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  1. Chronic hepatitis B virus (HBV) infection is an important cause of hepatocellular carcinoma (HCC) worldwide. The pre-S1 and -S2 mutant large HBV surface antigen (LHBS), in which the pre-S1 and -S2 regions of the ...

    Authors: Fan-Ching Shen, Ih-Jen Su, Han-Chieh Wu, Yi-Hsuan Hsieh, Wei-Jen Yao, Kung-Chia Young, Tsung-Chuan Chang, Hui-Chuan Hsieh, Han-Ni Tsai and Wenya Huang

    Citation: Journal of Biomedical Science 2009 16:84

    Content type: Research

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  2. Metastatic renal cell carcinoma (RCC) is highly resistant to conventional systemic treatments, including chemotherapy, radiotherapy and hormonal therapies. Previous studies have shown over-expression of EGFR i...

    Authors: Yeong-Shiau Pu, Chao-Yuan Huang, Yi-Zih Kuo, Wang-Yi Kang, Guang-Yaw Liu, A-Mei Huang, Hong-Jeng Yu, Ming-Kuen Lai, Shu-Pin Huang, Wen-Jeng Wu, Shean-Jaw Chiou and Tzyh-Chyuan Hour

    Citation: Journal of Biomedical Science 2009 16:82

    Content type: Research

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  3. The Mexican axolotl, Ambystoma mexicanum, carries the naturally-occurring recessive mutant gene 'c' that results in a failure of homozygous (c/c) embryos to form hearts that beat because of an absence of organize...

    Authors: Chi Zhang, Pingping Jia, Xupei Huang, Gian Franco Sferrazza, Gagani Athauda, Mohan P Achary, Jikui Wang, Sharon L Lemanski, Dipak K Dube and Larry F Lemanski

    Citation: Journal of Biomedical Science 2009 16:81

    Content type: Research

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  4. To search for cellular genes up-regulated by vaccinia virus (VV) infection, differential display-reverse transcription-polymerase chain reaction (ddRT-PCR) assays were used to examine the expression of mRNAs f...

    Authors: Chia-Wei Chang, Hui-Chun Li, Che-Fang Hsu, Chiao-Yen Chang and Shih-Yen Lo

    Citation: Journal of Biomedical Science 2009 16:80

    Content type: Research

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  5. Heat shock protein 70 (HSP70) protects inner ear cells from damage and death induced by e.g. heat or toxins. Benzoquinone ansamycin antibiotic geldanamycin (GA) was demonstrated to induce the expression of HSP...

    Authors: Yang Yu, Agnieszka J Szczepek, Heidemarie Haupt and Birgit Mazurek

    Citation: Journal of Biomedical Science 2009 16:79

    Content type: Research

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  6. Activation of hepatic stellate cells (HSCs) plays a crucial role in liver fibrogenesis. armepavine (Arm, C19H23O3N), an active compound from Nelumbo nucifera, has been shown to exert immunosuppressive effects on ...

    Authors: Ting-Chun Weng, Chien-Chang Shen, Yung-Tsung Chiu, Yun-Lian Lin, Cheng-Deng Kuo and Yi-Tsau Huang

    Citation: Journal of Biomedical Science 2009 16:78

    Content type: Research

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  7. In this study, we established systemic in-vivo evidence from molecular to organism level to explain how diabetes can aggravate myocardial ischemia-reperfusion (I/R) injury and revealed the role of insulin sign...

    Authors: Jiung-Pang Huang, Shiang-Suo Huang, Jen-Ying Deng and Li-Man Hung

    Citation: Journal of Biomedical Science 2009 16:77

    Content type: Research

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  8. Attenuation of inflammatory cell deposits and associated cytokines prevented the apoptosis of transplanted stem cells in a sciatic nerve crush injury model. Suppression of inflammatory cytokines by fermented s...

    Authors: Hung-Chuan Pan, Dar-Yu Yang, Shu-Peng Ho, Meei-Ling Sheu, Chung-Jung Chen, Shiaw-Min Hwang, Ming-Hong Chang and Fu-Chou Cheng

    Citation: Journal of Biomedical Science 2009 16:75

    Content type: Research

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  9. Mesenchymal stem cells (MSCs)-based regenerative therapy is currently regarded as an alternative approach to salvage the acute myocardial infarcted hearts. However, the efficiency of MSCs transplantation is li...

    Authors: Yongwei Yao, Fumin Zhang, Liansheng Wang, Guohui Zhang, Zhaojun Wang, Jianmei Chen and Xiang Gao

    Citation: Journal of Biomedical Science 2009 16:74

    Content type: Research

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  10. The application of a subset of single nucleotide polymorphisms, the tagSNPs, can be useful in capturing untyped SNPs information in a genomic region. TagSNP transferability from the HapMap dataset to admixed p...

