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  1. Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. hACE2 expression is low in the lungs and is upregulated after SAR...

    Authors: Chao-Fu Yang, Chun-Che Liao, Hung-Wei Hsu, Jian-Jong Liang, Chih-Shin Chang, Hui-Ying Ko, Rue-Hsin Chang, Wei-Chun Tang, Ming-Hao Chang, I-Hsuan Wang and Yi-Ling Lin
    Citation: Journal of Biomedical Science 2023 30:87
    Content type: Research Published on:

  3. mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high e...

    Authors: Yu-Shiuan Wang, Monika Kumari, Guan-Hong Chen, Ming-Hsiang Hong, Joyce Pei-Yi Yuan, Jui-Ling Tsai and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:84
    Content type: Review Published on:

  6. The induction of a cells destiny is a tightly controlled process that is regulated through communication between the matrix and cell signalling proteins. Cell signalling activates distinctive subsections of ta...

    Authors: Sandy Winfield Jere, Heidi Abrahamse and Nicolette Nadene Houreld
    Citation: Journal of Biomedical Science 2023 30:81
    Content type: Review Published on:

  7. Metastasis is a multistep process involving the migration and invasion of cancer cells and is a hallmark of cancer malignancy. Long non-coding RNAs (lncRNAs) play critical roles in the regulation of metastasis...

    Authors: Yi-Ling Chen, Yi-Nan Liu, Yen-Ting Lin, Meng-Feng Tsai, Shang-Gin Wu, Tzu-Hua Chang, Chia-Lang Hsu, Huey-Dong Wu and Jin-Yuan Shih
    Citation: Journal of Biomedical Science 2023 30:80
    Content type: Research Published on:

  8. Platelets are small anucleated blood cells primarily known for their vital hemostatic role. Allogeneic platelet concentrates (PCs) collected from healthy donors are an essential cellular product transfused by ...

    Authors: Thierry Burnouf, Ming-Li Chou, David J. Lundy, Er-Yuan Chuang, Ching-Li Tseng and Hadi Goubran
    Citation: Journal of Biomedical Science 2023 30:79
    Content type: Review Published on:

  9. Dysregulated long noncoding RNA (lncRNA) expression with increased apoptosis has been demonstrated in systemic lupus erythematosus (SLE) patients with alveolar hemorrhage (AH). SNHG16, a lncRNA, can enhance pu...

    Authors: Yu-Tung Hsieh, Yi-Cheng Chen, Yu-Chi Chou, Pin‑Yu Kuo, Yi-Ting Yen, Hung-Wen Tsai and Chrong-Reen Wang
    Citation: Journal of Biomedical Science 2023 30:78
    Content type: Research Published on:

  10. Bioactive materials have now raised considerable attention for the treatment of osteoarthritis (OA), such as knee OA, rheumatoid OA, and temporomandibular joint (TMJ) OA. TMJ-OA is a common disease associated ...

    Authors: Bou-Yue Peng, Abhinay Kumar Singh, Ching-Yu Tsai, Chun-Hao Chan, Yue-Hua Deng, Chi-Ming Wu, Yen-Ru Chou, Wen Tsao, Chia-Yu Wu and Win-Ping Deng
    Citation: Journal of Biomedical Science 2023 30:77
    Content type: Research Published on:

  11. Stroke remains one of the leading causes of long-term disability worldwide, and the development of effective restorative therapies is hindered by an incomplete understanding of intrinsic brain recovery mechani...

    Authors: Egor Dzyubenko, Katrin I. Willig, Dongpei Yin, Maryam Sardari, Erdin Tokmak, Patrick Labus, Ben Schmermund and Dirk M. Hermann
    Citation: Journal of Biomedical Science 2023 30:76
    Content type: Research Published on:

  12. Klebsiella aerogenes can cause ventilator-associated pneumonia by forming biofilms, and it is frequently associated with multidrug resistance. Phages are good antibiotic alternatives with unique advantages. There...

