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  1. Lynch syndrome is a hereditary cancer predisposition syndrome caused by a mutation in one of the DNA mismatch repair (MMR) genes. About 24% of the mutations identified in Lynch syndrome are missense substituti...

    Authors: Hiroko Terui, Kiwamu Akagi, Hiroshi Kawame and Kei Yura
    Citation: Journal of Biomedical Science 2013 20:25
    Content type: Research Published on:

  2. mTOR is a genetically conserved serine/threonine protein kinase, which controls cell growth, proliferation, and survival. A multifunctional protein CAD, catalyzing the initial three steps in de novo pyrimidine sy...

    Authors: Akio Nakashima, Ippei Kawanishi, Sumiko Eguchi, Eugene Hsin Yu, Satoshi Eguchi, Noriko Oshiro, Ken-ichi Yoshino, Ushio Kikkawa and Kazuyoshi Yonezawa
    Citation: Journal of Biomedical Science 2013 20:24
    Content type: Research Published on:

  3. Intracellular Ca2+ is one of the crucial signalings that modulate various cellular functions. The dysregulation of Ca2+ homeostasis has been suggested as an important event in driving the expression of the malign...

    Authors: Yih-Fung Chen, Ying-Ting Chen, Wen-Tai Chiu and Meng-Ru Shen
    Citation: Journal of Biomedical Science 2013 20:23
    Content type: Review Published on:

  4. Somatic mutations of the epidermal growth factor receptor (EGFR) are reportedly associated with various responses in non-small cell lung cancer (NSCLC) patients receiving the anti-EGFR agents. Detection of the mu...

    Authors: Tiffany Ng Shi Yeen, Rajadurai Pathmanathan, Mohd Sidik Shiran, Fattah Azman Ahmad Zaid and Yoke Kqueen Cheah
    Citation: Journal of Biomedical Science 2013 20:22
    Content type: Research Published on:

  5. Authors: Shui-Yi Tung, Shun-Fu Chang, Ming-Hui Chou, Wen-Shih Huang, Yung-Yu Hsieh, Chien-Heng Shen, Hsing-Chun Kuo and Cheng-Nan Chen
    Citation: Journal of Biomedical Science 2013 20:21
    Content type: Erratum Published on:

    The original article was published in Journal of Biomedical Science 2012 19:91

  6. A recessive mutation “c” in the Mexican axolotl, Ambystoma mexicanum, results in the failure of normal heart development. In homozygous recessive embryos, the hearts do not have organized myofibrils and fail to b...

    Authors: Andrei Kochegarov, Ashley Moses, William Lian, Jessica Meyer, Michael C Hanna and Larry F Lemanski
    Citation: Journal of Biomedical Science 2013 20:20
    Content type: Research Published on:

  7. Influenza virus has antigen drift and antigen shift effect, vaccination with some influenza vaccine might not induce sufficient immunity for host to the threat of other influenza virus strains. S-OIV H1N1 and ...

    Authors: Hui-Tsu Lin, Chuan-Chang Chuang, Hsieh-Ling Wu, Der-Ming Chu and Yeau-Ching Wang
    Citation: Journal of Biomedical Science 2013 20:19
    Content type: Research Published on:

  9. Houttuynia cordata Thunb (HCT) is commonly used in Taiwan and other Asian countries as an anti-inflammatory, antibacterial and antiviral herbal medicine. In this study, we investigated the anti-human lung cancer ...

    Authors: Yuh-Fung Chen, Jai-Sing Yang, Wen-Shin Chang, Shih-Chang Tsai, Shu-Fen Peng and Yuan-Ru Zhou
    Citation: Journal of Biomedical Science 2013 20:18
    Content type: Research Published on:

  10. Rivaroxaban reduces stroke in patients with atrial fibrillation (AF). Left atrium (LA) plays a critical role in the pathophysiology of AF. However, the electromechanical effects of rivaroxaban on LA are not cl...