    Authors: Tulio C Lins, Breno S Abreu and Rinaldo W Pereira

    Citation: Journal of Biomedical Science 2009 16:73

    Content type: Research

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  11. The study examined the effects of a norepinephrine transporter (NET) inhibitor reboxetine (RBX) on an attentional performance test. Adult SD rats trained with five-choice serial reaction time task (5-CSRTT) we...

    Authors: Yia-Ping Liu, Yu-Lung Lin, Chia-Hsin Chuang, Yu-Cheng Kao, Shang-Tang Chang and Che-Se Tung

    Citation: Journal of Biomedical Science 2009 16:72

    Content type: Research

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  12. Pancreatic islet transplantation is considered an appropriate treatment to achieve insulin independence in type I diabetic patients. However, islet isolation and transplantation-induced oxidative stress and au...

    Authors: Feng-Cheng Chou and Huey-Kang Sytwu

    Citation: Journal of Biomedical Science 2009 16:71

    Content type: Research

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  13. Heart ischemia can rapidly induce apoptosis and mitochondrial dysfunction via mitochondrial permeability transition-induced cytochrome c release. We tested whether nitric oxide (NO) can block this damage in isola...

    Authors: Vilmante Borutaite, Ramune Morkuniene, Odeta Arandarcikaite, Aiste Jekabsone, Jurgita Barauskaite and Guy C Brown

    Citation: Journal of Biomedical Science 2009 16:70

    Content type: Research

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  14. Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. Some VLPs have been proven successful as vaccines, and others have recently found applications ...

    Authors: Chien-Der Lee, Yao-Pei Yan, Shu-Mei Liang and Ting-Fang Wang

    Citation: Journal of Biomedical Science 2009 16:69

    Content type: Research

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  15. Diabetes Mellitus is a chronic disease and many patients of which require frequent subcutaneous insulin injection to maintain proper blood glucose levels. Due to the inconvenience of insulin administration, an...

    Authors: Henry J Tsai and Shan-Yen Chou

    Citation: Journal of Biomedical Science 2009 16:68

    Content type: Research

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  16. Parkinson's disease (PD) is the second most common form of human degenerative disorder. Mutation of parkin is one of the most prevalent causes of autosomal recessive PD. Parkin is an E3 ubiquitin ligase that acts...

    Authors: Shyan-Yuan Kao

    Citation: Journal of Biomedical Science 2009 16:67

    Content type: Research

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  17. In this study, we report the physico-chemical and biological properties of a novel biodegradable composite scaffold made of nano-hydroxyapatite and natural derived polymers of chitosan and carboxymethyl cellul...

    Authors: Jiang Liuyun, Li Yubao and Xiong Chengdong

    Citation: Journal of Biomedical Science 2009 16:65

    Content type: Research

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  18. This study aimed to investigate if food components that exert anti-inflammatory effects may be used for inflammatory disorders by examining alfalfa sprout ethyl acetate extract (ASEA). The cytokine profile and...

    Authors: Yong-Han Hong, Wen-Wan Chao, Miaw-Ling Chen and Bi-Fong Lin

    Citation: Journal of Biomedical Science 2009 16:64

    Content type: Research

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  19. Parkinson's disease (PD) is a neurodegenerative disorder. The diagnosis of Parkinsonism is challenging because currently none of the clinical tests have been proven to help in diagnosis. PD may produce charact...

    Authors: Shiek SSJ Ahmed, Winkins Santosh, Suresh Kumar and Hema T Thanka Christlet

    Citation: Journal of Biomedical Science 2009 16:63

    Content type: Research

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  20. The genotype of Hepatitis C Virus (HCV) strains is an important determinant of the severity and aggressiveness of liver infection as well as patient response to antiviral therapy. Fast and accurate determinati...

    Authors: Ping Qiu, Xiao-Yan Cai, Wei Ding, Qing Zhang, Ellie D Norris and Jonathan R Greene

    Citation: Journal of Biomedical Science 2009 16:62

    Content type: Research

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  21. Oxidative stress induced by the production of reactive oxygen species may play a critical role in the stimulation of HIV replication and the development of immunodeficiency. This study was conducted as there a...

    Authors: DR Suresh, Vamseedhar Annam, K Pratibha and BV Maruti Prasad

    Citation: Journal of Biomedical Science 2009 16:61

    Content type: Research

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  22. Apart from their well-known peripheral cardiovascular effects, emerging evidence indicates that estrogen acts as a modulator in the brain to regulate cardiovascular functions. The underlying mechanisms of estr...

