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  1. The microRNAs let-7 g and miR-221 have been demonstrated to be related to the glucose metabolism. This study assessed the serum levels of these two microRNAs in subjects with and without metabolic syndrome (Me...

    Authors: Yu-Ting Wang, Pei-Chien Tsai, Yi-Chu Liao, Chung-Y Hsu and Suh-Hang Hank Juo
    Citation: Journal of Biomedical Science 2013 20:72
    Content type: Research Published on:

  2. Mesenchymal Stem Cells (MSC) are important candidates for therapeutic applications due to their ex vivo proliferation and differentiation capacity. MSC differentiation is controlled by both intrinsic and extri...

    Authors: Himangshu Sonowal, Atul Kumar, Jina Bhattacharyya, Pabitra Kumar Gogoi and Bithiah Grace Jaganathan
    Citation: Journal of Biomedical Science 2013 20:71
    Content type: Research Published on:

  3. Xeroderma Pigmentosum (XP) is a rare skin disorder characterized by skin hypersensitivity to sunlight and abnormal pigmentation. The aim of this study was to investigate the genetic cause of a severe XP phenot...

    Authors: Muhammad Nasir, Nafees Ahmad, Christian MK Sieber, Amir Latif, Salman Akbar Malik and Abdul Hameed
    Citation: Journal of Biomedical Science 2013 20:70
    Content type: Research Published on:

  4. Reactive oxygen species (ROS) are products of normal cellular metabolism and derive from various sources in different cellular compartments. Oxidative stress resultant from imbalance between ROS generation and...

    Authors: Miroslava Majzunova, Ima Dovinova, Miroslav Barancik and Julie YH Chan
    Citation: Journal of Biomedical Science 2013 20:69
    Content type: Review Published on:

  5. Epithelial barrier dysfunction is associated with the pathogenesis of a number of immune inflammations; the etiology is not fully understood. The fusion of endosome/lysosome is a critical process in the degrad...

    Authors: Yu-Wei Liao, Xing-Mao Wu, Jia Jia, Xiao-Lei Wu, Tao Hong, Ling-Xin Meng and Xiu-Ying Wu
    Citation: Journal of Biomedical Science 2013 20:68
    Content type: Research Published on:

  6. Among viral enzymes, the human HIV-1 protease comprises the most interesting target for drug discovery. There are increasing efforts focused on designing more effective inhibitors for HIV-1 protease in order t...

    Authors: Mohammad Reza Dayer and Mohammad Saaid Dayer
    Citation: Journal of Biomedical Science 2013 20:67
    Content type: Research Published on:

  7. Hematopoietic stem/progenitor cells (HSPCs) maintain the hematopoietic system by balancing their self-renewal and differentiation events. Hematopoietic stem cells also migrate to various sites and interact wit...

    Authors: Bithiah Grace Jaganathan, Fernando Anjos-Afonso, Atul Kumar and Dominique Bonnet
    Citation: Journal of Biomedical Science 2013 20:66
    Content type: Research Published on:

  8. We and others have reported that autophagy is induced by dengue viruses (DVs) in various cell lines, and that it plays a supportive role in DV replication. This study intended to clarify whether DV infection c...

    Authors: Ying-Ray Lee, Hsuan-Yun Hu, Szu-Han Kuo, Huan-Yao Lei, Yee-Shin Lin, Trai-Ming Yeh, Ching-Chuan Liu and Hsiao-Sheng Liu
    Citation: Journal of Biomedical Science 2013 20:65
    Content type: Research Published on:

  9. The lack of noninvasive biomarkers of rejection remains a challenge in the accurate monitoring of deeply buried nerve allografts and precludes optimization of therapeutic intervention. This study aimed to esta...

    Authors: Cheng-Shyuan Rau, Johnson Chia-Shen Yang, Shao-Chun Wu, Yi-Chun Chen, Tsu-Hsiang Lu, Ming-Wei Lin, Yi-Chan Wu, Siou-Ling Tzeng, Chia-Jung Wu and Ching-Hua Hsieh
    Citation: Journal of Biomedical Science 2013 20:64
    Content type: Research Published on:

  10. The efficiency of regenerative medicine can be ameliorated by improving the biological performances of stem cells before their transplantation. Several ex-vivo protocols of non-damaging cell hypoxia have been ...

