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  1. Alzheimer’s disease (AD) is the most common type of dementia and typically manifests through a progressive loss of episodic memory and cognitive function, subsequently causing language and visuospatial skills ...

    Authors: Marcos Vinícius Ferreira Silva, Cristina de Mello Gomide Loures, Luan Carlos Vieira Alves, Leonardo Cruz de Souza, Karina Braga Gomes Borges and Maria das Graças Carvalho
    Citation: Journal of Biomedical Science 2019 26:33
    Content type: Review Published on:

  2. Our previous studies have demonstrated that Ca2+ desensitizing catechin could correct diastolic dysfunction in experimental animals with restrictive cardiomyopathy. In this study, it is aimed to assess the effect...

    Authors: Junjun Quan, Zhongli Jia, Tiewei Lv, Lei Zhang, Lingjuan Liu, Bo Pan, Jing Zhu, Ira J. Gelb, Xupei Huang and Jie Tian
    Citation: Journal of Biomedical Science 2019 26:32
    Content type: Research Published on:

  3. In the original publication of this article [1], there are two errors in the article which the cDNA position of the pathogenic variant WNT1 p.Gly324Cys should be c.970G>T instead of c.1168G>T.

    Authors: Mehran Kausar, Saima Siddiqi, Muhammad Yaqoob, Sajid Mansoor, Outi Makitie, Asif Mir, Chiea Chuen Khor, Jia Nee Foo and Mariam Anees
    Citation: Journal of Biomedical Science 2019 26:31
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2018 25:82

  4. Promyelocytic leukemia zinc finger (Plzf), a transcriptional regulator involved in a lot of important biological processes during development, has been implied to maintain neural stem cells and inhibit their d...

    Authors: Hsin-Chuan Lin, Yung-Hao Ching, Chi-Chen Huang, Ping-Chieh Pao, Yi-Hua Lee, Wen-Chang Chang, Tzu-Jen Kao and Yi-Chao Lee
    Citation: Journal of Biomedical Science 2019 26:30
    Content type: Research Published on:

  6. Cervical cancer is the fourth most frequent cancer in women worldwide and a major cause of mortality in developing countries. Persistent infection with high-risk human papillomavirus (HPV) is a necessary cause...

    Authors: Sadhana M. Gupta and Jayanti Mania-Pramanik
    Citation: Journal of Biomedical Science 2019 26:28
    Content type: Review Published on:

    The Retraction Note to this article has been published in Journal of Biomedical Science 2019 26:50

  7. Promoting post-stroke neurogenesis has long been proposed to be a therapeutic strategy for the enhancement of functional recovery after cerebral ischemic stroke. Despite numerous approaches have been widely re...

    Authors: Joen-Rong Sheu, Cheng-Ying Hsieh, Thanasekaran Jayakumar, Guan-Yi Lin, Hsing-Ni Lee, Shin-Wei Huang and Chih-Hao Yang
    Citation: Journal of Biomedical Science 2019 26:27
    Content type: Research Published on:

  8. Traumatic experience may lead to various psychological sequelae including the unforgettable trauma-associated memory as seen in posttraumatic stress disorder (PTSD), with a mechanism of impaired fear extinctio...

    Authors: Sheng-Chiang Wang, Chen-Cheng Lin, Nian-Sheng Tzeng, Che-Se Tung and Yia-Ping Liu
    Citation: Journal of Biomedical Science 2019 26:26
    Content type: Research Published on:

  9. Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute k...

    Authors: Vladislav Volarevic, Bojana Djokovic, Marina Gazdic Jankovic, C. Randall Harrell, Crissy Fellabaum, Valentin Djonov and Nebojsa Arsenijevic
    Citation: Journal of Biomedical Science 2019 26:25
    Content type: Review Published on:

  10. The liver is controlled by several metabolic hormones, including thyroid hormone, and characteristically displays high lysosomal activity as well as metabolic stress-triggered autophagy, which is stringently r...