    Authors: Cheng-Dean Shih

    Citation: Journal of Biomedical Science 2009 16:60

    Content type: Research

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  23. During apoptosis several mitochondrial proteins are released. Some of them participate in caspase-independent nuclear DNA degradation, especially apoptosis-inducing factor (AIF) and endonuclease G (endoG). Ano...

    Authors: Miroslav Vařecha, Michal Zimmermann, Jana Amrichová, Vladimír Ulman, Pavel Matula and Michal Kozubek

    Citation: Journal of Biomedical Science 2009 16:59

    Content type: Research

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  24. Airborne particulate matter, from cooking oil, smoking, engine exhaust and other sources, is associated with the development of atherosclerosis and myocardial infarction. In order to explore the cellular and m...

    Authors: Li Ping-Chia, Lai I-Ju, Lin Yu-Ching, Chang Li-Ching and Chen Wen-Chung

    Citation: Journal of Biomedical Science 2009 16:58

    Content type: Research

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  25. Lysophosphatidylcholine (LPC), an atherogenic component of oxidized low-density lipoprotein, has been shown to induce the attenuation of endothelium-dependent vascular relaxation. Although benidipine, a dihydr...

    Authors: Makoto Takayama, Kozo Yao and Michihito Wada

    Citation: Journal of Biomedical Science 2009 16:57

    Content type: Research

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  26. RhoGDIβ, a Rho GDP dissociation inhibitor, induced hypertrophic growth and cell migration in a cultured cardiomyoblast cell line, H9c2. We demonstrated that RhoGDIβ plays a previously undefined role in regulat...

    Authors: Chih-Yang Huang, Li-Chiu Yang, Kuan-Yu Liu, I-Chang Chang, Pao-Hsin Liao, Janet Ing-Yuh Chou, Ming-Yung Chou, Wei-Wen Lin and Jaw-Ji Yang

    Citation: Journal of Biomedical Science 2009 16:56

    Content type: Research

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  27. Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is th...

    Authors: Anne Jämsä, Karin Agerman, Ann-Cathrin Radesäter, Jan Ottervald, Jonas Malmström, Gösta Hiller, Gang Liu and Mervi Vasänge

    Citation: Journal of Biomedical Science 2009 16:55

    Content type: Research

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  28. The use of radioisotopes has a long history in biomedical science, and the technique of accelerator mass spectrometry (AMS), an extremely sensitive nuclear physics technique for detection of very low-abundant,...

    Authors: Sang Soo Hah

    Citation: Journal of Biomedical Science 2009 16:54

    Content type: Review

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    The Erratum to this article has been published in Journal of Biomedical Science 2009 16:111

  29. Clinical chemical blood analysis including plasma electrolytes is routinely carried out for the diagnosis of various organ diseases. Phenotype-driven N-ethyl-N-nitrosourea (ENU) mouse mutagenesis projects used...

    Authors: Bernhard Aigner, Birgit Rathkolb, Martina Klempt, Sibylle Wagner, Dian Michel, Martin Hrabé de Angelis and Eckhard Wolf

    Citation: Journal of Biomedical Science 2009 16:53

    Content type: Research

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  30. High levels of Hepatoma Up-Regulated Protein (HURP) and Tousled-Like Kinase (TLK) transcripts are found in hepatocellular carcinoma. HURP overexpression induces anchorage-independent growth of 293-T cells and enh...

    Authors: Hsing-Hsi Li, Chuen-Sheue Chiang, Hsiao-Yu Huang and Gwo-Jen Liaw

    Citation: Journal of Biomedical Science 2009 16:51

    Content type: Research

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  31. Atorvastatin has been shown to reduce resistin expression in macrophages after pro-inflammatory stimulation. However, the mechanism of reducing resistin expression by atorvastatin is not known. Therefore, we s...

    Authors: Kou-Gi Shyu, Su-Kiat Chua, Bao-Wai Wang and Peiliang Kuan

    Citation: Journal of Biomedical Science 2009 16:50

    Content type: Research

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  32. It is important to develop innovative therapies for advanced stage cancers in addition to the conventional therapies including chemotherapy, radiation and surgery. Antigen-specific immunotherapy has emerged as...

    Authors: Chi-Mu Chuang, Archana Monie, Annie Wu and Chien-Fu Hung

    Citation: Journal of Biomedical Science 2009 16:49

    Content type: Research

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  33. Human interleukin-15 (hIL15) has anti-tumor activities, but it is not convenient for tumor treatment because of its short half-life. A gene therapy for mouse lung cancer using an adenovirus vector expressing I...

