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Figure 5 | Journal of Biomedical Science

Figure 5

From: The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat

Figure 5

Sympathoexcitation is attenuated with MF. (A) Sympathoexcitation elicited by NaCN (arrows) during control (A), with MF (B) and after washout (C). Sympathoexcitation is attenuated with MF, this effect is reversed upon washout (D) (n = 12). Sympathoexcitation in all conditions is accompanied by increased PND rate. (E) Analysis of the respiratory related sympathetic bursts reveals the increase in ∫SND upon chemoreceptor stimulation is significantly attenuated during both the inspiratory and expiratory phase of the PND cycle in comparison to control. (Values are normalised from baseline values at 100%). Asterisks denote significance; NS: not significant.

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Journal of Biomedical Science

ISSN: 1423-0127