    Authors: Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh and Kwang-Huei Lin
    Citation: Journal of Biomedical Science 2019 26:24
    Content type: Review Published on:

  11. Helicobacter pylori bacteria colonize human gastric mucosa, cause chronic inflammation, peptic ulcers and gastric cancer. Colonization is mediated by H. pylori adhesins, which preferentially bind mucin 5 (MUC5AC)...

    Authors: Weronika Gonciarz, Maria Walencka, Anthony P. Moran, Krzysztof Hinc, Michał Obuchowski and Magdalena Chmiela
    Citation: Journal of Biomedical Science 2019 26:23
    Content type: Research Published on:

  12. Psychological investigations and functional imaging technology have been used to describe neural correlations of different types of memory with various stimuli. Memory with limited storage capacity and a short...

    Authors: Jingxin Nie, Zengqiang Zhang, Bin Wang, Hong Li, Jianghua Xu, Sheng Wu, Chunhua Zhu, Xin Yang, Bin Liu, Yongming Wu, Sheng Tan, Zhibo Wen, Jinlong Zheng, Siyun Shu and Lin Ma
    Citation: Journal of Biomedical Science 2019 26:22
    Content type: Research Published on:

  13. The most important limitations of morphine in pain therapy are its tolerance and dependence. In this study, we evaluated the protective effect of glucosamine against morphine-induced tolerance and dependence i...

    Authors: Faezeh Basiri, Abolfazl Rad, Davood Mahdian, Mehdi Molavi and Bahareh Amin
    Citation: Journal of Biomedical Science 2019 26:21
    Content type: Research Published on:

  14. Prognosis of esophageal squamous cell carcinoma (ESCC) patients is poor and the concurrent chemoradiation therapy (CCRT) provided to ESCC patients often failed due to resistance. Therefore, development of biom...

    Authors: I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai and Yi-Ching Wang
    Citation: Journal of Biomedical Science 2019 26:20
    Content type: Research Published on:

  15. The intestinal mucosa is a site of multiple stressors and forms the barrier between the internal and external environment. In the intestine, a complex interplay between the microbiota, epithelial barrier and t...

    Authors: Sabah Haq, Jensine Grondin, Suhrid Banskota and Waliul I. Khan
    Citation: Journal of Biomedical Science 2019 26:19
    Content type: Review Published on:

  17. Head and neck squamous carcinoma (HNSCC) is one of the most invasive types of cancer with high mortality. A previous study has indicated that low levels of let-7d and miR-205 in HNSCC patients are correlated w...

    Authors: Tomasz Kolenda, Kacper Guglas, Anna Teresiak, Renata Bliźniak and Katarzyna Lamperska
    Citation: Journal of Biomedical Science 2019 26:17
    Content type: Research Published on:

  18. Shiga toxin 2 from enterohemorrhagic Escherichia coli is the etiologic agent of bloody diarrhea, hemolytic uremic syndrome and derived encephalopathies that may result to death in patients. Being a Gram negative ...

    Authors: Clara Berdasco, Alipio Pinto, Valeria Calabró, David Arenas, Adriana Cangelosi, Patricia Geoghegan, Pablo Evelson and Jorge Goldstein
    Citation: Journal of Biomedical Science 2019 26:16
    Content type: Research Published on:

  19. Among the various types of dementia, Alzheimer’s disease (AD) is the most prevalent and is clinically defined as the appearance of progressive deficits in cognition and memory. Considering that AD is a central...

    Authors: Fernanda Majolo, Daniel Rodrigo Marinowic, Denise Cantarelli Machado and Jaderson Costa Da Costa
    Citation: Journal of Biomedical Science 2019 26:15
    Content type: Review Published on:

  20. Nasopharyngeal carcinoma (NPC), a highly invasive tumor, exhibits a distinctive racial and geographic distribution. As options of agents for effective combination chemoradiotherapy for advanced NPC are limited...