    Authors: Claudio Muscari, Emanuele Giordano, Francesca Bonafè, Marco Govoni, Alice Pasini and Carlo Guarnieri
    Citation: Journal of Biomedical Science 2013 20:63
    Content type: Review Published on:

  11. Knockout of either toll-like receptor 4 (TLR4) or 2 (TLR2) had been reported to delay the Wallerian degeneration after peripheral nerve injury by deterring the recruitment of the macrophages and clearance of m...

    Authors: Shao-Chun Wu, Cheng-Shyuan Rau, Tsu-Hsiang Lu, Chia-Jung Wu, Yi-Chan Wu, Siou-Ling Tzeng, Yi-Chun Chen and Ching-Hua Hsieh
    Citation: Journal of Biomedical Science 2013 20:62
    Content type: Research Published on:

  12. Nephrotoxicity is a dose limiting side effect of tenofovir, a reverse transcriptase inhibitor that is used for the treatment of HIV infection. The mechanism of tenofovir nephrotoxicity is not clear. Tenofovir ...

    Authors: Premila Abraham, Hemalatha Ramamoorthy and Bina Isaac
    Citation: Journal of Biomedical Science 2013 20:61
    Content type: Research Published on:

  13. The NKG2D receptor confers important activating signals to NK cells via ligands expressed during cellular stress and viral infection. This receptor has generated great interest because not only is it expressed...

    Authors: Mariel Garcia-Chagollan, Luis F Jave-Suarez, Jesse Haramati, Pedro E Sanchez-Hernandez, Adriana Aguilar-Lemarroy, Miriam R Bueno-Topete, Ana L Pereira-Suarez, Mary Fafutis-Morris, Angel Cid-Arregui and Susana del Toro-Arreola
    Citation: Journal of Biomedical Science 2013 20:60
    Content type: Research Published on:

  14. Although donor age-related effects of characteristics of mesenchymal stem cells (MSC), such as a decrease in the proliferation and differentiation capacity and an increase of senescence and apoptosis, are evid...

    Authors: Dah-Ching Ding, Hsiang-Lan Chou, Wei-Ting Hung, Hwan-Wun Liu and Tang-Yuan Chu
    Citation: Journal of Biomedical Science 2013 20:59
    Content type: Research Published on:

  15. The relevance of recurrent molecular abnormalities in cytogenetically normal (CN) acute myeloid leukemia (AML) was recently acknowledged by the inclusion of molecular markers such as NPM1, FLT3, and CEBPA as a co...

    Authors: Wen-Chi Yang, Wan-Chi Tsai, Pai-Mei Lin, Ming-Yu Yang, Yi-Chang Liu, Chao-Sung Chang, Wen-Hui Yu and Sheng-Fung Lin
    Citation: Journal of Biomedical Science 2013 20:58
    Content type: Research Published on:

  16. Brain- derived neurotrophic factor (BDNF) is linked to neurodegenerative diseases (e.g. Alzheimer disease and Parkinson disease) which are often characterized by olfactory impairment. A specific single nucleot...

    Authors: Alessandro Tonacci, Andrea Borghini, Antonella Mercuri, Giovanni Pioggia and Maria Grazia Andreassi
    Citation: Journal of Biomedical Science 2013 20:57
    Content type: Research Published on:

  17. CIP4 is a scaffold protein that regulates membrane deformation and tubulation, organization of the actin cytoskeleton, endocytosis of growth factor receptors, and vesicle trafficking. Although expressed in the...

    Authors: Francesca Rusconi, Hrishikesh Thakur, Jinliang Li and Michael S Kapiloff
    Citation: Journal of Biomedical Science 2013 20:56
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2014 21:45

  18. Microglial inflammation may significantly contribute to the pathology of Alzheimer’s disease. To examine the potential of Cudrania cochinchinensis to ameliorate amyloid β protein (Aβ)-induced microglia activation...

    Authors: Chung-Jen Wang, Chien-Chih Chen, Huey-Jen Tsay, Feng-Yi Chiang, Mine-Fong Wu and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2013 20:55
    Content type: Research Published on:

  19. Insufficient clearance of soluble oligomeric amyloid-β peptide (oAβ) in the central nervous system leads to the synaptic and memory deficits in Alzheimer's disease (AD). Previously we have identified scavenger...

    Authors: Fong-Lee Huang, Young-Ji Shiao, Sheue-Jane Hou, Cheng-Ning Yang, Yi-Jen Chen, Chao-Hsiung Lin, Feng-Shiun Shie and Huey-Jen Tsay
    Citation: Journal of Biomedical Science 2013 20:54
    Content type: Research Published on:

  20. Antioxidants have been shown to enhance the proliferation of adipose-derived mesenchymal stem cells (ADMSCs) in vitro, although the detailed mechanism(s) and potential side effects are not fully understood.

