:90
    Content type: Research Published on:

  39. Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making ...

    Authors: Jih-Jin Tsai, Kulkanya Chokephaibulkit, Po-Chih Chen, Li-Teh Liu, Hui-Mien Hsiao, Yu-Chih Lo and Guey Chuen Perng
    Citation: Journal of Biomedical Science 2013 20:88
    Content type: Review Published on:

  40. Long non-coding RNAs (lncRNAs) have different functions in cells. They work as signals, decoys, guides, and scaffolds. Altered lncRNA levels can affect the expression of gene products. There are seldom studies...

    Authors: Yu Qi Qiao, Mei Lan Huang, An Tao Xu, Di Zhao, Zhi Hua Ran and Jun Shen
    Citation: Journal of Biomedical Science 2013 20:87
    Content type: Research Published on:

  41. Epigallocatechin-3-gallate (EGCg) with its potent anti-oxidative capabilities is known for its beneficial effects ameliorating oxidative injury to cardiac cells. Although studies have provided convincing evide...

    Authors: Shih-Ron Hsieh, Chen-Sen Hsu, Chen-Hua Lu, Wei-Cheng Chen, Chun-Hwei Chiu and Ying-Ming Liou
    Citation: Journal of Biomedical Science 2013 20:86
    Content type: Research Published on:

  42. Clinical and experimental evidence demonstrates that sleep and epilepsy reciprocally affect each other. Previous studies indicated that epilepsy alters sleep homeostasis; in contrast, sleep disturbance deterio...

    Authors: Pei-Lu Yi, Chin-Yu Lu, Chiung-Hsiang Cheng, Yi-Fong Tsai, Chung-Tien Lin and Fang-Chia Chang
    Citation: Journal of Biomedical Science 2013 20:85
    Content type: Research Published on:

  43. Wedelolactone (WEL), a major coumestan ingredient in Wedelia chinensis, has been used to treat septic shock, hepatitis and venom poisoning in traditional Chinese medicines. The objective of the study was to eluci...

    Authors: Fang Yuan, Jie Chen, Ping-ping Sun, Su Guan and Jing Xu
    Citation: Journal of Biomedical Science 2013 20:84
    Content type: Research Published on:

  44. Two isoforms of Rho-associated protein kinase (ROCK), ROCKI and ROCKII, play a pivotal role in regulation of cytoskeleton and are involved in multiple cellular processes in mammalian cells. Knockout mice exper...

    Authors: Hsiang-Hao Chuang, Shao-Wei Liang, Zee-Fen Chang and Hsiao-Hui Lee
    Citation: Journal of Biomedical Science 2013 20:83
    Content type: Research Published on:

  45. This study investigated the association between innate immune reaction and myocardial damage after acute myocardial infarction (AMI) and anti-inflammatory role of tacrolimus in reducing infarct size. Male mini...

    Authors: Jiunn-Jye Sheu, Pei-Hsun Sung, Steve Leu, Han-Tan Chai, Yen-Yi Zhen, Yi-Ching Chen, Sarah Chua, Yung-Lung Chen, Tzu-Hsien Tsai, Fan-Yen Lee, Hsueh-Wen Chang, Sheung-Fat Ko and Hon-Kan Yip
    Citation: Journal of Biomedical Science 2013 20:82
    Content type: Research Published on:

  46. Tamsulosin, an α1-adrenoceptor antagonist, and sildenafil, a phosphodiesterase (PDE) inhibitor, are reported to improve lower urinary tract symptoms including overactive bladder (OAB). This study is aimed at i...

    Authors: Sung-Eun Kim, Il-Gyu Ko, Lakkyong Hwang, In-Young Choi, Mal-Soon Shin, Chang-Ju Kim and Khae-Hawn Kim
    Citation: Journal of Biomedical Science 2013 20:81
    Content type: Research Published on:

  47. Type 2 diabetes mellitus (T2DM) is a non-autoimmune, complex, heterogeneous and polygenic metabolic disease condition characterized by persistent elevated blood glucose levels (hyperglycemia). India as said to...

    Authors: Shania Abbas, Syed Tasleem Raza, Faisal Ahmed, Absar Ahmad, Saliha Rizvi and Farzana Mahdi
    Citation: Journal of Biomedical Science 2013 20:80
    Content type: Review Published on:

  48. MiR-155 has emerged as an “oncomiR”, which is the most significantly up-regulated miRNA in breast cancer. However, the mechanisms of miR-155 functions as an oncomiR are mainly unknown. In this study, the aims ...

    Authors: Chun-Mei Zhang, Jing Zhao and Hua-Yu Deng
    Citation: Journal of Biomedical Science 2013 20:79
    Content type: Research Published on:

  49. The specific role of microglia on Aβ-mediated neurotoxicity is difficult to assign in vivo due to their complicated environment in the brain. Therefore, most of the current microglia-related studies employed the ...

    Authors: Huey-Jen Tsay, Yung-Cheng Huang, Fong-Lee Huang, Chia-Ping Chen, Yu-Chun Tsai, Ying-Hsiu Wang, Mine-Fong Wu, Feng-Yi Chiang and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2013 20:78
    Content type: Research Published on:

  50. The exact mechanisms of morphine-induced dependence and withdrawal symptoms remain unclear. In order to identify an agent that can prevent withdrawal syndrome, many studies have been performed. This study was ...

    Authors: Sabah Moradi, Mohammad Charkhpour, Hamed Ghavimi, Rasoul Motahari, Majid Ghaderi and Kambiz Hassanzadeh
    Citation: Journal of Biomedical Science 2013 20:77
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127