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  2. In epilepsy, seizures are generated by abnormal synchronous activity in neurons. In the rat hippocampus (HIP), epileptiform activity has been found to be associated with gap junctions (GJs). GJs are formed by ...

    Authors: Medina-Ceja Laura, Flores-Ponce Xóchitl, Santerre Anne and Morales-Villagrán Alberto
    Citation: Journal of Biomedical Science 2015 22:69
    Content type: Research Published on:

  4. Pulmonary emphysema is characterized histologically by destruction of alveolar walls and enlargement of air spaces due to lung epithelial cell apoptosis. Cell adhesion molecule 1 (CADM1) is an immunoglobulin s...

    Authors: Man Hagiyama, Azusa Yoneshige, Takao Inoue, Yasufumi Sato, Takahiro Mimae, Morihito Okada and Akihiko Ito
    Citation: Journal of Biomedical Science 2015 22:67
    Content type: Research Published on:

  6. Opportunistically nosocomial infections in hospitalized patients are often related to Clostridium difficile infections (CDI) due to disruption of the intestinal micro-flora by antibiotic therapies during hospital...

    Authors: Jui-Hsin Huang, Chia-Wei Wu, Shu-Pei Lien, Chih-Hsiang Leng, Kuang-Nan Hsiao, Shih-Jen Liu, Hsin-Wei Chen, Leung-Kei Siu and Pele Chong
    Citation: Journal of Biomedical Science 2015 22:65
    Content type: Research Published on:

  7. Osteoarthritis (OA) is a common joint disease that causes disabilities in elderly. However, few agents with high efficacy and low side effects have been developed to treat OA. In this study, we evaluated the e...

    Authors: Hsien-Tseng Lu, Ming-Shium Hsieh, Chao-Wen Cheng, Li-Fan Yao, Tsuey-Ying Hsu, Jai Lan, Kwang Yoon Kim, Suk Jung Oh, Yung-Hsiang Chang, Chian-Her Lee, Yung-Feng Lin and Chien-Ho Chen
    Citation: Journal of Biomedical Science 2015 22:64
    Content type: Research Published on:

  9. Reduced cell spreading is a prominent feature of aged dermal fibroblasts in human skin in vivo. Mitochondrial DNA (mtDNA) common deletion has been reported to play a role in the human aging process, however the r...

    Authors: Chunji Quan, Moon Kyun Cho, Daniel Perry and Taihao Quan
    Citation: Journal of Biomedical Science 2015 22:62
    Content type: Research Published on:

  10. Melatonin, the chief secretary product of pineal gland, is a strong free radical scavenger and antioxidant molecule. The radioprotective efficacy and underlying mechanisms refer to its antioxidant role in soma...

    Authors: Shahanshah Khan, Jawahar Singh Adhikari, Moshahid Alam Rizvi and Nabo Kumar Chaudhury
    Citation: Journal of Biomedical Science 2015 22:61
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2022 29:91

  12. The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) influences nigral dopaminergic neurons via autocrine and paracrine mechanisms. The reduction of BDNF expression in Parkinson’s disease substantia nigra...

    Authors: Nancy G. Hernandez-Chan, Michael J. Bannon, Carlos E. Orozco-Barrios, Lourdes Escobedo, Sergio Zamudio, Fidel De la Cruz, Jose L. Gongora-Alfaro, Juan Armendáriz-Borunda, David Reyes-Corona, Armando J. Espadas-Alvarez, Yazmin M. Flores-Martínez, Jose Ayala-Davila, Maria E. Hernandez-Gutierrez, Lenin Pavón, Refugio García-Villegas, Rasajna Nadella…
    Citation: Journal of Biomedical Science 2015 22:59
    Content type: Research Published on:

  14. Although Imatinib mesylate has revolutionized the treatment of chronic myeloid leukemia, some patients develop resistance with progression of leukemia. Alternative or additional targeting of signalling pathway...

    Authors: Samuel Troadec, Mélina Blairvacq, Nassima Oumata, Hervé Galons, Laurent Meijer and Christian Berthou
    Citation: Journal of Biomedical Science 2015 22:57
    Content type: Research Published on:

  15. Recently accumulated evidence suggests that Raf kinase inhibitor protein (RKIP) participates in regulation of many signaling pathways and plays an important role in tumorigenesis and tumor metastasis. However,...

