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  1. Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is th...

    Authors: Anne Jämsä, Karin Agerman, Ann-Cathrin Radesäter, Jan Ottervald, Jonas Malmström, Gösta Hiller, Gang Liu and Mervi Vasänge
    Citation: Journal of Biomedical Science 2009 16:55
  2. The use of radioisotopes has a long history in biomedical science, and the technique of accelerator mass spectrometry (AMS), an extremely sensitive nuclear physics technique for detection of very low-abundant,...

    Authors: Sang Soo Hah
    Citation: Journal of Biomedical Science 2009 16:54

    The Erratum to this article has been published in Journal of Biomedical Science 2009 16:111

  3. Clinical chemical blood analysis including plasma electrolytes is routinely carried out for the diagnosis of various organ diseases. Phenotype-driven N-ethyl-N-nitrosourea (ENU) mouse mutagenesis projects used...

    Authors: Bernhard Aigner, Birgit Rathkolb, Martina Klempt, Sibylle Wagner, Dian Michel, Martin Hrabé de Angelis and Eckhard Wolf
    Citation: Journal of Biomedical Science 2009 16:53
  4. High levels of Hepatoma Up-Regulated Protein (HURP) and Tousled-Like Kinase (TLK) transcripts are found in hepatocellular carcinoma. HURP overexpression induces anchorage-independent growth of 293-T cells and enh...

    Authors: Hsing-Hsi Li, Chuen-Sheue Chiang, Hsiao-Yu Huang and Gwo-Jen Liaw
    Citation: Journal of Biomedical Science 2009 16:51
  5. Atorvastatin has been shown to reduce resistin expression in macrophages after pro-inflammatory stimulation. However, the mechanism of reducing resistin expression by atorvastatin is not known. Therefore, we s...

    Authors: Kou-Gi Shyu, Su-Kiat Chua, Bao-Wai Wang and Peiliang Kuan
    Citation: Journal of Biomedical Science 2009 16:50
  6. It is important to develop innovative therapies for advanced stage cancers in addition to the conventional therapies including chemotherapy, radiation and surgery. Antigen-specific immunotherapy has emerged as...

    Authors: Chi-Mu Chuang, Archana Monie, Annie Wu and Chien-Fu Hung
    Citation: Journal of Biomedical Science 2009 16:49
  7. Human interleukin-15 (hIL15) has anti-tumor activities, but it is not convenient for tumor treatment because of its short half-life. A gene therapy for mouse lung cancer using an adenovirus vector expressing I...

    Authors: Giou-Teng Yiang, Horng-Jyh Harn, Yung-Luen Yu, Sheng-Chuan Hu, Yu-Ting Hung, Chia-Jung Hsieh, Shinn-Zong Lin and Chyou-Wei Wei
    Citation: Journal of Biomedical Science 2009 16:47
  8. Asthma has become an important public health issue and approximately 300 million people have suffered from the disease worldwide. Nowadays, the use of acupuncture in asthma is increasing. This study intended t...

    Authors: Lei-Miao Yin, Gong-Hao Jiang, Yu Wang, Yan Wang, Yan-Yan Liu, Wei-Rong Jin, Yu-Dong Xu, Qing-Hua Zhang and Yong-Qing Yang
    Citation: Journal of Biomedical Science 2009 16:46
  9. Segments of the canine internal mammary artery (35 mm in length) were suspended in vitro in an organ chamber containing physiological salt solution (95% O2/5% CO2, pH = 7.4, 37°C). Segments were individually cann...

    Authors: Nilce Mitiko Matsuda, Paul J Pearson, Hartzell V Schaff, Carlos E Piccinato, Alfredo J Rodrigues and Paulo Roberto Barbosa Evora
    Citation: Journal of Biomedical Science 2009 16:45
  10. An isolated thoracic spinal cord of the neonatal rat in vitro spontaneously generates sympathetic nerve discharge (SND) at ~25°C, but it fails in SND genesis at ≤ 10°C. Basal levels of the c-Fos expression in ...

