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  1. Granulocyte-colony stimulating factor (G-CSF) is a major regulator of the production and survival of neutrophils. Regulation of G-CSF expression is complex and occurs at both transcription and post-transcripti...

    Authors: Shwu-Fen Chang, Huai-Ci Li, Yu-Pei Huang, Wen-Ju Tasi, Yuan-Yi Chou and Shao-Chun Lu
    Citation: Journal of Biomedical Science 2016 23:3
  2. 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) is a potential anticancer drug that may activate soluble guanylyl cyclase (sGC) and increase the level of cyclic guanosine monophosphate (cGMP). The aim of...

    Authors: Leo Tsui, Shwu-Fen Chang, Hsiang-Po Huang, Tsorng-Harn Fong and I-Jong Wang
    Citation: Journal of Biomedical Science 2016 23:2
  3. Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder and is a common genetic cause of chronic renal failure in children and adults. The enzyme renin plays a key role in the RAAS cascade...

    Authors: Gnanasambandan Ramanathan, Ramprasad Elumalai, Soundararajan Periyasamy and Bhaskar V. K. S. Lakkakula
    Citation: Journal of Biomedical Science 2016 23:1
  4. This study aimed at developing nerve growth factor (NGF) mimetics that selectively activate specific biological signals and, as a result, lack the side effects of the full-length protein. Two dimeric dipeptide...

    Authors: Tatyana A. Gudasheva, Polina Yu Povarnina, Tatyana A. Antipova, Yulia N. Firsova, Mark A. Konstantinopolsky and Sergey B. Seredenin
    Citation: Journal of Biomedical Science 2015 22:106
  5. Mounting evidences have showed the important role of transforming growth factor-β (TGF-β) in immunological surveillance of tumors. Some studies have also indicated human leukocyte antigen (HLA)-G-associated im...

    Authors: Zhongzheng Guan, Bingtan Song, Fengjun Liu, Dong Sun, Kexin Wang and Hui Qu
    Citation: Journal of Biomedical Science 2015 22:107
  6. Caffeine, the main component of coffee, has showed its protective effect on non-alcoholic fatty liver disease (NAFLD) in many studies. However, the hepatoprotection of caffeine and its mechanisms in zebrafish ...

    Authors: Xinchun Zheng, Wencong Dai, Xiaohui Chen, Kunyuan Wang, Wenqing Zhang, Li Liu and Jinlin Hou
    Citation: Journal of Biomedical Science 2015 22:105
  7. The specification of vein and the patterning of intersegmental vessels (ISV) controlled by transcription factor is not fully characterized. The orphan nuclear receptor Chicken ovalbumin upstream promoter trans...

    Authors: Ru-Fang Li, Ting-Yun Wu, Yu-Zheng Mou, Yi-Shan Wang, Chun-Lin Chen and Chang-Yi Wu
    Citation: Journal of Biomedical Science 2015 22:104
  8. Highly desaturated n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are synthesized by desaturases and elongase. They exert hepatoprotective effects ...

    Authors: Chih-Lun Cheng, Shin-Jie Huang, Chih-Lu Wu, Hong-Yi Gong, Chuian-Fu Ken, Shao-Yang Hu and Jen-Leih Wu
    Citation: Journal of Biomedical Science 2015 22:103
  9. Mutations in mitogen-activated protein kinase (MAPK) kinase 1 (MEK1) that occur during cell proliferation and tumor formation are well described. Information on the roles of MEK2 in these effects is still limi...

    Authors: Chih-Ming Chou, Yi-Chung Chen, San Su, Gen-Der Chen, Kai-Yun Huang, Huang-Wei Lien, Chang-Jen Huang and Chia-Hsiung Cheng
    Citation: Journal of Biomedical Science 2015 22:102
  10. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor expressed in many cell types, including osteoblasts, osteocytes, and osteoclasts. Nrf2 has been considered a master regulator of cyt...

    Authors: Yong-Xin Sun, Ai-Hua Xu, Yang Yang and Jiliang Li
    Citation: Journal of Biomedical Science 2015 22:101
  11. Growth arrest-specific 5 (GAS5) was reported to be implicated and aberrantly express in multiple cancers. However, the expression and mechanism of action of GAS5 were largely poor understood in endometrial car...

    Authors: Chen Guo, Wei-qi Song, Ping Sun, Lian Jin and Hong-yan Dai
    Citation: Journal of Biomedical Science 2015 22:100
  12. The H-RAS-like suppressor (HRASLS) subfamily consists of five enzymes (1–5) in humans and three (1, 3, and 5) in mice and rats that share sequence homology with lecithin:retinol acyltransferase (LRAT). All HRA...

