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  1. Triple-negative breast cancer (TNBC) lacks specific therapeutic target and limits to chemotherapy and is essential to develop novel therapeutic regimens. Increasing studies indicated that tamoxifen, a selectiv...

    Authors: Sheng-Tang Wu, Guang-Huan Sun, Tai-Lung Cha, Chien-Chang Kao, Sun-Yran Chang, Sheng-Chu Kuo and Tzong-Der Way

    Citation: Journal of Biomedical Science 2016 23:60

    Content type: Research

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  2. Development of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions. Previousl...

    Authors: Lawrence Yu-Min Liu, Min-Hsuan Lin, Zih-Yin Lai, Jie-Peng Jiang, Yi-Ching Huang, Li-En Jao and Yung-Jen Chuang

    Citation: Journal of Biomedical Science 2016 23:59

    Content type: Research

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  3. The incidence of lung adenocarcinoma (LUAD) is increasing worldwide with different prognosis even in early-stage patients. We aimed to identify a prognostic panel with multiple DNA methylation biomarkers to pr...

    Authors: I-Ying Kuo, Jayu Jen, Lien-Huei Hsu, Han-Shui Hsu, Wu-Wei Lai and Yi-Ching Wang

    Citation: Journal of Biomedical Science 2016 23:58

    Content type: Research

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  4. Autophagy participates in plaque formation and progression; however, its association with foam cells’ fate is unknown. To investigate autophagy features and its effect on the fate of different-stage macrophage...

    Authors: Xiaopeng Liu, Yue Tang, Yongchun Cui, Hong Zhang and Dong Zhang

    Citation: Journal of Biomedical Science 2016 23:57

    Content type: Research

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  5. The impact of vitamin D3 (VD3) on obesity has been reported in the past. Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet.

    Authors: Yue Fan, Kumi Futawaka, Rie Koyama, Yuki Fukuda, Misa Hayashi, Miyuki Imamoto, Takashi Miyawaki, Masato Kasahara, Tetsuya Tagami and Kenji Moriyama

    Citation: Journal of Biomedical Science 2016 23:56

    Content type: Research

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  6. Numerous studies have demonstrated that the NDV-mediated gene therapy is a promising new approach for treatment of cancers. P53 plays a vital role in tumor suppression and surveillance. Therefore, we hypothesi...

    Authors: Ying An, Tianyan Liu, Jinjiao He, Hongsong Wu, Rui Chen, Yunye Liu, Yunzhou Wu, Yin Bai, Xiaochen Guo, Qi Zheng, Chang Liu, Jiechao Yin, Deshan Li and Guiping Ren

    Citation: Journal of Biomedical Science 2016 23:55

    Content type: Research

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  7. Zinc finger proteins are the largest transcription factor family in human genome. The diverse combinations and functions of zinc finger motifs make zinc finger proteins versatile in biological processes, inclu...

    Authors: Jayu Jen and Yi-Ching Wang

    Citation: Journal of Biomedical Science 2016 23:53

    Content type: Review

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  8. Diastolic dysfunction refers to an impaired relaxation and an abnormality in a heart’s filling during diastole while left ventricular systolic function is preserved. Diastolic dysfunction is commonly observed ...

    Authors: Xiaoqin Wang, Zhengyu Zhang, Gang Wu, Changlong Nan, Wen Shen, Yimin Hua and Xupei Huang

    Citation: Journal of Biomedical Science 2016 23:51

    Content type: Research

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  9. Recently, NAD+ has been considered as an essential factor, participating in nerve control of physiological functions and intercellular communication. NAD+ also has been supposed as endogenous activator of P1 a...

    Authors: Vladislav S. Kuzmin, Ksenia B. Pustovit and Denis V. Abramochkin

    Citation: Journal of Biomedical Science 2016 23:50

    Content type: Research

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  10. The fruiting body of Hericium erinaceus has been demonstrated to possess anti-dementia activity in mouse model of Alzheimer’s disease and people with mild cognitive impairment. However, the therapeutic potential ...