    Authors: Li-Yi Sun, Cheng-Yoong Pang, Dian-Kun Li, Chia-Hsin Liao, Wei-Chao Huang, Chao-Chuan Wu, Yi-Yo Chou, Wei Wu Li, Shin-Yuan Chen, Hwan-Wun Liu, Yao-Jen Chang and Ching-Feng Cheng
    Citation: Journal of Biomedical Science 2013 20:53
    Content type: Research Published on:

  21. Cancer cell differentiation is an important characteristic of malignant tumor and has a great impact on prognosis and therapeutic decision for patients. The N-myc downstream regulated gene 1 (NDRG1), a putativ...

    Authors: Lin-Lin Han, Lin Hou, Ming-Jin Zhou, Zhong-liang Ma, Dong-Liang Lin, Li Wu and Yin-lin Ge
    Citation: Journal of Biomedical Science 2013 20:52
    Content type: Research Published on:

  22. Wound healing is a complex biologic process that involves the integration of inflammation, mitosis, angiogenesis, synthesis, and remodeling of the extracellular matrix. However, some wounds fail to heal proper...

    Authors: Sheng-Ping Huang, Chun-Hsiang Huang, Jia-Fwu Shyu, Herng-Sheng Lee, Shyi-Gen Chen, James Yi-Hsin Chan and Shih-Ming Huang
    Citation: Journal of Biomedical Science 2013 20:51
    Content type: Research Published on:

  23. The expression of myocardin, a cardiac-restricted gene, increases during environmental stress. How mechanical stretch affects the regulation of myocardin in vascular smooth muscle cells (VSMCs) is not fully un...

    Authors: Chiung-Zuan Chiu, Bao-Wei Wang and Kou-Gi Shyu
    Citation: Journal of Biomedical Science 2013 20:50
    Content type: Research Published on:

  25. Oxidative stress increases the cytosolic content of calcium in the cytoplasm through a combination of effects on calcium pumps, exchangers, channels and binding proteins. In this study, oxidative stress was pr...

    Authors: Tso-Hao Tang, Chiung-Tan Chang, Hsiu-Jen Wang, Joshua D Erickson, Rhett A Reichard, Alexis G Martin, Erica K Shannon, Adam L Martin, Yue-Wern Huang and Robert S Aronstam
    Citation: Journal of Biomedical Science 2013 20:48
    Content type: Research Published on:

  26. The coupling between neuronal activity and vascular responses is controlled by the neurovascular unit (NVU), which comprises multiple cell types. Many different types of dysfunction in these cells may impair t...

    Authors: Chiao-Chi V Chen, Yu-Chen Chen, Han-Yun Hsiao, Chen Chang and Yijuang Chern
    Citation: Journal of Biomedical Science 2013 20:47
    Content type: Review Published on:

  27. Prostate smooth muscle tone is regulated by α1-adrenoceptor-induced contraction and cAMP-mediated relaxation. EPAC is an effector of cAMP, being involved in smooth muscle relaxation and cell cycle control outs...

    Authors: Martin Hennenberg, Frank Strittmatter, Henning Schmetkamp, Beata Rutz, Sebastian Walther, Christian G Stief and Christian Gratzke
    Citation: Journal of Biomedical Science 2013 20:46
    Content type: Research Published on:

  28. Increased lipid accumulation and mitochondrial dysfunction within skeletal muscle have been shown to be strongly associated with insulin resistance. However, the role of mitofusion-2 (MFN2), a key factor in mi...

    Authors: Xuemei Zhang, Chao Wang, Guangyao Song, Kexin Gan, Dexian Kong, Qian Nie and Luping Ren
    Citation: Journal of Biomedical Science 2013 20:45
    Content type: Research Published on:

  29. gp340, a member of scavenger receptor cysteine rich family encoded by Deleted in Malignant Brain Tumors 1 (DMBT1), is an important component in innate immune defense. The first scavenger receptor cysteine rich do...

    Authors: Ying Chu, Jiahuang Li, Xilin Wu, Zichun Hua and Zhiwei Wu
    Citation: Journal of Biomedical Science 2013 20:44
    Content type: Research Published on:

  30. Dysregulated epidermal growth factor receptor (EGFR)-phosphoinositide-3-kinase (PI3K)-AKT signaling is considered pivotal for oral cancer, and the pathway is a potential candidate for therapeutic targeting.

