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Page 23 of 32

  1. Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees and present in Asian herbal teas, has a unique array of pharmacological actions, including the inhibition of multiple autono...

    Authors: Hsiu-Jen Wang, Alexis G Martin, Po-Kuan Chao, Rhett A Reichard, Adam L Martin, Yue-wern Huang, Ming-Huan Chan and Robert S Aronstam
    Citation: Journal of Biomedical Science 2013 20:11
  2. The central molecule in the pathogenesis of Alzheimer’s disease (AD) is believed to be a small-sized polypeptide – beta amyloid (Aβ) which has an ability to assemble spontaneously into oligomers. Various studi...

    Authors: Indre Dalgediene, Rita Lasickiene, Rima Budvytyte, Gintaras Valincius, Ramune Morkuniene, Vilmante Borutaite and Aurelija Zvirbliene
    Citation: Journal of Biomedical Science 2013 20:10
  3. MicroRNAs (miRNAs), a class of highly conserved small non-coding RNA molecules, are known to play essential roles in central nervous system (CNS) by causing post-transcriptional gene silencing. There is much e...

    Authors: Si Yun Shu, Di Qing, Bin Wang, Qi-yi Zeng, Yan-chen Chen, Ying Jin, Chang-chun Zeng and Rong Bao
    Citation: Journal of Biomedical Science 2013 20:9
  4. Immunotherapy with vaccines is attractive for the treatment of cancer. This study is aimed at determining the effect of recombinant Salmonella (SL3261)-based 4-1BB ligand (4-1BBL) vaccine on the development of...

    Authors: Jianxin Ye, Ling Li, Yuanting Zhang, Xueguang Zhang, Daming Ren and Weichang Chen
    Citation: Journal of Biomedical Science 2013 20:8
  5. Human cancer cells resemble stem cells in expression signatures leading them to share some features, most notably, self-renewal. A complex network of transcription factors and signaling molecules are required ...

    Authors: Mohammad Mahdi Forghanifard, Meysam Moghbeli, Reza Raeisossadati, Alireza Tavassoli, Afsaneh Javdani Mallak, Samaneh Boroumand-Noughabi and Mohammad Reza Abbaszadegan
    Citation: Journal of Biomedical Science 2013 20:6
  6. Thymidylate synthase (TS) is a key enzyme responsible for DNA synthesis and repair. Altered expression of TS protein or TS gene polymorphisms has been associated with cancer progression and treatment response. Th...

    Authors: Xia Wang, Yadi Wang, Yue Wang, Jian Cheng, Yanyun Wang and Minwen Ha
    Citation: Journal of Biomedical Science 2013 20:5
  7. IκB kinase (IKK) complex, the master kinase for NF-κB activation, contains two kinase subunits, IKKα and IKKβ. In addition to mediating NF-κB signaling by phosphorylating IκB proteins during inflammatory and i...

    Authors: Wei-Chien Huang and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2013 20:3
  8. Previously, we had identified a specific whole blood–derived microRNAs (miRNAs) signature in mice following in vivo injection of lipopolysaccharide (LPS) originated from Gram-negative bacteria. This study was des...

    Authors: Ching-Hua Hsieh, Johnson Chia-Shen Yang, Jonathan Chris Jeng, Yi-Chun Chen, Tsu-Hsiang Lu, Siou-Ling Tzeng, Yi-Chan Wu, Chia-Jung Wu and Cheng-Shyuan Rau
    Citation: Journal of Biomedical Science 2013 20:2
  9. Epicutaneous sensitization with protein allergen that induces predominant Th2 responses is an important sensitization route in atopic dermatitis. Fungal components have been shown to modulate Th cell different...

    Authors: Jing-Yi Lin, Jau-Shiuh Chen, Pei-Chun Chen, Ming-Hui Chung, Ching-Yi Liu, Shi-Chuen Miaw and Li-Fang Wang
    Citation: Journal of Biomedical Science 2013 20:1
  10. Aggregation of soluble, monomeric β- amyloid (Aβ) to oligomeric and then insoluble fibrillar Aβ is a key pathogenic feature in development of Alzheimer’s disease (AD). Increasing evidence suggests that toxicit...

