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Table 1 The ten most upregulated and down regulated primary epithelial genes in response to stroma, in 3D culture

From: Stromal upregulation of lateral epithelial adhesions: Gene expression analysis of signalling pathways in prostate epithelium

Gene Symbol

Gene Title

Fold change

Probe ID

FGFBP1

fibroblast growth factor binding protein 1

3.078

H300006842

OR4N5

olfactory receptor, family 4, subfamily N, member 5

2.993

opHsV0400002653

KLRC4

killer cell lectin-like receptor subfamily C, member 4

2.735

H300021805

TESSP1

testis serine protease 1

2.656

opHsV0400002778

KT3K

Ketosamine-3-kinase

2.528

H200004088

KLRC1

killer cell lectin-like receptor subfamily C, member 1

2.420

H200005914

SNX12

sorting nexin 12

2.330

H200009199

PABPC1

poly(A) binding protein, cytoplasmic 1

2.323

H200014179

DNMBP

Dynamin binding protein

2.282

opHsV0400003719

MSH4

mutS homolog 4

2.265

H200011946

IL23R

interleukin 23 receptor

-2.489

H300020818

DYNC2LI1

dynein 2 light intermediate chain isoform 1

-2.553

opHsV0400000277

KRT6B

keratin 6B

-2.560

H300014335

SAA1

serum amyloid A1

-2.600

opHsV0400005893

TOP1

topoisomerase (DNA) I

-2.844

opHsV0400006965

PTPLAD1

protein tyrosine phosphatase domain containing 1

-2.859

H300003447

SEMA3C

sema domain, secreted 3C

-3.412

H200008006

KRT23

keratin 23

-3.552

H300014341

C3

complement component 3

-3.553

H20000880

MAGI1

membrane associated guanylate kinase, WWW and PDZ domain containing 1

-4.678

H200002533

  1. Values are the mean fold expression changes of ten primary epithelial cell cultures, abstracted from Operon datasets. All genes showed significant differential expression (p < 0.05). Positive values indicate up regulation, negative values indicate down regulation of epithelial genes cultured with stroma compared to without stroma. Hypothetical or unassigned genes were removed from the list.