From: Membrane proteomic analysis of pancreatic cancer cells
Protein name | Accession # | Unique peptides | Total peptides | Mr (KDa) | PI | Biological process |
---|---|---|---|---|---|---|
2-oxoglutarate dehydrogenase E1 component, mitochondrial | ODO1_HUMAN | 4 | 4 | 115.9 | 6.39 | Glycolysis |
3-ketoacyl-CoA thiolase, mitochondrial | THIM_HUMAN | 2 | 4 | 41.9 | 8.32 | Fatty acid metabolism Lipid metabolism |
78 kDa glucose-regulated protein | GRP78_HUMAN | 31 | 91 | 72.3 | 5.07 | ER-associated protein catabolic process ER unfolded protein response ER regulation of protein folding |
Adenylate kinase 2, mitochondrial | KAD2_HUMAN | 4 | 7 | 26.5 | 7.67 | Nucleotide/nucleic acid metabolic process |
ADP/ATP translocase 2 | ADT2_HUMAN | 2 | 5 | 32.9 | 9.76 | Transmembrane transporter activity |
Alpha-aminoadipic semialdehyde dehydrogenase | AL7A1_HUMAN | 2 | 2 | 55.3 | 6.44 | Cellular aldehyde metabolic process; oxidation reduction |
Alpha-enolase | ENOA_HUMAN | 3 | 5 | 47.1 | 7.01 | Glycolysis |
Annexin A1 | ANXA1_HUMAN | 4 | 5 | 38.7 | 6.57 | Anti-apoptosis; Exocytosis; Lipid metabolic process |
Aspartate aminotransferase, mitochondrial precursor | AATM_HUMAN | 2 | 7 | 47.4 | 9.14 | Lipid transport |
ATP synthase subunit alpha, mitochondrial | ATPA_HUMAN | 3 | 6 | 59.7 | 9.16 | ATP synthesis |
ATP synthase subunit beta, mitochondrial | ATPB_HUMAN | 4 | 13 | 56.5 | 5.26 | ATP synthesis |
ATP synthase subunit d, mitochondrial | ATP5H_HUMAN | 2 | 4 | 18.5 | 5.21 | ATP synthesis; Ion transport |
ATP synthase subunit gamma, mitochondrial | ATPG_HUMAN | 2 | 3 | 33 | 9.23 | ATP synthesis; Proton transport |
ATP synthase subunit O, mitochondrial | ATPO_HUMAN | 2 | 3 | 23.3 | 9.97 | ATP synthesis; Ion transport ATP catabolic process |
Calcium-binding mitochondrial carrier protein Aralar2 | CMC2_HUMAN | 2 | 4 | 74.1 | 7.14 | Mitochondrial aspartate and glutamate carrier |
Citrate synthase, mitochondrial; | CISY_HUMAN | 3 | 5 | 51.7 | 8.45 | Tricarboxylic acid cycle |
Cytochrome b-c1 complex subunit 1, mitochondrial | QCR1_HUMAN | 3 | 5 | 52.6 | 5.94 | Electron transport |
Cytochrome b-c1 complex subunit 2, mitochondrial | QCR2_HUMAN | 2 | 2 | 48.4 | 8.74 | Aerobic respiration; Electron transport chain; Oxidative phosphorylation |
Cytochrome c oxidase subunit 2 | COX2_HUMAN | 2 | 4 | 25.5 | 4.67 | Electron transport chain |
Cytochrome c oxidase subunit 5B, mitochondrial precursor | COX5B_HUMAN | 2 | 2 | 13.7 | 9.07 | Respiratory gaseous exchange |
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor | ECH1_HUMAN | 2 | 6 | 35.8 | 8.16 | Fatty acid metabolism; Lipid metabolism |
Delta-1-pyrroline-5-carboxylate synthetase | P5CS_HUMAN | 2 | 3 | 87.2 | 6.66 | Amino-acid biosynthesis; Proline biosynthesis |
Dihydrolipoyl dehydrogenase, mitochondrial | DLDH_HUMAN | 5 | 13 | 54.1 | 7.95 | Cell redox homeostasis |
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial | ODO2_HUMAN | 3 | 6 | 48.6 | 9.01 | Tricarboxylic acid cycle |
Electron transfer flavoprotein subunit alpha, mitochondrial | ETFA_HUMAN | 3 | 7 | 35.1 | 8.62 | Electron transport |
Electron transfer flavoprotein subunit beta | ETFB_HUMAN | 2 | 3 | 27.8 | 8.25 | Electron transport |
Endoplasmin | ENPL_HUMAN | 16 | 31 | 92.4 | 4.76 | ER-associated protein catabolic process; protein folding/transport; response to hypoxia |
Enoyl-CoA hydratase, mitochondrial | ECHM_HUMAN | 3 | 12 | 31.4 | 8.34 | Fatty acid metabolism; Lipid metabolism |
ERO1-like protein alpha precursor | ERO1A_HUMAN | 2 | 3 | 54.4 | 5.48 | Electron transport |
Glucosidase 2 subunit beta | GLU2B_HUMAN | 2 | 5 | 59.4 | 4.33 | ER protein kinase cascade |