    Authors: Zhihai Wang, Wenqi Zuo, Quan Zeng, Yi Qian, Yanshi Li, Chuan Liu, Jue Wang, Shixun Zhong, Youquan Bu and Guohua Hu
    Citation: Journal of Biomedical Science 2019 26:14
    Content type: Research Published on:

  21. Dysregulated long noncoding RNAs (lncRNAs) are involved in the development of tumor. Aberrant methylation is one of the most frequent epigenetic alterations that regulate the expression of genes. The aim of th...

    Authors: Wenxia Meng, Weina Cui, Lei Zhao, Weiwei Chi, Huan Cao and Baoshan Wang
    Citation: Journal of Biomedical Science 2019 26:13
    Content type: Research Published on:

  22. Osteoclasts (OCs) are motile multinucleated cells derived from differentiation and fusion of hematopoietic progenitors of the monocyte-macrophage lineage that undergo a multistep process called osteoclastogene...

    Authors: Chu-Lung Chan, Jiann-Yeu Chen, Ming-Chih Shih, Chih-Lueh Albert Wang and Ying-Ming Liou
    Citation: Journal of Biomedical Science 2019 26:12
    Content type: Research Published on:

  23. Stress is deeply rooted in the modern society due to limited resources and large competition to achieve the desired goal. Women are more frequently exposed to several stressors during their reproductive age th...

    Authors: Govind R. Chaudhary, Pramod K. Yadav, Anil K. Yadav, Meenakshi Tiwari, Anumegha Gupta, Alka Sharma, Ashutosh N. Pandey, Ajai K. Pandey and Shail K. Chaube
    Citation: Journal of Biomedical Science 2019 26:11
    Content type: Review Published on:

  24. Toxoplasma gondii is a protozoan parasite that causes congenital toxoplasmosis by transplacental transmission. Parasite strains are genetically diverse and disease severity is related to the genotype. In Uberlând...

    Authors: Priscila Silva Franco, Paula Suellen Guimarães Gois, Thádia Evelyn de Araújo, Rafaela José da Silva, Bellisa de Freitas Barbosa, Angelica de Oliveira Gomes, Francesca Ietta, Lara Affonso dos Santos, Maria Célia dos Santos, José Roberto Mineo and Eloisa Amália Vieira Ferro
    Citation: Journal of Biomedical Science 2019 26:10
    Content type: Research Published on:

  27. Cancer metastasis is the major cause of mortality in cancer cases and is responsible for cancer deaths. It is known that cancer cells communicate with surrounding microenvironmental cells, such as fibroblast c...

    Authors: Akiko Kogure, Nobuyoshi Kosaka and Takahiro Ochiya
    Citation: Journal of Biomedical Science 2019 26:7
    Content type: Review Published on:

  28. Pulmonary hypertension (PH) is a progressive disease leading to death ultimately. Our recently published data demonstrated that inhibiting dipeptidyl peptidase IV (DPP-4) alleviated pulmonary vascular remodeli...

    Authors: Jingjing Wang, Min Yu, Jian Xu, Yusheng Cheng, Xiang Li, Guihong Wei, Hong Wang, Hui Kong and Weiping Xie
    Citation: Journal of Biomedical Science 2019 26:6
    Content type: Research Published on:

  29. Rosmarinus officinalis L. (rosemary) is a medicinal plant native to the Mediterranean region and cultivated around the world. Besides the therapeutic purpose, it is commonly used as a condiment and food preservat...

    Authors: Jonatas Rafael de Oliveira, Samira Esteves Afonso Camargo and Luciane Dias de Oliveira
    Citation: Journal of Biomedical Science 2019 26:5
    Content type: Review Published on:

  30. H. pylori CagL-Y58/E59 increase gastric cancer risk by stronger binding with integrin to faciliate type IV secretory system (T4SS). H. pylori can secrete high temperature requirement A (HtrA) to mediate E-Cadheri...

