Table 1 Role of plasmalemmal Ca ²⁺ channels in cell migration and tumor metastasis

Store-dependent SOC channels

STIM1-Orai1

• Human cervical cancer SiHa and CaSki cells

• Increase in EGF-stimulated cellular migration and invasion

• Increase in focal adhesion dynamics through the Ca²⁺-regulated protease calpain and cytoplasmic kinase Pyk2

• Upregulation of EGF-induced MLC phosphorylation and actomyosin reorganization

• Upregulation of VEGF production

• Promotion of tumor growth and angiogenesis in a xenograft mice model

• Human breast cancer MDA-MB-231 cells and mouse mammary tumor 4 T1 cells

• Increase in serum-induced cellular migration and invasion

• Increase in focal adhesion turnover rates through Ras and Rac1

• Promotion of tumor growth and metastasis in a xenograft mice model

STIM-Orai3

• Human breast cancer MCF7 cells (ER⁺ breast cancer cells)

• Increase in anchorage-independent growth and Matrigel invasion

• Increase in tumorigenesis in a xenograft mice model

Store-independent SOC channel

SPCA2-Orai1

• Human breast cancer MCF-7 cells

• Constitutively active store-independent Ca²⁺ influx

• Promotion of proliferation and colony formation

• Increase in tumorigenesis in a xenograft mice model

TRP channels

TRPM1

• Murine melanoma B16-F1 cells

• Reduce in tumor metastasis

TRPM7

• Human breast cancer MDA-MB-231 cells and MEF cells

• Increase in cellular migration

• Guidance of polarized cellular migration

• Increase in peripheral focal adhesion turnovers through the Ca²⁺-regulated protease m-calpain

• Inhibition of myosin II-based cell contractility

• Increase in tumorigenesis in a xenograft mice model

• Human nasopharyngeal cancer 5-8 F and 6-10B cells

• Increase in cellular migration

• Human lung cancer A549 cells

• Increase in EGF-stimulated cellular migration

TRPM8

• Human prostate cancer PC-3 cells

• Decrease in cellular migration

• Inactivation of FAK

TRPV1

• Human hepatoblastoma HepG2 cells

• Increase in HGF-stimulated cellular migration

TRPV2

• Human prostate cancer LNCaP and PC-3 cells

• Increase in cellular migration and invasion

• Induction of invasive enzymes MMP-2, MMP-9 and cathepsin B

• Increase in tumorigenesis in a xenograft mice model

TRPC6

• Human glioblastoma cells

• Increase in cell proliferation through regulation of CDK1 activation and Cdc25C expression

• Increase in anchorage-independent growth and Matrigel invasion

• Increase in endothelial cell tube formation

• Increase in tumorigenesis in a xenograft mice model