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Table 2 Scatchard Analysis of Glutamate receptors using [3H]Glutamate binding against glutamate in the Cerebral cortex of experimental rats

From: Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of Unilateral 6-hydroxydopamine induced Parkinson's rats: Effect of 5-HT, GABA and bone marrow cell supplementation

Animal Status

Bmax (fmoles/mg protein)

Kd (nM)

Control

1584.04 ± 14.12

146.39 ± 16.41

6-OHDA

3598.40 ± 35.88a

138.58 ± 17.12

6-OHDA +5HT

1892.12 ± 18.41b,f

131.24 ± 19.85

6-OHDA +GABA

1984.05 ± 24.25b,f

128.12 ± 18.24

6-OHDA +BMC

3295.12 ± 29.12a, f

145.15 ± 11.22

6-OHDA +5HT + BMC

1775.41 ± 13.65b,e

125.13 ± 18.14

6-OHDA + GABA + BMC

1776.11 ± 14.21b,e

124.22 ± 22.11

6-OHDA +5HT + GABA+ BMC

1711.51 ± 10.18c,d

155.23 ± 15.26

  1. Values are Mean ± S.E.M of 4-6 separate experiments. Each group consist 6-8 rats.
  2. Bmax - Maximal binding; Kd - Dissociation constant
  3. a p < 0.001, b p < 0.01, c P < 0.05 when compared to Control
  4. d p < 0.001, e p < 0.01, f P < 0.05 when compared to 6-OHDA group.
  5. C - Control, 6-OHDA - 6-OHDA infused, 6-OHDA +5-HT - 6-OHDA infused treated with Serotonin, 6-OHDA +GABA - 6-OHDA infused treated with GABA, 6-OHDA +BMC- 6-OHDA infused treated with BMC, 6-OHDA +5-HT+BMC- 6-OHDA infused treated with Serotonin and BMC, 6-OHDA + GABA +BMC- 6-OHDA infused treated with GABA and BMC, 6-OHDA +5-HT + GABA+ BMC- 6-OHDA infused treated with Serotonin, GABA and BMC.
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Journal of Biomedical Science

ISSN: 1423-0127