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  1. Metabolic diseases such as obesity, type 2 diabetes (T2D) and insulin resistance have attracted great attention from biomedical researchers and clinicians because of the astonishing increase in its prevalence....

    Authors: Chih-Hao Wang and Yau-Huei Wei

    Citation: Journal of Biomedical Science 2017 24:70

    Content type: Review

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  2. The type VI adenylyl cyclase (AC6) is a main contributor of cAMP production in the heart. The amino acid (aa) sequence of AC6 is highly homologous to that of another major cardiac adenylyl cyclase, AC5, except...

    Authors: Yu-Shuo Wu, Chien-Chang Chen, Chen-Li Chien, Hsing-Lin Lai, Si-Tse Jiang, Yong-Cyuan Chen, Lin-Ping Lai, Wei-Fan Hsiao, Wen-Pin Chen and Yijuang Chern

    Citation: Journal of Biomedical Science 2017 24:68

    Content type: Research

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  3. The aim of this study was to determine the biofilm formation, the extracellular enzymatic activities of 182 clinical isolates of the Candida parapsilosis complex.

    Authors: Sourour Neji, Ines Hadrich, Houaida Trabelsi, Salma Abbes, Fatma Cheikhrouhou, Hayet Sellami, Fattouma Makni and Ali Ayadi

    Citation: Journal of Biomedical Science 2017 24:67

    Content type: Research

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  4. Malnutrition resulting from protein and calorie deficiency continues to be a major concern worldwide especially in developing countries. Specific deficiencies in the protein intake can adversely influence repr...

    Authors: Omar A.H. Ahmed-Farid, Maha Nasr, Rania F. Ahmed and Rofanda M. Bakeer

    Citation: Journal of Biomedical Science 2017 24:66

    Content type: Research

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  5. This review examines the biology of the Fat mass- and obesity-associated gene (FTO), and the implications of genetic association of FTO SNPs with obesity and genetic aging. Notably, we focus on the role of FTO...

    Authors: Yuling Zhou, Brett D. Hambly and Craig S. McLachlan

    Citation: Journal of Biomedical Science 2017 24:65

    Content type: Review

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  6. Kidneys play an important role in glucose homeostasis. Renal gluconeogenesis prevents hypoglycemia by releasing glucose into the blood stream. Glucose homeostasis is also due, in part, to reabsorption and excr...

    Authors: Leszek Szablewski

    Citation: Journal of Biomedical Science 2017 24:64

    Content type: Review

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  7. Since the first discovery in 1996, the engagement of TRIM28 in distinct aspects of cellular biology has been extensively studied resulting in identification of a complex nature of TRIM28 protein. In this revie...

    Authors: Patrycja Czerwińska, Sylwia Mazurek and Maciej Wiznerowicz

    Citation: Journal of Biomedical Science 2017 24:63

    Content type: Review

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  8. Hepatoblastoma, a leading primary hepatic malignant tumor in children, is originated from primitive hepatic stem cells. We aimed to elucidate the relationships between the histological distribution of β-cateni...

    Authors: Jia-Feng Wu, Hsiu-Hao Chang, Meng-Yao Lu, Shiann-Tarng Jou, Kai-Chi Chang, Yen-Hsuan Ni and Mei-Hwei Chang

    Citation: Journal of Biomedical Science 2017 24:62

    Content type: Research

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  9. Lutheran/basal cell adhesion molecule (Lu/BCAM) is a membrane bound glycoprotein. This study was performed to investigate the role and downstream signaling pathway of Lu/BCAM in human bladder tumorigenesis.

    Authors: Hong-Yi Chang, Hsin-Mei Chang, Tsung-Jung Wu, Chang-Yao Chaing, Tzong-Shin Tzai, Hong-Lin Cheng, Giri Raghavaraju, Nan-Haw Chow and Hsiao-Sheng Liu

    Citation: Journal of Biomedical Science 2017 24:61

    Content type: Research

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  10. Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), appear to recapitulate the brain’s 3D...

    Authors: Chun-Ting Lee, Raphael M. Bendriem, Wells W. Wu and Rong-Fong Shen

    Citation: Journal of Biomedical Science 2017 24:59

    Content type: Review

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  11. Vibrio vulnificus is a marine bacterial species that causes opportunistic infections manifested by serious skin lesions and fulminant septicemia in humans. We have previously shown tha...

