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  1. Research

    Dl-3-n-butylphthalide protects the heart against ischemic injury and H9c2 cardiomyoblasts against oxidative stress: involvement of mitochondrial function and biogenesis

    Myocardial infarction (MI) is an acute and fatal condition that threatens human health. Dl-3-n-butylphthalide (NBP) has been used for the treatment of acute ischemic stroke. Mitochondria may play a protective ...

    Xiaochao Tian, Weiliang He, Rong Yang and Yingping Liu

    Journal of Biomedical Science 2017 24:38

    Published on: 15 June 2017

  2. Review

    Quantitative proteomics in lung cancer

    Lung cancer is the most common cause of cancer-related death worldwide, less than 7% of patients survive 10 years following diagnosis across all stages of lung cancer. Late stage of diagnosis and lack of effec...

    Chantal Hoi Yin Cheung and Hsueh-Fen Juan

    Journal of Biomedical Science 2017 24:37

    Published on: 14 June 2017

  3. Review

    Metaproteomic analysis of human gut microbiota: where are we heading?

    The human gut is home to complex microbial populations that change dynamically in response to various internal and external stimuli. The gut microbiota provides numerous functional benefits that are crucial fo...

    Pey Yee Lee, Siok-Fong Chin, Hui-min Neoh and Rahman Jamal

    Journal of Biomedical Science 2017 24:36

    Published on: 12 June 2017

  4. Research

    Improving the regenerative potential of olfactory ensheathing cells by overexpressing prostacyclin synthetase and its application in spinal cord repair

    Olfactory ensheathing cells (OEC), specialized glia that ensheathe bundles of olfactory nerves, have been reported as a favorable substrate for axonal regeneration. Grafting OEC to injured spinal cord appears ...

    May-Jywan Tsai, Chi-Ting Huang, Yong-San Huang, Ching-Feng Weng, Song-Kun Shyue, Ming-Chao Huang, Dann-Ying Liou, Yan-Ru Lin, Chu-Hsun Cheng, Huai-Sheng Kuo, Yilo Lin, Meng-Jen Lee, Wen-Hung Huang, Wen-Cheng Huang and Henrich Cheng

    Journal of Biomedical Science 2017 24:34

    Published on: 25 May 2017

  5. Research

    Nintedanib antiangiogenic inhibitor effectiveness in delaying adenocarcinoma progression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP)

    In recent times, anti-cancer treatments have focused on Fibroblast Growth Factor (FGF) and Vascular-Endothelial Growth Factor (VEGF) pathway inhibitors so as to target tumor angiogenesis and cellular prolifera...

    Raquel Frenedoso da Silva, Ellen Nogueira-Pangrazi, Larissa Akemi Kido, Fabio Montico, Sarah Arana, Dileep Kumar, Komal Raina, Rajesh Agarwal and Valéria Helena Alves Cagnon

    Journal of Biomedical Science 2017 24:31

    Published on: 12 May 2017

  6. Research

    Adducin family proteins possess different nuclear export potentials

    The adducin (ADD) family proteins, namely ADD1, ADD2, and ADD3, are actin-binding proteins that play important roles in the stabilization of membrane cytoskeleton and cell-cell junctions. All the ADD proteins ...

    Chia-Mei Liu, Wen-Hsin Hsu, Wan-Yi Lin and Hong-Chen Chen

    Journal of Biomedical Science 2017 24:30

    Published on: 10 May 2017

  7. Research

    Differentiation of mesenchymal stem cells into cardiomyocytes is regulated by miRNA-1-2 via WNT signaling pathway

    Bone marrow derived stem cells (BMSCs) have the potential to differentiate into cardiomyocytes, but the rate of differentiation is low and the mechanism of differentiation is unclear completely. Here, we aimed...

    Xing Shen, Bo Pan, Huiming Zhou, Lingjuan Liu, Tiewei Lv, Jing Zhu, Xupei Huang and Jie Tian

    Journal of Biomedical Science 2017 24:29

    Published on: 10 May 2017

  8. Research

    KB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment

    Neonatal monosodium glutamate (MSG) treatment triggers excitotoxicity and induces a degenerative process that affects several brain regions in a way that could lead to epileptogenesis. Na+/Ca2+ exchangers (NCX1-3...

    Mariana Hernandez-Ojeda, Monica E. Ureña-Guerrero, Paola E. Gutierrez-Barajas, Jazmin A. Cardenas-Castillo, Antoni Camins and Carlos Beas-Zarate

    Journal of Biomedical Science 2017 24:27

    Published on: 9 May 2017

  9. Review

    Cancer immunotherapies targeting the PD-1 signaling pathway

    Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-ch...

    Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto and Tasuku Honjo

    Journal of Biomedical Science 2017 24:26

    Published on: 4 April 2017

  10. Research

    Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke

    Estrogen plays an important role as an anti-inflammatory and neuroprotective agent in ischemic stroke. In this study, we analyzed the effect of a polygenic risk score (PRS) constructed using inflammatory genes...

    Yi-Chen Hsieh, Fang-I Hsieh, Yih-Ru Chen, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Nai-Fang Chi, Huey-Juan Lin, Li-Ming Lien, Giia-Sheun Peng and Hung-Yi Chiou

    Journal of Biomedical Science 2017 24:25

    Published on: 28 March 2017

  11. Research

    Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88

    GPR88 is an orphan G protein-coupled receptor highly expressed in the striatum and is implicated in basal ganglia-associated disorders. However, the receptor functions of GPR88 are still largely unknown due to...

    Ann M. Decker, Elaine A. Gay, Kelly M. Mathews, Taylor C. Rosa, Tiffany L. Langston, Rangan Maitra and Chunyang Jin

    Journal of Biomedical Science 2017 24:23

    Published on: 27 March 2017

  12. Review

    Evaluation of the use of therapeutic peptides for cancer treatment

    Cancer along with cardiovascular disease are the main causes of death in the industrialised countries around the World. Conventional cancer treatments are losing their therapeutic uses due to drug resistance, ...

    Susan Marqus, Elena Pirogova and Terrence J. Piva

    Journal of Biomedical Science 2017 24:21

    Published on: 21 March 2017

  13. Research

    Selective activation of miRNAs of the primate-specific chromosome 19 miRNA cluster (C19MC) in cancer and stem cells and possible contribution to regulation of apoptosis

    The human chromosome 19 miRNA cluster (C19MC) of 43 genes is a primate-specific miRNA cluster that may have biological significance in the genetic complexity of the primate. Despite previous reports on individ...

    Phan Nguyen Nhi Nguyen, Chiu-Jung Huang, Shigeki Sugii, Soon Keng Cheong and Kong Bung Choo

    Journal of Biomedical Science 2017 24:20

    Published on: 7 March 2017

  14. Review

    State of the art in anti-cancer mAbs

    Following Milstein’s discovery, the monoclonal antibodies (mAbs) became a basic tool for biomedical science. In cancer field, since the first mAb was approved by the FDA a great improvement took place making o...

    S. M. Chiavenna, J. P. Jaworski and A. Vendrell

    Journal of Biomedical Science 2017 24:15

    Published on: 20 February 2017

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Journal of Biomedical Science is supported by the Ministry of Science and Technology (MOST), Taiwan.

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