    Authors: Chien-Jung Chang, Yao-Chang Chen, Yung-Kuo Lin, Jen-Hung Huang, Shih-Ann Chen and Yi-Jen Chen
    Citation: Journal of Biomedical Science 2013 20:17
    Content type: Research Published on:

  11. Targeted therapy of human cancers is an attractive approach and has been investigated with limited success. We have developed novel cytotoxic agents for targeted therapy of human cancers based on the extracell...

    Authors: Derek V Chan, Rahul Sharma, Chiao-Ying A Ju, Steve R Roffler and Shyr-Te Ju
    Citation: Journal of Biomedical Science 2013 20:16
    Content type: Research Published on:

  12. MicroRNAs (miRNAs) are evolutionarily conserved, naturally abundant, small, regulatory non-coding RNAs that inhibit gene expression at the post-transcriptional level in a sequence-specific manner. Due to invol...

    Authors: Pravin Kumar Singh, Ajay Vir Singh and Devendra Singh Chauhan
    Citation: Journal of Biomedical Science 2013 20:14
    Content type: Review Published on:

  13. In Oncology, the resistance of the cancerous cells to chemotherapy continues to be the principal limitation. The nuclear factor-kappa B (NF-κB) transcription factor plays an important role in tumor escape and ...

    Authors: Alejandro Bravo-Cuellar, Georgina Hernández-Flores, José Manuel Lerma-Díaz, Jorge Ramiro Domínguez-Rodríguez, Luis F Jave-Suárez, Ruth De Célis-Carrillo, Adriana Aguilar-Lemarroy, Paulina Gómez-Lomeli and Pablo Cesar Ortiz-Lazareno
    Citation: Journal of Biomedical Science 2013 20:13
    Content type: Research Published on:

  14. Several studies have demonstrated a fundamental role for the HLA in the susceptibility of, or protection to, type 1 diabetes mellitus (T1DM). However, this has not been adequately studied in Asian Indian popul...

    Authors: Oindrila Raha, Biswanath Sarkar, Bhaskar VKS Lakkakula, Veerraju Pasumarthy, Sudhakar Godi, Subhankar Chowdhury, Pradip Raychaudhuri and Raghavendra Rao Vadlamudi
    Citation: Journal of Biomedical Science 2013 20:12
    Content type: Research Published on:

  15. Honokiol, a cell-permeable phenolic compound derived from the bark of magnolia trees and present in Asian herbal teas, has a unique array of pharmacological actions, including the inhibition of multiple autono...

    Authors: Hsiu-Jen Wang, Alexis G Martin, Po-Kuan Chao, Rhett A Reichard, Adam L Martin, Yue-wern Huang, Ming-Huan Chan and Robert S Aronstam
    Citation: Journal of Biomedical Science 2013 20:11
    Content type: Research Published on:

  16. The central molecule in the pathogenesis of Alzheimer’s disease (AD) is believed to be a small-sized polypeptide – beta amyloid (Aβ) which has an ability to assemble spontaneously into oligomers. Various studi...

    Authors: Indre Dalgediene, Rita Lasickiene, Rima Budvytyte, Gintaras Valincius, Ramune Morkuniene, Vilmante Borutaite and Aurelija Zvirbliene
    Citation: Journal of Biomedical Science 2013 20:10
    Content type: Research Published on:

  17. MicroRNAs (miRNAs), a class of highly conserved small non-coding RNA molecules, are known to play essential roles in central nervous system (CNS) by causing post-transcriptional gene silencing. There is much e...

    Authors: Si Yun Shu, Di Qing, Bin Wang, Qi-yi Zeng, Yan-chen Chen, Ying Jin, Chang-chun Zeng and Rong Bao
    Citation: Journal of Biomedical Science 2013 20:9
    Content type: Research Published on:

  18. Immunotherapy with vaccines is attractive for the treatment of cancer. This study is aimed at determining the effect of recombinant Salmonella (SL3261)-based 4-1BB ligand (4-1BBL) vaccine on the development of...

