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Figure 4 | Journal of Biomedical Science

Figure 4

From: mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway

Figure 4

PKC inhibitor influences the effects of mGluR5 modulators on NMDA receptor activation and suppression. Pretreatment of hippocampal slices with chelerythrine (10 μM), a PKC inhibitor, inhibited the enhancing effects of DFB (10 μM), CHPG (50 μM), and CDPPB (10 μM) on NMDA-induced field potentials (a) and reversed the attenuating effects of mGluR5 modulators on ketamine (b, 10 μM) or D-APV (c, 50 μM)-evoked NMDA receptor suppression. All values are expressed as the mean ± S.E.M. (n = 5). Data were statistically analyzed by one-way ANOVA followed by a Student-Newman-Keuls post-hoc test.

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Journal of Biomedical Science

ISSN: 1423-0127