    Authors: Tzeng Tsai-Teng, Chen Chin-Chu, Lee Li-Ya, Chen Wan-Ping, Lu Chung-Kuang, Shen Chien-Chang, Huang F. Chi-Ying, Chen Chien-Chih and Young-Ji Shiao

    Citation: Journal of Biomedical Science 2016 23:49

    Content type: Research

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  11. Down syndrome (DS), caused by triplication of human chromosome 21, is the most common aneuploidies. The main characteristic of DS patients is intellectual disability. MicroRNAs (miRNAs) play important regulato...

    Authors: Wei-li Shi, Zhong-zhen Liu, Hong-dan Wang, Dong Wu, Hui Zhang, Hai Xiao, Yan Chu, Qiao-fang Hou and Shi-xiu Liao

    Citation: Journal of Biomedical Science 2016 23:48

    Content type: Research

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  12. Resveratrol, a phytoalexin found in grapes and red wine, exhibits diverse pharmacological activities. However, relatively little is known about whether resveratrol modulates the ion channels in cortical neuron...

    Authors: Ya-Jean Wang, Ming-Huan Chan, Linyi Chen, Sheng-Nan Wu and Hwei-Hisen Chen

    Citation: Journal of Biomedical Science 2016 23:47

    Content type: Research

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  13. The aim of the study was to develop a nude mouse xenograft model implanted with both benign and malignant xenografts as the preliminary candidate screening tool for contrast agent development in lesion maligna...

    Authors: Tsung-Hsien Yen, Gi-Da Lee, Jyn-Wen Chai, Jiunn-Wang Liao, Jia-Yu Lau, Li-Che Hu and Kuo-Chih Liao

    Citation: Journal of Biomedical Science 2016 23:46

    Content type: Research

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  14. Healing of bone defects is a dynamic and orchestrated process that relies on multiple growth factors and cell types. Bone morphogenetic protein 2 (BMP2) is a key growth factor for bone healing, which stimulate...

    Authors: Hyuck Choi, Byung-Chul Jeong, Min-Suk Kook and Jeong-Tae Koh

    Citation: Journal of Biomedical Science 2016 23:45

    Content type: Research

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  15. Dynamin-related protein 1 (Drp1) is a mitochondrial fission protein that, upon phosphorylation at serine 616 (p-Drp1(Ser616)), plays a pivotal role in neuronal death after ischemia. In the present study, we hy...

    Authors: Yao-Chung Chuang, Tsu-Kung Lin, Ding-I Yang, Jenq-Lin Yang, Chia-Wei Liou and Shang-Der Chen

    Citation: Journal of Biomedical Science 2016 23:44

    Content type: Research

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  16. Cervical cancer is one of the most common female cancers and is caused by human papillomavirus (HPV). Viral infection leads to cell cycle deregulation by inactivating p53 and retinoblastoma protein by viral on...

    Authors: Adrya Lúcia Peres, Keilla Maria Paz e Silva, Rosângela Ferreira Frade de Araújo, José Luiz de Lima Filho, Mário Ribeiro de Melo Júnior, Danyelly Bruneska Gondim Martins and Nicodemos Teles de Pontes Filho

    Citation: Journal of Biomedical Science 2016 23:42

    Content type: Research

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  17. Mesenchymal stem cells hold the promise to treat not only several congenital and acquired bone degenerative diseases but also to repair and regenerate morbid bone tissues. Utilizing MSCs, several lines of evid...

    Authors: Hamid Saeed, Muhammad Ahsan, Zikria Saleem, Mehwish Iqtedar, Muhammad Islam, Zeeshan Danish and Asif Manzoor Khan

    Citation: Journal of Biomedical Science 2016 23:41

    Content type: Review

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  18. Breast cancer is considered as an increasing major life-threatening concern among the malignancies encountered globally in females. Traditional therapy is far from satisfactory due to drug resistance and vario...