    Authors: Jianxin Ye, Ling Li, Yuanting Zhang, Xueguang Zhang, Daming Ren and Weichang Chen
    Citation: Journal of Biomedical Science 2013 20:8
    Content type: Research Published on:

  20. Human cancer cells resemble stem cells in expression signatures leading them to share some features, most notably, self-renewal. A complex network of transcription factors and signaling molecules are required ...

    Authors: Mohammad Mahdi Forghanifard, Meysam Moghbeli, Reza Raeisossadati, Alireza Tavassoli, Afsaneh Javdani Mallak, Samaneh Boroumand-Noughabi and Mohammad Reza Abbaszadegan
    Citation: Journal of Biomedical Science 2013 20:6
    Content type: Research Published on:

  21. Thymidylate synthase (TS) is a key enzyme responsible for DNA synthesis and repair. Altered expression of TS protein or TS gene polymorphisms has been associated with cancer progression and treatment response. Th...

    Authors: Xia Wang, Yadi Wang, Yue Wang, Jian Cheng, Yanyun Wang and Minwen Ha
    Citation: Journal of Biomedical Science 2013 20:5
    Content type: Research Published on:

  23. IκB kinase (IKK) complex, the master kinase for NF-κB activation, contains two kinase subunits, IKKα and IKKβ. In addition to mediating NF-κB signaling by phosphorylating IκB proteins during inflammatory and i...

    Authors: Wei-Chien Huang and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2013 20:3
    Content type: Review Published on:

  24. Previously, we had identified a specific whole blood–derived microRNAs (miRNAs) signature in mice following in vivo injection of lipopolysaccharide (LPS) originated from Gram-negative bacteria. This study was des...

    Authors: Ching-Hua Hsieh, Johnson Chia-Shen Yang, Jonathan Chris Jeng, Yi-Chun Chen, Tsu-Hsiang Lu, Siou-Ling Tzeng, Yi-Chan Wu, Chia-Jung Wu and Cheng-Shyuan Rau
    Citation: Journal of Biomedical Science 2013 20:2
    Content type: Research Published on:

  25. Epicutaneous sensitization with protein allergen that induces predominant Th2 responses is an important sensitization route in atopic dermatitis. Fungal components have been shown to modulate Th cell different...

    Authors: Jing-Yi Lin, Jau-Shiuh Chen, Pei-Chun Chen, Ming-Hui Chung, Ching-Yi Liu, Shi-Chuen Miaw and Li-Fang Wang
    Citation: Journal of Biomedical Science 2013 20:1
    Content type: Research Published on:

  26. Aggregation of soluble, monomeric β- amyloid (Aβ) to oligomeric and then insoluble fibrillar Aβ is a key pathogenic feature in development of Alzheimer’s disease (AD). Increasing evidence suggests that toxicit...

    Authors: Md Golam Sharoar, Arjun Thapa, Mohammad Shahnawaz, Vijay Sankar Ramasamy, Eun-Rhan Woo, Song Yub Shin and Il-Seon Park
    Citation: Journal of Biomedical Science 2012 19:104
    Content type: Research Published on:

  27. Mefloquine is an anti-malarial drug that can have neurological side effects. This study examines how mefloquine (MF) influences central nervous control of autonomic and respiratory systems using the arterially...

    Authors: Varinder K Lall, Mathias Dutschmann, Jim Deuchars and Susan A Deuchars
    Citation: Journal of Biomedical Science 2012 19:103
    Content type: Research Published on:

  28. Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-...

    Authors: Ya-Ping Tsai and Kou-Juey Wu
    Citation: Journal of Biomedical Science 2012 19:102
    Content type: Review Published on:

  29. The tubby (tub) and tubby-like protein (tulp) genes encode a small family of proteins found in many organisms. Previous studies have shown that TUB and TULP genes in mammalian involve in obesity, neural developme...

