Figure 3From: Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implicationsDevices used to carry out in vitro studies to examine the influence of flow (shear stress) on ECs. (A) Parallel-plate flow chamber. In a parallel-plate flow chamber system ECs monolayers are exposed to well-defined flow and thus shear stress (denoted by Ï„) in a small channel with fixed height. (B) Cone-and-plate flow chamber. In a cone-and-plate flow chamber system ECs monolayers are exposed to shear stress (Ï„) generated by a rotating cone. The magnitude of shear stress can be calculated using the respective formula shown in A and B.Back to article page