    Authors: Md Golam Sharoar, Arjun Thapa, Mohammad Shahnawaz, Vijay Sankar Ramasamy, Eun-Rhan Woo, Song Yub Shin and Il-Seon Park
    Citation: Journal of Biomedical Science 2012 19:104
  11. Mefloquine is an anti-malarial drug that can have neurological side effects. This study examines how mefloquine (MF) influences central nervous control of autonomic and respiratory systems using the arterially...

    Authors: Varinder K Lall, Mathias Dutschmann, Jim Deuchars and Susan A Deuchars
    Citation: Journal of Biomedical Science 2012 19:103
  12. Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-...

    Authors: Ya-Ping Tsai and Kou-Juey Wu
    Citation: Journal of Biomedical Science 2012 19:102
  13. The tubby (tub) and tubby-like protein (tulp) genes encode a small family of proteins found in many organisms. Previous studies have shown that TUB and TULP genes in mammalian involve in obesity, neural developme...

    Authors: Shu-Fen Chen, Yu-Chen Tsai and Seng-Sheen Fan
    Citation: Journal of Biomedical Science 2012 19:101
  14. Gly1057Asp polymorphism in insulin receptor substrate (IRS)-2 is related to insulin resistance and diabetes mellitus (DM), which both contribute to the pathogenesis of coronary artery disease (CAD). Hence, we ...

    Authors: Shih-Hung Chan, Jyh-Hong Chen, Yi-Heng Li and Liang-Miin Tsai
    Citation: Journal of Biomedical Science 2012 19:100
  15. The effects of atorvastatin on SDF-1α expression under acute myocardial infarction (AMI) are still unclear. Therefore, our present study is to investigate the roles and mechanisms of atorvastatin treatment on ...

    Authors: Ruofeng Qiu, Anping Cai, Yugang Dong, Yingling Zhou, Danqing Yu, Yuli Huang, Dongdan Zheng, Shaoqi Rao, Yingqing Feng and Weiyi Mai
    Citation: Journal of Biomedical Science 2012 19:99
  16. Lethal toxin (LT) is a major virulence factor of Bacillus anthracis. Sprague Dawley rats manifest pronounced lung edema and shock after LT treatments, resulting in high mortality. The heart failure that is induce...

    Authors: Jyh-Hwa Kau, Yung-Luen Shih, Te-Sheng Lien, Chin-Cheng Lee, Hsin-Hsien Huang, Hung-Chi Lin, Der-Shan Sun and Hsin-Hou Chang
    Citation: Journal of Biomedical Science 2012 19:98
  17. Interleukin 12B (IL12B) gene polymorphisms have been linked to several inflammatory diseases, but their role in the development of Graves ophthalmopathy (GO) in Graves disease (GD) patients is unclear. The purpos...

    Authors: Yu-Huei Liu, Ching-Chu Chen, Li-Ling Liao, Lei Wan, Chang-Hai Tsai and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2012 19:97
  18. Based on an experimental brain stem death model, we demonstrated previously that activation of the mitogen-activated protein kinase kinase 1/2 (MEK1/2)/extracellular signal-regulated kinase 1/2 (ERK1/2)/mitoge...

    Authors: Alice YW Chang
    Citation: Journal of Biomedical Science 2012 19:96
  19. Beckwith-Wiedemann syndrome (BWS) is a loss-of-imprinting pediatric overgrowth syndrome. The primary features of BWS include macrosomia, macroglossia, and abdominal wall defects. Secondary features that are fr...

    Authors: Katherine Marie Robbins, Zhiyuan Chen, Kevin Dale Wells and Rocío Melissa Rivera
    Citation: Journal of Biomedical Science 2012 19:95
  20. Tissue engineering scaffold constitutes a new strategy of myocardial repair. Here, we studied the contribution of a patch using autologous mesenchymal stem cells (MSCs) seeded on collagen-1 scaffold on the car...

    Authors: Pablo Maureira, Pierre-Yves Marie, Fengxu Yu, Sylvain Poussier, Yihua Liu, Frederique Groubatch, Aude Falanga and Nguyen Tran
    Citation: Journal of Biomedical Science 2012 19:93
  21. Autophagy is a protein degradative process important for normal cellular metabolism. It is apparently used also by cells to eliminate invading pathogens. Interestingly, many pathogens have learned to subvert t...

    Authors: Sai-Wen Tang, Aurelie Ducroux, Kuan-Teh Jeang and Christine Neuveut
    Citation: Journal of Biomedical Science 2012 19:92
  22. The CXC chemokine ligand 12 (CXCL12)/stromal cell-derived factor-1 (SDF-1) and CXC receptor 4 (CXCR4) axis is involved in human colorectal cancer (CRC) carcinogenesis and can promote the progression of CRC. In...

