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  1. Opioid analgesics such as morphine and meperidine have been used to control moderate to severe pain for many years. However, these opioids have many side effects, including the development of tolerance and dep...

    Authors: Shiou-Lan Chen, Hsin-I Ma, Jun-Ming Han, Ru-Band Lu, Pao-Luh Tao, Ping-Yee Law and Horace H Loh

    Citation: Journal of Biomedical Science 2010 17:28

    Content type: Research

    Published on:

  2. We observed previously that cisplatin-resistant HeLa cells were cross-resistant to UV light due to accumulation of DDB2, a protein implicated in DNA repair. More recently, we found that cFLIP, which represents...

    Authors: Nian-Kang Sun, Chun-Ling Sun, Chia-Hua Lin, Li-Mai Pai and Chuck CK Chao

    Citation: Journal of Biomedical Science 2010 17:27

    Content type: Research

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  3. Enzyme replacement therapy (ERT) with α-galactosidase A (α-Gal A) is currently the most effective therapeutic strategy for patients with Fabry disease, a lysosomal storage disease. However, ERT has limitations...

    Authors: Jin-Ok Choi, Mi Hee Lee, Hae-Young Park and Sung-Chul Jung

    Citation: Journal of Biomedical Science 2010 17:26

    Content type: Research

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  4. The highly pathogenic H5N1 is a major avian pathogen that crosses species barriers and seriously affects humans as well as some mammals. It mutates in an intensified manner and is considered a potential candid...

    Authors: Ahmed S Abdel-Moneim, Ahmad E Abdel-Ghany and Salama AS Shany

    Citation: Journal of Biomedical Science 2010 17:25

    Content type: Research

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  6. The association of TGF β1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The p...

    Authors: Yongzheng Wang, Xuwei Hou and Yuliang Li

    Citation: Journal of Biomedical Science 2010 17:23

    Content type: Research

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  7. The human lmo2 gene plays important roles in hematopoiesis and is associated with acute T lymphocyte leukemia. The gene encodes two protein isoforms, a longer form LMO2-L and a shorter form LMO2-S. Both isoforms ...

    Authors: Wei Sun, Wen-Wen Shen, Shuang Yang, Fen Hu, Yang Gao, Yu-Huan Qiao and Tian-Hui Zhu

    Citation: Journal of Biomedical Science 2010 17:22

    Content type: Research

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  8. Resistance to conventional anticancer therapies in patients with advanced solid tumors has prompted the need of alternative cancer therapies. Moreover, the success of novel cancer therapies depends on their se...

    Authors: S Patyar, R Joshi, DS Prasad Byrav, A Prakash, B Medhi and BK Das

    Citation: Journal of Biomedical Science 2010 17:21

    Content type: Review

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  9. Pulmonary veins (PVs) are the most important sources of ectopic beats with the initiation of paroxysmal atrial fibrillation, or the foci of ectopic atrial tachycardia and focal atrial fibrillation. Elimination...

    Authors: Yung-Kuo Lin, Yen-Yu Lu, Yao-Chang Chen, Yi-Jen Chen and Shih-Ann Chen

    Citation: Journal of Biomedical Science 2010 17:20

    Content type: Research

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  10. Diffuse noxious inhibitory controls (DNIC) can be produced by different types of conditioning stimuli, but the analgesic properties and underlying mechanisms remain unclear. The aim of this study was to differ...

    Authors: Yeong-Ray Wen, Chia-Chuan Wang, Geng-Chang Yeh, Sheng-Feng Hsu, Yung-Jen Huang, Yen-Li Li and Wei-Zen Sun

    Citation: Journal of Biomedical Science 2010 17:19

    Content type: Research

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  11. Akt regulates various cellular processes, including cell growth, survival, and metabolism. Recently, Akt's role in neurite outgrowth has also emerged. We thus aimed to identify neuronal function-related genes ...

    Authors: Young-Tae Ro, Bo-Kwang Jang, Chan Young Shin, Eui U Park, Chul Geun Kim and Sung-Il Yang

    Citation: Journal of Biomedical Science 2010 17:18

    Content type: Research

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  12. As the origin of a life-and-death signal detected from systemic arterial pressure, which sequentially increases (pro-life) and decreases (pro-death) to reflect progressive dysfunction of central cardiovascular...

    Authors: Samuel HH Chan, Enya YH Sun and Alice YW Chang

    Citation: Journal of Biomedical Science 2010 17:17

    Content type: Research

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  13. Valproic acid, a widely used anticonvulsant drug, is a potent teratogen resulting in various congenital abnormalities. However, the mechanisms underlying valproic acid induced teratogenesis are nor clear. Rece...

