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  3. Reperfusion after resuscitation from cardiac arrest (CA) is an event that increases reactive oxygen species production leading to oxidative stress. More specifically, myocardial oxidative stress may play a rol...

    Authors: Fernanda Schäfer Hackenhaar, Francesca Fumagalli, Giovanni Li Volti, Valeria Sorrenti, Ilaria Russo, Lidia Staszewsky, Serge Masson, Roberto Latini and Giuseppe Ristagno
    Citation: Journal of Biomedical Science 2014 21:70
    Content type: Research Published on:

  4. Aberrant DNA methylation as the most important reason making epigenetic silencing of genes is a main mechanism of gene inactivation in patients with colorectal cancer. In this study, we decided to identify pro...

    Authors: Nader Mansour Samaei, Yaghoub Yazdani, Reza Alizadeh-Navaei, Hossein Azadeh and Touraj Farazmandfar
    Citation: Journal of Biomedical Science 2014 21:73
    Content type: Research Published on:

  5. Noopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cognition enhancer, piracetam. Our previous experiments have demonstrated the cognition restoring eff...

    Authors: Rita U Ostrovskaya, Yulia V Vakhitova, Uliyana Sh Kuzmina, Milyausha Kh Salimgareeva, Liana F Zainullina, Tatiana A Gudasheva, Vener A Vakhitov and Sergey B Seredenin
    Citation: Journal of Biomedical Science 2014 21:74
    Content type: Research Published on:

  6. The DEP domain is a globular domain containing approximately 90 amino acids, which was first discovered in 3 proteins: Drosophila disheveled, Caenorhabditis elegans EGL-10, and mammalian Pleckstrin; hence the ter...

    Authors: Ying-Fang Su, Chi-Yen Liang, Chih-Yang Huang, Chih-Yu Peng, Claire Chiyu Chen, Ming-Cheng Lin, Rong-Kai Lin, Wei-Wen Lin, Ming-Yung Chou, Pao-Hsin Liao and Jaw-Ji Yang
    Citation: Journal of Biomedical Science 2014 21:67
    Content type: Research Published on:

  7. Type I Bartter syndrome is a recessive human nephropathy caused by loss-of-function mutations in the SLC12A1 gene coding for the Na+-K+-2Cl− cotransporter NKCC2. We recently established the mutant mouse line Slc1...

    Authors: Elisabeth Kemter, Birgit Rathkolb, Lore Becker, Ines Bolle, Dirk H Busch, Claudia Dalke, Ralf Elvert, Jack Favor, Jochen Graw, Wolfgang Hans, Boris Ivandic, Svetoslav Kalaydjiev, Thomas Klopstock, Ildikó Rácz, Jan Rozman, Anja Schrewe…
    Citation: Journal of Biomedical Science 2014 21:68
    Content type: Research Published on:

  8. Cervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors. In th...

    Authors: Alireza Tahamtan, Amir Ghaemi, Ali Gorji, Hamid R Kalhor, Azadeh Sajadian, Alijan Tabarraei, Abdolvahab Moradi, Fatemeh Atyabi and Mishar Kelishadi
    Citation: Journal of Biomedical Science 2014 21:69
    Content type: Research Published on:

  9. Enzyme prodrug therapy shows promise for the treatment of solid tumors, but current approaches lack effective/safe delivery strategies. To address this, we previously developed three enzyme-containing fusion p...

    Authors: Katrin P Guillen, Carla Kurkjian and Roger G Harrison
    Citation: Journal of Biomedical Science 2014 21:65
    Content type: Research Published on:

  10. Methionine, an essential amino acid, is required for protein synthesis and normal cell metabolism. The transmethylation pathway and methionine salvage pathway (MTA cycle) are two major pathways regulating meth...

    Authors: He-Yen Chou, Yu-Hung Lin, Guan-Lin Shiu, Hsiang-Yu Tang, Mei-Ling Cheng, Ming-Shi Shiao and Li-Mei Pai
    Citation: Journal of Biomedical Science 2014 21:64
    Content type: Research Published on:

  11. Snake venoms are a complex mixture of active principles mainly peptides and proteins also including amino acids, nucleotides, free lipids, carbohydrates and metallic elements bound to proteins that interfere i...