    Authors: Shui-Yi Tung, Shun-Fu Chang, Ming-Hui Chou, Wen-Shih Huang, Yung-Yu Hsieh, Chien-Heng Shen, Hsing-Chun Kuo and Cheng-Nan Chen
    Citation: Journal of Biomedical Science 2012 19:91

    The Erratum to this article has been published in Journal of Biomedical Science 2013 20:21

  23. MicroRNAs (miRNAs) are involved in multiple biological activities as well as disease progression including cancer. Interestingly, miRNAs could act as either tumor suppressors or oncogenes depending on the func...

    Authors: Pai-Sheng Chen, Jen-Liang Su and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2012 19:90
  24. Several low-molecular-weight phenolic acids are present in the blood of septic patients at high levels. The microbial origin of the most of phenolic acids in the human body was shown previously, but pathophysi...

    Authors: Natalia Beloborodova, Iskander Bairamov, Andrei Olenin, Victoria Shubina, Vera Teplova and Nadezhda Fedotcheva
    Citation: Journal of Biomedical Science 2012 19:89
  25. Zerumbone, a sesquiterpene compound isolated from subtropical ginger, Zingiber zerumbet Smith, has been documented to exert antitumoral and anti- inflammatory activities. In this study, we demonstrate that zerumb...

    Authors: Hsing-Yu Weng, Ming-Jen Hsu, Ching-Chung Wang, Bing-Chang Chen, Chuang-Ye Hong, Mei-Chieh Chen, Wen-Ta Chiu and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2012 19:86
  26. MALT1 belongs to a family of paracaspase and modulates NF-κB signaling pathways through its scaffolding function and proteolytic activity. MALT1 cleaves protein substrates after a positively charged Arginine r...

    Authors: Shin-Yi Jou, Chien-Chih Chang, Chun-Hsien Wu, Mei-Ru Chen, Ching-Hwa Tsai, Wen-Hui Chuang, Yun-Hui Chen, Ann-Lii Cheng and Shin-Lian Doong
    Citation: Journal of Biomedical Science 2012 19:85
  27. Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia. Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been i...

    Authors: Mohamed Fouda Salama, Henry K Bayele and Surjit SK Srai
    Citation: Journal of Biomedical Science 2012 19:83
  28. The root bark of Paeonia suffruticosa Andrews (PSE), also known as Moutan Cortex, has been widely used in Asia to treat various diseases. The molecular mechanisms by which PSE exerts its anti-oxidant and anti-inf...

    Authors: Hyeong Sim Choi, Hye-Sook Seo, Ji Hye Kim, Jae-Young Um, Yong Cheol Shin and Seong-Gyu Ko
    Citation: Journal of Biomedical Science 2012 19:82
  29. Tumor suppressors are frequently downregulated in human cancers and understanding of the mechanisms through which tumor cells restrict the expression of tumor suppressors is important for the prognosis and int...

    Authors: Ruey-Hwa Chen, Yu-Ru Lee and Wei-Chien Yuan
    Citation: Journal of Biomedical Science 2012 19:81
  30. Daidzein, a phytoestrogen found in isoflavone, is known to exert neurotrophic and neuroprotective effects on the nervous system. Using primary rat dorsal root ganglion (DRG) neuronal cultures, we have examined...

    Authors: Shih-Hung Yang, Chih-Chen Liao, Ying Chen, Jhih-Pu Syu, Chung-Jiuan Jeng and Seu-Mei Wang
    Citation: Journal of Biomedical Science 2012 19:80
  31. Atherosclerosis is commonly appreciated to represent a chronic inflammatory response of the vascular wall, and its complications cause high mortality in patients. Angioplasty with stent replacement is commonly...

    Authors: Li-Jing Chen, Seh Hong Lim, Yi-Ting Yeh, Sheng-Chieh Lien and Jeng-Jiann Chiu
    Citation: Journal of Biomedical Science 2012 19:79
  32. Epilepsy is a neurological disorder produced by an imbalance between excitatory and inhibitory neurotransmission, in which transporters of both glutamate and GABA have been implicated. Hence, at different time...