    Authors: Shu-Fen Chen, Yu-Chen Tsai and Seng-Sheen Fan
    Citation: Journal of Biomedical Science 2012 19:101
    Content type: Research Published on:

  30. Gly1057Asp polymorphism in insulin receptor substrate (IRS)-2 is related to insulin resistance and diabetes mellitus (DM), which both contribute to the pathogenesis of coronary artery disease (CAD). Hence, we ...

    Authors: Shih-Hung Chan, Jyh-Hong Chen, Yi-Heng Li and Liang-Miin Tsai
    Citation: Journal of Biomedical Science 2012 19:100
    Content type: Research Published on:

  31. The effects of atorvastatin on SDF-1α expression under acute myocardial infarction (AMI) are still unclear. Therefore, our present study is to investigate the roles and mechanisms of atorvastatin treatment on ...

    Authors: Ruofeng Qiu, Anping Cai, Yugang Dong, Yingling Zhou, Danqing Yu, Yuli Huang, Dongdan Zheng, Shaoqi Rao, Yingqing Feng and Weiyi Mai
    Citation: Journal of Biomedical Science 2012 19:99
    Content type: Research Published on:

  32. Lethal toxin (LT) is a major virulence factor of Bacillus anthracis. Sprague Dawley rats manifest pronounced lung edema and shock after LT treatments, resulting in high mortality. The heart failure that is induce...

    Authors: Jyh-Hwa Kau, Yung-Luen Shih, Te-Sheng Lien, Chin-Cheng Lee, Hsin-Hsien Huang, Hung-Chi Lin, Der-Shan Sun and Hsin-Hou Chang
    Citation: Journal of Biomedical Science 2012 19:98
    Content type: Research Published on:

  33. Interleukin 12B (IL12B) gene polymorphisms have been linked to several inflammatory diseases, but their role in the development of Graves ophthalmopathy (GO) in Graves disease (GD) patients is unclear. The purpos...

    Authors: Yu-Huei Liu, Ching-Chu Chen, Li-Ling Liao, Lei Wan, Chang-Hai Tsai and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2012 19:97
    Content type: Research Published on:

  34. Based on an experimental brain stem death model, we demonstrated previously that activation of the mitogen-activated protein kinase kinase 1/2 (MEK1/2)/extracellular signal-regulated kinase 1/2 (ERK1/2)/mitoge...

    Authors: Alice YW Chang
    Citation: Journal of Biomedical Science 2012 19:96
    Content type: Research Published on:

  35. Beckwith-Wiedemann syndrome (BWS) is a loss-of-imprinting pediatric overgrowth syndrome. The primary features of BWS include macrosomia, macroglossia, and abdominal wall defects. Secondary features that are fr...

    Authors: Katherine Marie Robbins, Zhiyuan Chen, Kevin Dale Wells and Rocío Melissa Rivera
    Citation: Journal of Biomedical Science 2012 19:95
    Content type: Research Published on:

  37. Tissue engineering scaffold constitutes a new strategy of myocardial repair. Here, we studied the contribution of a patch using autologous mesenchymal stem cells (MSCs) seeded on collagen-1 scaffold on the car...

    Authors: Pablo Maureira, Pierre-Yves Marie, Fengxu Yu, Sylvain Poussier, Yihua Liu, Frederique Groubatch, Aude Falanga and Nguyen Tran
    Citation: Journal of Biomedical Science 2012 19:93
    Content type: Research Published on:

  38. Autophagy is a protein degradative process important for normal cellular metabolism. It is apparently used also by cells to eliminate invading pathogens. Interestingly, many pathogens have learned to subvert t...

    Authors: Sai-Wen Tang, Aurelie Ducroux, Kuan-Teh Jeang and Christine Neuveut
    Citation: Journal of Biomedical Science 2012 19:92
    Content type: Review Published on:

  39. The CXC chemokine ligand 12 (CXCL12)/stromal cell-derived factor-1 (SDF-1) and CXC receptor 4 (CXCR4) axis is involved in human colorectal cancer (CRC) carcinogenesis and can promote the progression of CRC. In...