Glutamate dehydrogenase 1, mitochondrial | DHE3_HUMAN | 2 | 2 | 61.4 | 7.66 | Glutamate metabolism |
Glyceraldehyde-3-phosphate dehydrogenase | G3P_HUMAN | 2 | 2 | 36 | 8.57 | Glycolysis |
Glycerol-3-phosphate dehydrogenase, mitochondrial | GPDM_HUMAN | 2 | 4 | 80.8 | 7.23 | Glycolysis |
Heme oxygenase 2 | HMOX2_HUMAN | 2 | 4 | 36 | 5.31 | Heme oxidation; Oxidation reduction; Response to hypoxia |
Hexokinase-1 | HXK1_HUMAN | 2 | 3 | 102.4 | 6.36 | Glycolysis |
L-2-hydroxyglutarate dehydrogenase, mitochondrial | L2HDH_HUMAN | 2 | 2 | 50.3 | 8.57 | Cellular protein metabolic process; Oxidation reduction |
Lon protease homolog, mitochondrial | LONM_HUMAN | 2 | 2 | 106.4 | 6.01 | Required for intramitochondrial proteolysis |
Long-chain-fatty-acid--CoA ligase 3 | ACSL3_HUMAN | 2 | 3 | 80.4 | 8.65 | Fatty acid metabolism; Lipid metabolism |
Long-chain-fatty-acid--CoA ligase 4 | ACSL4_HUMAN | 2 | 3 | 79.1 | 8.66 | Fatty acid metabolism; Lipid metabolism |
Malate dehydrogenase, mitochondrial | MDHM_HUMAN | 3 | 4 | 35.5 | 8.92 | TCA glycolysis |
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | ACADM_HUMAN| | 2 | 3 | 46.6 | 8.61 | Fatty acid metabolism; Lipid metabolism |
Methylenetetrahydrofolate reductase | MTHR_HUMAN | 2 | 2 | 74.5 | 5.22 | Methionine metabolic process; Oxidation reduction |
Mitochondrial 2-oxoglutarate/malate carrier protein | M2OM_HUMAN | 2 | 2 | 34 | 9.92 | Transport |
Mitochondrial import receptor subunit TOM40 homolog | TOM40_HUMAN | 3 | 3 | 37.9 | 6.79 | Ion transport; Protein transport |
Neutral alpha-glucosidase AB | GANAB_HUMAN | 7 | 10 | 106.8 | 5.74 | Carbohydrate metabolic process |
Neutral cholesterol ester hydrolase 1 | ADCL1_HUMAN | 2 | 4 | 45.8 | 6.76 | Lipid degradation |
Ornithine aminotransferase, mitochondrial precursor | OAT_HUMAN | 4 | 6 | 48.5 | 6.57 | Mitochondrial matrix protein binding |
Phosphoenolpyruvate carboxykinase, mitochondrial | PPCKM_HUMAN | 2 | 3 | 70.6 | 7.56 | Gluconeogenesis |
Protein disulfide-isomerase | PDIA1_HUMAN | 8 | 14 | 57.1 | 4.76 | Cell redox homeostasis |
Protein disulfide-isomerase A3 | PDIA3_HUMAN | 16 | 25 | 56.7 | 5.98 | Cell redox homeostasis |
Protein disulfide-isomerase A4 | PDIA4_HUMAN | 7 | 11 | 72.9 | 4.96 | Cell redox homeostasis; Protein secretion |
Protein disulfide-isomerase A6 | PDIA6_HUMAN | 2 | 4 | 48.1 | 4.95 | Cell redox homeostasis; Protein folding |
Pyruvate kinase isozymes M1/M2 | KPYM_HUMAN | 5 | 7 | 57.9 | 7.96 | Glycolysis; Programmed cell death |
Serine hydroxymethyltransferase, mitochondrial precursor | GLYM_HUMAN | 2 | 4 | 56 | 8.76 | L-serine metabolic process; Glycine metabolic process; One-carbon metabolic process |
Sterol regulatory element-binding protein 2 | SRBP2_HUMAN | 2 | 2 | 123.6 | 8.72 | Cholesterol metabolism; Lipid metabolism; Steroid metabolism; |
Succinate dehydrogenase flavoprotein subunit, mitochondrial | DHSA_HUMAN | 3 | 10 | 72.6 | 7.06 | Electron transport; Tricarboxylic acid cycle |
Succinyl-CoA:3-ketoacid-coenzyme A transferase 1 | SCOT_HUMAN | 2 | 5 | 56.1 | 7.13 | Ketone body catabolic process |
Sulfide:quinone oxidoreductase, mitochondrial | SQRD_HUMAN | 6 | 9 | 49.9 | 9.18 | Oxidation reduction |
Superoxide dismutase [Mn], mitochondrial | SODM_HUMAN | 2 | 5 | 24.7 | 8.35 | Elimination of radicals |
Transmembrane emp24 domain-containing protein 10 | TMEDA_HUMAN | 2 | 3 | 25 | 6.98 | ER-Golgi protein transport |
Trifunctional enzyme subunit alpha, mitochondrial | ECHA_HUMAN | 4 | 7 | 82.9 | 9.16 | Fatty acid metabolism; Lipid metabolism |
Trifunctional enzyme subunit beta, mitochondrial | ECHB_HUMAN | 2 | 4 | 51.3 | 9.45 | Fatty acid metabolism |