    Authors: Malabika Banerjee, Subrata Chattopadhyay, Tathagata Choudhuri, Rammohan Bera, Sanjay Kumar, Biswajit Chakraborty and Samir Kumar Mukherjee

    Citation: Journal of Biomedical Science 2016 23:40

    Content type: Research

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  19. Familial Hypercholesterolaemia is an autosomal, dominant genetic disorder that leads to elevated blood cholesterol and a dramatically increased risk of atherosclerosis. It is perceived as a rare condition. How...

    Authors: Raymond Henderson, Maurice O’Kane, Victoria McGilligan and Steven Watterson

    Citation: Journal of Biomedical Science 2016 23:39

    Content type: Review

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  20. Mitochondria play important roles in providing metabolic energy and key metabolites for synthesis of cellular building blocks. Mitochondria have additional functions in other cellular processes, including prog...

    Authors: Han-Zen Tsai, Ren-Kuo Lin and Tao-Shih Hsieh

    Citation: Journal of Biomedical Science 2016 23:38

    Content type: Research

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  21. Stress is an important factor that affects physical and mental status of a healthy person disturbing homeostasis of the body. Changes in the lifestyle are one of the major causes that lead to psychological str...

    Authors: Shilpa Prasad, Meenakshi Tiwari, Ashutosh N. Pandey, Tulsidas G. Shrivastav and Shail K. Chaube

    Citation: Journal of Biomedical Science 2016 23:36

    Content type: Review

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  22. In all eukaryotes, the plasma membrane is critically important as it maintains the architectural integrity of the cell. Proper anchorage and interaction between the plasma membrane and the cytoskeleton is crit...

    Authors: Godwin A. Ponuwei

    Citation: Journal of Biomedical Science 2016 23:35

    Content type: Review

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  23. Parkinson’s disease (PD) is a severe neurodegenerative disease associated with loss of dopaminergic neurons. Derivation of dopaminergic neurons from human embryonic stem cells (hESCs) could provide new therape...

    Authors: Mingming Li, Yu Zou, Qiqi Lu, Ning Tang, Alexis Heng, Intekhab Islam, Huei Jinn Tong, Gavin S. Dawe and Tong Cao

    Citation: Journal of Biomedical Science 2016 23:34

    Content type: Research

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  24. Diabetes mellitus is a major chronic disease that continues to increase significantly. One of the most important and costly complications of diabetes are foot infections that may be colonized by pathogenic and an...

    Authors: Carla Mottola, Teresa Semedo-Lemsaddek, João J. Mendes, José Melo-Cristino, Luís Tavares, Patrícia Cavaco-Silva and Manuela Oliveira

    Citation: Journal of Biomedical Science 2016 23:33

    Content type: Research

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  25. Electroacupuncture (EA) is a modern application based on combination of traditional manual acupuncture and electrotherapy that is frequently recommended as an adjuvant treatment for ischemic stroke. EA precond...

    Authors: Yeon Suk Jung, Sae-Won Lee, Jung Hwa Park, Hyung Bum Seo, Byung Tae Choi and Hwa Kyoung Shin

    Citation: Journal of Biomedical Science 2016 23:32

    Content type: Research

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  26. Yin Yang 1 (YY1) is a ubiquitously expressed GLI-Kruppel zinc finger-containing transcriptional regulator. YY1 plays a fundamental role in normal biologic processes such as embryogenesis, differentiation, and ...

    Authors: Wei-Lun Shiu, Kuan-Rong Huang, Jo-Chi Hung, Jen-Leih Wu and Jiann-Ruey Hong

    Citation: Journal of Biomedical Science 2016 23:31

    Content type: Research

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  27. TGF-β is a key modulator in the regulation of cell proliferation and migration, and is also involved in the process of cancer development and progression. Previous studies have indicated that TGF-β responsiven...

    Authors: C. L. Chen, C. Y. Chen, Y. P. Chen, Y. B. Huang, M. W. Lin, D. C. Wu, H. T. Huang, M. Y. Liu, H. W. Chang, Y. C. Kao and P. H. Yang

    Citation: Journal of Biomedical Science 2016 23:30

    Content type: Research

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  28. Cryptococcus neoformans (Cn) is an important opportunistic pathogen in the immunocompromised people, including AIDS patients, which leads to fatal cryptococcal meningitis with high mor...

