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  1. Antigen-specific immunotherapy using DNA vaccines has emerged as an attractive approach for the control of tumors. Another novel cancer therapy involves the employment of the vascular disrupting agent, 5,6-dim...

    Authors: Shiwen Peng, Archana Monie, Xiaowu Pang, Chien-Fu Hung and T-C Wu
    Citation: Journal of Biomedical Science 2011 18:21
    Content type: Research Published on:

  2. Japanese encephalitis (JE) virus is the most common cause of epidemic viral encephalitis in the world. The virus mainly infects neuronal cells and causes an inflammatory response after invasion of the parenchy...

    Authors: Yu-Fen Tseng, Chien-Chih Wang, Shuen-Kuei Liao, Ching-Kai Chuang and Wei-June Chen
    Citation: Journal of Biomedical Science 2011 18:20
    Content type: Research Published on:

  3. In order to understand the interaction between the metabotropic glutamate subtype 5 (mGluR5) and N-methyl-D-aspartate (NMDA) receptors, the influence of mGluR5 positive modulators in the inhibition of NMDA rec...

    Authors: Hwei-Hsien Chen, Pei-Fei Liao and Ming-Huan Chan
    Citation: Journal of Biomedical Science 2011 18:19
    Content type: Research Published on:

  4. Myocardial ischemia/reperfusion injury is the major cause of morbidity and mortality for cardiovascular diseases. Dopamine D2 receptors are expressed in cardiac tissues. However, the roles of dopamine D2 receptor...

    Authors: Hong-zhu Li, Jin Guo, Jun Gao, Li-ping Han, Chun-ming Jiang, Hong-xia Li, Shu-zhi Bai, Wei-hua Zhang, Guang-wei Li, Li-na Wang, Hong Li, Ya-jun Zhao, Yan Lin, Ye Tian, Guang-dong Yang, Rui Wang…
    Citation: Journal of Biomedical Science 2011 18:18
    Content type: Research Published on:

  5. Fragile X syndrome (FXS), the most commonly inherited mental retardation and single gene cause of autistic spectrum disorder, occurs when the Fmr1 gene is mutated. The product of Fmr1, fragile X linked mental ...

    Authors: Se Jin Jeon, Jung Eun Seo, Sung-Il Yang, Ji Woong Choi, David Wells, Chan Young Shin and Kwang Ho Ko
    Citation: Journal of Biomedical Science 2011 18:17
    Content type: Research Published on:

  6. The extracellular calcium-sensing receptor (CaSR) belongs to family C of the G protein coupled receptors. Whether the CaSR is expressed in the pulmonary artery (PA) is unknown.

    Authors: Guang-wei Li, Qiu-shi Wang, Jing-hui Hao, Wen-jing Xing, Jin Guo, Hong-zhu Li, Shu-zhi Bai, Hong-xia Li, Wei-hua Zhang, Bao-feng Yang, Guang-dong Yang, Ling-yun Wu, Rui Wang and Chang-qing Xu
    Citation: Journal of Biomedical Science 2011 18:16
    Content type: Research Published on:

  7. Serum response factor (SRF) regulates certain microRNAs that play a role in cardiac and skeletal muscle development. However, the role of SRF in the regulation of microRNA expression and microRNA biogenesis in...

    Authors: Xiaomin Zhang, Gohar Azhar, Scott A Helms and Jeanne Y Wei
    Citation: Journal of Biomedical Science 2011 18:15
    Content type: Research Published on:

  8. Aging is a progressive process related to the accumulation of oxidative damage and neuroinflammation. We tried to find the anti-amnesic effect of the Scutellaria baicalens Georgia (SBG) ethanol extract and its ma...

    Authors: Kukhuon Jeong, Yong-Cheol Shin, Sunju Park, Jeong-Su Park, Namil Kim, Jae-Young Um, Hoyeon Go, Seungho Sun, Sundong Lee, Wansu Park, Youkyung Choi, Yunkyung Song, Gyungjun Kim, Chanyong Jeon, Jonghyeong Park, Keysang Lee…
    Citation: Journal of Biomedical Science 2011 18:14
    Content type: Research Published on:

  9. Traumatic spinal cord injury (SCI) forms a disadvantageous microenvironment for tissue repair at the lesion site. To consider an appropriate time window for giving a promising therapeutic treatment for subacut...