    Authors: Giou-Teng Yiang, Horng-Jyh Harn, Yung-Luen Yu, Sheng-Chuan Hu, Yu-Ting Hung, Chia-Jung Hsieh, Shinn-Zong Lin and Chyou-Wei Wei

    Citation: Journal of Biomedical Science 2009 16:47

    Content type: Research

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  34. Asthma has become an important public health issue and approximately 300 million people have suffered from the disease worldwide. Nowadays, the use of acupuncture in asthma is increasing. This study intended t...

    Authors: Lei-Miao Yin, Gong-Hao Jiang, Yu Wang, Yan Wang, Yan-Yan Liu, Wei-Rong Jin, Yu-Dong Xu, Qing-Hua Zhang and Yong-Qing Yang

    Citation: Journal of Biomedical Science 2009 16:46

    Content type: Research

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  35. Segments of the canine internal mammary artery (35 mm in length) were suspended in vitro in an organ chamber containing physiological salt solution (95% O2/5% CO2, pH = 7.4, 37°C). Segments were individually cann...

    Authors: Nilce Mitiko Matsuda, Paul J Pearson, Hartzell V Schaff, Carlos E Piccinato, Alfredo J Rodrigues and Paulo Roberto Barbosa Evora

    Citation: Journal of Biomedical Science 2009 16:45

    Content type: Research

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  36. An isolated thoracic spinal cord of the neonatal rat in vitro spontaneously generates sympathetic nerve discharge (SND) at ~25°C, but it fails in SND genesis at ≤ 10°C. Basal levels of the c-Fos expression in ...

    Authors: Chun-Kuei Su, Chiu-Ming Ho, Hsiao-Hui Kuo, Yu-Chuan Wen and Chok-Yung Chai

    Citation: Journal of Biomedical Science 2009 16:44

    Content type: Research

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  37. In the present study, we explore the role of apoptosis signal-regulating kinase 1 (ASK1) in denbinobin-induced apoptosis in human lung adenocarcinoma (A549) cells. Denbinobin-induced cell apoptosis was attenua...

    Authors: Chen-Tzu Kuo, Bing-Chang Chen, Chung-Chi Yu, Chih-Ming Weng, Ming-Jen Hsu, Chien-Chih Chen, Mei-Chieh Chen, Che-Ming Teng, Shiow-Lin Pan, Mauo-Ying Bien, Chung-Hung Shih and Chien-Huang Lin

    Citation: Journal of Biomedical Science 2009 16:43

    Content type: Research

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  38. Interleukin-6 (IL-6) is a pleiotropic cytokine with pivotal functions in the regulation of the biological responses of several target cells including hepatocytes. The level of serum IL-6 has been reported to b...

    Authors: Tzer-Min Kuo, Cheng-po Hu, Ya-Ling Chen, Ming-Hsiang Hong, King-Song Jeng, Chun-Chin T Liang, Mong-Liang Chen and Chungming Chang

    Citation: Journal of Biomedical Science 2009 16:41

    Content type: Research

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  39. Replication of the Japanese encephalitis virus (JEV) genome depends on host factors for successfully completing their life cycles; to do this, host factors have been recruited and/or relocated to the site of v...

    Authors: Shang-Hua Yang, Mei-Lan Liu, Chih-Feng Tien, Shih-Jie Chou and Ruey-Yi Chang

    Citation: Journal of Biomedical Science 2009 16:40

    Content type: Research

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  40. It is widely believed that atherosclerotic plaque rupture and subsequent thrombosis leads to acute coronary events and stroke. However, study of the mechanism and treatment of human plaque rupture is hampered ...

    Authors: Shun-Miao Fang, Qing-Hua Zhang and Zhi-Xin Jiang

    Citation: Journal of Biomedical Science 2009 16:39

    Content type: Research

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  41. Acetylcholine (ACh), the first neurotransmitter to be identified, regulate the activities of central and peripheral functions through interactions with muscarinic receptors. Changes in muscarinic acetylcholine...

    Authors: G Gireesh, T Peeyush Kumar, Jobin Mathew and CS Paulose

    Citation: Journal of Biomedical Science 2009 16:38

    Content type: Research

    Published on:

  42. Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial ap...

    Authors: Bor-Ru Lin, Chia-Jung Yu, Wang-Chuan Chen, Hsuan-Shu Lee, Huei-Min Chang, Yen-Chih Lee, Chiang-Ting Chien and Chau-Fong Chen

    Citation: Journal of Biomedical Science 2009 16:35

    Content type: Research

    Published on:

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