    Authors: Mukunda Chethankumar and Leela Srinivas
    Citation: Journal of Biomedical Science 2014 21:66
    Content type: Research Published on:

  12. Neks, mammalian orthologs of the fungal protein kinase never-in-mitosis A, have been implicated in the pathogenesis of polycystic kidney disease. Among them, Nek1 is the primary protein inactivated in kat2J mo...

    Authors: Yumay Chen, Huai-Chin Chiang, Patricia Litchfield, Michelle Pena, Charity Juang and Daniel J Riley
    Citation: Journal of Biomedical Science 2014 21:63
    Content type: Research Published on:

  13. Acute spinal cord injury (SCI) leads to a series of reactive changes and causes severe neurological deficits. A pronounced inflammation contributes to secondary pathology after SCI. Astroglia respond to SCI by...

    Authors: Fan-Wei Tseng, Dann-Ying Liou, May-Jywan Tsai, Wen-Cheng Huang and Henrich Cheng
    Citation: Journal of Biomedical Science 2014 21:60
    Content type: Research Published on:

  14. Opioids have been used for the management of pain and coadministration of two opioids may induce synergism. In a model of tonic pain, the acetic acid writhing test and in a phasic model, the hot plate, the ant...

    Authors: Hugo F Miranda, Viviana Noriega, Pilar Zanetta, Juan Carlos Prieto, Juan Carlos Prieto-Rayo, Nicolás Aranda and Fernando Sierralta
    Citation: Journal of Biomedical Science 2014 21:62
    Content type: Research Published on:

  15. Caffeic acid phenethyl ester (CAPE), a component of propolis, is reported to possess anti-inflammatory, anti-bacterial, anti-viral, and anti-tumor activities. Previously, our laboratory demonstrated the in vitro ...

    Authors: Tsui-Hwa Tseng, Chien-Heng Shen, Wen-Shih Huang, Cheng-Nan Chen, Wen-Hai Liang, Tseng-Hsi Lin and Hsing-Chun Kuo
    Citation: Journal of Biomedical Science 2014 21:61
    Content type: Research Published on:

  16. Stromal cell-derived factor-1 (SDF-1) (CXC chemokine ligand-12)/CXC chemokine receptor 4 (CXCR4) is involved in the carcinogenesis of human gastric cancer, where it stimulates angiogenesis and favors metastasi...

    Authors: Yung-Yu Hsieh, Chien-Heng Shen, Wen-Shih Huang, Chih-Chien Chin, Yi-Hung Kuo, Meng Chiao Hsieh, Hong-Ren Yu, Te-Sheng Chang, Tseng-Hsi Lin, Yung-Wei Chiu, Cheng-Nan Chen, Hsing-Chun Kuo and Shui-Yi Tung
    Citation: Journal of Biomedical Science 2014 21:59
    Content type: Research Published on:

  17. Sudden cardiac death (SCD) is the clinical outcome of a lethal arrhythmia that can develop on the background of unrecognized channelopathies or cardiomyopathies. Several susceptibility genes have been identifi...

    Authors: Vincenzo Lariccia, Annamaria Assunta Nasti, Federica Alessandrini, Mauro Pesaresi, Santo Gratteri, Adriano Tagliabracci and Salvatore Amoroso
    Citation: Journal of Biomedical Science 2014 21:58
    Content type: Research Published on:

  18. In congestive heart failure the balance between cell death and cell survival in cardiomyocytes is compromised. Sirtuin 1 (Sirt1) activates cell survival machinery and has been shown to be protective against is...

    Authors: Tse-Min Lu, Jia-Yun Tsai, Yen-Chung Chen, Chun-Yang Huang, Hung-Lung Hsu, Chi-Feng Weng, Chun-Che Shih and Chiao-Po Hsu
    Citation: Journal of Biomedical Science 2014 21:57
    Content type: Research Published on:

  19. Epigallocatechin-3-gallate (EGCG) has been documented for its beneficial effects protecting oxidative stress to cardiac cells. Previously, we have shown the EGCG-mediated cardiac protection by attenuating reac...

    Authors: Wei-Cheng Chen, Shih-Rong Hsieh, Chun-Hwei Chiu, Ban-Dar Hsu and Ying-Ming Liou
    Citation: Journal of Biomedical Science 2014 21:56
    Content type: Research Published on:

  20. Adipose tissue provides a readily available source of autologous stem cells. Adipose-derived stem cells (ASCs) have been proposed as a source for endothelial cell substitutes for lining the luminal surface of ...