    Authors: Chih-Yen Wang, Jen-Kun Chen, Yi-Ting Wu, May-Jywan Tsai, Song-Kun Shyue, Chung-Shi Yang and Shun-Fen Tzeng
    Citation: Journal of Biomedical Science 2011 18:13
    Content type: Research Published on:

  10. The Cdc42-interacting protein-4, Trip10 (also known as CIP4), is a multi-domain adaptor protein involved in diverse cellular processes, which functions in a tissue-specific and cell lineage-specific manner. We...

    Authors: Chia-Chen Hsu, Yu-Wei Leu, Min-Jen Tseng, Kuan-Der Lee, Tzen-Yu Kuo, Jia-Yi Yen, Yen-Ling Lai, Yi-Chen Hung, Wei-Sheng Sun, Chien-Min Chen, Pei-Yi Chu, Kun-Tu Yeh, Pearlly S Yan, Yu-Sun Chang, Tim H-M Huang and Shu-Huei Hsiao
    Citation: Journal of Biomedical Science 2011 18:12
    Content type: Research Published on:

  11. Taurine has chemical structure similar to an inhibitory neurotransmitter, γ-aminobutyric acid (GABA). Previous studies on GABA in the stomach suggest GABAergic neuron is involved in acid secretion, but the eff...

    Authors: Kai-Han Huang, Chia-Chieh Chang, Jau-Der Ho, Ruey-Hwa Lu and Li Hsueh Tsai
    Citation: Journal of Biomedical Science 2011 18:11
    Content type: Research Published on:

  12. Transfer of full-length genes including regulatory elements has been the preferred gene therapy strategy for clinical applications. However, with significant drawbacks emerging, targeted gene alteration (TGA) ...

    Authors: Nanna M Jensen, Trine Dalsgaard, Maria Jakobsen, Roni R Nielsen, Charlotte B Sørensen, Lars Bolund and Thomas G Jensen
    Citation: Journal of Biomedical Science 2011 18:10
    Content type: Review Published on:

  13. Dystonia musculorum (dt) is an autosomal recessive hereditary neuropathy with a characteristic uncoordinated movement and is caused by a defect in the bullous pemphigoid antigen 1 (BPAG1) gene. The neural isoform...

    Authors: Kuang-Wen Tseng, Mei-Lin Peng, Yang-Cheng Wen, Kang-Jen Liu and Chung-Liang Chien
    Citation: Journal of Biomedical Science 2011 18:9
    Content type: Research Published on:

  14. Alzheimer's disease (AD) is the most common cause of dementia characterized by progressive cognitive impairment in the elderly people. The most dramatic abnormalities are those of the cholinergic system. Acety...

    Authors: Shin-Hua Lu, Josephine W Wu, Hsuan-Liang Liu, Jian-Hua Zhao, Kung-Tien Liu, Chih-Kuang Chuang, Hsin-Yi Lin, Wei-Bor Tsai and Yih Ho
    Citation: Journal of Biomedical Science 2011 18:8
    Content type: Research Published on:

  15. The physiological processes in the cell are regulated by reversible, electrostatic protein-protein interactions. Apoptosis is such a regulated process, which is critically important in tissue homeostasis and d...

    Authors: Halina Z Malina
    Citation: Journal of Biomedical Science 2011 18:7
    Content type: Research Published on:

  16. Hedgehog signalling has been implicated in prostate tumorigenesis in human subjects and mouse models, but its effects on transforming normal basal/stem cells toward malignant cancer stem cells remain poorly un...

    Authors: Han-Hsin Chang, Bo-Yie Chen, Chia-Yung Wu, Zih-Jay Tsao, Ying-Yu Chen, Chin-Pao Chang, Chi-Rei Yang and David Pei-Cheng Lin
    Citation: Journal of Biomedical Science 2011 18:6
    Content type: Research Published on:

  17. Parkinson's disease is characterized by progressive cell death in the substantia nigra pars compacta, which leads to dopamine depletion in the striatum and indirectly to cortical dysfunction. Increased glutama...