    Authors: Chun-Liang Chen, Shu-Chun Chien, Tzeng-Horng Leu, Hans I-Chen Harn, Ming-Jer Tang and Lien-I Hor

    Citation: Journal of Biomedical Science 2017 24:58

    Content type: Research

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  12. Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU m...

    Authors: Sudhir Kumar, Birgit Rathkolb, Sibylle Sabrautzki, Stefan Krebs, Elisabeth Kemter, Lore Becker, Johannes Beckers, Raffi Bekeredjian, Robert Brommage, Julia Calzada-Wack, Lillian Garrett, Sabine M. Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Kristin Moreth…

    Citation: Journal of Biomedical Science 2017 24:57

    Content type: Research

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  13. Sudden cardiac death (SCD) describes a natural and unexpected death from cardiac causes occurring within a short period of time (generally within 1 h of symptom onset) in the absence of any other potentially l...

    Authors: Simona Magi, Vincenzo Lariccia, Marta Maiolino, Salvatore Amoroso and Santo Gratteri

    Citation: Journal of Biomedical Science 2017 24:56

    Content type: Review

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  14. Epigallocatechin gallate (EGCG) is the major ingredient of sinecatechins ointment, approved for the treatment of external genital and perianal warts. However, the molecular mechanism for EGCG’s effect on warts...

    Authors: Yu-Wen Chu, Shu-Ting Liu, Ya-Lan Yang, Shih-Ming Huang and Wei-Ming Wang

    Citation: Journal of Biomedical Science 2017 24:55

    Content type: Research

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  15. An attenuated mutant (designated NY303) of Vibrio vulnificus, which causes serious wound infection and septicemia in humans, was isolated fortuitously from a clinical strain YJ016. This mutant was defective in cy...

    Authors: Yu-Chi Ho, Feng-Ru Hung, Chao-Hui Weng, Wei-Ting Li, Tzu-Hung Chuang, Tsung-Lin Liu, Ching-Yuan Lin, Chien-Jung Lo, Chun-Liang Chen, Jen-Wei Chen, Masayuki Hashimoto and Lien-I Hor

    Citation: Journal of Biomedical Science 2017 24:54

    Content type: Research

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  16. Baicalin, an important flavonoid in Scutellaria baicalensis Georgi extracts, exerts a variety of pharmacological effects. In this study, we explored the effects of baicalin on chronic hypoxia-induced pulmonary ar...

    Authors: Xiaoying Huang, Peiliang Wu, Feifei Huang, Min Xu, Mayun Chen, Kate Huang, Guo-ping Li, Manhuan Xu, Dan Yao and Liangxing Wang

    Citation: Journal of Biomedical Science 2017 24:52

    Content type: Research

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  17. Obesity and its comorbidities constitute a serious health burden worldwide. Leptin plays an important role in diet control; however, it has a stimulatory potential on cancer cell proliferation. The OB3 peptide...

    Authors: Yu-Tang Chin, Le-Ming Wang, Meng-Ti Hsieh, Ya-Jung Shih, André Wendindondé Nana, Chun A. Changou, Yu-Chen S. H. Yang, Hsien-Chung Chiu, Earl Fu, Paul J. Davis, Heng-Yuan Tang and Hung-Yun Lin

    Citation: Journal of Biomedical Science 2017 24:51

    Content type: Research

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  18. Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular diseases. Increasing evidence show...

    Authors: Arijit Ghosh, Lei Gao, Abhimanyu Thakur, Parco M. Siu and Christopher W. K. Lai

    Citation: Journal of Biomedical Science 2017 24:50

    Content type: Review

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  19. B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the development and function of antibody-producing B cells. Given that its function in T lymphocytes has been identified with...

    Authors: Shin-Huei Fu, Li-Tzu Yeh, Chin-Chen Chu, B. Lin-Ju Yen and Huey-Kang Sytwu

    Citation: Journal of Biomedical Science 2017 24:49

    Content type: Review

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  20. Alzheimer’s disease (AD) is a major form of senile dementia, characterized by progressive memory and neuronal loss combined with cognitive impairment. AD is the most common neurodegenerative disease worldwide,...

    Authors: Shih-Ya Hung and Wen-Mei Fu

    Citation: Journal of Biomedical Science 2017 24:47

    Content type: Review

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  21. Although vertebrates are bilaterally symmetric organisms, their internal organs are distributed asymmetrically along a left-right axis. Disruption of left-right axis asymmetric patterning often occurs in human...

