| Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | ||
Age# | ≤30 | NA§ |  | NA§ |  |
 | 31-40 | 1 (reference) |  | 1 (reference) |  |
 | 41-50 | 0.88 (0.43–1.81) | 0.721 | 0.64 (0.25–1.62) | 0.343 |
 | 51-60 | 0.67 (0.31–1.47) | 0.318 | 0.83 (0.32–2.15) | 0.705 |
 | 61-70 | 1.17 (0.52–2.66) | 0.704 | 0.96 (0.30–3.08) | 0.949 |
 | ≥71 | 0.51 (0.11–2.29) | 0.376 | 0.52 (0.06–4.73) | 0.564 |
Alcohol# | No | 1 (reference) | Â | 1 (reference) | Â |
 | Yes | 1.03 (0.62–1.74) | 0.899 | 1.07 (0.54–2.11) | 0.842 |
Smoking# | No | 1 (reference) | Â | 1 (reference) | Â |
 | Yes | 1.44 (0.71–2.93) | 0.315 | 1.98 (0.79–4.97) | 0.145 |
Betel nut# | No | 1 (reference) | Â | 1 (reference) | Â |
 | Yes | 1.64 (0.83–3.26) | 0.156 | 1.00 (0.42–2.37) | 0.999 |
TNM staging# | 1 | 1 (reference) | Â | 1 (reference) | Â |
 | 2 | 1.18 (0.50–2.78) | 0.703 | 0.76 (0.26–2.23) | 0.618 |
 | 3 | 2.35 (0.95–5.86) | 0.066 | 2.16 (0.78–6.02) | 0.140 |
 | 4 | 4.21 (2.12–8.40) | <0.001 | 3.53 (1.41–8.81) | 0.007 |
EGFR | Negative | 1 (reference) | Â | Â | Â |
 | Positive | 1.19 (0.70–2.02) | 0.516 | NA |  |
EGFR GCN | Non-amplified | 1 (reference) | Â | Â | Â |
 | Amplified | 0.94 (0.57–1.57) | 0.822 | NA |  |
EGFRvIII# | Low | 1 (reference) | Â | Â | Â |
 | High | 2.27 (1.36–3.79) | 0.002 | 1.98 (1.01–3.87) | 0.046 |
PTEN | Negative | 1 (reference) | Â | Â | Â |
 | Positive | 1.26 (0.77–2.08) | 0.359 | NA |  |
pAKT# | Negative | 1 (reference) | Â | Â | Â |
 | Positive | 2.51 (1.00–6.27) | 0.050 | 2.67 (1.01–7.07) | 0.049 |