    Authors: MS Nandhu, Jes Paul, Korah P Kuruvilla, Anitha Malat, Chinthu Romeo and CS Paulose
    Citation: Journal of Biomedical Science 2011 18:5
    Content type: Research Published on:

  18. There are three apolipoprotein E (apoE) isoforms involved in human lipid homeostasis. In the present study, truncated apoE2-, apoE3- and apoE4-(72-166) peptides that are tailored to lack domain interactions ar...

    Authors: Yi-Hui Hsieh and Chi-Yuan Chou
    Citation: Journal of Biomedical Science 2011 18:4
    Content type: Research Published on:

  19. Targeting abnormal DNA methylation represents a therapeutically relevant strategy for cancer treatment as demonstrated by the US Food and Drug Administration approval of the DNA methyltransferase inhibitors az...

    Authors: Yi-Shiuan Lin, Arthur Y Shaw, Shi-Gang Wang, Chia-Chen Hsu, I-Wen Teng, Min-Jen Tseng, Tim HM Huang, Ching-Shih Chen, Yu-Wei Leu and Shu-Huei Hsiao
    Citation: Journal of Biomedical Science 2011 18:3
    Content type: Research Published on:

  21. Nijmegen breakage syndrome (NBS) is a chromosomal-instability syndrome associated with cancer predisposition, radiosensitivity, microcephaly, and growth retardation. The NBS gene product, NBS1 (p95) or nibrin,...

    Authors: Chung-Yin Wu, Chih-Ta Lin, Min-Zu Wu and Kou-Juey Wu
    Citation: Journal of Biomedical Science 2011 18:1
    Content type: Research Published on:

  23. The gibbon ape leukemia virus (GALV), the amphotropic murine leukemia virus (AMLV) and the human T-cell leukemia virus (HTLV) are retroviruses that specifically bind nutrient transporters with their envelope g...

    Authors: Emmanuelle Lagrue, Hiroyuki Abe, Madakasira Lavanya, Jawida Touhami, Sylvie Bodard, Sylvie Chalon, Jean-Luc Battini, Marc Sitbon and Pierre Castelnau
    Citation: Journal of Biomedical Science 2010 17:91
    Content type: Research Published on:

  24. Cytochrome b5 performs central roles in various biological electron transfer reactions, where difference in the redox potential of two reactant proteins provides the driving force. Redox potentials of cytochromes...

    Authors: Tomomi Aono, Yoichi Sakamoto, Masahiro Miura, Fusako Takeuchi, Hiroshi Hori and Motonari Tsubaki
    Citation: Journal of Biomedical Science 2010 17:90
    Content type: Research Published on:

  25. Sodium/iodide symporter (NIS) mediates the active transport and accumulation of iodide from the blood into the thyroid gland. His-226 located in the extracellular region of NIS has been demonstrated to be crit...

    Authors: Chia-Cheng Li, Tin-Yun Ho, Chia-Hung Kao, Shih-Lu Wu, Ji-An Liang and Chien-Yun Hsiang
    Citation: Journal of Biomedical Science 2010 17:89
    Content type: Research Published on:

  26. Effective vaccination against human papillomavirus (HPV) represents an opportunity to control cervical cancer. Peptide-based vaccines targeting HPV E6 and/or E7 antigens while safe, will most likely require ad...

    Authors: Chao-Yi Wu, Archana Monie, Xiaowu Pang, Chien-Fu Hung and T-C Wu
    Citation: Journal of Biomedical Science 2010 17:88
    Content type: Research Published on:

  27. Melanomas, highly malignant tumors arise from the melanocytes which originate as multipotent neural crest cells during neural tube genesis. The purpose of this study is to assess the pattern of neural differen...

    Authors: Bhanu Iyengar and Avantika V Singh
    Citation: Journal of Biomedical Science 2010 17:87
    Content type: Research Published on:

  28. Bacillus thuringiensis (Bt), an ubiquitous gram-positive spore-forming bacterium forms parasporal proteins during the stationary phase of its growth. Recent findings of selective human cancer cell-killing activit...

    Authors: Kanakeswary Krishnan, Jeremy Er An Ker, Shar Mariam Mohammed and Vishna Devi Nadarajah
    Citation: Journal of Biomedical Science 2010 17:86
    Content type: Research Published on:

  29. Prenatal ethanol exposure during pregnancy induces a spectrum of mental and physical disorders called fetal alcohol spectrum disorder (FASD). The central nervous system is the main organ influenced by FASD, an...