    Authors: Xiaohu Cui, Bing Du, Junxia Feng, Yanling Feng, Zheng Fan, Jinfeng Chen, Jinghua Cui, Lin Gan, Tongtong Fu, Ziyan Tian, Rui Zhang, Chao Yan, Hanqing Zhao, Wenjian Xu, Ziying Xu, Zihui Yu…
    Citation: Journal of Biomedical Science 2023 30:75
    Content type: Research Published on:

  13. Electrical impulses from cardiac pacemaker cardiomyocytes initiate cardiac contraction and blood pumping and maintain life. Abnormal electrical impulses bring patients with low heart rates to cardiac arrest. T...

    Authors: Chih-Min Liu, Yi-Chun Chen and Yu-Feng Hu
    Citation: Journal of Biomedical Science 2023 30:74
    Content type: Review Published on:

  14. Certain clonal complexes (CCs) of Klebsiella pneumoniae such as CC147 (ST147 and ST392) are major drivers of blaNDM dissemination across the world. ST147 has repeatedly reported from our geographical region, but ...

    Authors: Omid Pajand, Hamzeh Rahimi, Farzad Badmasti, Faeze Gholami, Tahereh Alipour, Narges Darabi, Frank M. Aarestrup and Pimlapas Leekitcharoenphon
    Citation: Journal of Biomedical Science 2023 30:73
    Content type: Research Published on:

  15. Epithelial-to-mesenchymal transition (EMT) of malignant cells is a driving force of disease progression in human papillomavirus-negative (HPV-negative) head and neck squamous cell carcinomas (HNSCC). Sustained...

    Authors: Enxian Shi, Zhengquan Wu, Birnur Sinem Karaoglan, Sabina Schwenk-Zieger, Gisela Kranz, Nilofer Abdul Razak, Christoph A. Reichel, Martin Canis, Philipp Baumeister, Reinhard Zeidler and Olivier Gires
    Citation: Journal of Biomedical Science 2023 30:72
    Content type: Research Published on:

  17. Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is a rare inherited mitochondrial disease mainly caused by the m.8344A > G mutation in mitochondrial tRNALys gene, and usually manifested as complex neur...

    Authors: Yu-Ting Wu, Hui-Yi Tay, Jung-Tse Yang, Hsiao-Hui Liao, Yi-Shing Ma and Yau-Huei Wei
    Citation: Journal of Biomedical Science 2023 30:70
    Content type: Research Published on:

  18. Extracellular communication, in other words, crosstalk between cells, has a pivotal role in the survival of an organism. This communication occurs by different methods, one of which is extracellular vesicles. ...

    Authors: Howida M. Nail, Chien-Chih Chiu, Chung-Hang Leung, Mahmoud M. M. Ahmed and Hui-Min David Wang
    Citation: Journal of Biomedical Science 2023 30:69
    Content type: Review Published on:

  19. KH-type splicing regulatory protein (KHSRP, also called KSRP), a versatile RNA-binding protein, plays a critical role in various physiological and pathological conditions through modulating gene expressions at...

    Authors: Yi-Chieh Yang, Yung-Wei Lin, Wei-Jiunn Lee, Feng-Ru Lai, Kuo-Hao Ho, Chih-Ying Chu, Kuo-Tai Hua, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Yu-Ching Wen and Ming-Hsien Chien
    Citation: Journal of Biomedical Science 2023 30:68
    Content type: Research Published on:

  20. Beyond the development of resistance, the effects of antibiotics on bacteria and microbial communities are complex and far from exhaustively studied. In the context of the current global antimicrobial resistan...

    Authors: Claudia C. Paredes-Amaya, María Teresa Ulloa and Víctor Antonio García-Angulo
    Citation: Journal of Biomedical Science 2023 30:67
    Content type: Review Published on:

  21. Parkinson’s disease (PD) is the second most frequent age-related neurodegenerative disorder and is characterized by the loss of dopaminergic neurons. Both environmental and genetic aspects are involved in the ...