    Authors: Xiaolong He, Xiaolu Shi, Santhosh Puthiyakunnon, Like Zhang, Qing Zeng, Yan Li, Swapna Boddu, Jiawen Qiu, Zhihao Lai, Chao Ma, Yulong Xie, Min Long, Lei Du, Sheng-He Huang and Hong Cao

    Citation: Journal of Biomedical Science 2016 23:28

    Content type: Research

    Published on:

  29. The accumulation of soluble oligomeric amyloid-β peptide (oAβ) proceeding the formation of senile plaques contributes to synaptic and memory deficits in Alzheimer’s disease. Our previous studies have indentifi...

    Authors: Huey-Jen Tsay, Yung-Cheng Huang, Yi-Jen Chen, Yun-Hao Lee, Shu-Meng Hsu, Keng-Chang Tsai, Cheng-Ning Yang, Fong-Lee Huang, Feng-Shiun Shie, Lin-Chien Lee and Young-Ji Shiao

    Citation: Journal of Biomedical Science 2016 23:27

    Content type: Research

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  30. Thrombus formation, a phenomenon primarily related to increased platelet activation, plays a key role in cardiovascular and cerebrovascular diseases. Although the established antiplatelet agents, such as aspir...

    Authors: Ting-Lin Yen, Ming-Ping Wu, Chi-Li Chung, Wen-Bin Yang, Thanasekaran Jayakumar, Pitchairaj Geraldine, Chih-Ming Chou, Chia-Yau Chang, Wan-Jung Lu and Joen-Rong Sheu

    Citation: Journal of Biomedical Science 2016 23:26

    Content type: Research

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  31. The axonal tau protein is a tubulin-binding protein, which plays important roles in the formation and stability of the microtubule. Mutations in the tau gene are associated with familial forms of frontotempora...

    Authors: Bo-Kai Wu, Rey-Yue Yuan, Huang-Wei Lien, Chin-Chun Hung, Pung-Pung Hwang, Rita Pei-Yeh Chen, Chun-Che Chang, Yung-Feng Liao and Chang-Jen Huang

    Citation: Journal of Biomedical Science 2016 23:25

    Content type: Research

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  32. suPAR biomarker generally considered a pathogenic factor in FSGS. However, studies have been published that dispute this conclusion. The current study was designed to investigate the roles of uPA and suPAR in ...

    Authors: Jin-Shuen Chen, Li-Chien Chang, Chung-Ze Wu, Tzu-Ling Tseng, Jui-An Lin, Yuh-Feng Lin and Chao-Wen Cheng

    Citation: Journal of Biomedical Science 2016 23:24

    Content type: Research

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    The Erratum to this article has been published in Journal of Biomedical Science 2017 24:48

  33. Carcinogens in cigarette smoke can induce the formation of DNA-DNA cross-links, which are repaired by the Fanconi anemia (FA) pathway, and it is tempting to speculate that this pathway is involved in lung tumo...

    Authors: Shi-Yi Yang, Chia-Ni Hsiung, Yao-Jen Li, Gee-Chen Chang, Ying-Huang Tsai, Kuan-Yu Chen, Ming-Shyan Huang, Wu-Chou Su, Yuh-Min Chen, Chao A. Hsiung, Pan-Chyr Yang, Chien-Jen Chen, Pei-Ei Wu, Jyh-Cherng Yu, Chen-Yang Shen and Huan-Ming Hsu

    Citation: Journal of Biomedical Science 2016 23:23

    Content type: Research

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  34. Tumor initiation presents a complex and unstable genomic landscape; one of the earliest hallmark events of cancer, and its progression is probably based on selection mechanisms under specific environments that...

    Authors: Robson José de Oliveira-Júnior, Carlos Ueira-Vieira, Angela Aparecida Servino Sena, Carolina Fernandes Reis, José Roberto Mineo, Luiz Ricardo Goulart and Sandra Morelli

    Citation: Journal of Biomedical Science 2016 23:22

    Content type: Research

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  35. Monoamine oxidase (MAO) enzymes play a critical role in controlling the catabolism of monoamine neurotransmitters and biogenic trace amines and behavior in humans. However, the mechanisms that regulate MAO are...