    Authors: Ki Chan Kim, Hyo Sang Go, Hae Rang Bak, Chang Soon Choi, Inha Choi, Pitna Kim, Seol-Heui Han, So Min Han, Chan Young Shin and Kwang Ho Ko
    Citation: Journal of Biomedical Science 2010 17:85
    Content type: Research Published on:

  30. Plumbagin is found in many herbal plants and inhibits the growth of various bacteria. Escherichia coli strains are relatively resistant to this drug. The mechanism of resistance is not clear. Previous findings sh...

    Authors: Ching-Nan Lin, Wan-Jr Syu, Wei-Sheng W Sun, Jenn-Wei Chen, Tai-Hung Chen, Ming-Jaw Don and Shao-Hung Wang
    Citation: Journal of Biomedical Science 2010 17:84
    Content type: Research Published on:

  31. To assess the effects of Glycine tomentella Hayata (GTH), a traditional herbal medicine for treatment of rheumatic diseases on the expression of the proinflammatory cytokines and on the clearance of apoptotic cel...

    Authors: Jia-Hau Yen, Deng-Jye Yang, Meng-Chi Chen, Yu-Fan Hsieh, Yu-Shu Sun and Gregory J Tsay
    Citation: Journal of Biomedical Science 2010 17:83
    Content type: Research Published on:

  32. Multicellular organisms are characterized by a remarkable diversity of morphologically distinct and functionally specialized cell types. Transgenic techniques for the manipulation of gene expression in specifi...

    Authors: Gerard Honig, Angela Liou, Miles Berger, Michael S German and Laurence H Tecott
    Citation: Journal of Biomedical Science 2010 17:82
    Content type: Research Published on:

  33. Idiopathic membranous nephropathy (IMN) is one of the most common forms of autoimmune nephritic syndrome in adults. The purpose of this study is to evaluate whether polymorphisms of PLA2R1 affect the development ...

    Authors: Yu-Huei Liu, Cheng-Hsu Chen, Shih-Yin Chen, Ying-Ju Lin, Wen-Ling Liao, Chang-Hai Tsai, Lei Wan and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2010 17:81
    Content type: Research Published on:

  34. Heme oxygenase-1 (HO-1) is a stress-inducible enzyme with diverse cytoprotective effects, and reported to have an important role in angiogenesis recently. Here we investigated whether HO-1 transduced by mesenc...

    Authors: Bin Zeng, Guosheng Lin, Xiaofeng Ren, Yan Zhang and Honglei Chen
    Citation: Journal of Biomedical Science 2010 17:80
    Content type: Research Published on:

  35. GM1 gangliosidosis (GM1) is an autosomal recessive lysosomal storage disease caused by deficiency of acid beta-galactosidase (GLB1; EC3.2.1.23). Here, we identify three novel mutations in the GLB1 gene from tw...

    Authors: Chi-Fan Yang, Jer-Yuarn Wu and Fuu-Jen Tsai
    Citation: Journal of Biomedical Science 2010 17:79
    Content type: Research Published on:

  36. Diabetes and stress stimulate hippocampal 5-HT synthesis, metabolism and release. The present study was carried out to find the effects of insulin, Aegle marmelose alone and in combination with pyridoxine on the ...

    Authors: Pretty Mary Abraham, Korah P Kuruvilla, Jobin Mathew, Anitha Malat, Shilpa Joy and CS Paulose
    Citation: Journal of Biomedical Science 2010 17:78
    Content type: Research Published on:

  37. Nasopharyngeal carcinoma (NPC) is commonly found in Southern China and South East Asia. Epstein-Barr virus (EBV) infection is well associated with NPC and has been implicated in its pathogenesis. Moreover, var...

    Authors: Peter Han-Chung Yee and Sai-Peng Sim
    Citation: Journal of Biomedical Science 2010 17:77
    Content type: Research Published on:

  39. We postulated that combining high-dose simvastatin with bone marrow derived-mesenchymal stem cells (MSCs) delivery may give better prognosis in a mouse hindlimb ischemia model.