    Authors: Yi-Chun Yeh, Hsin-Yu Kuo, Wei-Lun Chang, Hsiao-Bai Yang, Cheng-Chan Lu, Hsiu-Chi Cheng, Ming-Shiang Wu and Bor-Shyang Sheu
    Citation: Journal of Biomedical Science 2019 26:4
    Content type: Research Published on:

  31. Dysbiosis of gut microbiota is closely related to occurrence of many important chronic inflammations-related diseases. So far the traditionally prescribed prebiotics and probiotics do not show significant impa...

    Authors: Yu-Ling Tsai, Tzu-Lung Lin, Chih-Jung Chang, Tsung-Ru Wu, Wei-Fan Lai, Chia-Chen Lu and Hsin-Chih Lai
    Citation: Journal of Biomedical Science 2019 26:3
    Content type: Review Published on:

  32. Human corneal endothelial cells are notorious for their restricted proliferative ability in vivo and in vitro. Hence, injury or dysfunction of these cells may easily result in blindness. Currently, the only tr...

    Authors: Shuangling Chen, Qin Zhu, Hong Sun, Yuan Zhang, Sean Tighe, Li Xu and Yingting Zhu
    Citation: Journal of Biomedical Science 2019 26:2
    Content type: Review Published on:

  33. Gut microbiota interacting with an intact mucosal surface are key to the maintenance of homeostasis and health. This review discusses the current state of knowledge of the biofilm mode of growth of these micro...

    Authors: Andre Gerald Buret, Jean-Paul Motta, Thibault Allain, Jose Ferraz and John Lawrence Wallace
    Citation: Journal of Biomedical Science 2019 26:1
    Content type: Review Published on:

  34. Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles released by cells. They range from 30 nm to several micrometers in diameter, and ferry biological cargos such as proteins, lipids, RNAs and...

    Authors: Steven Ting-Yu Chuo, Jasper Che-Yung Chien and Charles Pin-Kuang Lai
    Citation: Journal of Biomedical Science 2018 25:91
    Content type: Review Published on:

  35. The nervous system is a crucial component of the body and damages to this system, either by of injury or disease, can result in serious or potentially lethal consequences. Restoring the damaged nervous system ...

    Authors: Rossana Boni, Azam Ali, Amin Shavandi and Andrew N. Clarkson
    Citation: Journal of Biomedical Science 2018 25:90
    Content type: Review Published on:

  36. Obesity is one of the most invaliding and preventable diseases in the United States. Growing evidence suggests that there are sex differences in obesity in human and experimental animals. However, the specific...

    Authors: Sarah Jayne Fitzgerald, Amol Vijay Janorkar, Allison Barnes and Rodrigo Oscar Maranon
    Citation: Journal of Biomedical Science 2018 25:89
    Content type: Review Published on:

  37. Cytokines play an important role in controlling the homeostasis of the immune system and infection with Human Immunodeficiency virus (HIV) leads to deregulated production of both pro- and anti-inflammatory cyt...

    Authors: Faustina Nkechi Osuji, Charles Chinedu Onyenekwe, Joseph Ebere Ahaneku and Nkiruka Rose Ukibe
    Citation: Journal of Biomedical Science 2018 25:88
    Content type: Research Published on:

  38. Mitochondria autophagy, termed as mitophagy, is a mechanism of specific autophagic elimination of mitochondria. Mitophagy controls the quality and the number of mitochondria, eliminating dysfunctional or exces...