    Authors: Divya Arya, Shaohua Chang, Paul DiMuzio, Jeffrey Carpenter and Thomas N Tulenko
    Citation: Journal of Biomedical Science 2014 21:55
    Content type: Research Published on:

  21. A new highly pathogenic human coronavirus (CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), has emerged in Jeddah and Saudi Arabia and quickly spread to some European countries since September 20...

    Authors: Min-Han Lin, Shang-Ju Chuang, Chiao-Che Chen, Shu-Chun Cheng, Kai-Wen Cheng, Chao-Hsiung Lin, Chiao-Yin Sun and Chi-Yuan Chou
    Citation: Journal of Biomedical Science 2014 21:54
    Content type: Research Published on:

  22. Hairy and Enhancer of split 1 (Hes-1) is a transcriptional repressor that plays an important role in neuronal differentiation and development, but post-translational modifications of Hes-1 are much less known. In...

    Authors: Hsin-Ying Clair Chiou, Shau-Yu Liu, Cheng-Hsiung Lin and Eminy HY Lee
    Citation: Journal of Biomedical Science 2014 21:53
    Content type: Research Published on:

  24. Cancer immunoediting is a dynamic process composed of three phases: elimination (EL), equilibrium (EQ) and escape (ES) that encompasses the potential host-protective and tumor-sculpting functions of the immune...

    Authors: Lucas Pagura, Juan Manuel Cáceres, Albertina Cardinale, Olga Graciela Scharovsky, Ricardo José Di Masso, Mariano Federico Zacarías-Fluck, María José Rico and Viviana Rosa Rozados
    Citation: Journal of Biomedical Science 2014 21:52
    Content type: Research Published on:

  25. Excessive manganese exposure induced cognitive deficit. Several lines of evidence have demonstrated that taurine improves cognitive impairment induced by numerous neurotoxins. However, the role of taurine on m...

    Authors: Cai-Ling Lu, Shen Tang, Zhi-Juan Meng, Yi-Yuan He, Ling-Yong Song, Yin-Pin Liu, Ning Ma, Xi-Yi Li and Song-Chao Guo
    Citation: Journal of Biomedical Science 2014 21:51
    Content type: Research Published on:

  26. Decay Accelerating Factor (DAF) and Coxsackievirus-Adenovirus Receptor (CAR) have been identified as cellular receptors for Coxsackie B viruses (CV-B). The aim of this study is to elucidate the different bindi...

    Authors: Samira Riabi, Rafik Harrath, Imed Gaaloul, Lamjed Bouslama, Dorsaf Nasri, Mahjoub Aouni, Sylvie Pillet and Bruno Pozzetto
    Citation: Journal of Biomedical Science 2014 21:50
    Content type: Research Published on:

  27. Among a variety of inflammatory mediators, visfatin is a proinflammatory adipocytokine associated with inflammatory reactions in obesity, metabolic syndrome, chronic inflammatory disease, and autoimmune diseas...

    Authors: Si-Youn Song, Eun Chae Jung, Chang Hoon Bae, Yoon Seok Choi and Yong-Dae Kim
    Citation: Journal of Biomedical Science 2014 21:49
    Content type: Research Published on:

  28. MicroRNAs have been implicated in cancer but studies on their role in precancer, such as leukoplakia, are limited. Sequence variations at eight miRNA and four miRNA processing genes were studied in 452 healthy...

    Authors: Roshni Roy, Navonil De Sarkar, Sandip Ghose, Ranjan R Paul, Anindita Ray, Indranil Mukhopadhyay and Bidyut Roy
    Citation: Journal of Biomedical Science 2014 21:48
    Content type: Research Published on:

  29. Tissue and organ regeneration via transplantation of cell bodies in-situ has become an interesting strategy in regenerative medicine. Developments of cell carriers to systematically deliver cell bodies in the ...

    Authors: Mohammod K Bhuyan, Jorge I Rodriguez-Devora, Kym Fraser and Tzu-Liang Bill Tseng
    Citation: Journal of Biomedical Science 2014 21:47
    Content type: Research Published on:

  30. Intermittent hypoxia (IH) plays a critical role in sleep breathing disorder-associated hippocampus impairments, including neurocognitive deficits, irreversible memory and learning impairments. IH-induced neuro...