    Authors: Yong Li, Dingguo Zhang, Yuqing Zhang, Guoping He and Fumin Zhang
    Citation: Journal of Biomedical Science 2010 17:75
    Content type: Research Published on:

  40. Pancreatic cancer is one of the most aggressive human tumors due to its high potential of local invasion and metastasis. The aim of this study was to characterize the membrane proteomes of pancreatic ductal ad...

    Authors: Xiaojun Liu, Min Zhang, Vay Liang W Go and Shen Hu
    Citation: Journal of Biomedical Science 2010 17:74
    Content type: Research Published on:

  41. Vulvar squamous cell carcinoma (VSCC) is a rare female genital neoplasm. Although numerous molecular changes have been reported in VSCC, biomarkers of clinical relevance are still lacking. On the other hand, t...

    Authors: Aleksandra Klemba, Magdalena Kowalewska, Wojciech Kukwa, Katarzyna Tonska, Aleksandra Szybinska, Malgorzata Mossakowska, Anna Scinska, Paweł Golik, Kamil Koper, Jakub Radziszewski, Andrzej Kukwa, Anna M Czarnecka and Ewa Bartnik
    Citation: Journal of Biomedical Science 2010 17:73
    Content type: Research Published on:

  42. Despite its clinical importance, a dearth of information exists on the cellular and molecular mechanisms that underpin brain stem death. A suitable neural substrate for mechanistic delineation on brain stem de...

    Authors: Kuang-Yu Dai, Samuel HH Chan and Alice YW Chang
    Citation: Journal of Biomedical Science 2010 17:72
    Content type: Research Published on:

  43. l-Dopa has been used for Parkinson's disease management for a long time. However, its wide variety in the rate and the extent of absorption remained challenge in designing suitable therapeutic regime. We report.....

    Authors: Chun-Li Wang, Yang-Bin Fan, Hsiao-Hwa Lu, Tung-Hu Tsai, Ming-Cheng Tsai and Hui-Po Wang
    Citation: Journal of Biomedical Science 2010 17:71
    Content type: Research Published on:

  44. Arsenic is a strong stimulus of heme oxygenase (HO)-1 expression in experimental studies in response to oxidative stress caused by a stimulus. A functional GT-repeat polymorphism in the HO-1 gene promoter was ...

    Authors: Meei-Maan Wu, Hung-Yi Chiou, Te-Chang Lee, Chi-Ling Chen, Ling-I Hsu, Yuan-Hung Wang, Wen-Ling Huang, Yi-Chen Hsieh, Tse-Yen Yang, Cheng-Yeh Lee, Ping-Keung Yip, Chih-Hao Wang, Yu-Mei Hsueh and Chien-Jen Chen
    Citation: Journal of Biomedical Science 2010 17:70
    Content type: Research Published on:

  46. In 1889 Dr. John Bland-Sutton, a prominent London surgeon, was consulted about fatal rickets in over 20 successive litters of lion cubs born at the London Zoo. He evaluated the diet and found the cause of rick...

    Authors: Russell W Chesney and Gail Hedberg
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S36
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  47. Prevalence of metabolic syndrome (MS) is rapidly increasing worldwide. To investigate the spread of MS risks and its relationship with eating habits including fish intake, we carried out a health examination f...

    Authors: Atsumi Hamada, Mari Mori, Hideki Mori, Alfa Muhihi, Marina Njelekela, Zablon Masesa, Jacob Mtabaji and Yukio Yamori
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S34
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  48. Cisplatin is a commonly used chemotherapeutic agent that has a major limitation because of its nephrotoxicity. We have demonstrated that cisplatin down-regulates the expression of the taurine transporter gene (Ta...

    Authors: Xiaobin Han and Russell W Chesney
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S28
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

  49. Arsenic exposure induces overproduction of reactive nitrogen species (RNS) in brain tissue and results in nucleic acid damage to the nerve cells. The 8-nitroguanine is one of the major products formed by the r...

    Authors: Ning Ma, Mikio Sasoh, Shosuke Kawanishi, Hiromichi Sugiura and Fengyuan Piao
    Citation: Journal of Biomedical Science 2010 17(Suppl 1):S7
    Content type: Review Published on:

    This article is part of a Supplement: Volume 17 Supplement 1

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Journal of Biomedical Science

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