    Authors: Gang Wu, Changlong Nan, Johnathon C Rollo, Xupei Huang and Jie Tian

    Citation: Journal of Biomedical Science 2010 17:16

    Content type: Research

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  14. Toll-like receptor 4 (TLR4) plays an important role in innate immunity. The role of TLR4 in stretched cardiomyocytes is not known. We sought to investigate whether mechanical stretch could regulate TLR4 expres...

    Authors: Kou-Gi Shyu, Bao-Wei Wang, Chiu-Mei Lin and Hang Chang

    Citation: Journal of Biomedical Science 2010 17:15

    Content type: Research

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  15. Both hypoxia and hyperoxia, deregulating the oxidative balance, may play a role in the pathology of neurodegenerative disorders underlain by cerebral ischemia. In the present study, quantitative proton magneti...

    Authors: Maria A Macri, Nicola D'Alessandro, Camillo Di Giulio, Patrizia Di Iorio, Silvano Di Luzio, Patricia Giuliani, Ennio Esposito and Mieczyslaw Pokorski

    Citation: Journal of Biomedical Science 2010 17:14

    Content type: Research

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  16. Influenza viruses are a major cause of morbidity and mortality around the world. More recently, a swine-origin influenza A (H1N1) virus that is spreading via human-to-human transmission has become a serious pu...

    Authors: Shin-Ru Shih, Tzu-Yun Chu, Gadarla Randheer Reddy, Sung-Nain Tseng, Hsiun-Ling Chen, Wen-Fang Tang, Ming-sian Wu, Jiann-Yih Yeh, Yu-Sheng Chao, John TA Hsu, Hsing-Pang Hsieh and Jim-Tong Horng

    Citation: Journal of Biomedical Science 2010 17:13

    Content type: Research

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  17. The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been shown to be associated with the susceptibility to ischemic event, including coronary artery disease (CAD), myocardial infarction,...

    Authors: Chyi-Huey Bai, Jiunn-Rong Chen, Hou-Chang Chiu, Chia-Chi Chou, Lee-Young Chau and Wen-Harn Pan

    Citation: Journal of Biomedical Science 2010 17:12

    Content type: Research

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  18. Functional cooperation between FACT and the MCM helicase complex constitutes an integral step during DNA replication initiation. However, mode of regulation that underlies the proper functional interaction of ...

    Authors: Bertrand Chin-Ming Tan, Hsuan Liu, Chih-Li Lin and Sheng-Chung Lee

    Citation: Journal of Biomedical Science 2010 17:11

    Content type: Research

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  19. Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. Degradation of matrix is a key event in progression, invasio...

    Authors: Ajay Kumar Chaudhary, Mamta Singh, Alok C Bharti, Kamlesh Asotra, Shanthy Sundaram and Ravi Mehrotra

    Citation: Journal of Biomedical Science 2010 17:10

    Content type: Review

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  20. Although gait change is considered a useful indicator of severity in animal models of Parkinson's disease, systematic and extensive gait analysis in animal models of neurological deficits is not well establish...

    Authors: Chieh-Sen Chuang, Hong-Lin Su, Fu-Chou Cheng, Shan-hui Hsu, Chi-Fen Chuang and Chin-San Liu

    Citation: Journal of Biomedical Science 2010 17:9

    Content type: Research

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  21. Hyaluronic acid (HA) is present in many tissues; its presence in serum may be related to certain inflammatory conditions, tissue damage, sepsis, liver malfunction and some malignancies. In the present work, ou...

    Authors: A Luquita, L Urli, MJ Svetaz, AM Gennaro, ME Giorgetti, G Pistone, R Volpintesta, S Palatnik and M Rasia

    Citation: Journal of Biomedical Science 2010 17:8

    Content type: Research

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  22. Glucose homeostasis in humans is an important factor for the functioning of nervous system. Hypoglycemia and hyperglycemia is found to be associated with central and peripheral nerve system dysfunction. Change...

    Authors: Sherin Antony, Peeyush Kumar T, Jobin Mathew, TR Anju and CS Paulose

    Citation: Journal of Biomedical Science 2010 17:7

    Content type: Research

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  23. Migration of vascular smooth muscle cells (SMCs) from the media to intima constitutes a critical step in the development of proliferative vascular diseases. To elucidate the regulatory mechanism of vacular SMC...

    Authors: Qifeng Jiang, Renjian Huang, Shaoxi Cai and Chih-Lueh A Wang

    Citation: Journal of Biomedical Science 2010 17:6

    Content type: Research

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  24. Androgen ablation is one of the viable therapeutic options for patients with primary hormone (androgen)-dependent prostate cancer. However, an antibiotic brefeldin A (BFA) has been shown to exhibit the growth ...

