Articles

Lectin of Concanavalin A as an anti-hepatoma therapeutic agent

Liver cancer is the predominant cause of cancer mortality in males of Southern China and Taiwan. The current therapy is not satisfactory, and more effective treatments are needed. In the search for new therapi...

Authors: Huan-Yao Lei and Chih-Peng Chang

Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats

Puerarin, a major isoflavonoid derived from the Chinese medical herb Radix puerariae (kudzu root), has been reported to be useful in the treatment of various cardiovascular diseases. In the present study, we exam...

Authors: Yi Chang, Cheng-Ying Hsieh, Zi-Aa Peng, Ting-Lin Yen, George Hsiao, Duen-Suey Chou, Chien-Ming Chen and Joen-Rong Sheu

Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia

Both overproduction of nitric oxide (NO) and oxidative injury of cardiovascular and pulmonary systems contribute to fatal cardiovascular depression during endotoxemia. We investigated in the present study the ...

Authors: Yen-Chin Liu, Alice YW Chang, Yu-Chuan Tsai and Julie YH Chan

The effects of the bacterial interaction with visible-light responsive titania photocatalyst on the bactericidal performance

Bactericidal activity of traditional titanium dioxide (TiO₂) photocatalyst is effective only upon irradiation by ultraviolet light, which restricts the potential applications of TiO₂ for use in our living environ...

Authors: Chia-Liang Cheng, Der-Shan Sun, Wen-Chen Chu, Yao-Hsuan Tseng, Han-Chen Ho, Jia-Bin Wang, Pei-Hua Chung, Jiann-Hwa Chen, Pei-Jane Tsai, Nien-Tsung Lin, Mei-Shiuan Yu and Hsin-Hou Chang

Mutagenesis identifies the critical amino acid residues of human endonuclease G involved in catalysis, magnesium coordination, and substrate specificity

Endonuclease G (EndoG), a member of DNA/RNA nonspecific ββα-Me-finger nucleases, is involved in apoptosis and normal cellular proliferation. In this study, we analyzed the critical amino acid residues of EndoG...

Authors: Shih-Lu Wu, Chia-Cheng Li, Jaw-Chyun Chen, Yi-Jin Chen, Ching-Ting Lin, Tin-Yun Ho and Chien-Yun Hsiang

Requirement of focal adhesion kinase in branching tubulogenesis

We previously demonstrated that α3β1 integrins are essential to hepatocyte growth factor (HGF)-independent branching tubulogenesis in Mardin-Darby Canine Kidney (MDCK) cells. However, the involvement of integr...

Authors: Wei-Chun Wei, Anna K Kopec and Ming-Jer Tang

Molecular mechanisms of cell proliferation induced by low power laser irradiation

Low power laser irradiation (LPLI) promotes proliferation of multiple cells, which (especially red and near infrared light) is mainly through the activation of mitochondrial respiratory chain and the initiatio...

Authors: Xuejuan Gao and Da Xing

A novel 9-bp insertion detected in steroid 21-hydroxylase gene (CYP21A2): prediction of its structural and functional implications by computational methods

Steroid 21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia (CAH). Detection of underlying mutations in CYP21A2 gene encoding steroid 21-hydroxylase enzyme is helpful both for con...

Authors: Sudhisha Dubey, Susan Idicula-Thomas, Mohammad Anwaruddin, Chinnaraj Saravanan, R Raveendra Varma and Anurupa Maitra

Transgenic mice exhibiting inducible and spontaneous Cre activities driven by a bovine keratin 5 promoter that can be used for the conditional analysis of basal epithelial cells in multiple organs

Cre/lox P-mediated genetic modification is the most widely used conditional genetic approach used in the mouse. Engineered Cre and the mutated ligand-binding domain of estrogen receptor fusion recombinase (CreER^T

Authors: Chih-Chia Liang, Li-Ru You, Junn-Liang Chang, Ting-Fen Tsai and Chun-Ming Chen

Journal of Biomedical Science, marking a new epoch: moving to open access in 2009

Authors: Michael MC Lai

Persistent H. pylori colonization in early acquisition age of mice related with higher gastric sialylated Lewis x, IL-10, but lower interferon-γ expressions

H. pylori infection is less prevalent in childhood. This study validated whether the rates of H. pylori colonization depend on different acquisition ages, and correlate with the different gastric Lewis antigens o...

Authors: Yao-Jong Yang, Hsiao-Bai Yang, Jiunn-Jong Wu and Bor-Shyang Sheu

Downregulation of developmentally regulated endothelial cell locus-1 inhibits the growth of colon cancer

Developmentally regulated endothelial cell locus-1 (Del1) is an embryonic angiogenic factor expressed in early embryonic endothelial cells, but recently has been found to be expressed in some forms of cancers ...

Authors: Xiaolong Zou, Haiquan Qiao, Xian Jiang, Xuesong Dong, Hongchi Jiang and Xueying Sun