https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-16-15
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https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-16-21
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https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-16-20
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