    Authors: Srinivas Rajamahanty, Catherine Alonzo, Shahrad Aynehchi, Muhammad Choudhury and Sensuke Konno

    Citation: Journal of Biomedical Science 2010 17:5

    Content type: Research

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  25. Caffeine, a nonselective adenosine A1 and A2A receptor antagonist, is the most widely used psychoactive substance in the world. Evidence demonstrates that caffeine and selective adenosine A2A antagonists interact...

    Authors: Chih W Hsu, Chin S Wang and Ted H Chiu

    Citation: Journal of Biomedical Science 2010 17:4

    Content type: Research

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  26. The importance of the Notch signaling in the development of glomerular diseases has been recently described. Therefore we analyzed in podocytes the expression and activity of ADAM10, one important component of...

    Authors: Paul Gutwein, Anja Schramme, Mohamed Sadek Abdel-Bakky, Kai Doberstein, Ingeborg A Hauser, Andreas Ludwig, Peter Altevogt, Stefan Gauer, Anja Hillmann, Thomas Weide, Christine Jespersen, Wolfgang Eberhardt and Josef Pfeilschifter

    Citation: Journal of Biomedical Science 2010 17:3

    Content type: Research

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  28. Glutaminase predominates in periportal hepatocytes and it has been proposed that it determines the glutamine-derived nitrogen flow through the urea cycle. Glutamine-derived urea production should, thus, be con...

    Authors: Jurandir F Comar, Fumie Suzuki-Kemmelmeier, Jorgete Constantin and Adelar Bracht

    Citation: Journal of Biomedical Science 2010 17:1

    Content type: Research

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  29. Several lines of evidence point to a particularly important role of the left atrium (LA) in initiating and maintaining atrial fibrillation (AF). This role may be related to the location of pulmonary veins (PVs...

    Authors: Yue-Xia Loh, Kuo-Ho Wu, Yao-Chang Chen, Chih-Hsiung Hsu, Jeng Wei and Cheng-I Lin

    Citation: Journal of Biomedical Science 2009 16:114

    Content type: Research

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  30. The uptake of abortion-inducing pathogens by trophoblast giant (TG) cells is a key event in infectious abortion. However, little is known about phagocytic functions of TG cells against the pathogens. Here we s...

    Authors: Kenta Watanabe, Masato Tachibana, Suk Kim and Masahisa Watarai

    Citation: Journal of Biomedical Science 2009 16:113

    Content type: Research

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  31. An important role in atherogenesis is played by oxidative stress, which may be induced by common risk factors. Mitochondria are both sources and targets of reactive oxygen species, and there is growing evidenc...

    Authors: Paolo Puddu, Giovanni M Puddu, Eleonora Cravero, Susanna De Pascalis and Antonio Muscari

    Citation: Journal of Biomedical Science 2009 16:112

    Content type: Review

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  32. After publication of our article, it was noted that we inadvertently failed to include the complete list of authors. The full list, including co-authors, has now been added and the Authors' contributions and C...

    Authors: Sang Soo Hah, Paul T Henderson and Kenneth W Turteltaub

    Citation: Journal of Biomedical Science 2009 16:111

    Content type: Erratum

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    The original article was published in Journal of Biomedical Science 2009 16:54

  33. Autophagy has been shown recently to play an important role in the intracellular survival of several pathogenic bacteria. In this study, we investigated the effect of a novel small-molecule autophagy-inducing ...

    Authors: Hao-Chieh Chiu, Shilpa Soni, Samuel K Kulp, Heather Curry, Dasheng Wang, John S Gunn, Larry S Schlesinger and Ching-Shih Chen

    Citation: Journal of Biomedical Science 2009 16:110

    Content type: Research

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  35. Neural tissue repair and regeneration strategies have received a great deal of attention because it directly affects the quality of the patient's life. There are many scientific challenges to regenerate nerve ...

    Authors: Anuradha Subramanian, Uma Maheswari Krishnan and Swaminathan Sethuraman

    Citation: Journal of Biomedical Science 2009 16:108

    Content type: Review

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  36. Human cytomegalovirus (HCMV) is known to induce chromosome aberrations in infected cells, which can lead to congenital abnormalities in infected fetuses. HCMV UL76 belongs to a conserved protein family from he...

    Authors: Voon-Kwan Siew, Chang-Yih Duh and Shang-Kwei Wang

    Citation: Journal of Biomedical Science 2009 16:107

    Content type: Research

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  37. Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring. No evidence was presente...