    Authors: Chun-Kuei Su, Chiu-Ming Ho, Hsiao-Hui Kuo, Yu-Chuan Wen and Chok-Yung Chai
    Citation: Journal of Biomedical Science 2009 16:44
  11. In the present study, we explore the role of apoptosis signal-regulating kinase 1 (ASK1) in denbinobin-induced apoptosis in human lung adenocarcinoma (A549) cells. Denbinobin-induced cell apoptosis was attenua...

    Authors: Chen-Tzu Kuo, Bing-Chang Chen, Chung-Chi Yu, Chih-Ming Weng, Ming-Jen Hsu, Chien-Chih Chen, Mei-Chieh Chen, Che-Ming Teng, Shiow-Lin Pan, Mauo-Ying Bien, Chung-Hung Shih and Chien-Huang Lin
    Citation: Journal of Biomedical Science 2009 16:43
  12. Interleukin-6 (IL-6) is a pleiotropic cytokine with pivotal functions in the regulation of the biological responses of several target cells including hepatocytes. The level of serum IL-6 has been reported to b...

    Authors: Tzer-Min Kuo, Cheng-po Hu, Ya-Ling Chen, Ming-Hsiang Hong, King-Song Jeng, Chun-Chin T Liang, Mong-Liang Chen and Chungming Chang
    Citation: Journal of Biomedical Science 2009 16:41
  13. Replication of the Japanese encephalitis virus (JEV) genome depends on host factors for successfully completing their life cycles; to do this, host factors have been recruited and/or relocated to the site of v...

    Authors: Shang-Hua Yang, Mei-Lan Liu, Chih-Feng Tien, Shih-Jie Chou and Ruey-Yi Chang
    Citation: Journal of Biomedical Science 2009 16:40
  14. It is widely believed that atherosclerotic plaque rupture and subsequent thrombosis leads to acute coronary events and stroke. However, study of the mechanism and treatment of human plaque rupture is hampered ...

    Authors: Shun-Miao Fang, Qing-Hua Zhang and Zhi-Xin Jiang
    Citation: Journal of Biomedical Science 2009 16:39
  15. Acetylcholine (ACh), the first neurotransmitter to be identified, regulate the activities of central and peripheral functions through interactions with muscarinic receptors. Changes in muscarinic acetylcholine...

    Authors: G Gireesh, T Peeyush Kumar, Jobin Mathew and CS Paulose
    Citation: Journal of Biomedical Science 2009 16:38
  16. Oxidative stress and inflammation contributed to the propagation of acute liver injury (ALI). The present study was undertaken to determine whether D-galactosamine (D-GalN) induces ALI via the mitochondrial ap...

    Authors: Bor-Ru Lin, Chia-Jung Yu, Wang-Chuan Chen, Hsuan-Shu Lee, Huei-Min Chang, Yen-Chih Lee, Chiang-Ting Chien and Chau-Fong Chen
    Citation: Journal of Biomedical Science 2009 16:35
  17. Statins reduce cholesterol biosynthesis by inhibiting HMG-CoA reductase and thereby lower total cholesterol and LDL cholesterol levels in serum, which in turn lower the incidence of cardiovascular disease (CVD...

    Authors: Chung-Eun Ha, Ji-Sook Ha, Andre G Theriault and Nadhipuram V Bhagavan
    Citation: Journal of Biomedical Science 2009 16:32
  18. Increasing evidence suggests that immune responses are involved in the control of cancer and that the immune system can be manipulated in different ways to recognize and attack tumors. Progress in immune-based...

    Authors: Pablo Matar, Laura Alaniz, Viviana Rozados, Jorge B Aquino, Mariana Malvicini, Catalina Atorrasagasti, Manuel Gidekel, Marcelo Silva, O Graciela Scharovsky and Guillermo Mazzolini
    Citation: Journal of Biomedical Science 2009 16:30
  19. Exposure to protein allergen epicutaneously, inducing a Th2-dominant immune response, sensitizes the host to the development of atopic disease. Antigen-driven bystander effect demonstrates that polarized T cel...

    Authors: Li-Fang Wang, Jau-Shiuh Chen, Chih-Jung Hsu, Ching-Yi Liu, Jhang-Sian Yu and Shi-Chuen Miaw
    Citation: Journal of Biomedical Science 2009 16:28
  20. Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by mutations leading to dysfunction of one of enzymes involved in degradation of glycosaminoglycans (GAGs). Due to their impaired degradatio...