    Authors: Fang Nie, Jianguo Cao, Jinlu Tong, Mingming Zhu, Yuan Gao and Zhihua Ran
    Citation: Journal of Biomedical Science 2015 22:56
    Content type: Research Published on:

  16. Dengue is an important mosquito-borne viral infection that affects millions of persons worldwide. Early diagnosis is necessary to effect appropriate management and decrease mortality. Immunochromatographic tes...

    Authors: Ivan E. Vickers, Kevin M. Harvey, Michelle G. Brown, Kereann Nelson, Marion Bullock DuCasse and John F. Lindo
    Citation: Journal of Biomedical Science 2015 22:55
    Content type: Research Published on:

  18. Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine and elevated in the regions of tissue injury and inflammatory diseases. The deleterious effects of TNF-α on fibroblasts may aggravate heart inflamm...

    Authors: Chih-Chung Lin, Chih-Shuo Pan, Chen-Yu Wang, Shiau-Wen Liu, Li-Der Hsiao and Chuen-Mao Yang
    Citation: Journal of Biomedical Science 2015 22:53
    Content type: Research Published on:

  19. SLC34A2 with highest expressions in lung, small intestine and kidney encoded a type 2b sodium-dependent phosphate transporter (NaPi-IIb). In lung, SLC34A2 only expressed in the apical membran...

    Authors: Yu Wang, Weihan Yang, Qiang Pu, Yan Yang, Sujuan Ye, Qingping Ma, Jiang Ren, Zhixing Cao, Guoxing Zhong, Xuechao Zhang, Lunxu Liu and Wen Zhu
    Citation: Journal of Biomedical Science 2015 22:52
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Biomedical Science 2019 26:18

  21. Hydrogen sulfide (H2S), a novel gaseous mediator, has been recognized as an important neuromodulator and neuroprotective agent in the nervous system. The present study was undertaken to study the effects of ex...

    Authors: Lei Li, Hong-kun Jiang, Yun-peng Li and Yan-ping Guo
    Citation: Journal of Biomedical Science 2015 22:50
    Content type: Research Published on:

  22. The positive effects of acupuncture at Feng-Chi acupoints on treating epilepsy and insomnia have been well-documented in ancient Chinese literature. However, there is a lack of scientific evidence to elucidate...

    Authors: Pei-Lu Yi, Chin-Yu Lu, Shuo-Bin Jou and Fang-Chia Chang
    Citation: Journal of Biomedical Science 2015 22:49
    Content type: Research Published on:

  23. Breast cancer is classified into three subtypes by the expression of biomarker receptors such as hormone receptors and human epidermal growth factor receptor 2. Triple-negative breast cancer (TNBC) expresses n...

    Authors: Masaaki Kawai, Akio Nakashima, Shinji Kamada and Ushio Kikkawa
    Citation: Journal of Biomedical Science 2015 22:48
    Content type: Research Published on:

  24. Wound healing is an intricate process whereby the skin repairs itself after injury. The epithelial-mesenchymal transition (EMT) is associated with wound healing and tissue regeneration. Naphthochalcone derivat...

    Authors: Ga Young Seo, Manh Tin Ho, Ngoc Thuy Bui, Young Mee Kim, Dongsoo Koh, Youngho Lim, Changlim Hyun and Moonjae Cho
    Citation: Journal of Biomedical Science 2015 22:47
    Content type: Research Published on:

  25. Neuroinflammation with activation of microglia and production of proinflammatory cytokines in the brain plays an active role in epileptic disorders. Brain oxidative stress has also been implicated in the patho...

    Authors: Ying-Hao Ho, Yu-Te Lin, Chih-Wei J. Wu, Yung-Mei Chao, Alice Y. W. Chang and Julie Y. H. Chan
    Citation: Journal of Biomedical Science 2015 22:46
    Content type: Research Published on:

  27. The epidermis forms a critical barrier that is maintained by orchestrated programs of proliferation, differentiation, and cell death. Gene mutations that disturb this turnover process may cause skin diseases. ...

    Authors: Pei-Hsuan Lin, Hsien-Yi Lin, Cheng-Chin Kuo and Liang-Tung Yang
    Citation: Journal of Biomedical Science 2015 22:44
    Content type: Research Published on:

  28. Mutations in heat shock 27 kDa protein 1 (HSP27 or HSPB1) cause distal hereditary motor neuropathy (dHMN) or Charcot-Marie-Tooth disease type 2 F (CMT2F) according to unknown factors. Mutant HSP27 proteins aff...