    Authors: Che-Yi Lin, Ming-Yuan Tsai, Yu-Hsiu Liu, Yu-Fen Lu, Yi-Chung Chen, Yun-Ren Lai, Hsin-Chi Liao, Huang-Wei Lien, Chung-Hsiang Yang, Chang-Jen Huang and Sheng-Ping L. Hwang

    Citation: Journal of Biomedical Science 2017 24:45

    Content type: Research

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  22. The inward rectifier potassium current IK1 contributes to a stable resting membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain-of-function mutations V93I and D172N associate ...

    Authors: Yuan Ji, Marlieke G. Veldhuis, Jantien Zandvoort, Fee L. Romunde, Marien J. C. Houtman, Karen Duran, Gijs van Haaften, Eva-Maria Zangerl-Plessl, Hiroki Takanari, Anna Stary-Weinzinger and Marcel A. G. van der Heyden

    Citation: Journal of Biomedical Science 2017 24:44

    Content type: Research

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  23. Anemia is common among end-stage renal disease (ESRD) patients who undergone hemodialysis. The total reduction of red blood cell (RBC) count is associated with poor prognosis in these patients. Although erythr...

    Authors: Henry Sung-Ching Wong, Che-Mai Chang, Chih-Chin Kao, Yu-Wen Hsu, Xiao Liu, Wen-Chang Chang, Mai-Szu Wu and Wei-Chiao Chang

    Citation: Journal of Biomedical Science 2017 24:43

    Content type: Research

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  24. Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system. It also affects periphe...

    Authors: Peggy Sfyri and Antonios Matsakas

    Citation: Journal of Biomedical Science 2017 24:42

    Content type: Review

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  25. Compensatory lung growth (CLG) is a well-established lung regeneration model. However, the sequential mechanisms, including unknown molecular triggers or regulators, remain unclear. Nuclear factor- kappa B (NF...

    Authors: Yusuke Takahashi, Noriyuki Matsutani, Hitoshi Dejima, Takashi Nakayama, Hirofumi Uehara and Masafumi Kawamura

    Citation: Journal of Biomedical Science 2017 24:41

    Content type: Research

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  26. Dengue and leptospirosis infections are currently two major endemics in Malaysia. Owing to the overlapping clinical symptoms between both the diseases, frequent misdiagnosis and confusion of treatment occurs. ...

    Authors: Jeyanthi Suppiah, Shie-Yien Chan, Min-Wern Ng, Yam-Sim Khaw, Siew-Mooi Ching, Lailatul Akmar Mat-Nor, Naematul Ain Ahmad-Najimudin and Hui-Yee Chee

    Citation: Journal of Biomedical Science 2017 24:40

    Content type: Research

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  27. Myocardial infarction (MI) is an acute and fatal condition that threatens human health. Dl-3-n-butylphthalide (NBP) has been used for the treatment of acute ischemic stroke. Mitochondria may play a protective ...

    Authors: Xiaochao Tian, Weiliang He, Rong Yang and Yingping Liu

    Citation: Journal of Biomedical Science 2017 24:38

    Content type: Research

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  28. Lung cancer is the most common cause of cancer-related death worldwide, less than 7% of patients survive 10 years following diagnosis across all stages of lung cancer. Late stage of diagnosis and lack of effec...

    Authors: Chantal Hoi Yin Cheung and Hsueh-Fen Juan

    Citation: Journal of Biomedical Science 2017 24:37

    Content type: Review

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  29. The human gut is home to complex microbial populations that change dynamically in response to various internal and external stimuli. The gut microbiota provides numerous functional benefits that are crucial fo...

    Authors: Pey Yee Lee, Siok-Fong Chin, Hui-min Neoh and Rahman Jamal

    Citation: Journal of Biomedical Science 2017 24:36

    Content type: Review

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  30. Immune checkpoints or coinhibitory receptors, such as cytotoxic T lymphocyte antigen (CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses, and they were proven to be effect...

    Authors: Hwei-Fang Tsai and Ping-Ning Hsu

    Citation: Journal of Biomedical Science 2017 24:35

    Content type: Review

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  31. Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration. Grafting OEC to injured spinal cord appears ...

