| Zinc-binding Signature | Met-turn |
---|
ADAM | TAAHQLGHVFNMLHDNSK | PLSTSRHVMAPVMAHVD |
Astacin | TIIHELMHAIGFYHEHT | EDYQYYSIMHYGKYSFS |
Adamalysin II | TMAHELGHNLGMEHDGK | LRGASLCIMRPGLTPGR |
Matrilysin | AATHELGHSLGMGHSSD | HSSDPNAVMYPTYGNGD |
- Only the sections containing the zinc-binding histidine residues and the Met-loop areshown. The histidine zinc-ligands, the catalytically active glutamic acid residue, the residue directly following the third His ligand, the conserved Met residue, and the two positions after the Met are in.
- a Pseudomonas aeruginosa alkaline proteinase.
- b 3.4.24.11 protease.
- PDB code: (ADAM: 2RJP[20], Astacin: 1QJI[21], Adamlysin II: 2AIG[22], HumanMMP-7: 1MMR[3], P. aeruginosa alkaline protease: 1AKL[23], 3.4.24.11 protease: 1THL[10].)