    Authors: Jinho Lee, Sung-Chul Jung, Jaesoon Joo, Yu-Ri Choi, Hyo Won Moon, Geon Kwak, Ha Kyung Yeo, Ji-Su Lee, Hye-Jee Ahn, Namhee Jung, Sunhee Hwang, Jingeun Rheey, So-Youn Woo, Ji Yon Kim, Young Bin Hong and Byung-Ok Choi
    Citation: Journal of Biomedical Science 2015 22:43
    Content type: Research Published on:

  29. 5-hydroxytryptamine (5-HT)-induced coronary artery responses have both vasoconstriction and vasorelaxation components. The vasoconstrictive effects of 5-HT have been well studied while the mechanism(s) of how ...

    Authors: Ching-Chia Chang Chien and Ming-Jai Su
    Citation: Journal of Biomedical Science 2015 22:42
    Content type: Research Published on:

  30. Down syndrome (DS) is one of the commonest disorders with huge medical and social cost. DS is associated with number of phenotypes including congenital heart defects, leukemia, Alzeihmer’s disease, Hirschsprun...

    Authors: Ambreen Asim, Ashok Kumar, Srinivasan Muthuswamy, Shalu Jain and Sarita Agarwal
    Citation: Journal of Biomedical Science 2015 22:41
    Content type: Review Published on:

  31. The NF-κB signaling pathway plays a role in local and remote tissue damage following ischemia-reperfusion (I/R) injury to skeletal muscles. Evidence suggests that exosomes can act as intercellular communicator...

    Authors: Johnson Chia-Shen Yang, Ming-Wei Lin, Cheng-Shyuan Rau, Seng-Feng Jeng, Tsu-Hsiang Lu, Yi-Chan Wu, Yi-Chun Chen, Siou-Ling Tzeng, Chia-Jung Wu and Ching-Hua Hsieh
    Citation: Journal of Biomedical Science 2015 22:40
    Content type: Research Published on:

  33. EGFR, a receptor tyrosine kinase (RTK), is frequently overexpressed and mutated in non-small cell lung cancer (NSCLC). Tyrosine kinase inhibitors (TKIs) have been widely used in the treatment of many cancers, ...

    Authors: Chi-Yuan Chen, Zhu-Yun Yu, Yen-Shu Chuang, Rui-Mei Huang and Tzu-Chien V Wang
    Citation: Journal of Biomedical Science 2015 22:38
    Content type: Research Published on:

  34. Parkinson’s disease is the second most common neurodegenerative disorders after Alzheimer’s disease. The main cause of the disease is the massive degeneration of dopaminergic neurons in the substantia nigra. N...

    Authors: Yun-Lian Lin, Huey-Jen Tsay, Tzu-Hsuan Lai, Tsai-Teng Tzeng and Young-Ji Shiao
    Citation: Journal of Biomedical Science 2015 22:37
    Content type: Research Published on:

  36. The purpose of this study was to evaluate the efficacy of a multi-layered conductive nanofibrous hollow conduit in combination with olfactory ensheathing cells (OEC) to promote peripheral nerve regeneration. W...

    Authors: Mahboubeh Kabiri, Saeed Oraee-Yazdani, Abbas Shafiee, Hana Hanaee-Ahvaz, Masumeh Dodel, Mohammad Vaseei and Masoud Soleimani
    Citation: Journal of Biomedical Science 2015 22:35
    Content type: Research Published on:

  37. Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are systemic autoimmune connective tissue diseases that share overlapping clinico-pathological features. It is highly probable that there is an o...

    Authors: Puleng Matatiele, Mohamed Tikly, Gareth Tarr and Mary Gulumian
    Citation: Journal of Biomedical Science 2015 22:34
    Content type: Research Published on:

  38. MSP58 is a nucleolar protein associated with rRNA transcription and cell proliferation. Its mechanism of translocation into the nucleus or the nucleolus, however, is not entirely known. In order to address thi...

    Authors: Chuan-Pin Yang, Chi-Wu Chiang, Chang-Han Chen, Yi-Chao Lee, Mei-Hsiang Wu, Yi-Huan Tsou, Yu-San Yang, Wen-Chang Chang and Ding-Yen Lin
    Citation: Journal of Biomedical Science 2015 22:33
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2015 22:60

  39. Cytochrome P450 metabolizes many drugs in the liver. Three genotypes of CYP2C19 with extensive, intermediate, and poor metabolizing activity, respectively, have been identified in peripheral blood of transplan...