    Authors: Tsung-I Chen, Hung-Wen Chiu, Yi-Chung Pan, Shih-Ting Hsu, Jian-Hong Lin and Kun-Ta Yang
    Citation: Journal of Biomedical Science 2014 21:46
    Content type: Research Published on:

  31. Although runt-related transcription factor 2 (RUNX2) has been considered a determinant of cleidocranial dysplasia (CCD), some CCD patients were free of RUNX2 mutations. CCAAT/enhancer-binding protein beta (Ceb...

    Authors: Boyen Huang, Katsu Takahashi, Ernest A Jennings, Pongthorn Pumtang-on, Honoka Kiso, Yumiko Togo, Kazuyuki Saito, Manabu Sugai, Shizuo Akira, Akira Shimizu and Kazuhisa Bessho
    Citation: Journal of Biomedical Science 2014 21:44
    Content type: Research Published on:

  32. Spinal cord injury (SCI) deteriorates various physical functions, in particular, bladder problems occur as a result of damage to the spinal cord. Stem cell therapy for SCI has been focused as the new strategy ...

    Authors: Young-Sam Cho, Il-Gyu Ko, Sung-Eun Kim, Sung-Min Lee, Mal-Soon Shin, Chang-Ju Kim, Sang-Hoon Kim, Jun-Jang Jin and Khae-Hawn Kim
    Citation: Journal of Biomedical Science 2014 21:43
    Content type: Research Published on:

  34. As compared to cisplatin, trinuclear platinum compounds such as BBR3464 and DH6Cl have an altered spectrum of activity possibly because they form long-range adducts with DNA as against mainly intrastrand 1,2-b...

    Authors: Shahnaz A Hamad, Philip Beale, Jun Q Yu and Fazlul Huq
    Citation: Journal of Biomedical Science 2014 21:41
    Content type: Research Published on:

  35. p53 is a major tumor suppressor that is inactivated in over 50% of human cancer types through either mutation or inactivating interactions with viral or cellular proteins. The uncertainties around the link bet...

    Authors: James Yi-Hsin Chan, Ying-Chuan Chen, Shu-Ting Liu, Wei-Yuan Chou, Ching-Liang Ho and Shih-Ming Huang
    Citation: Journal of Biomedical Science 2014 21:40
    Content type: Research Published on:

  36. Riboflavin (RF) or vitamin B2 is known to have neuroprotective effects. In the present study, we report the attenuation of the neuroprotective effects of RF under UV-B irradiation. Preconditioning of UV-B irra...

    Authors: Amit Kumar Tripathi, Ashish Dwivedi, Manish Kumar Pal, Namrata Rastogi, Priyanka Gupta, Shakir Ali, Manjunatha Prabhu BH, Hari Narayan Kushwaha, Ratan Singh Ray, Shio Kumar Singh, Shivali Duggal, Bhaskar Narayan and Durga Prasad Mishra
    Citation: Journal of Biomedical Science 2014 21:39
    Content type: Research Published on:

  37. Reduction of pancreatic β-cells mass, major secondary to increased β-cells apoptosis, is increasingly recognized as one of the main contributing factors to the pathogenesis of type 2 diabetes (T2D), and satura...

    Authors: Shan Huang, Minghui Zhu, Wei Wu, Abid Rashid, Yan Liang, Ling Hou, Qin Ning and Xiaoping Luo
    Citation: Journal of Biomedical Science 2014 21:38
    Content type: Research Published on:

  38. An endogenous dopaminergic (DA) tone acting on D3 receptors has been shown to inhibit tuberoinfundibular (TI) DA neuron activity and stimulate prolactin (PRL) surge in the afternoon of estrogen-primed ovariectomi...

    Authors: Shu-Ling Liang, Sheng-Chieh Hsu and Jenn-Tser Pan
    Citation: Journal of Biomedical Science 2014 21:37
    Content type: Research Published on:

  39. H-rev107, also called HRASLS3 or PLA2G16, is a member of the HREV107 type II tumor suppressor gene family. Previous studies showed that H-rev107 exhibits phospholipase A/acyltransferase (PLA/AT) activity and d...