    Authors: Emily B. Mardian, Ryan M. Bradley and Robin E. Duncan
    Citation: Journal of Biomedical Science 2015 22:99
  13. Notch may behave as an oncogene or a tumor suppressor gene in lung cancer cells. Notch receptor undergoes cleavage by enzymes, including γ-secretase, generating the active Notch intracellular domain (NICD). Th...

    Authors: Efstathia Giannopoulou, Achilleas Nikolakopoulos, Dimitra Kotsirilou, Angeliki Lampropoulou, Sofia Raftopoulou, Evangelia Papadimitriou, Achilleas D. Theocharis, Thomas Makatsoris, Konstantinos Fasseas and Haralabos P. Kalofonos
    Citation: Journal of Biomedical Science 2015 22:98
  14. Stem cells of intensely regenerative tissues are susceptible to cellular damage. Although the response to this process in hematopoietic stem cells (HSCs) is crucial, the mechanisms by which hematopoietic homeo...

    Authors: Marcella L. Porto, Bianca P. Rodrigues, Thiago N. Menezes, Sara L. Ceschim, Dulce E. Casarini, Agata L. Gava, Thiago Melo C. Pereira, Elisardo C. Vasquez, Bianca P. Campagnaro and Silvana S. Meyrelles
    Citation: Journal of Biomedical Science 2015 22:97
  15. Serum sialic acid levels are positively correlated with coronary artery disease and inflammation. Although sialic acid is a non-specific marker, it is considered sensitive likely due to its influence in sialyl...

    Authors: Zhang Yida, Mustapha Umar Imam, Maznah Ismail, Norsharina Ismail, Aini Ideris and Maizaton Atmadini Abdullah
    Citation: Journal of Biomedical Science 2015 22:96
  16. The HCMV UL76 gene is a member of UL24 family in herpes virus and encodes a highly conserved herpes virus protein. Inherited from common ancestor, members of Herpes_UL24 family encode proteins with a conserved N ...

    Authors: Wenchang Zhang, Yao Yao, Jingxian Chen and Mingli Wang
    Citation: Journal of Biomedical Science 2015 22:95
  17. The soluble epoxide hydrolase (sEH) is an important enzyme chiefly involved in the metabolism of fatty acid signaling molecules termed epoxyeicosatrienoic acids (EETs). sEH inhibition (sEHI) has proven to be p...

    Authors: Han-Fang Wu, Hsin-Ju Yen, Chi-Chen Huang, Yi-Chao Lee, Su-Zhen Wu, Tzong-Shyuan Lee and Hui-Ching Lin
    Citation: Journal of Biomedical Science 2015 22:94
  18. Chronic hepatitis B virus (HBV) infection in endemic areas usually starts since infancy and early childhood and persists lifelong. The clinical course varies among different chronic infected subjects. Majority...

    Authors: Jia-Feng Wu and Mei-Hwei Chang
    Citation: Journal of Biomedical Science 2015 22:92
  19. NKG2D, an activating immunoreceptor, is primarily restricted to NK cells and CD8+ T cells. The existence of an atypical cytotoxic CD4+NKG2D+ T cell population has also been found in patients with autoimmune dysfu...

    Authors: Mariel Garcia-Chagollan, Luis Felipe Jave-Suarez, Jesse Haramati, Miriam Ruth Bueno-Topete, Adriana Aguilar-Lemarroy, Ciro Estrada-Chavez, Blanca Estela Bastidas-Ramirez, Ana Laura Pereira-Suarez and Susana del Toro-Arreola
    Citation: Journal of Biomedical Science 2015 22:91
  20. Increasing evidence suggests that transforming growth factor-beta 1 (TGF-β1) triggers epithelial to mesenchymal transition (EMT) and facilitates breast cancer stem cell differentiation. Gelsolin (GSN) is a ubi...

    Authors: Zhi-Yuan Chen, Pei-Wen Wang, Dar-Bin Shieh, Kuan-Ying Chiu and Ying-Ming Liou
    Citation: Journal of Biomedical Science 2015 22:90
  21. Canine parvovirus 2 (CPV-2) remains a significant worldwide canine pathogen and the most common cause of viral enteritis in dogs. The 1 L15 and 7 L15 peptides overlap each other with QPDGGQPAV residues (7-15 o...

    Authors: Serap Derman, Zeynep Akdeste Mustafaeva, Emrah Sefik Abamor, Melahat Bagirova and Adil Allahverdiyev
    Citation: Journal of Biomedical Science 2015 22:89
  22. It is well known that epigenetic modifications play an important role in controlling the regulation of gene expression during the development. Our previous studies have demonstrated that the expression of feta...