    Authors: Jun Sung Park, Kyonghwan Choe, Hyeon Jin Lee, Tae Ju Park and Myeong Ok Kim
    Citation: Journal of Biomedical Science 2023 30:66
    Content type: Research Published on:

  22. Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract cancer and account for 931,922 new cases and 467,125 deaths worldwide. About 90% of these cancers are of squamous cell origin...

    Authors: Xiaomin Huang, Pascal H. G. Duijf, Sharath Sriram, Ganganath Perera, Sarju Vasani, Lizbeth Kenny, Paul Leo and Chamindie Punyadeera
    Citation: Journal of Biomedical Science 2023 30:65
    Content type: Review Published on:

  23. Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger associated molecular patterns (...

    Authors: Reiner Kunze, Silvia Fischer, Hugo H. Marti and Klaus T. Preissner
    Citation: Journal of Biomedical Science 2023 30:64
    Content type: Review Published on:

  24. Leber’s hereditary optic neuropathy (LHON) is a maternally inherited eye disease due to mutations in mitochondrial DNA. However, there is no effective treatment for this disease. LHON-linked ND6 14484T > C (p....

    Authors: Jing Wang, Yanchun Ji, Cheng Ai, Jia-Rong Chen, Dingyi Gan, Juanjuan Zhang, Jun Q. Mo and Min-Xin Guan
    Citation: Journal of Biomedical Science 2023 30:63
    Content type: Research Published on:

  25. Excess polymorphonuclear neutrophil (PMN) recruitment or excessive neutrophil extracellular trap (NET) formation can lead to the development of multiple organ dysfunction during sepsis. M2 macrophage-derived e...

    Authors: Yang Jiao, Ti Zhang, Mei Liu, Luyang Zhou, Mengzhi Qi, Xin Xie, Xueyin Shi, Xiaoping Gu and Zhengliang Ma
    Citation: Journal of Biomedical Science 2023 30:62
    Content type: Research Published on:

  27. Dysregulation of various cells in the tumor microenvironment (TME) causes immunosuppressive functions and aggressive tumor growth. In combination with immune checkpoint blockade (ICB), epigenetic modification-...

    Authors: M A A Mamun, Yu Zhang, Jin-Yuan Zhao, Dan-Dan Shen, Ting Guo, Yi-Chao Zheng, Li-Juan Zhao and Hong-Min Liu
    Citation: Journal of Biomedical Science 2023 30:60
    Content type: Review Published on:

  28. The COVID-19 pandemic continues to pose a significant worldwide threat to human health, as emerging SARS-CoV-2 Omicron variants exhibit resistance to therapeutic antibodies and the ability to evade vaccination...

    Authors: Hsiao-Ling Chiang, Kang-Hao Liang, Ruei-Min Lu, Ting-Wen Kuo, Yi‑Ling Lin and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:59
    Content type: Research Published on:

  29. Phenotypic heterogeneity is very common in genetic systems and in human diseases and has important consequences for disease diagnosis and treatment. In addition to the many genetic and non-genetic (e.g., epige...

    Authors: Y. Henry Sun, Yueh-Lin Wu and Ben-Yang Liao
    Citation: Journal of Biomedical Science 2023 30:58
    Content type: Review Published on:

  30. Supplemental oxygen impairs lung development in newborn infants with respiratory distress. Lactobacillus johnsonii supplementation attenuates respiratory viral infection in mice and exhibits anti-inflammatory eff...

    Authors: Chung-Ming Chen, Yu-Chen S. H. Yang, Hsiu-Chu Chou and Shan Lin
    Citation: Journal of Biomedical Science 2023 30:57
    Content type: Research Published on:

  31. The influenza virus enters the host via hemagglutinin protein binding to cell surface sialic acid. Receptor-mediated endocytosis is followed by viral nucleocapsid uncoating for replication aided by the transme...