    Authors: Chun-Hua Wang, Rong-Yaun Shyu, Chang-Chieh Wu, Tzung-Chieh Tsai, Lu-Kai Wang, Mao-Liang Chen, Shun-Yuan Jiang and Fu-Ming Tsai
    Citation: Journal of Biomedical Science 2014 21:36
    Content type: Research Published on:

  40. The aim of this study was to develop the near infrared fluorescence (NIRF)-based imaging agent for the visualization of vascular endothelial growth factor (VEGF) in colon cancer. AlexaFluor 750 conjugating wit...

    Authors: Bishnuhari Paudyal, Pramila Paudyal, Dilip Shah, Hideyuki Tominaga, Yoshito Tsushima and Keigo Endo
    Citation: Journal of Biomedical Science 2014 21:35
    Content type: Research Published on:

  41. Coronavirus membrane (M) proteins are capable of interacting with nucleocapsid (N) and envelope (E) proteins. Severe acute respiratory syndrome coronavirus (SARS-CoV) M co-expression with either N or E is suff...

    Authors: Ying-Tzu Tseng, Shiu-Mei Wang, Kuo-Jung Huang and Chin-Tien Wang
    Citation: Journal of Biomedical Science 2014 21:34
    Content type: Research Published on:

  42. Clinical manifestations of enterovirus 71 (EV71) range from herpangina, hand-foot-and-mouth disease (HFMD), to severe neurological complications. Unlike the situation of switching genotypes seen in EV71 outbre...

    Authors: Sheng-Wen Huang, Hui-Li Cheng, Hsin-Yi Hsieh, Chia-Lun Chang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Ih-Jen Su and Jen-Ren Wang
    Citation: Journal of Biomedical Science 2014 21:33
    Content type: Research Published on:

  43. Membranous nephropathy (MN) is a common cause of nephrotic syndrome that may progress to end-stage renal disease (ESRD). The formation of MN involves the in situ formation of subepithelial immune deposits and lea...

    Authors: Chao-Wen Cheng, Li-Chien Chang, Tzu-Ling Tseng, Chia-Chao Wu, Yuh-Feng Lin and Jin-Shuen Chen
    Citation: Journal of Biomedical Science 2014 21:573
    Content type: Research Published on:

    The Erratum to this article has been published in Journal of Biomedical Science 2016 23:37

  45. Dioscin, a typical steroid saponin, is isolated from Dioscorea nipponica Makino and Dioscorea zingiberensis Wright. It has estrogenic activity and many studies have also reported that dioscorea plants have an ...

    Authors: Chunfang Zhang, Jinyong Peng, Shan Wu, Yue Jin, Fan Xia, Changyuan Wang, Kexin Liu, Huijun Sun and Mozhen Liu
    Citation: Journal of Biomedical Science 2014 21:30
    Content type: Research Published on:

  46. The epithelial barrier dysfunction plays a critical role in the pathogenesis of a broad array of immune diseases. Alix protein is involved in the endolysosome system. This study aims to elucidate the role of A...

    Authors: Hao Yan, Haitao Yi, Lixin Xia, Zhenke Zhan, Weiyi He, Jijuan Cao, Ping-Chang Yang and Zhigang Liu
    Citation: Journal of Biomedical Science 2014 21:29
    Content type: Research Published on:

  48. Specific vulnerability and degeneration of the dopaminergic neurons in the substantia nigra pars compacta of the midbrain is the pathological hallmark of Parkinson’s disease. A number of transcription factors ...

    Authors: Kambiz N Alavian, Sharmin Jeddi, Sahar I Naghipour, Pegah Nabili, Pawel Licznerski and Travis S Tierney
    Citation: Journal of Biomedical Science 2014 21:27
    Content type: Review Published on:

  49. Thalassemias (Thal) are forms of inherited autosomal recessive blood disorders arising out of mutations in the chromosomes 11 or 16. These disorders lead to poor oxygen delivery to blood vessels and consequent...

    Authors: M S AlSalhi, Farjah H AlGahtani, S Devanesan, V Trinka Vijmasi, K Jeyaprakash, Abbas H AlSaeed and V Masilamani
    Citation: Journal of Biomedical Science 2014 21:26
    Content type: Research Published on:
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Journal of Biomedical Science

ISSN: 1423-0127