    Authors: Shui-Yi Tung, Shun-Fu Chang, Ming-Hui Chou, Wen-Shih Huang, Yung-Yu Hsieh, Chien-Heng Shen, Hsing-Chun Kuo and Cheng-Nan Chen
    Citation: Journal of Biomedical Science 2012 19:91
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2013 20:21

  40. MicroRNAs (miRNAs) are involved in multiple biological activities as well as disease progression including cancer. Interestingly, miRNAs could act as either tumor suppressors or oncogenes depending on the func...

    Authors: Pai-Sheng Chen, Jen-Liang Su and Mien-Chie Hung
    Citation: Journal of Biomedical Science 2012 19:90
    Content type: Review Published on:

  41. Several low-molecular-weight phenolic acids are present in the blood of septic patients at high levels. The microbial origin of the most of phenolic acids in the human body was shown previously, but pathophysi...

    Authors: Natalia Beloborodova, Iskander Bairamov, Andrei Olenin, Victoria Shubina, Vera Teplova and Nadezhda Fedotcheva
    Citation: Journal of Biomedical Science 2012 19:89
    Content type: Research Published on:

  44. Zerumbone, a sesquiterpene compound isolated from subtropical ginger, Zingiber zerumbet Smith, has been documented to exert antitumoral and anti- inflammatory activities. In this study, we demonstrate that zerumb...

    Authors: Hsing-Yu Weng, Ming-Jen Hsu, Ching-Chung Wang, Bing-Chang Chen, Chuang-Ye Hong, Mei-Chieh Chen, Wen-Ta Chiu and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2012 19:86
    Content type: Research Published on:

  45. MALT1 belongs to a family of paracaspase and modulates NF-κB signaling pathways through its scaffolding function and proteolytic activity. MALT1 cleaves protein substrates after a positively charged Arginine r...

    Authors: Shin-Yi Jou, Chien-Chih Chang, Chun-Hsien Wu, Mei-Ru Chen, Ching-Hwa Tsai, Wen-Hui Chuang, Yun-Hui Chen, Ann-Lii Cheng and Shin-Lian Doong
    Citation: Journal of Biomedical Science 2012 19:85
    Content type: Research Published on:

  47. Iron homeostasis is chiefly regulated by hepcidin whose expression is tightly controlled by inflammation, iron stores, and hypoxia. Hemojuvelin (HJV) is a bone morphogenetic protein co-receptor that has been i...

    Authors: Mohamed Fouda Salama, Henry K Bayele and Surjit SK Srai
    Citation: Journal of Biomedical Science 2012 19:83
    Content type: Research Published on:

  48. The root bark of Paeonia suffruticosa Andrews (PSE), also known as Moutan Cortex, has been widely used in Asia to treat various diseases. The molecular mechanisms by which PSE exerts its anti-oxidant and anti-inf...

    Authors: Hyeong Sim Choi, Hye-Sook Seo, Ji Hye Kim, Jae-Young Um, Yong Cheol Shin and Seong-Gyu Ko
    Citation: Journal of Biomedical Science 2012 19:82
    Content type: Research Published on:

  49. Tumor suppressors are frequently downregulated in human cancers and understanding of the mechanisms through which tumor cells restrict the expression of tumor suppressors is important for the prognosis and int...

    Authors: Ruey-Hwa Chen, Yu-Ru Lee and Wei-Chien Yuan
    Citation: Journal of Biomedical Science 2012 19:81
    Content type: Review Published on:

  50. Daidzein, a phytoestrogen found in isoflavone, is known to exert neurotrophic and neuroprotective effects on the nervous system. Using primary rat dorsal root ganglion (DRG) neuronal cultures, we have examined...

    Authors: Shih-Hung Yang, Chih-Chen Liao, Ying Chen, Jhih-Pu Syu, Chung-Jiuan Jeng and Seu-Mei Wang
    Citation: Journal of Biomedical Science 2012 19:80
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127