    Authors: Ujjwal Kumar, Priya Goyal, Zaid K. Madni, Kajal Kamble, Vineet Gaur, Maitreyi S. Rajala and Dinakar M. Salunke
    Citation: Journal of Biomedical Science 2023 30:56
    Content type: Research Published on:

  32. Sustained, chronic activation of β-adrenergic receptor (β-AR) signaling leads to cardiac arrhythmias, with exchange proteins directly activated by cAMP (Epac1 and Epac2) as key mediators. This study aimed to e...

    Authors: Yi-Hsin Chan, Feng-Chun Tsai, Gwo-Jyh Chang, Ying-Ju Lai, Shang-Hung Chang, Wei-Jan Chen and Yung-Hsin Yeh
    Citation: Journal of Biomedical Science 2023 30:55
    Content type: Research Published on:

  33. Authors: Sheng-Chieh Lin, Yi-Chu Liao, Po-Ming Chen, Ya-Yu Yang, Yi-Hsiang Wang, Shiao-Lin Tung, Chi-Mu Chuang, Yu-Wen Sung, Te-Hsuan Jang, Shuang-En Chuang and Lu-Hai Wang
    Citation: Journal of Biomedical Science 2023 30:54
    Content type: Correction Published on:

    The original article was published in Journal of Biomedical Science 2022 29:109

  35. Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information and/o...

    Authors: Patience Shumba, Thomas Sura, Kirsten Moll, Bhavya Chakrakodi, Lea A. Tölken, Jörn Hoßmann, Katharina J. Hoff, Ole Hyldegaard, Michael Nekludov, Mattias Svensson, Per Arnell, Steinar Skrede, Anna Norrby-Teglund and Nikolai Siemens
    Citation: Journal of Biomedical Science 2023 30:52
    Content type: Research Published on:

  36. Genome editing technologies hold great promise for numerous applications including the understanding of cellular and disease mechanisms and the development of gene and cellular therapies. Achieving high editin...

    Authors: Nanna S. Mikkelsen and Rasmus O. Bak
    Citation: Journal of Biomedical Science 2023 30:51
    Content type: Review Published on:

  37. Sotorasib is the first KRASG12C inhibitor approved by the US Food and Drug Administration for treating KRASG12C-mutant non-small-cell lung cancer (NSCLC). Clinical trials on the therapeutic use of sotorasib for c...

    Authors: Li-Wen Chiou, Chien-Hui Chan, Yu-Ling Jhuang, Ching-Yao Yang and Yung-Ming Jeng
    Citation: Journal of Biomedical Science 2023 30:50
    Content type: Research Published on:

  38. The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interacti...

    Authors: Andrey Popugailo, Ziv Rotfogel, Michal Levy, Orli Turgeman, Dalia Hillman, Revital Levy, Gila Arad, Tomer Shpilka and Raymond Kaempfer
    Citation: Journal of Biomedical Science 2023 30:49
    Content type: Research Published on:

  40. A large proportion of the patients with cancer do not respond to immunotherapies. Recent studies suggested an important role for tumor-infiltrating cytotoxic T lymphocytes (CTL) in enhancing response to immuno...

    Authors: Peisi Li, Dawang Zhou, Dongwen Chen, Yikan Cheng, Yuan Chen, Zhensen Lin, Xi Zhang, Zhihong Huang, Jiawei Cai, Wenfeng Huang, Yanyun Lin, Haoxian Ke, Jiahui Long, Yifeng Zou, Shubiao Ye and Ping Lan
    Citation: Journal of Biomedical Science 2023 30:47
    Content type: Research Published on:

  41. Sequential infections with SARS-CoV-2 variants such as Alpha, Delta, Omicron and its sublineages may cause high morbidity, so it is necessary to develop vaccines that can protect against both wild-type (WT) vi...

    Authors: Monika Kumari, Shih-Chieh Su, Kang-Hao Liang, Hsiu-Ting Lin, Yu-Feng Lu, Kai-Chi Chen, Wan-Yu Chen and Han-Chung Wu
    Citation: Journal of Biomedical Science 2023 30:46
    Content type: Research Published on:

  42. Emerging research has reported that circular RNAs (circRNAs) play important roles in cardiac cell death after myocardial ischemia and reperfusion (I/R). Ferroptosis, a new form of cell death discovered in rece...