    Authors: Joanna Jakóbkiewicz-Banecka, Ewa Piotrowska, Magdalena Narajczyk, Sylwia Barańska and Grzegorz Węgrzyn
    Citation: Journal of Biomedical Science 2009 16:26
  21. Histone acetyltransferases (HATs), p300 and cAMP response element binding protein (CREB)-binding protein (CBP) are two structurally related transcriptional co-activators that activate expression of many eukary...

    Authors: Guozhen Chen, Jing Zhu, Tiewei Lv, Gang Wu, Huichao Sun, Xupei Huang and Jie Tian
    Citation: Journal of Biomedical Science 2009 16:24
  22. The Brugada syndrome is characterized by ST segment elevation in the right precodial leads V1-V3 on surface ECG accompanied by episodes of ventricular fibrillation causing syncope or even sudden death. The mol...

    Authors: Chia-Hsiang Hsueh, Wen-Pin Chen, Jiunn-Lee Lin, Chia-Ti Tsai, Yen-Bin Liu, Jyh-Ming Juang, Hsuan-Ming Tsao, Ming-Jai Su and Ling-Ping Lai
    Citation: Journal of Biomedical Science 2009 16:23
  23. Interferons (IFNs) are key regulators for both innate and adaptive immune responses. By screening ENU-mutagenized mice, we identified a pedigree- P117 which displayed impaired response to type I, but not type ...

    Authors: Lan-Sun Chen, Pei-Chi Wei, Taming Liu, Chung-Hsuan Kao, Li-Mei Pai and Chien-Kuo Lee
    Citation: Journal of Biomedical Science 2009 16:22
  24. The endocardial endothelium that lines the inner cavity of the heart is distinct from the microvascular endothelial cells and modulates cardiac muscle performance in a manner similar to the vascular endothelia...

    Authors: Leena Kuruvilla and Cheranellore Chandrasekharan Kartha
    Citation: Journal of Biomedical Science 2009 16:21
  25. Prolonged ischemia amplified iscehemia/reperfusion (IR) induced renal apoptosis and autophagy. We hypothesize that ischemic conditioning (IC) by a briefly intermittent reperfusion during a prolonged ischemic p...

    Authors: Hsing-Hui Wu, Tzu-Yu Hsiao, Chiang-Ting Chien and Ming-Kuen Lai
    Citation: Journal of Biomedical Science 2009 16:19
  26. Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA ...

    Authors: Yi-Hsuan Wu, Mei-Ling Cheng, Hung-Yao Ho, Daniel Tsun-Yee Chiu and Tzu-Chien V Wang
    Citation: Journal of Biomedical Science 2009 16:18
  27. Despite infections by the dengue virus being a significant problem in tropical and sub-tropical countries, the mechanism by which the dengue virus enters into mammalian cells remains poorly described.

    Authors: Lukkana Suksanpaisan, Tharinee Susantad and Duncan R Smith
    Citation: Journal of Biomedical Science 2009 16:17
  28. Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, isolated from the traditional Chinese herb Artemisia annua, is recommended as the first-line anti-malarial drug with low toxicity. DHA has ...

    Authors: Ying-Ying Lu, Tong-Sheng Chen, Jun-Le Qu, Wen-Liang Pan, Lei Sun and Xun-Bin Wei
    Citation: Journal of Biomedical Science 2009 16:16
  29. Increased reactive oxygen species (ROS) and hyperlipidemia can promote arterial thrombus. We evaluated the potential of a partially hydrolyzed guar gum (PHGG) as dietary fiber on lipid profiles and FeCl3-induced ...

    Authors: Dar-Chih Kuo, Shih-Ping Hsu and Chiang-Ting Chien
    Citation: Journal of Biomedical Science 2009 16:15
  30. Human parvovirus B19 infection has been postulated to the anti-phospholipid syndrome (APS) in autoimmunity. However, the influence of anti-B19-VP1u antibody in autoimmune diseases is still obscure.

    Authors: Chun-Chou Tsai, Bor-Show Tzang, Szu-Yi Chiang, Gwo-Jong Hsu and Tsai-Ching Hsu
    Citation: Journal of Biomedical Science 2009 16:14
  31. Activity of secreted phospholipase A (sPLA2) has been implicated in a wide range of cellular responses. However, little is known about the function of human parvovirus B19-VP1 unique region (VP1u) with sPLA2 a...