    Authors: Laura Medina-Ceja, Flavio Sandoval-García, Alberto Morales-Villagrán and Silvia J López-Pérez
    Citation: Journal of Biomedical Science 2012 19:78
  33. Estrogen acts on the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons are located, to elicit vasodepressor effects via an estrogen receptor (ER)β-dependent mechanism. We investigated in...

    Authors: Kay LH Wu, Chen-Hsiu Chen and Cheng-Dean Shih
    Citation: Journal of Biomedical Science 2012 19:76
  34. TRPM7 (T ransient R eceptor P otential of the M elastatin subfamily) proteins are highly expressed in the heart, however, electrophysiological studies, demonstrating and characterizing these channels in human car...

    Authors: Regina Macianskiene, Irma Martisiene, Danguole Zablockaite and Vida Gendviliene
    Citation: Journal of Biomedical Science 2012 19:75
  35. Intrauterine balloon aortic valvuloplasty (IUBAV) has been used for critical aortic stenosis. However, it is necessary to determine the fetal impairments such as preterm birth after this approach and to find a...

    Authors: Kaiyu Zhou, Gang Wu, Yifei Li, Liang Zhao, Rong Zhou, Qi Zhu, Xupei Huang, Dezhi Mu and Yimin Hua
    Citation: Journal of Biomedical Science 2012 19:74
  36. Enterovirus 71 (EV71) is a highly infectious agent that plays an etiological role in hand, foot, and mouth disease. It is associated with severe neurological complications and has caused significant mortalitie...

    Authors: Jun-Xia Deng, Xiao-Jing Nie, Ying-Feng Lei, Chao-Feng Ma, Dong-Liang Xu, Biao Li, Zhi-Kai Xu and Guo-Cheng Zhang
    Citation: Journal of Biomedical Science 2012 19:73
  37. PUMA (p53-up-regulated modulator of apoptosis), an apoptosis regulated gene, increased during endoplasmic reticulum stress. However, the expression of PUMA in cardiomyocytes under mechanical stress is little k...

    Authors: Wen-Pin Cheng, Gong-Jhe Wu, Bao-Wei Wang and Kou-Gi Shyu
    Citation: Journal of Biomedical Science 2012 19:72
  38. Endoplasmic reticulum (ER) and mitochondria have been implicated in the pathology of renal ischemia/reperfusion (I/R). In the present study, we investigated whether the use of ischemic postconditioning (IPostC...

    Authors: Asma Mahfoudh-Boussaid, Mohamed Amine Zaouali, Thierry Hauet, Kaouther Hadj-Ayed, Abdel-Hédi Miled, Sonia Ghoul-Mazgar, Dalila Saidane-Mosbahi, Joan Rosello-Catafau and Hassen Ben Abdennebi
    Citation: Journal of Biomedical Science 2012 19:71
  39. Lipopolysaccharide (LPS) is recognized as the most potent microbial mediator presaging the threat of invasion of Gram-negative bacteria that implicated in the pathogenesis of sepsis and septic shock. This stud...

    Authors: Ching-Hua Hsieh, Cheng-Shyuan Rau, Jonathan Chris Jeng, Yi-Chun Chen, Tsu-Hsiang Lu, Chia-Jung Wu, Yi-Chan Wu, Siou-Ling Tzeng and Johnson Chia-Shen Yang
    Citation: Journal of Biomedical Science 2012 19:69
  40. The mechanisms of the antinociceptive activity of (−) epicatechin (EPI), a compound isolated from the hydroalcoholic fraction of Combreum leprosum Mart & Eicher.

    Authors: Luciano da Silva Lopes, Rosemarie Brandin Marques, Heliana Barros Fernandes, Sergio da Silva Pereira, Mariane CC Ayres, Mariana Helena Chaves and Fernanda RC Almeida
    Citation: Journal of Biomedical Science 2012 19:68
  41. The roles of circulating endothelial progenitor cell (EPC) and mononuclear cell apoptosis (MCA) in liver cirrhosis (LC) patients are unknown. Moreover, vascular endothelial growth factor (VEGF) and stromal cel...

    Authors: Chih-Hung Chen, Li-Teh Chang, Wei-Chih Tung, Yung-Lung Chen, Chia-Lo Chang, Steve Leu, Cheuk-Kwan Sun, Tzu-Hsien Tsai, I-Ting Tsai, Hsueh-Wen Chang and Hon-Kan Yip
    Citation: Journal of Biomedical Science 2012 19:66

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