    Authors: Jie Ju, Xin-Min Li, Xue-Mei Zhao, Fu-Hai Li, Shao-Cong Wang, Kai Wang, Rui-Feng Li, Lu-Yu Zhou, Lin Liang, Yin Wang, Yu-Hui Zhang and Kun Wang
    Citation: Journal of Biomedical Science 2023 30:45
    Content type: Research Published on:

  43. Cholesterol gallstone disease is a common disease. Reducing cholesterol burden is important to prevent/treat gallstone. In this study, we investigated the application of diosgenin (DG) to prevent the formation...

    Authors: Weiyi Shen, Wentao Shao, Qihan Wang, Bo Wang, Gang Zhao, Aihua Gu, Zhaoyan Jiang and Hai Hu
    Citation: Journal of Biomedical Science 2023 30:44
    Content type: Research Published on:

  45. The global burden of invasive fungal infections (IFIs) has shown an upsurge in recent years due to the higher load of immunocompromised patients suffering from various diseases. The role of early and accurate ...

    Authors: Wenjie Fang, Junqi Wu, Mingrong Cheng, Xinlin Zhu, Mingwei Du, Chang Chen, Wanqing Liao, Kangkang Zhi and Weihua Pan
    Citation: Journal of Biomedical Science 2023 30:42
    Content type: Review Published on:

  46. Flavivirus causes many serious public health problems worldwide. However, licensed DENV vaccine has restrictions on its use, and there is currently no approved ZIKV vaccine. Development of a potent and safe fl...

    Authors: Li-Chen Yen, Hsin-Wei Chen, Chia-Lo Ho, Chang-Chi Lin, Yi-Ling Lin, Qiao-Wen Yang, Kuo-Chou Chiu, Shu-Pei Lien, Ren-Jye Lin and Ching-Len Liao
    Citation: Journal of Biomedical Science 2023 30:41
    Content type: Research Published on:

  47. Reduction of histone deacetylase (HDAC) 2 expression and activity may contribute to amplified inflammation in patients with severe asthma. Connective tissue growth factor (CTGF) is a key mediator of airway fib...

    Authors: Hung-Sheng Hua, Heng-Ching Wen, Hong-Sheng Lee, Chih-Ming Weng, Fara Silvia Yuliani, Han-Pin Kuo, Bing-Chang Chen and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2023 30:40
    Content type: Research Published on:

  48. Pancreatic adenocarcinoma (PDAC) is well known for its rapid distant metastasis and local destructive behavior. Loss of Krüppel-like factor 10 (KLF10) contributes to distant migration of PDAC. The role of KLF1...

    Authors: Yi-Chih Tsai, Kung Hung Cheng, Shih Sheng Jiang, John R. Hawse, Shun En Chuang, Su Liang Chen, Tze-Sing Huang and Hui-Ju Ch’ang
    Citation: Journal of Biomedical Science 2023 30:39
    Content type: Research Published on:

  49. The intestinal epithelial barrier is the interface for interaction between gut microbiota and host metabolic systems. Akkermansia muciniphila (A. muciniphila) is a key player in the colonic microbiota that reside...

    Authors: Henry Wade, Kaichao Pan, Qihua Duan, Szczepan Kaluzny, Ekta Pandey, Linda Fatumoju, Viswanathan Saraswathi, Rongxue Wu, Edward N. Harris and Qiaozhu Su
    Citation: Journal of Biomedical Science 2023 30:38
    Content type: Research Published on:

  50. We investigated the presence of heteroresistance against both tigecycline and colistin in Acinetobacter baumannii and then evaluated the effectiveness of combined antibiotic treatment given the existence of discr...

    Authors: Jeongwoo Jo, Ki Tae Kwon and Kwan Soo Ko
    Citation: Journal of Biomedical Science 2023 30:37
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127