Type of cell | Stimuli inducing production of ROS | Phosphorylation pathways | Transcription factors | Effects of ROS in target cells | Ref.: |
---|---|---|---|---|---|
Endothelial cells | Ang II | ERKs, JNKs | NFκB | Apoptosis | |
p38-MAPKs | Â | Dysfunction | |||
Vascular smooth muscle cells | PDGF, phenylephrine, thrombin | MAPKs | NFκB | Proliferation | |
Ang II | p38-MAPK | NFκB? | Hypertrophy, migration | ||
Ang II | PI3K/Akt | Â | |||
ET-1 | |||||
Shear stress | |||||
Cardiomyocytes | Ang II | MAPKs | NFκB | Hypertrophy, inflammation, necrosis, apoptosis | [20] |
ET-1 | PI3K/Akt | AP-1 | |||
NE | Â | p53 | |||
Mechanical stress | |||||
Central cardiovascular neurons | Ang II | p38-MAPK, | ?? | Increased sympathetic nerve activity, vasopressin release, drinking behavior | |
 | ERK 1/2 |  | |||
PLC/IP3 ? | |||||
(or NO ?) | |||||
Cells of kidney | Ang II | MAPKs | Â | Augmentation of epithelial-mesenchymal transition, mesangial cells apoptosis, hypertrophy | [42] |
Aldosterone | ERK1/2 | ||||
Chemokines |