    Authors: Yang Xu, Lingjuan Liu, Bo Pan, Jing Zhu, Changlong Nan, Xupei Huang and Jie Tian
    Citation: Journal of Biomedical Science 2015 22:88
  23. We have shown previously that microvesicle (MV)-delivered miR-130b (miR-130b-MV) is able to target PPAR-γ and subsequently reduce the lipid accumulation in vitro. However, the in vivo effect of miR-130b on fat de...

    Authors: Shifeng Pan, Xiaojing Yang, Yimin Jia, Yue Li, Rirong Chen, Min Wang, Demin Cai and Ruqian Zhao
    Citation: Journal of Biomedical Science 2015 22:86
  24. Reactive oxygen species (ROS) have been long considered simply as harmful by-products of metabolism, which damage cellular proteins, lipids, and nucleic acids. ROS are also known as a wea...

    Authors: Aleksey V. Belikov, Burkhart Schraven and Luca Simeoni
    Citation: Journal of Biomedical Science 2015 22:85
  25. We have previously demonstrated that cigarette smoke is associated with a significant reduction of retinoic acid in rat lungs and the formation of tracheal precancerous lesions. However, the underlying mechani...

    Authors: Yuan Xue, Ethan Harris, Weiqun Wang and Richard C. Baybutt
    Citation: Journal of Biomedical Science 2015 22:84
  26. Dengue virus infection presents a wide spectrum of manifestations including asymptomatic condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in...

    Authors: Daisy Vanitha John, Yee-Shin Lin and Guey Chuen Perng
    Citation: Journal of Biomedical Science 2015 22:83
  27. Morphine-induced tolerance is associated with the spinal neuroinflammation. The aim of this study was to explore the effects of oral administration of the pioglitazone, the peroxisome proliferator activated re...

    Authors: Mohammad Charkhpour, Hamed Ghavimi, Saeed Ghanbarzadeh, Bahman Yousefi, Arash Khorrami, Mehran Mesgari and Kambiz Hassanzadeh
    Citation: Journal of Biomedical Science 2015 22:82
  28. Neuropathic pain is a very troublesome and difficult pain to treat. Although opioids are the best analgesics for cancer and surgical pain in clinic, only oxycodone among opioids shows better efficacy to allevi...

    Authors: Pao-Pao Yang, Geng-Chang Yeh, Eagle Yi-Kung Huang, Ping-Yee Law, Horace H. Loh and Pao-Luh Tao
    Citation: Journal of Biomedical Science 2015 22:81
  29. Cardiac oxidative stress, bioenergetics and catecholamine play major roles in heart failure progression. However, the relationships between these three dominant heart failure factors are not fully elucidated. ...

    Authors: Shih-Yi Lee, Hui-Chun Ku, Yueh-Hsiung Kuo, Kai-Chien Yang, Ping-Chen Tu, His-Lin Chiu and Ming-Jai Su
    Citation: Journal of Biomedical Science 2015 22:80
  30. The descending noradrenergic (NAergic) system is one of the important endogenous analgesia systems. It has been suggested that noxious stimuli could activate descending NAergic system; nevertheless, the underl...

    Authors: Chia-Yi Liu, Meng-Lam Lee, Chi-Sheng Yang, Chuan-Mu Chen, Ming-Yuan Min and Hsiu-Wen Yang
    Citation: Journal of Biomedical Science 2015 22:79
  31. In 2011, there was an outbreak of Shiga toxin-producing Escherichia coli (STEC) infections in Japan. Approximately 62 % of patients with hemolytic-uremic syndrome also showed symptoms of encephalopathy. To determ...

    Authors: Naotoshi Sugimoto, Hue Leu, Natsumi Inoue, Masaki Shimizu, Tomoko Toma, Mondo Kuroda, Takekatsu Saito, Taizo Wada and Akihiro Yachie
    Citation: Journal of Biomedical Science 2015 22:78
  32. Cisplatin is one of the most commonly used chemotherapy agent for lung cancer. The therapeutic efficacy of cisplatin is limited by the development of resistance.

    Authors: Chun-Hua Dai, Jian Li, Ping Chen, He-Guo Jiang, Ming Wu and Yong-Chang Chen
    Citation: Journal of Biomedical Science 2015 22:77
  33. Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a key regulator of signal cascades of TNF-α receptor and TLR4, and can induce NF-κB activation for preventing cell apoptosis and eliciting infl...