    Authors: Ling-Yi Wu, Jain-Fang Chen, Pao-Luh Tao and Eagle Yi-Kung Huang

    Citation: Journal of Biomedical Science 2009 16:106

    Content type: Research

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  38. Epithelial-mesenchymal transition (EMT) is an important process in tumor metastasis. The EMT-related events associated with metastasis of NPC in the absence of EBV have not been elucidated. We established an E...

    Authors: Jung-Chung Lin, Shuen-Kuei Liao, En-Huei Lee, Man-Shan Hung, Yiyang Sayion, Hung-Chang Chen, Chen-Chen Kang, Liang-Sheng Huang and Jaw-Ming Cherng

    Citation: Journal of Biomedical Science 2009 16:105

    Content type: Research

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  40. Picornaviruses cause several diseases, not only in humans but also in various animal hosts. For instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina, myocarditis, acute flaccid paral...

    Authors: Jing-Yi Lin, Tzu-Chun Chen, Kuo-Feng Weng, Shih-Cheng Chang, Li-Lien Chen and Shin-Ru Shih

    Citation: Journal of Biomedical Science 2009 16:103

    Content type: Review

    Published on:

  41. Anaemia is a frequent complication of infection with the human immunodeficiency virus (HIV) and may have multiple causes. The objective of this study was to find out if blood haemoglobin measurement could be u...

    Authors: Christian Obirikorang and Francis A Yeboah

    Citation: Journal of Biomedical Science 2009 16:102

    Content type: Research

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  42. The diastolic oscillatory after-potential Vos and pre-potential ThVos play an essential role in the pacemaker mechanism of sino-atrial node (SAN). The aim of this study was to investigate whether these oscillator...

    Authors: Mario Vassalle, John N Catanzaro, Michael P Nett and Marcello Rota

    Citation: Journal of Biomedical Science 2009 16:101

    Content type: Research

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  43. The progression and metastasis of solid tumors, including head and neck squamous cell carcinoma (HNSCC), have been related to the behavior of a small subpopulation of cancer stem cells. Here, we have establish...

    Authors: Chi-Yuan Chen, Shih-Hwa Chiou, Chih-Yang Huang, Chia-Ing Jan, Shu-Chun Lin, Ming-Long Tsai and Jeng-Fan Lo

    Citation: Journal of Biomedical Science 2009 16:100

    Content type: Research

    Published on:

  44. Metabotrophic glutamate receptors (mGluRs) modulate cellular activities involved in the processes of differentiation and degeneration. In this study, we have analysed the expression pattern of group-I metabotr...

    Authors: Savitha Balakrishnan, Peeyush Kumar T and CS Paulose

    Citation: Journal of Biomedical Science 2009 16:99

    Content type: Research

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  45. Reactive oxygen species (ROS) play an important role in aging and age-related diseases such as Parkinson's disease and Alzheimer's disease. Much of the ROS production under conditions of toxic stress is from m...

    Authors: Yuanbin Liu and David R Schubert

    Citation: Journal of Biomedical Science 2009 16:98

    Content type: Research

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  46. To investigate the mechanism how Transforming growth factor-β(TGF-β) represses Interleukin-1β (IL-1β)-induced Proteinase-Activated Receptor-2 (PAR-2) expression in human primary synovial cells (h PSCs). Human cho...

    Authors: Shin-Han Tsai, Ming-Thau Sheu, Yu-Chih Liang, Hsiu-Tan Cheng, Sheng-Shiung Fang and Chien-Ho Chen

    Citation: Journal of Biomedical Science 2009 16:97

    Content type: Research

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  47. The nuclear envelope (NE) consists of two membrane layers that segregate the nuclear from the cytoplasmic contents. Recent progress in our understanding of nuclear-lamina associated diseases has revealed intri...

    Authors: Ya-Hui Chi, Zi-Jie Chen and Kuan-Teh Jeang

    Citation: Journal of Biomedical Science 2009 16:96

    Content type: Review

    Published on:

  49. The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal hyperalgesia induced by gl...

    Authors: Yi-Ruu Lin, Hwei-Hsien Chen, Yu-Chin Lin, Chien-Hsin Ko and Ming-Huan Chan

    Citation: Journal of Biomedical Science 2009 16:94

    Content type: Research

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  50. Glycosylphosphatidylinositol-anchored proteins (GPI-APs) represent an interesting amalgamation of the three basic kinds of cellular macromolecules viz. proteins, carbohydrates and lipids. An unusually hybrid m...

    Authors: Shaheen E Lakhan, Shefali Sabharanjak and Ananya De

    Citation: Journal of Biomedical Science 2009 16:93

    Content type: Review

    Published on:

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ISSN: 1423-0127