    Authors: Ruiqiao Guan, Wei Zou, Xiaohong Dai, Xueping Yu, Hao Liu, Qiuxin Chen and Wei Teng
    Citation: Journal of Biomedical Science 2018 25:87
    Content type: Review Published on:

  40. Sensing tissue acidosis is an important function of the somatosensory nervous system to response to noxious stimuli.

    Authors: Jiann-Her Lin, Chih-Hsien Hung, Der-Sheng Han, Shih-Ting Chen, Cheng-Han Lee, Wei-Zen Sun and Chih-Cheng Chen
    Citation: Journal of Biomedical Science 2018 25:85
    Content type: Review Published on:

  43. Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disease with skeletal fragility and variable extra-skeletal manifestations. To date several point mutations in 18 different genes causing...

    Authors: Mehran Kausar, Saima Siddiqi, Muhammad Yaqoob, Sajid Mansoor, Outi Makitie, Asif Mir, Chiea Chuen Khor, Jia Nee Foo and Mariam Anees
    Citation: Journal of Biomedical Science 2018 25:82
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2019 26:31

  44. Metformin is the most commonly used first-line medicine for type II diabetes mellitus. Acting via AMP-activated protein kinase, it has been used for more than 60 years and has an outstanding safety record. Met...

    Authors: Shu-Man Hsieh Li, Shu-Ting Liu, Yung-Lung Chang, Ching-Liang Ho and Shih-Ming Huang
    Citation: Journal of Biomedical Science 2018 25:81
    Content type: Research Published on:

  45. TNS2 is a focal adhesions protein and a binding partner for many proteins, including the receptor tyrosine kinase Axl. Although TNS2 can bind with Axl, the details of their interactions have not been elucidate...

    Authors: Li-Chun Cheng, Yen-Lin Chen, An-Ning Cheng, Alan Yueh-Luen Lee, Chun-Yu Cho, Jhy-Shrian Huang and Shuang-En Chuang
    Citation: Journal of Biomedical Science 2018 25:80
    Content type: Research Published on:

  46. Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the interaction of genetic, environmental, barrier and microbial factors leading to chronic inflammation in the intestin...

    Authors: Linda Chia-Hui Yu
    Citation: Journal of Biomedical Science 2018 25:79
    Content type: Review Published on:

  47. Helicobacter pylori - (H. pylori) play a role in the pathogenesis of gastritis, gastric and duodenal ulcers as well as gastric cancer. A possible involvement of outer membrane vesicles (OMVs) produced by H. pylor...

    Authors: Magdalena Chmiela, Natalia Walczak and Karolina Rudnicka
    Citation: Journal of Biomedical Science 2018 25:78
    Content type: Review Published on:

  48. Dengue virus, the causative agent of dengue disease which may have hemorrhagic complications, poses a global health threat. Among the numerous target cells for dengue virus in humans are monocytes, macrophages...

    Authors: Shu-Wen Wan, Betty A. Wu-Hsieh, Yee-Shin Lin, Wen-Yu Chen, Yan Huang and Robert Anderson
    Citation: Journal of Biomedical Science 2018 25:77
    Content type: Review Published on:

  49. The brain predominantly expressed RING finger protein, Znf179, is known to be important for embryonic neuronal differentiation during brain development. Downregulation of Znf179 has been observed in motor neur...

    Authors: Yi-Chao Lee, Wan-Chen Huang, Jiann-Her Lin, Tzu-Jen Kao, Hui-Ching Lin, Kuen-Haur Lee, Hsin-Chuan Lin, Che-Kun James Shen, Wen-Chang Chang and Chi-Chen Huang
    Citation: Journal of Biomedical Science 2018 25:76
    Content type: Research Published on:

  50. Jaundice is a common symptom of inherited or acquired liver diseases or a manifestation of diseases involving red blood cell metabolism. Recent progress has elucidated the molecular mechanisms of bile metaboli...

    Authors: Huey-Ling Chen, Shang-Hsin Wu, Shu-Hao Hsu, Bang-Yu Liou, Hui-Ling Chen and Mei-Hwei Chang
    Citation: Journal of Biomedical Science 2018 25:75
    Content type: Review Published on:
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ISSN: 1423-0127