Platelet function and Isoprostane biology. Should Isoprostanes be the newest member of the Orphan-ligand family?

Table 1 A comparison between certain biological properties of TXA₂ and 8-iso-PGF_2α

Lipid	Half life (T_1/2)	Plasma Concentration (endogenous)	Method of synthesis	Receptors
TXA ₂	20-30 seconds¹¹¹	TXB₂ (1-66 pg/ml)¹¹³	Enzymatic²⁶	TPR_α & TPR_β³¹
8-iso-PGF _2α	1-10 minutes¹¹²	351-1831 pg/ml (dinordihydro metabolite)¹¹⁴	Non-emzymatic & enzymatic^73,115	TPR_α⁸⁰ & TPR_β^74,91 and ISR^70,74,97

ISSN: 1423-0127