    Authors: Kwang-Yu Chang, Shan-Yin Tsai, Shang-Hung Chen, Hsiao-Hui Tsou, Chia-Jui Yen, Ko-Jiunn Liu, Hsun-Lang Fang, Hung-Chang Wu, Bin-Fay Chuang, Shao-Wen Chou, Careen K Tang, Shyun-Yeu Liu, Pei-Jung Lu, Ching-Yu Yen and Jang-Yang Chang
    Citation: Journal of Biomedical Science 2013 20:43
    Content type: Research Published on:

  31. Dengue virus (DENV) infection can cause life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Vascular leakage and abnormal hemorrhage are the two major pathogenic changes found in t...

    Authors: Yung-Chun Chuang, Shu-Ying Wang, Yee-Shin Lin, Hong-Ru Chen and Trai-Ming Yeh
    Citation: Journal of Biomedical Science 2013 20:42
    Content type: Review Published on:

  32. In non-excitable cells, one major route for calcium entry is through store-operated calcium (SOC) channels in the plasma membrane. These channels are activated by the emptying of intracellular Ca2+ store. STIM1 a...

    Authors: I-Hui Yang, Yao-Ting Tsai, Siou-Jin Chiu, Li-Teh Liu, Hsuan-Hung Lee, Ming-Feng Hou, Wen-Li Hsu, Ben-Kuen Chen and Wei-Chiao Chang
    Citation: Journal of Biomedical Science 2013 20:41
    Content type: Research Published on:

  33. Infection with dengue virus (DENV) causes both mild dengue fever and severe dengue diseases, such as dengue hemorrhagic fever and dengue shock syndrome. The pathogenic mechanisms for DENV are complicated, invo...

    Authors: Tsung-Ting Tsai, Yi-Jui Chuang, Yee-Shin Lin, Shu-Wen Wan, Chia-Ling Chen and Chiou-Feng Lin
    Citation: Journal of Biomedical Science 2013 20:40
    Content type: Review Published on:

  34. Placenta growth factor (PlGF), a dimeric glycoprotein with 53% homology to VEGF, binds to VEGF receptor-1 (Flt-1), but not to VEGF receptor-2 (Flk-1), and may function by modulating VEGF activity. We previousl...

    Authors: Shu-Chen Wei, Po-Nien Tsao, Meng-Tzu Weng, Zhifang Cao and Jau-Min Wong
    Citation: Journal of Biomedical Science 2013 20:39
    Content type: Research Published on:

  35. Effective and validated animal models are valuable to investigate the pathogenesis and potential therapeutics for human diseases. There is much concern for diabetic retinopathy (DR) in that it affects substant...

    Authors: Dong Hyun Jo, Chang Sik Cho, Jin Hyoung Kim, Hyoung Oh Jun and Jeong Hun Kim
    Citation: Journal of Biomedical Science 2013 20:38
    Content type: Review Published on:

  36. Dengue is one of the most important emerging vector-borne viral diseases. There are four serotypes of dengue viruses (DENV), each of which is capable of causing self-limited dengue fever (DF) or even life-thre...

    Authors: Shu-Wen Wan, Chiou-Feng Lin, Shuying Wang, Yu-Hung Chen, Trai-Ming Yeh, Hsiao-Sheng Liu, Robert Anderson and Yee-Shin Lin
    Citation: Journal of Biomedical Science 2013 20:37
    Content type: Review Published on:

  38. Research on the conjugates of synthetic polyelectrolytes with antigenic molecules, such as proteins, peptides, or carbohydrates, is an attractive area due to their highly immunogenic character in comparison to...

    Authors: Murat Topuzogullari, Rabia Cakir Koc, Sevil Dincer Isoglu, Melahat Bagirova, Zeynep Akdeste, Serhat Elcicek, Olga N Oztel, Serap Yesilkir Baydar, Sezen Canim Ates and Adil M Allahverdiyev
    Citation: Journal of Biomedical Science 2013 20:35
    Content type: Research Published on:

  40. TDP-43, a multi-functional DNA/ RNA-binding protein encoded by the TARDBP gene, has emerged as a major patho-signature factor of the ubiquitinated intracellular inclusions (UBIs) in the diseased cells of a range ...

