Journal of Biomedical Science is supported by the National Science and Technology Council (NSTC), Taiwan.
Structure-guided mutagenesis of active site residues in the dengue virus two-component protease NS2B-NS3
The dengue virus two-component protease NS2B/NS3 mediates processing of the viral polyprotein precursor and is therefore an important determinant of virus replication. The enzyme is now intensively studied wit...