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Table 1 Effects of ischemia-hypoxia and ischemia-hyperoxia in the fronto-parietal cortex of young rats

From: Region-specific effects on brain metabolites of hypoxia and hyperoxia overlaid on cerebral ischemia in young and old rats: a quantitative proton magnetic resonance spectroscopy study

Metabolite

Control

Ischemia-hypoxia

Ischemia-hyperoxia

Right

Left

Right

Left

Alanine

0.66 ± 0.05

0.60 ± 0.03

0.66 ± 0.09

0.39 ± 0.07*

0.60 ± 0.08

Choline

3.74 ± 0.22

3.47 ± 0.13

3.88 ± 0.15

3.73 ± 0.26

3.58 ± 0.16

Creatine

10.99 ± 0.50

11.90 ± 0.10

12.78 ± 0.75

11.44 ± 0.65

11.43 ± 0.44

GABA

2.16 ± 0.11

1.40 ± 0.08**

1.67 ± 0.34

1.53 ± 0.28*

1.88 ± 0.28

Glutamate

14.44 ± 0.45

13.88 ± 0.45*

15.96 ± 0.93

13.78 ± 0.80

13.98 ± 0.70

Lactate

11.88 ± 0.28

15.18 ± 0.29**

17.01 ± 1.00**

13.55 ± 1.10*

13.93 ± 0.23**

Myo-inositol

4.98 ± 0.62

6.47 ± 0.80

7.36 ± 0.40*

6.74 ± 0.26*

5.63 ± 0.24

N-acetylaspartate

10.29 ± 0.16

10.33 ± 0.40

12.08 ± 0.50**

10.41 ± 0.65

10.64 ± 0.60

  1. Concentrations of metabolites (mmol/kg w/w) in young rats, under normoxic condition (control), ischemia-hypoxia, and ischemia-hyperoxia. Data are means ± SE (n = 10 rats/group). Values, determined by proton MRS as outlined in the Methods, are given for the right (ipsilateral to cerebral ischemic injury) and left (contralateral) hemisphere. *P < 0.05 and **P < 0.01 compared with controls.