    Authors: King-Wah Chiu, Toshiaki Nakano, Kuang-Den Chen, Li-Wen Hsu, Chia-Yun Lai, Ching-Yin Huang, Yu-Fan Cheng, Shigeru Goto and Chao-Long Chen
    Citation: Journal of Biomedical Science 2015 22:32
    Content type: Review Published on:

  40. Adenoviral vector is an efficient tool for gene transfer. Protein expression is regulated by a number of factors, but the regulation by gene copy number remains to be investigated further.

    Authors: Yi-Chen Tsai, Tsung-Huang Tsai, Chen-Ping Chang, Shu-Fen Chen, Yen-Ming Lee and Song-Kun Shyue
    Citation: Journal of Biomedical Science 2015 22:31
    Content type: Research Published on:

  41. Small heterodimer partner (SHP, NR0B2) is involved in diverse metabolic pathways, including hepatic bile acid, lipid and glucose homeostasis, and has been implicated in effects on the peroxisome proliferator-a...

    Authors: Hsiu-Ting Tseng, Young Joo Park, Yoon Kwang Lee and David D Moore
    Citation: Journal of Biomedical Science 2015 22:30
    Content type: Research Published on:

  42. Dengue virus (DENV), a member of the family Flaviviridae, is at present the most widespread causative agent of a human viral disease transmitted by mosquitoes. Despite the increasing incidence of this pathogen, t...

    Authors: María B Mazzucco, Laura B Talarico, Sezen Vatansever, Ana C Carro, Mirta L Fascio, Norma B D’Accorso, Cybele C García and Elsa B Damonte
    Citation: Journal of Biomedical Science 2015 22:29
    Content type: Research Published on:

  43. Identifying the drug-deliverables that target autophagy is crucial to finding a cure for pancreatic cancer (PC), as activated autophagy is associated with poor patient outcomes. Our recent studies recognized t...

    Authors: Sheeja Aravindan, Satish Kumar Ramraj, Somasundaram T Somasundaram and Natarajan Aravindan
    Citation: Journal of Biomedical Science 2015 22:28
    Content type: Research Published on:

  44. ESBL-producing bacteria are a clinical problem in the management of diseases caused by these pathogens. Worldwide, systemic infections with BL enzymes are evolving by mutations from classical bla genes in an inte...

    Authors: Amel Bourouis, Mouhamed Ben moussa and Omrane Belhadj
    Citation: Journal of Biomedical Science 2015 22:27
    Content type: Research Published on:

  45. Despite the recent progress in screening and therapy, a majority of prostate cancer cases eventually attain hormone refractory and chemo-resistant attributes. Conventional chemotherapeutic strategies are effec...

    Authors: Rishi Kumar Gara, Vikas Kumar Srivastava, Shivali Duggal, Jaspreet Kaur Bagga, MLB Bhatt, Sabyasachi Sanyal and Durga Prasad Mishra
    Citation: Journal of Biomedical Science 2015 22:26
    Content type: Research Published on:

  46. Homozygous 32-bp deletion of the chemokine receptor 5 gene (CCR5) is associated with resistance to human immunodeficiency virus (HIV) infection, while heterozygosity delays HIV progression. Bone marrow transplant...

    Authors: Krissanapong Manotham, Supreecha Chattong and Anant Setpakdee
    Citation: Journal of Biomedical Science 2015 22:25
    Content type: Research Published on:

  47. Experimental models of pneumonia with penicillin non-susceptible Streptococcus pneumoniae (PNSSP) are hard to reproduce because the majority of strains with clinical relevance (like serotypes 6B, 9 V and 19 F) ha...

    Authors: Andres F Zuluaga, Beatriz E Salazar, Maria Agudelo, Carlos A Rodriguez and Omar Vesga
    Citation: Journal of Biomedical Science 2015 22:24
    Content type: Research Published on:

  48. The estimated glomerular filtration rate (eGFR) is a well-known measure of kidney function and is commonly used for the diagnosis and management of patients with chronic kidney disease. The inter-individual va...

    Authors: Farook Thameem, V Saroja Voruganti, John Blangero, Anthony G Comuzzie and Hanna E Abboud
    Citation: Journal of Biomedical Science 2015 22:23
    Content type: Research Published on:

  49. Heme oxygenase-1 (HO-1) is a rate-limiting enzyme catalyzing oxidative degradation of cellular heme to liberate free iron, carbon monoxide (CO) and biliverdin in mammalian cells. In addition to its primary rol...

    Authors: Lee-Young Chau
    Citation: Journal of Biomedical Science 2015 22:22
    Content type: Review Published on:
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Journal of Biomedical Science

ISSN: 1423-0127