    Authors: Bor-Show Tzang, Chun-Ching Chiu, Chun-Chou Tsai, Yi-Ju Lee, I-Jung Lu, Jing-Yu Shi and Tsai-Ching Hsu
    Citation: Journal of Biomedical Science 2009 16:13
  32. Vascular endothelial cells (ECs) constantly experience fluid shear stresses generated by blood flow. Laminar flow is known to produce atheroprotective effects on ECs. Nrf2 is a transcription factor that is ess...

    Authors: Chung-Yu Hsieh, Huai-Yu Hsiao, Wan-Yi Wu, Ching-Ann Liu, Yu-Chih Tsai, Yuen-Jen Chao, Danny L Wang and Hsyue-Jen Hsieh
    Citation: Journal of Biomedical Science 2009 16:12
  33. We found that overexpression of RhoGDIβ, a Rho GDP dissociation inhibitor, induced hypertrophic growth and suppressed cell cycle progression in a cultured cardiomyoblast cell line. Knockdown of RhoGDIβ express...

    Authors: Chih-Yang Huang, Li-Chiu Yang, Kuan-Yu Liu, Pao-Hsin Liao, Janet Ing-Yuh Chou, Ming-Yung Chou, Wei-Wen Lin and Jaw-Ji Yang
    Citation: Journal of Biomedical Science 2009 16:11
  34. Liver cancer is the predominant cause of cancer mortality in males of Southern China and Taiwan. The current therapy is not satisfactory, and more effective treatments are needed. In the search for new therapi...

    Authors: Huan-Yao Lei and Chih-Peng Chang
    Citation: Journal of Biomedical Science 2009 16:10
  35. Puerarin, a major isoflavonoid derived from the Chinese medical herb Radix puerariae (kudzu root), has been reported to be useful in the treatment of various cardiovascular diseases. In the present study, we exam...

    Authors: Yi Chang, Cheng-Ying Hsieh, Zi-Aa Peng, Ting-Lin Yen, George Hsiao, Duen-Suey Chou, Chien-Ming Chen and Joen-Rong Sheu
    Citation: Journal of Biomedical Science 2009 16:9
  36. Both overproduction of nitric oxide (NO) and oxidative injury of cardiovascular and pulmonary systems contribute to fatal cardiovascular depression during endotoxemia. We investigated in the present study the ...

    Authors: Yen-Chin Liu, Alice YW Chang, Yu-Chuan Tsai and Julie YH Chan
    Citation: Journal of Biomedical Science 2009 16:8
  37. Bactericidal activity of traditional titanium dioxide (TiO2) photocatalyst is effective only upon irradiation by ultraviolet light, which restricts the potential applications of TiO2 for use in our living environ...

    Authors: Chia-Liang Cheng, Der-Shan Sun, Wen-Chen Chu, Yao-Hsuan Tseng, Han-Chen Ho, Jia-Bin Wang, Pei-Hua Chung, Jiann-Hwa Chen, Pei-Jane Tsai, Nien-Tsung Lin, Mei-Shiuan Yu and Hsin-Hou Chang
    Citation: Journal of Biomedical Science 2009 16:7
  38. Endonuclease G (EndoG), a member of DNA/RNA nonspecific ββα-Me-finger nucleases, is involved in apoptosis and normal cellular proliferation. In this study, we analyzed the critical amino acid residues of EndoG...

    Authors: Shih-Lu Wu, Chia-Cheng Li, Jaw-Chyun Chen, Yi-Jin Chen, Ching-Ting Lin, Tin-Yun Ho and Chien-Yun Hsiang
    Citation: Journal of Biomedical Science 2009 16:6
  39. We previously demonstrated that α3β1 integrins are essential to hepatocyte growth factor (HGF)-independent branching tubulogenesis in Mardin-Darby Canine Kidney (MDCK) cells. However, the involvement of integr...

    Authors: Wei-Chun Wei, Anna K Kopec and Ming-Jer Tang
    Citation: Journal of Biomedical Science 2009 16:5

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