    Authors: Lien-Szu Wu, Wei-Cheng Cheng and Che-Kun James Shen
    Citation: Journal of Biomedical Science 2013 20:33
    Content type: Research Published on:

  41. To characterize single nucleotide polymorphisms (SNPs) within the promoter region of the estrogen receptor beta (ERβ) gene and to analyze the association of ERβ SNPs with susceptibility to breast cancer. Genot...

    Authors: Li Chen, Yan Liang, Juhui Qiu, Lingling Zhang, Xianchun Chen, Xiangdong Luo and Jun Jiang
    Citation: Journal of Biomedical Science 2013 20:32
    Content type: Research Published on:

  42. Even though osteoarthritis (OA) is the most common musculoskeletal dysfunction, there are no effective pharmacological treatments to treat OA due to lack of understanding in OA pathology. To better understand ...

    Authors: Jinsoo Song, Dongkyun Kim, Chang Hoon Lee, Myeung Su Lee, Churl-Hong Chun and Eun-Jung Jin
    Citation: Journal of Biomedical Science 2013 20:31
    Content type: Research Published on:

  43. H-rev107 is a member of the HREV107 type II tumor suppressor gene family which includes H-REV107, RIG1, and HRASLS. H-REV107 has been shown to express at high levels in differentiated tissues of post-meiotic t...

    Authors: Rong-Yaun Shyu, Chang-Chieh Wu, Chun-Hua Wang, Tzung-Chieh Tsai, Lu-Kai Wang, Mao-Liang Chen, Shun-Yuan Jiang and Fu-Ming Tsai
    Citation: Journal of Biomedical Science 2013 20:30
    Content type: Research Published on:

  44. Developmental haemostatic studies may help identifying new elements involved in the control of key haemostatic proteins like antithrombin, the most relevant endogenous anticoagulant.

    Authors: Raúl Teruel, Irene Martínez-Martínez, José A Guerrero, Rocío González-Conejero, María E de la Morena-Barrio, Salam Salloum-Asfar, Ana B Arroyo, Sonia Águila, Nuria García-Barberá, Antonia Miñano, Vicente Vicente, Javier Corral and Constantino Martínez
    Citation: Journal of Biomedical Science 2013 20:29
    Content type: Research Published on:

  45. Tendon injury is one of the orthopedic conditions poses with a significant clinical challenge to both the surgeons and patients. The major limitations to manage these injuries are poor healing response and dev...

    Authors: Abdolhamid Meimandi-Parizi, Ahmad Oryan and Ali Moshiri
    Citation: Journal of Biomedical Science 2013 20:28
    Content type: Research Published on:

  46. Antibodies against spliceosome Sm proteins (anti-Sm autoantibodies) are specific to the autoimmune disease systemic lupus erythematosus (SLE). Anti-Sm autosera have been reported to specifically recognize Sm D...

    Authors: Hong-How Chang, Huan-Hsuan Hu, Yu-Jen Lee, Hung-Ming Wei, Ming-Chun Fan-June, Tsai-Ching Hsu, Gregory J Tsay and Chuan Li
    Citation: Journal of Biomedical Science 2013 20:27
    Content type: Research Published on:

  48. Lynch syndrome is a hereditary cancer predisposition syndrome caused by a mutation in one of the DNA mismatch repair (MMR) genes. About 24% of the mutations identified in Lynch syndrome are missense substituti...

    Authors: Hiroko Terui, Kiwamu Akagi, Hiroshi Kawame and Kei Yura
    Citation: Journal of Biomedical Science 2013 20:25
    Content type: Research Published on:

  49. mTOR is a genetically conserved serine/threonine protein kinase, which controls cell growth, proliferation, and survival. A multifunctional protein CAD, catalyzing the initial three steps in de novo pyrimidine sy...

    Authors: Akio Nakashima, Ippei Kawanishi, Sumiko Eguchi, Eugene Hsin Yu, Satoshi Eguchi, Noriko Oshiro, Ken-ichi Yoshino, Ushio Kikkawa and Kazuyoshi Yonezawa
    Citation: Journal of Biomedical Science 2013 20:24
    Content type: Research Published on:

  50. Intracellular Ca2+ is one of the crucial signalings that modulate various cellular functions. The dysregulation of Ca2+ homeostasis has been suggested as an important event in driving the expression of the malign...

    Authors: Yih-Fung Chen, Ying-Ting Chen, Wen-Tai Chiu and Meng-Ru Shen
    Citation: Journal of Biomedical Science 2013 20:23
    Content type: Review Published on:
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Journal of Biomedical Science

ISSN: 1423-0127