    Authors: Jang-Shiun Wang, Dean Wu, Duen-Yi Huang and Wan-Wan Lin
    Citation: Journal of Biomedical Science 2015 22:76
  34. Studies in recent years have shown that undercarboxylated osteocalcin (uOC) not only maintains bone mineralization, but is also involved in the regulation of atherosclerosis. However, a correlation between uOC...

    Authors: Minfang Zhang, Zhaohui Ni, Wenyan Zhou and Jiaqi Qian
    Citation: Journal of Biomedical Science 2015 22:75
  35. To construct safer recombinant flavivirus vaccine, we exploited Japanese encephalitis virus (JEV) replicon-based platform to generate single-round infectious particles (SRIPs) that expressed heterologous neutr...

    Authors: Yi-Ting Huang, Jia-Teh Liao, Li-Chen Yen, Yung-Kun Chang, Yi-Ling Lin and Ching-Len Liao
    Citation: Journal of Biomedical Science 2015 22:74
  36. Adiponectin levels have been shown to be associated with colorectal cancer (CRC). Furthermore, a newly identified adiponectin receptor, T-cadherin, has been associated with plasma adiponectin levels. Therefore...

    Authors: Jongkeun Park, Injung Kim, Keum Ji Jung, Soriul Kim, Sun Ha Jee and Sungjoo Kim Yoon
    Citation: Journal of Biomedical Science 2015 22:73
  37. Gene mutations that produce misprocessed proteins are linked to many human disorders. Interestingly, some misprocessed proteins retained their biological function when stabilized by low temperature treatment o...

    Authors: Yueqiang Zhang, William G. O’Brien III, Zhaoyang Zhao and Cheng Chi Lee
    Citation: Journal of Biomedical Science 2015 22:72
  38. Many patients with nasopharyngeal carcinoma (NPC) face poor prognosis. Due to its hidden anatomical location, the tumor is usually diagnosed quite late, and despite initially successful treatment with radiatio...

    Authors: Thomas C. Chen, Hee-Yeon Cho, Weijun Wang, Stephanie J. Wetzel, Anupam Singh, Jenny Nguyen, Florence M. Hofman and Axel H. Schönthal
    Citation: Journal of Biomedical Science 2015 22:71
  39. In epilepsy, seizures are generated by abnormal synchronous activity in neurons. In the rat hippocampus (HIP), epileptiform activity has been found to be associated with gap junctions (GJs). GJs are formed by ...

    Authors: Medina-Ceja Laura, Flores-Ponce Xóchitl, Santerre Anne and Morales-Villagrán Alberto
    Citation: Journal of Biomedical Science 2015 22:69
  40. Pulmonary emphysema is characterized histologically by destruction of alveolar walls and enlargement of air spaces due to lung epithelial cell apoptosis. Cell adhesion molecule 1 (CADM1) is an immunoglobulin s...

    Authors: Man Hagiyama, Azusa Yoneshige, Takao Inoue, Yasufumi Sato, Takahiro Mimae, Morihito Okada and Akihiko Ito
    Citation: Journal of Biomedical Science 2015 22:67
  41. Opportunistically nosocomial infections in hospitalized patients are often related to Clostridium difficile infections (CDI) due to disruption of the intestinal micro-flora by antibiotic therapies during hospital...

    Authors: Jui-Hsin Huang, Chia-Wei Wu, Shu-Pei Lien, Chih-Hsiang Leng, Kuang-Nan Hsiao, Shih-Jen Liu, Hsin-Wei Chen, Leung-Kei Siu and Pele Chong
    Citation: Journal of Biomedical Science 2015 22:65
  42. Osteoarthritis (OA) is a common joint disease that causes disabilities in elderly. However, few agents with high efficacy and low side effects have been developed to treat OA. In this study, we evaluated the e...

    Authors: Hsien-Tseng Lu, Ming-Shium Hsieh, Chao-Wen Cheng, Li-Fan Yao, Tsuey-Ying Hsu, Jai Lan, Kwang Yoon Kim, Suk Jung Oh, Yung-Hsiang Chang, Chian-Her Lee, Yung-Feng Lin and Chien-Ho Chen
    Citation: Journal of Biomedical Science 2015 22:64
  43. Reduced cell spreading is a prominent feature of aged dermal fibroblasts in human skin in vivo. Mitochondrial DNA (mtDNA) common deletion has been reported to play a role in the human aging process, however the r...

    Authors: Chunji Quan, Moon Kyun Cho, Daniel Perry and Taihao Quan
    Citation: Journal of Biomedical Science 2015 22:62

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