    Authors: May-Jywan Tsai, Chi-Ting Huang, Yong-San Huang, Ching-Feng Weng, Song-Kun Shyue, Ming-Chao Huang, Dann-Ying Liou, Yan-Ru Lin, Chu-Hsun Cheng, Huai-Sheng Kuo, Yilo Lin, Meng-Jen Lee, Wen-Hung Huang, Wen-Cheng Huang and Henrich Cheng

    Citation: Journal of Biomedical Science 2017 24:34

    Content type: Research

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  32. The aldehyde dehydrogenase (ALDH) enzyme family metabolizes and detoxifies both exogenous and endogenous aldehydes. Since chemotherapeutic agents, such as cisplatin, generate cytotoxic aldehydes and oxidative ...

    Authors: Jeewon Kim, Che-Hong Chen, Jieying Yang and Daria Mochly-Rosen

    Citation: Journal of Biomedical Science 2017 24:33

    Content type: Research

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  33. In recent times, anti-cancer treatments have focused on Fibroblast Growth Factor (FGF) and Vascular-Endothelial Growth Factor (VEGF) pathway inhibitors so as to target tumor angiogenesis and cellular prolifera...

    Authors: Raquel Frenedoso da Silva, Ellen Nogueira-Pangrazi, Larissa Akemi Kido, Fabio Montico, Sarah Arana, Dileep Kumar, Komal Raina, Rajesh Agarwal and Valéria Helena Alves Cagnon

    Citation: Journal of Biomedical Science 2017 24:31

    Content type: Research

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  34. The adducin (ADD) family proteins, namely ADD1, ADD2, and ADD3, are actin-binding proteins that play important roles in the stabilization of membrane cytoskeleton and cell-cell junctions. All the ADD proteins ...

    Authors: Chia-Mei Liu, Wen-Hsin Hsu, Wan-Yi Lin and Hong-Chen Chen

    Citation: Journal of Biomedical Science 2017 24:30

    Content type: Research

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  35. Bone marrow derived stem cells (BMSCs) have the potential to differentiate into cardiomyocytes, but the rate of differentiation is low and the mechanism of differentiation is unclear completely. Here, we aimed...

    Authors: Xing Shen, Bo Pan, Huiming Zhou, Lingjuan Liu, Tiewei Lv, Jing Zhu, Xupei Huang and Jie Tian

    Citation: Journal of Biomedical Science 2017 24:29

    Content type: Research

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  36. Neonatal monosodium glutamate (MSG) treatment triggers excitotoxicity and induces a degenerative process that affects several brain regions in a way that could lead to epileptogenesis. Na+/Ca2+ exchangers (NCX1-3...

    Authors: Mariana Hernandez-Ojeda, Monica E. Ureña-Guerrero, Paola E. Gutierrez-Barajas, Jazmin A. Cardenas-Castillo, Antoni Camins and Carlos Beas-Zarate

    Citation: Journal of Biomedical Science 2017 24:27

    Content type: Research

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  37. Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-ch...

    Authors: Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto and Tasuku Honjo

    Citation: Journal of Biomedical Science 2017 24:26

    Content type: Review

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  38. Estrogen plays an important role as an anti-inflammatory and neuroprotective agent in ischemic stroke. In this study, we analyzed the effect of a polygenic risk score (PRS) constructed using inflammatory genes...

    Authors: Yi-Chen Hsieh, Fang-I Hsieh, Yih-Ru Chen, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Nai-Fang Chi, Huey-Juan Lin, Li-Ming Lien, Giia-Sheun Peng and Hung-Yi Chiou

    Citation: Journal of Biomedical Science 2017 24:25

    Content type: Research

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  39. Malfunctioning of the serotonergic system in Parkinson’s disease may contribute to non-motor symptoms such as respiratory complications. Thus the aim of our study was to investigate the role of serotonin 5-HT2 re...

    Authors: Kryspin Andrzejewski, Katarzyna Kaczyńska and Małgorzata Zaremba

    Citation: Journal of Biomedical Science 2017 24:24

    Content type: Research

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  40. GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to...

    Authors: Ann M. Decker, Elaine A. Gay, Kelly M. Mathews, Taylor C. Rosa, Tiffany L. Langston, Rangan Maitra and Chunyang Jin

    Citation: Journal of Biomedical Science 2017 24:23

    Content type: Research

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  41. Cancer along with cardiovascular disease are the main causes of death in the industrialised countries around the World. Conventional cancer treatments are losing their therapeutic uses due to drug resistance, ...

    Authors: Susan Marqus, Elena Pirogova and Terrence J. Piva

    Citation: Journal of Biomedical Science 2017 24:21

    Content type: Review

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