    Authors: Christina H. Liu, Jiaqian Ren and Philip K. Liu

    Citation: Journal of Biomedical Science 2016 23:21

    Content type: Research

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  36. Technique failure in peritoneal dialysis (PD) due to fibrosis and angiogenesis is complicated by peritonitis. Staphylococcus aureus infection is one of the most common causes of peritonitis in PD. The heparan sul...

    Authors: Paulina M. Kowalewska, Uyen T. Nguyen, Lori L. Burrows and Alison E. Fox-Robichaud

    Citation: Journal of Biomedical Science 2016 23:20

    Content type: Research

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  37. Hypoxia in tumor niche is one of important factors to start regeneration of blood vessels, leading to increase survival, proliferation, and invasion in cancer cells. Under hypoxia microenvironment, furthermore...

    Authors: Chun-Chia Cheng, Siao-Syun Guan, Hao-Jhih Yang, Chun-Chao Chang, Tsai-Yueh Luo, Jungshan Chang and Ai-Sheng Ho

    Citation: Journal of Biomedical Science 2016 23:18

    Content type: Research

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  38. DNA vaccines have emerged as an attractive approach for the generation of cytotoxic T lymphocytes (CTL). In our previous study, we found That Toll like receptor (TLR) ligands are promising candidates for the d...

    Authors: Fateme Gableh, Mohsen Saeidi, Shaghayegh Hemati, Kasra Hamdi, Hoorieh Soleimanjahi, Ali Gorji and Amir Ghaemi

    Citation: Journal of Biomedical Science 2016 23:16

    Content type: Research

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  39. The enzyme-prodrug system is considered a promising tool for tumor treatment when conjugated with a targeting molecule. The asparagine-glycine-arginine (NGR) motif is a developing and interesting targeting pep...

    Authors: Jia-Je Li, Shun-Fu Chang, I-Iu Liau, Pei-Chia Chan, Ren-Shyan Liu, Sang-Hue Yen, Hsin-Ell Wang and Cheng Allen Chang

    Citation: Journal of Biomedical Science 2016 23:15

    Content type: Research

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  40. Severe acute respiratory syndrome coronavirus (SARS-CoV) caused a global panic due to its high morbidity and mortality during 2002 and 2003. Soon after the deadly disease outbreak, the angiotensin-converting e...

    Authors: Yvonne Ting-Chun Yu, Ssu-Chia Chien, I-Yin Chen, Chia-Tsen Lai, Yeou-Guang Tsay, Shin C. Chang and Ming-Fu Chang

    Citation: Journal of Biomedical Science 2016 23:14

    Content type: Research

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  41. Biomarkers for cardiometabolic risk (CMR) factors would be important tools to maximize the effectiveness of dietary interventions to prevent cardiovascular diseases. Thus, the aim of this work was to analyze s...

    Authors: Gabriela Alarcón, Julieta Roco, Analia Medina, Carina Van Nieuwenhove, Mirta Medina and Susana Jerez

    Citation: Journal of Biomedical Science 2016 23:13

    Content type: Research

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  42. Recent studies reported the critical role of the intrauterine environment of a fetus in growth or the development of disease in adulthood. In this article we discussed the implications of salt restriction in g...

    Authors: Hiroe Sakuyama, Minami Katoh, Honoka Wakabayashi, Anthony Zulli, Peter Kruzliak and Yoshio Uehara

    Citation: Journal of Biomedical Science 2016 23:12

    Content type: Review

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  43. Homeostasis of reactive oxygen species (ROS) in the skin is regulated by antioxidant defenses. The inflammatory states of skin diseases which range from acute rashes to chronic conditions are related to the le...

    Authors: Tsang-Pai Liu, Yi-Ping Chen, Chih-Ming Chou, Ting-Ting Chiu and Chien-Tsu Chen

    Citation: Journal of Biomedical Science 2016 23:11

    Content type: Research

    Published on:

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